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Plant Name: Vitex negundo




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
DRD4; FFAR1; FFAR4; ADORA3; ADORA2A; ADORA1; HCAR2;
Peptide receptor (family A GPCR)
TSHR; NPSR1; CXCR1;
Enzyme_unclassified
ALPL; PLA2G1B; TDP1; BLM; FAAH; RECQL; TERT; TK1; ADK; PIK3R1; GLO1; HPGD; HSD11B1; MPO; HSD17B1; AKR1B1; HSD17B10; ALOX15; ALDH1A1; HSD17B2; ALOX12; GFER; AKR1B10; NOX4; TNKS; PARP1; TNKS2; PYGL; APEX1; POLB; AOX1; CD38;
Hydrolase
MGAM; ACHE; GAA;
Protein Phosphatase
PTPN1;
Potassium channels
KCNH2;
Miscellaneous ion channel
BCL2;
Protein Kinase
MET; CAMK2B; NEK6; CSNK2A1; AKT1; DAPK1; FLT3; ABL1; SRC; IGF1R; PTK2; AURKB; GSK3B; CDK1; MAPK1; EGFR; PIM1; NUAK1; ALK; AXL; NEK2; KDR; PKN1;
Lyase
CA6; CA12; CA5A; CA3; CA14; CA5B; CA1; CA9; CA13; CA7; CA4; CA2;
Nuclear hormone receptor subfamily 1 group I
NR1I2;
Nuclear hormone receptor subfamily 3 group B
ESRRB; ESRRA;
Nuclear hormone receptor subfamily 1 group C
PPARA; PPARG; PPARD;
Nuclear hormone receptor subfamily 3 group A
ESR1; ESR2;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; PTGS1; XDH;
Cysteine protease
CASP7; CASP1;
Metallo protease
MMP13; MMP12; MMP3; MMP2; MMP9; MMP1;
Aspartic protease
BACE1;
Toll-like and Il-1 receptors
TLR2;
Transcription Factor
STAT6; HIF1A; NFKB1; TP53;
Transferase
FUT7;
SLC superfamily of solute carriers
SLC28A2; SLC28A1; SLC28A3; SLCO1B3; SLCO1B1;
ATP-binding cassette
ABCC1; ABCG2;
Unclassified
LMNA; FABP5; FABP2; FABP4; MCL1; MAPT; FABP3; HTT; THPO; RAB9A; NPC1; APP; TTR;
Methyl-lysine/arginine binding protein
L3MBTL1; SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: TBXAS1; CYP1A2; CYP19A1; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Cysteine protease CASP7 Caspase-7 P55210 CHEMBL3468
Cysteine protease CASP1 Caspase-1 P29466 CHEMBL4801
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Cytochrome P450 family 5 TBXAS1 Thromboxane-A synthase P24557 CHEMBL1835
Enzyme_unclassified TNKS2 Tankyrase-2 Q9H2K2 CHEMBL6154
Enzyme_unclassified PYGL Liver glycogen phosphorylase P06737 CHEMBL2568
Enzyme_unclassified APEX1 DNA-(apurinic or apyrimidinic site) lyase P27695 CHEMBL5619
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Enzyme_unclassified AOX1 Aldehyde oxidase Q06278 CHEMBL3257
Enzyme_unclassified CD38 Lymphocyte differentiation antigen CD38 P28907 CHEMBL4660
Enzyme_unclassified ALPL Alkaline phosphatase, tissue-nonspecific isozyme P05186 CHEMBL5979
Enzyme_unclassified PLA2G1B Phospholipase A2 group 1B P04054 CHEMBL4426
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified BLM Bloom syndrome protein P54132 CHEMBL1293237
Enzyme_unclassified FAAH Anandamide amidohydrolase O00519 CHEMBL2243
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified TERT Telomerase reverse transcriptase O14746 CHEMBL2916
Enzyme_unclassified TK1 Thymidine kinase, cytosolic P04183 CHEMBL2883
Enzyme_unclassified ADK Adenosine kinase P55263 CHEMBL3589
Enzyme_unclassified PIK3R1 PI3-kinase p85-alpha subunit P27986 CHEMBL2506
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] P15428 CHEMBL1293255
Enzyme_unclassified HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 P28845 CHEMBL4235
Enzyme_unclassified MPO Myeloperoxidase P05164 CHEMBL2439
Enzyme_unclassified HSD17B1 Estradiol 17-beta-dehydrogenase 1 P14061 CHEMBL3181
Enzyme_unclassified AKR1B1 Aldose reductase P15121 CHEMBL1900
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified ALDH1A1 Aldehyde dehydrogenase 1A1 P00352 CHEMBL3577
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified GFER FAD-linked sulfhydryl oxidase ALR P55789 CHEMBL1741189
Enzyme_unclassified AKR1B10 Aldo-keto reductase family 1 member B10 O60218 CHEMBL5983
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified TNKS Tankyrase-1 O95271 CHEMBL6164
Enzyme_unclassified PARP1 Poly [ADP-ribose] polymerase-1 P09874 CHEMBL3105
Hydrolase MGAM Maltase-glucoamylase O43451 CHEMBL2074
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Hydrolase GAA Lysosomal alpha-glucosidase P10253 CHEMBL2608
Lyase CA6 Carbonic anhydrase VI P23280 CHEMBL3025
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA5A Carbonic anhydrase VA P35218 CHEMBL4789
Lyase CA3 Carbonic anhydrase III P07451 CHEMBL2885
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA5B Carbonic anhydrase VB Q9Y2D0 CHEMBL3969
Lyase CA1 Carbonic anhydrase I P00915 CHEMBL261
Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Lyase CA13 Carbonic anhydrase XIII Q8N1Q1 CHEMBL3912
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP13 Matrix metalloproteinase 13 P45452 CHEMBL280
Metallo protease MMP12 Matrix metalloproteinase 12 P39900 CHEMBL4393
Metallo protease MMP3 Matrix metalloproteinase 3 P08254 CHEMBL283
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Metallo protease MMP1 Matrix metalloproteinase-1 P03956 CHEMBL332
Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 Q9Y468 CHEMBL1287622
Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein Q16637 CHEMBL1293232
Miscellaneous ion channel BCL2 Apoptosis regulator Bcl-2 P10415 CHEMBL4860
Nuclear hormone receptor subfamily 1 group C PPARA Peroxisome proliferator-activated receptor alpha Q07869 CHEMBL239
Nuclear hormone receptor subfamily 1 group C PPARG Peroxisome proliferator-activated receptor gamma P37231 CHEMBL235
Nuclear hormone receptor subfamily 1 group C PPARD Peroxisome proliferator-activated receptor delta Q03181 CHEMBL3979
Nuclear hormone receptor subfamily 1 group I NR1I2 Pregnane X receptor O75469 CHEMBL3401
Nuclear hormone receptor subfamily 3 group A ESR1 Estrogen receptor alpha P03372 CHEMBL206
Nuclear hormone receptor subfamily 3 group A ESR2 Estrogen receptor beta Q92731 CHEMBL242
Nuclear hormone receptor subfamily 3 group B ESRRB Estrogen-related receptor beta O95718 CHEMBL3751
Nuclear hormone receptor subfamily 3 group B ESRRA Estrogen-related receptor alpha P11474 CHEMBL3429
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase P09917 CHEMBL215
Oxidoreductase PTGS1 Cyclooxygenase-1 P23219 CHEMBL221
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A P25024 CHEMBL4029
Potassium channels KCNH2 HERG Q12809 CHEMBL240
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase CAMK2B CaM kinase II beta Q13554 CHEMBL4121
Protein Kinase NEK6 Serine/threonine-protein kinase NEK6 Q9HC98 CHEMBL4309
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Protein Kinase AKT1 Serine/threonine-protein kinase AKT P31749 CHEMBL4282
Protein Kinase DAPK1 Death-associated protein kinase 1 P53355 CHEMBL2558
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase ABL1 Tyrosine-protein kinase ABL P00519 CHEMBL1862
Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase GSK3B Glycogen synthase kinase-3 beta P49841 CHEMBL262
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Protein Kinase EGFR Epidermal growth factor receptor erbB1 P00533 CHEMBL203
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Protein Kinase ALK ALK tyrosine kinase receptor Q9UM73 CHEMBL4247
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 P51955 CHEMBL3835
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase PKN1 Protein kinase N1 Q16512 CHEMBL3384
Protein Phosphatase PTPN1 Protein-tyrosine phosphatase 1B P18031 CHEMBL335
SLC superfamily of solute carriers SLC28A2 Sodium/nucleoside cotransporter 2 O43868 CHEMBL5780
SLC superfamily of solute carriers SLC28A1 Sodium/nucleoside cotransporter 1 O00337 CHEMBL5551
SLC superfamily of solute carriers SLC28A3 Solute carrier family 28 member 3 Q9HAS3 CHEMBL5707
SLC superfamily of solute carriers SLCO1B3 Solute carrier organic anion transporter family member 1B3 Q9NPD5 CHEMBL1743121
SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 Q9Y6L6 CHEMBL1697668
Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor P21917 CHEMBL219
Small molecule receptor (family A GPCR) FFAR1 Free fatty acid receptor 1 O14842 CHEMBL4422
Small molecule receptor (family A GPCR) FFAR4 G-protein coupled receptor 120 Q5NUL3 CHEMBL5339
Small molecule receptor (family A GPCR) ADORA3 Adenosine A3 receptor P0DMS8 CHEMBL256
Small molecule receptor (family A GPCR) ADORA2A Adenosine A2a receptor P29274 CHEMBL251
Small molecule receptor (family A GPCR) ADORA1 Adenosine A1 receptor P30542 CHEMBL226
Small molecule receptor (family A GPCR) HCAR2 Hydroxycarboxylic acid receptor 2 Q8TDS4 CHEMBL3785
Toll-like and Il-1 receptors TLR2 Toll-like receptor 2 O60603 CHEMBL4163
Transcription Factor STAT6 Signal transducer and activator of transcription 6 P42226 CHEMBL5401
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 Q11130 CHEMBL3596077
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified FABP5 Fatty acid binding protein epidermal Q01469 CHEMBL3674
Unclassified FABP2 Fatty acid binding protein intestinal P12104 CHEMBL4879
Unclassified FABP4 Fatty acid binding protein adipocyte P15090 CHEMBL2083
Unclassified MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Q07820 CHEMBL4361
Unclassified MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Unclassified FABP3 Fatty acid binding protein muscle P05413 CHEMBL3344
Unclassified HTT Huntingtin P42858 CHEMBL5514
Unclassified THPO Thrombopoietin P40225 CHEMBL1293256
Unclassified RAB9A Ras-related protein Rab-9A P51151 CHEMBL1293294
Unclassified NPC1 Niemann-Pick C1 protein O15118 CHEMBL1293277
Unclassified APP Beta amyloid A4 protein P05067 CHEMBL2487
Unclassified TTR Transthyretin P02766 CHEMBL3194
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
BP Unclassified; GO:0032844; regulation of homeostatic process 6.623E-12 1.658E-09 ABL1, ADORA1, ADORA2A, AURKB, BCL2, CA2, CA7, CD38, EGFR, HCAR2, HIF1A, HTT, KDR, MAPK1, NEK2, NPC1, NPSR1, PARP1, PLA2G1B, SRC, TNKS, TNKS2
BP Unclassified; GO:0032846; positive regulation of homeostatic process 1.191E-11 2.819E-09 ABL1, ADORA2A, AURKB, CA2, CA7, EGFR, HCAR2, HIF1A, HTT, MAPK1, NEK2, NPC1, NPSR1, PLA2G1B, TNKS, TNKS2
MF GO:0005488; binding GO:0020037; heme binding 1.181E-11 2.819E-09 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, MPO, NOX4, PTGS1, SRC, TBXAS1
MF GO:0005488; binding GO:0005506; iron ion binding 1.426E-11 3.303E-09 ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, TBXAS1, XDH
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 3.036E-11 6.678E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
MF GO:0005488; binding GO:0019825; oxygen binding 3.661E-11 7.739E-09 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, NOX4
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 1.320E-10 2.355E-08 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4, NR1I2
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 2.880E-09 3.733E-07 CYP1A2, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0018107; peptidyl-threonine phosphorylation 6.128E-09 7.581E-07 AKT1, BCL2, CAMK2B, CDK1, CSNK2A1, GSK3B, MAPK1, PKN1, TNKS
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 7.337E-09 8.975E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 1.348E-08 1.468E-06 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4
BP GO:0008152; metabolic process GO:0018105; peptidyl-serine phosphorylation 4.133E-08 4.225E-06 AKT1, AURKB, BCL2, CAMK2B, CDK1, GSK3B, MAPK1, NEK6, PKN1, SRC, TNKS
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 4.271E-08 4.317E-06 CYP1A2, CYP2C19, CYP2C9, CYP3A4
BP Unclassified; GO:2000021; regulation of ion homeostasis 4.888E-08 4.860E-06 ABL1, ADORA1, ADORA2A, BCL2, CA2, CA7, HTT, KDR, NPSR1, PARP1, PLA2G1B, SRC
BP GO:0008152; metabolic process GO:0006691; leukotriene metabolic process 9.367E-08 8.829E-06 ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B, TLR2
MF GO:0005488; binding GO:0005524; ATP binding 9.474E-08 8.883E-06 ABCC1, ABCG2, ABL1, ADK, AKT1, ALK, AURKB, AXL, BLM, CAMK2B, CDK1, CSNK2A1, DAPK1, EGFR, FLT3, GSK3B, IGF1R, KDR, MAPK1, MET, NEK2, NEK6, NUAK1, PIM1, PKN1, PTK2, PYGL, RECQL, SRC, TK1, TP53
BP GO:0065007; biological regulation GO:1904355; positive regulation of telomere capping 1.194E-07 1.083E-05 AURKB, MAPK1, NEK2, TNKS, TNKS2
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 3.286E-07 2.660E-05 ABL1, AKR1B1, APEX1, AXL, CDK1, CYP1B1, STAT6
BP GO:0032501; multicellular organismal process GO:0048143; astrocyte activation 3.526E-07 2.844E-05 ADORA2A, APP, EGFR, MAPT
BP GO:0009987; cellular process GO:0043401; steroid hormone mediated signaling pathway 5.344E-07 4.021E-05 ESR1, ESR2, ESRRA, ESRRB, NR1I2, PPARA, PPARD, PPARG, SRC
CC GO:0043226; organelle GO:0005654; nucleoplasm 6.925E-07 5.146E-05 ABL1, ADK, AKR1B1, AKT1, ALOX5, APEX1, AURKB, BCL2, BLM, CAMK2B, CASP7, CDK1, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, FABP5, GSK3B, HIF1A, HPGD, HTT, L3MBTL1, LMNA, MAPK1, MCL1, NEK2, NEK6, NFKB1, NR1I2, NUAK1, PARP1, PIM1, PKN1, POLB, PPARA, PPARD, PPARG, RECQL, SMN1, SMN2, SRC, STAT6, TERT, TNKS, TP53
BP GO:0009987; cellular process GO:0030522; intracellular receptor signaling pathway 7.284E-07 5.340E-05 ESR1, ESR2, ESRRA, ESRRB, NR1I2, PIM1, PPARA, PPARD, PPARG, SRC
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 1.049E-06 7.299E-05 AKT1, BCL2, HIF1A, LMNA, PPARD, SRC, TERT, TP53
BP Unclassified; GO:0044243; multicellular organismal catabolic process 1.140E-06 7.853E-05 MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP Unclassified; GO:0044236; multicellular organism metabolic process 1.213E-06 8.307E-05 HIF1A, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 1.239E-06 8.433E-05 ABL1, EGFR, IGF1R, KDR, PTK2, SRC
CC GO:0016020; membrane GO:0016323; basolateral plasma membrane 1.271E-06 8.566E-05 ABCC1, ADORA1, CA2, CA4, CA9, EGFR, HPGD, SLCO1B1, SLCO1B3, TSHR
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 1.361E-06 9.122E-05 CYP1A2, CYP2C8, CYP2C9, CYP3A4
MF GO:0003824; catalytic activity GO:0004674; protein serine/threonine kinase activity 1.396E-06 9.322E-05 AKT1, ALK, AURKB, CAMK2B, CDK1, CSNK2A1, DAPK1, EGFR, GSK3B, MAPK1, NEK2, NEK6, NUAK1, PIM1, PKN1
MF GO:0005488; binding GO:0051721; protein phosphatase 2A binding 1.776E-06 1.145E-04 AKT1, BCL2, MAPT, PTPN1, TP53
BP GO:0050896; response to stimulus GO:0050728; negative regulation of inflammatory response 2.250E-06 1.404E-04 ADORA1, ADORA2A, CYP19A1, FFAR4, NFKB1, PPARA, PPARD, PPARG
MF Unclassified; GO:0004872; receptor activity 2.973E-06 1.798E-04 ADORA1, ADORA2A, ADORA3, ALK, AXL, CXCR1, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FFAR1, FFAR4, FLT3, HCAR2, HPGD, IGF1R, KCNH2, KDR, MET, NPC1, NPSR1, NR1I2, PPARA, PPARD, PPARG, TLR2, TSHR
BP GO:0009987; cellular process GO:0071276; cellular response to cadmium ion 3.017E-06 1.815E-04 AKT1, CYP1A2, EGFR, MAPK1, MMP9
BP GO:0008152; metabolic process GO:0006367; transcription initiation from RNA polymerase II promoter 3.031E-06 1.818E-04 CDK1, ESR1, ESR2, ESRRA, ESRRB, NR1I2, PPARA, PPARD, PPARG
MF GO:0005488; binding GO:0042562; hormone binding 3.207E-06 1.903E-04 ACHE, ALDH1A1, EGFR, HSD17B1, IGF1R, PIK3R1, TTR
BP Unclassified; GO:0044259; multicellular organismal macromolecule metabolic process 3.469E-06 2.031E-04 HIF1A, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
MF GO:0005488; binding GO:0005496; steroid binding 3.469E-06 2.031E-04 CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NPC1
MF GO:0003824; catalytic activity GO:0101020; estrogen 16-alpha-hydroxylase activity 3.930E-06 2.282E-04 CYP1A1, CYP2C8, CYP3A4
CC GO:0044464; cell part GO:0005829; cytosol 3.961E-06 2.288E-04 ABL1, ADK, AKR1B1, AKR1B10, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, AOX1, APP, AURKB, BCL2, BLM, CA1, CA13, CA2, CA3, CA7, CAMK2B, CASP1, CASP7, CDK1, CSNK2A1, FABP2, FABP3, FABP4, FABP5, FLT3, GFER, GLO1, GSK3B, HIF1A, HPGD, HSD17B1, HTT, LMNA, MAPK1, MAPT, MCL1, NEK2, NEK6, NFKB1, PIK3R1, PIM1, PKN1, PLA2G1B, PPARG, PTK2, PTPN1, PYGL, RAB9A, SMN1, SMN2, SRC, STAT6, TK1, TNKS, TNKS2, TP53, XDH
BP GO:0065007; biological regulation GO:0032212; positive regulation of telomere maintenance via telomerase 4.853E-06 2.716E-04 AURKB, MAPK1, NEK2, TNKS, TNKS2
BP GO:0009987; cellular process GO:2000811; negative regulation of anoikis 4.892E-06 2.717E-04 BCL2, MCL1, PTK2, SRC
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 4.892E-06 2.717E-04 ALOX12, ALOX15, ALOX5, HPGD
BP GO:0009987; cellular process GO:2001243; negative regulation of intrinsic apoptotic signaling pathway 6.750E-06 3.620E-04 AKT1, BCL2, HIF1A, MCL1, MMP9, PTPN1, SRC
BP GO:0008152; metabolic process GO:0002933; lipid hydroxylation 7.818E-06 4.112E-04 CYP1A1, CYP2C8, CYP3A4
BP GO:0051179; localization GO:0042307; positive regulation of protein import into nucleus 8.297E-06 4.343E-04 APP, CDK1, EGFR, MAPK1, PARP1, PIK3R1, TLR2
BP GO:0008152; metabolic process GO:0030574; collagen catabolic process 8.546E-06 4.463E-04 MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP GO:0048511; rhythmic process GO:0048511; rhythmic process 8.879E-06 4.612E-04 AXL, BCL2, CSNK2A1, DRD4, EGFR, ESR1, GSK3B, PPARA, PPARG, SRC, TP53
BP GO:0009987; cellular process GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage 1.112E-05 5.631E-04 ABL1, BCL2, MCL1, PIK3R1, POLB, TP53
MF GO:0005488; binding GO:0002039; p53 binding 1.316E-05 6.573E-04 BLM, GSK3B, HIF1A, HTT, NUAK1, TP53
MF GO:0098772; molecular function regulator GO:0030235; nitric-oxide synthase regulator activity 1.361E-05 6.673E-04 AKT1, EGFR, ESR1
MF GO:0060089; molecular transducer activity GO:0001609; G-protein coupled adenosine receptor activity 1.361E-05 6.673E-04 ADORA1, ADORA2A, ADORA3
CC GO:0016020; membrane GO:0005789; endoplasmic reticulum membrane 1.507E-05 7.291E-04 BCL2, CAMK2B, CDK1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP3A4, EGFR, FAAH, HSD11B1, HSD17B2, NOX4, PTGS1, RAB9A, SLC28A3, TBXAS1
BP GO:0050896; response to stimulus GO:0055093; response to hyperoxia 1.563E-05 7.496E-04 CYP1A1, POLB, PPARG, TP53
BP GO:0009987; cellular process GO:0070374; positive regulation of ERK1 and ERK2 cascade 1.634E-05 7.804E-04 ABL1, ALOX15, APP, EGFR, FFAR4, KDR, NOX4, SRC, THPO
BP GO:0002376; immune system process GO:0002684; positive regulation of immune system process 1.758E-05 8.338E-04 ABL1, AKT1, APP, AXL, BCL2, CA2, CD38, HCAR2, HIF1A, MAPK1, MMP12, MMP2, NFKB1, PIK3R1, PLA2G1B, PTK2, SRC, STAT6, THPO, TLR2, TP53
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 1.772E-05 8.387E-04 AXL, EGFR, MET, NOX4, PIK3R1, PTK2, SRC, THPO
MF GO:0003824; catalytic activity GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors 1.785E-05 8.429E-04 AKR1B1, AKR1B10, ALDH1A1, AOX1, XDH
BP GO:0008283; cell proliferation GO:1904707; positive regulation of vascular smooth muscle cell proliferation 1.899E-05 8.913E-04 HPGD, MMP2, MMP9, TERT
MF GO:0005488; binding GO:0046982; protein heterodimerization activity 1.991E-05 9.282E-04 ADORA1, ADORA2A, AXL, BCL2, EGFR, HIF1A, MCL1, NFKB1, PIK3R1, PPARD, PPARG, TLR2, TP53, TTR
BP GO:0032502; developmental process GO:0031100; animal organ regeneration 2.116E-05 9.762E-04 AXL, CDK1, CSNK2A1, EGFR, FLT3, PPARG
BP GO:0009987; cellular process GO:1903376; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 2.165E-05 9.926E-04 HIF1A, MCL1, PARP1
BP GO:0032501; multicellular organismal process GO:0001503; ossification 2.237E-05 1.017E-03 ALOX15, ALPL, BCL2, EGFR, MMP13, MMP2, MMP9
BP GO:0009987; cellular process GO:1901216; positive regulation of neuron death 2.281E-05 1.030E-03 ABL1, GSK3B, MAPT, MCL1, PARP1, TP53
MF Unclassified; GO:0032403; protein complex binding 2.420E-05 1.089E-03 ABL1, ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP12, MMP13, MMP9, PIK3R1, PPARA, PTPN1, SRC, TLR2, TSHR
BP GO:0002376; immune system process GO:0002521; leukocyte differentiation 2.525E-05 1.127E-03 ABL1, AXL, BCL2, FLT3, FUT7, GLO1, MMP9, PARP1, PIK3R1, PPARG
CC GO:0044464; cell part GO:0005739; mitochondrion 2.613E-05 1.154E-03 ABL1, AKT1, APEX1, BCL2, CA5A, CA5B, CASP1, CDK1, CYP1A1, CYP1B1, ESR2, GFER, GSK3B, HSD17B10, MAOA, MAPK1, MCL1, MMP2, MPO, NFKB1, NOX4, PARP1, SRC, TP53
BP GO:0009987; cellular process GO:0022617; extracellular matrix disassembly 2.642E-05 1.164E-03 MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP GO:0050896; response to stimulus GO:0070542; response to fatty acid 2.839E-05 1.231E-03 AKT1, FABP3, FFAR1, PPARG, SRC, TLR2
BP GO:0065007; biological regulation GO:0060249; anatomical structure homeostasis 3.065E-05 1.319E-03 AKR1B1, APEX1, BCL2, BLM, GAA, HIF1A, NOX4, PARP1, SRC, TERT
BP GO:0008152; metabolic process GO:0019433; triglyceride catabolic process 3.228E-05 1.379E-03 FABP2, FABP3, FABP4, FABP5
BP GO:0009987; cellular process GO:0000733; DNA strand renaturation 3.230E-05 1.379E-03 BLM, RECQL, TP53
BP GO:0009987; cellular process GO:0001973; adenosine receptor signaling pathway 3.230E-05 1.379E-03 ADORA1, ADORA2A, ADORA3
BP GO:0065007; biological regulation GO:1904357; negative regulation of telomere maintenance via telomere lengthening 4.428E-05 1.822E-03 PARP1, SRC, TNKS, TNKS2
BP GO:0050896; response to stimulus GO:1904646; cellular response to amyloid-beta 4.428E-05 1.822E-03 APP, GSK3B, IGF1R, PARP1
MF GO:0003824; catalytic activity GO:0033764; steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 4.428E-05 1.822E-03 HSD11B1, HSD17B1, HSD17B10, HSD17B2
BP GO:0008152; metabolic process GO:0051974; negative regulation of telomerase activity 4.590E-05 1.879E-03 PPARG, SRC, TP53
BP GO:0051179; localization GO:0042908; xenobiotic transport 4.590E-05 1.879E-03 ABCC1, ABCG2, NR1I2
BP GO:0050896; response to stimulus GO:0010332; response to gamma radiation 4.897E-05 1.982E-03 BCL2, NOX4, PARP1, POLB, TP53
BP GO:0008152; metabolic process GO:0046320; regulation of fatty acid oxidation 5.136E-05 2.056E-03 AKT1, FABP3, PPARA, PPARG
BP GO:0008152; metabolic process GO:0009115; xanthine catabolic process 5.443E-05 2.124E-03 AOX1, XDH
BP GO:0051179; localization GO:0015860; purine nucleoside transmembrane transport 5.443E-05 2.124E-03 SLC28A2, SLC28A3
BP GO:0009987; cellular process GO:0006286; base-excision repair, base-free sugar-phosphate removal 5.443E-05 2.124E-03 APEX1, POLB
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 5.443E-05 2.124E-03 ALOX12, ALOX15
MF GO:0060089; molecular transducer activity GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding 5.443E-05 2.124E-03 ESR1, ESR2
MF GO:0005215; transporter activity GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity 5.443E-05 2.124E-03 SLC28A1, SLC28A3
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 5.443E-05 2.124E-03 ALOX12, ALOX15
MF GO:0005215; transporter activity GO:0015211; purine nucleoside transmembrane transporter activity 5.443E-05 2.124E-03 SLC28A2, SLC28A3
BP GO:0008152; metabolic process GO:2000379; positive regulation of reactive oxygen species metabolic process 5.536E-05 2.153E-03 AKT1, EGFR, MAPT, NOX4, TP53, XDH
MF GO:0005488; binding GO:0034452; dynactin binding 6.277E-05 2.406E-03 GSK3B, HTT, MAPT
BP GO:0008283; cell proliferation GO:0008285; negative regulation of cell proliferation 6.760E-05 2.582E-03 ADORA1, ADORA2A, ADORA3, APP, BCL2, CYP1B1, FABP3, LMNA, NOX4, PKN1, PPARD, PPARG, TERT, TLR2, TP53, XDH
BP GO:0009987; cellular process GO:1901215; negative regulation of neuron death 7.471E-05 2.805E-03 ADORA2A, AKT1, AXL, BCL2, GSK3B, HIF1A, PPARA, TERT
BP GO:0008283; cell proliferation GO:0033598; mammary gland epithelial cell proliferation 8.323E-05 3.077E-03 ESR1, MAPK1, STAT6
BP GO:0065007; biological regulation GO:0051091; positive regulation of DNA binding transcription factor activity 8.404E-05 3.096E-03 AKT1, ALK, APP, ESR1, ESR2, NFKB1, PLA2G1B, PPARG, TLR2
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 8.815E-05 3.215E-03 CSNK2A1, HIF1A, KDR, MAPT
BP GO:0048511; rhythmic process GO:0042752; regulation of circadian rhythm 8.917E-05 3.247E-03 ADORA1, ADORA2A, DRD4, PPARA, PPARG, TP53
BP GO:0065007; biological regulation GO:0000187; activation of MAPK activity 9.508E-05 3.451E-03 ALK, CDK1, DRD4, MAPK1, PKN1, PLA2G1B, PTPN1
BP Unclassified; GO:0032845; negative regulation of homeostatic process 9.933E-05 3.583E-03 ADORA1, BCL2, CD38, PARP1, SRC, TNKS, TNKS2
MF GO:0005215; transporter activity GO:0005319; lipid transporter activity 9.933E-05 3.583E-03 ABCC1, ABCG2, FABP3, HTT, NPC1, SLCO1B1, SLCO1B3
BP GO:0008152; metabolic process GO:0010907; positive regulation of glucose metabolic process 9.974E-05 3.584E-03 AKT1, ESRRB, PPARA, SRC
BP GO:0008152; metabolic process GO:0006703; estrogen biosynthetic process 1.076E-04 3.798E-03 CYP19A1, HSD17B1, HSD17B2
BP GO:0023052; signaling GO:0032230; positive regulation of synaptic transmission, GABAergic 1.076E-04 3.798E-03 ADORA2A, CA2, CA7
BP GO:0009987; cellular process GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 1.124E-04 3.928E-03 AKT1, BCL2, MCL1, TERT
CC GO:0044425; membrane part GO:0005887; integral component of plasma membrane 1.217E-04 4.214E-03 ABCC1, ADORA1, ADORA2A, ADORA3, ALK, APP, AXL, BACE1, DRD4, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPC1, NPSR1, SLC28A1, SLC28A2, SLC28A3, SLCO1B1, SLCO1B3, TLR2, TSHR
BP GO:0032502; developmental process GO:0060065; uterus development 1.362E-04 4.694E-03 CYP19A1, ESR1, SRC
BP GO:0040011; locomotion GO:0014911; positive regulation of smooth muscle cell migration 1.411E-04 4.816E-03 BCL2, NOX4, SRC, TERT
BP GO:0065007; biological regulation GO:0045124; regulation of bone resorption 1.411E-04 4.816E-03 CA2, CD38, EGFR, SRC
BP GO:0065007; biological regulation GO:0048167; regulation of synaptic plasticity 1.509E-04 5.112E-03 ABL1, ADORA1, ADORA2A, APP, CAMK2B, CD38, MAPK1
MF GO:0003824; catalytic activity GO:0009055; electron transfer activity 1.526E-04 5.148E-03 AKR1B1, AOX1, CYP19A1, CYP1A2, NOX4, XDH
BP GO:0032501; multicellular organismal process GO:0014005; microglia development 1.625E-04 5.312E-03 APP, TLR2
BP GO:0051179; localization GO:1904823; purine nucleobase transmembrane transport 1.625E-04 5.312E-03 SLC28A1, SLC28A3
BP GO:0008152; metabolic process GO:0000023; maltose metabolic process 1.625E-04 5.312E-03 GAA, MGAM
BP GO:0002376; immune system process GO:0001922; B-1 B cell homeostasis 1.625E-04 5.312E-03 ABL1, HIF1A
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.625E-04 5.312E-03 CA2, CA7
BP GO:0051179; localization GO:0015855; pyrimidine nucleobase transport 1.625E-04 5.312E-03 SLC28A1, SLC28A3
MF GO:0003824; catalytic activity GO:0070576; vitamin D 24-hydroxylase activity 1.625E-04 5.312E-03 CYP1A1, CYP3A4
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.625E-04 5.312E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0032450; maltose alpha-glucosidase activity 1.625E-04 5.312E-03 GAA, MGAM
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.625E-04 5.312E-03 ALOX12, ALOX15
CC GO:0044464; cell part GO:0099056; integral component of presynaptic membrane 1.625E-04 5.312E-03 ADORA1, ADORA2A
BP GO:0051179; localization GO:0070198; protein localization to chromosome, telomeric region 1.694E-04 5.512E-03 TERT, TNKS, TNKS2
BP GO:0009987; cellular process GO:0097194; execution phase of apoptosis 1.748E-04 5.640E-03 AKT1, CASP1, CASP7, PTK2
BP GO:0008152; metabolic process GO:0031331; positive regulation of cellular catabolic process 1.762E-04 5.675E-03 AKT1, CDK1, DAPK1, ESRRB, GSK3B, HIF1A, HTT, KDR, PPARA, PTK2, PTPN1
BP GO:0032501; multicellular organismal process GO:2000026; regulation of multicellular organismal development 1.779E-04 5.713E-03 ABL1, AKT1, ALOX12, APP, AXL, BCL2, CA2, CAMK2B, CDK1, CYP1B1, EGFR, ESR1, ESRRA, GSK3B, HIF1A, KDR, L3MBTL1, MAPT, PIK3R1, PIM1, PPARD, PPARG, PTK2, SRC, STAT6, TERT, THPO, TLR2, XDH
BP GO:0008152; metabolic process GO:0010507; negative regulation of autophagy 1.823E-04 5.846E-03 AKT1, BCL2, MCL1, MET, NPC1
BP GO:0065007; biological regulation GO:0042593; glucose homeostasis 1.839E-04 5.880E-03 AKT1, FFAR1, HIF1A, NOX4, PIK3R1, PPARG, PYGL
BP GO:0009987; cellular process GO:0048010; vascular endothelial growth factor receptor signaling pathway 1.947E-04 6.190E-03 AXL, KDR, PIK3R1, PTK2, SRC
BP GO:0065007; biological regulation GO:0051101; regulation of DNA binding 1.955E-04 6.205E-03 MMP9, NEK2, PARP1, PPARA, PPARG, TNKS
BP GO:0050896; response to stimulus GO:0070920; regulation of production of small RNA involved in gene silencing by RNA 2.073E-04 6.524E-03 EGFR, ESR1, TERT
BP GO:0032501; multicellular organismal process GO:0048546; digestive tract morphogenesis 2.073E-04 6.524E-03 BCL2, EGFR, HIF1A
CC GO:0044464; cell part GO:0030673; axolemma 2.073E-04 6.524E-03 ADORA1, ADORA2A, MAPT
MF GO:0003824; catalytic activity GO:0004222; metalloendopeptidase activity 2.151E-04 6.710E-03 MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP GO:0050896; response to stimulus GO:0071214; cellular response to abiotic stimulus 2.192E-04 6.809E-03 AKT1, AURKB, BLM, CASP1, EGFR, NFKB1, NOX4, PIK3R1, TP53
BP GO:0051179; localization GO:0030100; regulation of endocytosis 2.303E-04 7.123E-03 ABL1, ALOX15, APP, AXL, PPARG, PTPN1, SRC, TLR2
BP GO:0008152; metabolic process GO:0046209; nitric oxide metabolic process 2.504E-04 7.657E-03 AKT1, CYP1B1, TLR2
BP GO:0050896; response to stimulus GO:0033189; response to vitamin A 2.504E-04 7.657E-03 CYP1A1, PPARD, PPARG
MF GO:0003824; catalytic activity GO:0008392; arachidonic acid epoxygenase activity 2.504E-04 7.657E-03 CYP2C19, CYP2C8, CYP2C9
MF GO:0003824; catalytic activity GO:0035173; histone kinase activity 2.504E-04 7.657E-03 AURKB, CDK1, PKN1
BP GO:0002376; immune system process GO:0043312; neutrophil degranulation 2.517E-04 7.675E-03 ALOX5, CXCR1, FABP5, GAA, MAPK1, MGAM, MMP9, MPO, NFKB1, PYGL, TLR2, TTR
BP GO:0050896; response to stimulus GO:0071496; cellular response to external stimulus 2.638E-04 7.989E-03 AKT1, AXL, BCL2, CASP1, EGFR, MAPK1, NFKB1, PPARG, TP53
BP GO:0050896; response to stimulus GO:0042060; wound healing 2.670E-04 8.071E-03 ALOX15, EGFR, PPARA, PPARD, TP53
MF GO:0005488; binding GO:0042803; protein homodimerization activity 2.718E-04 8.185E-03 ABCG2, ACHE, AKT1, AOX1, BCL2, BLM, CAMK2B, FLT3, HPGD, KCNH2, MAPT, MCL1, NFKB1, PYGL, TERT, XDH
BP GO:0009987; cellular process GO:0001961; positive regulation of cytokine-mediated signaling pathway 2.840E-04 8.495E-03 AXL, CASP1, HIF1A, MMP12
BP GO:0008152; metabolic process GO:0051000; positive regulation of nitric-oxide synthase activity 2.988E-04 8.853E-03 AKT1, HIF1A, TERT
BP GO:0050896; response to stimulus GO:0031000; response to caffeine 2.988E-04 8.853E-03 ADORA2A, PPARG, TP53
BP GO:0032501; multicellular organismal process GO:0043536; positive regulation of blood vessel endothelial cell migration 3.106E-04 9.141E-03 ABL1, AKT1, HIF1A, KDR
BP GO:0032501; multicellular organismal process GO:0097746; regulation of blood vessel diameter 3.233E-04 9.315E-03 ADORA1, ADORA2A, AKT1, CD38, EGFR, PPARD
BP GO:0050896; response to stimulus GO:0032355; response to estradiol 3.233E-04 9.315E-03 CD38, CYP1A2, EGFR, ESR1, ESRRA, HPGD
BP GO:0065007; biological regulation GO:0032431; activation of phospholipase A2 activity 3.234E-04 9.315E-03 EGFR, PLA2G1B
BP GO:0008152; metabolic process GO:0070213; protein auto-ADP-ribosylation 3.234E-04 9.315E-03 TNKS, TNKS2
BP GO:0032501; multicellular organismal process GO:0032640; tumor necrosis factor production 3.234E-04 9.315E-03 APP, TLR2
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 3.234E-04 9.315E-03 CYP1A1, CYP1A2
MF GO:0005488; binding GO:0034056; estrogen response element binding 3.234E-04 9.315E-03 ESR1, ESR2
MF GO:0003824; catalytic activity GO:0004558; alpha-1,4-glucosidase activity 3.234E-04 9.315E-03 GAA, MGAM
CC GO:0044464; cell part GO:0048471; perinuclear region of cytoplasm 3.243E-04 9.328E-03 ABL1, ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HTT, KCNH2, NOX4, NPC1, PPARG, SRC, TNKS2
BP GO:0050896; response to stimulus GO:1901655; cellular response to ketone 3.381E-04 9.662E-03 AKR1B1, AKT1, EGFR, PPARG, SRC
BP GO:0009987; cellular process GO:0090199; regulation of release of cytochrome c from mitochondria 3.390E-04 9.662E-03 AKT1, LMNA, MMP9, TP53
BP GO:0040007; growth GO:0045926; negative regulation of growth 3.396E-04 9.666E-03 BCL2, ESR2, HIF1A, MPO, PPARD, PPARG, PTK2, TP53
CC GO:0016020; membrane GO:0045121; membrane raft 3.404E-04 9.675E-03 APP, BACE1, EGFR, KDR, MAPK1, NPC1, SRC, STAT6, TLR2
BP GO:0009987; cellular process GO:1901796; regulation of signal transduction by p53 class mediator 3.419E-04 9.706E-03 AKT1, AURKB, BLM, CSNK2A1, L3MBTL1, NUAK1, TP53
BP GO:0032502; developmental process GO:0045597; positive regulation of cell differentiation 3.539E-04 9.995E-03 ABL1, AKT1, APP, AXL, BCL2, CA2, CAMK2B, HIF1A, KDR, MAPT, NFKB1, PARP1, PPARD, PPARG, TERT, THPO, TLR2
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 7.556E-24 7.644E-20 CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP GO:0051179; localization GO:0015701; bicarbonate transport 2.919E-16 2.302E-13 CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF GO:0005488; binding GO:0008270; zinc ion binding 7.169E-16 4.591E-13 BLM, CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, L3MBTL1, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, NR1I2, PARP1, PPARA, PPARD, PPARG, PTPN1, TK1, TNKS, TP53
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.271E-15 7.281E-13 CA1, CA12, CA13, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 6.690E-23 1.345E-20 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14; CA13
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 1.382E-12 1.389E-10 CAMK2B; SRC; MMP2; PIK3R1; HIF1A; ESR1; MMP9; PTK2; EGFR; IGF1R; KDR; AKT1; MAPK1; TP53; MET; TLR2
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 7.844E-12 5.255E-10 GSK3B; FLT3; MMP1; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; EGFR; NFKB1; PTK2; IGF1R; ABL1; BCL2; AKT1; MAPK1; PPARG; MET; TP53; PPARD
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 6.931E-10 2.322E-08 PLA2G1B; MAOA; ALOX15; ADK; AKR1B1; ALOX12; PYGL; CYP2C19; CYP3A4; CYP19A1; HSD17B10; PTGS1; HSD11B1; FUT7; HSD17B1; ALOX5; HSD17B2; CD38; AOX1; TK1; XDH; MGAM; GAA; CYP2C9; CYP2C8; AKR1B10; TBXAS1; CYP1A2; ALDH1A1; CYP1A1; ALPL
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 5.571E-10 2.240E-08 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; TBXAS1; ALOX12; CYP2C19; PTGS1
hsa05219 Bladder cancer_Homo sapiens_hsa05219 4.390E-10 2.206E-08 MMP1; DAPK1; SRC; MMP2; MAPK1; MMP9; TP53; EGFR
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 7.733E-09 1.776E-07 CYP2C9; APP; CYP2C8; MAOA; ALOX5; ALOX15; MAPK1; ALOX12; CYP2C19; PTGS1
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 2.345E-08 3.928E-07 GSK3B; PIK3R1; PTK2; EGFR; NFKB1; IGF1R; KDR; BCL2; AKT1; MAPK1; PKN1; TP53; MET; TLR2; MCL1
hsa05215 Prostate cancer_Homo sapiens_hsa05215 1.483E-08 2.710E-07 GSK3B; BCL2; AKT1; MAPK1; PIK3R1; TP53; EGFR; NFKB1; IGF1R
hsa04012 ErbB signaling pathway_Homo sapiens_hsa04012 1.211E-08 2.434E-07 CAMK2B; GSK3B; SRC; ABL1; AKT1; MAPK1; PIK3R1; EGFR; PTK2
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 1.128E-09 3.238E-08 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 7.951E-09 1.776E-07 HSD11B1; HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa04915 Estrogen signaling pathway_Homo sapiens_hsa04915 3.801E-08 5.094E-07 SRC; MMP2; AKT1; MAPK1; PIK3R1; ESR1; MMP9; EGFR; ESR2
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 2.563E-08 3.963E-07 FLT3; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A; EGFR
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 4.564E-08 5.734E-07 GSK3B; SRC; AKT1; MAPK1; PIK3R1; ESR1; NFKB1; ESR2
hsa04210 Apoptosis_Homo sapiens_hsa04210 6.615E-08 6.998E-07 CASP7; PARP1; LMNA; BCL2; AKT1; MAPK1; PIK3R1; TP53; NFKB1; MCL1
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 5.380E-08 6.361E-07 CAMK2B; BCL2; AKT1; MAPK1; PIK3R1; HIF1A; EGFR; NFKB1; IGF1R
hsa05161 Hepatitis B_Homo sapiens_hsa05161 9.840E-08 9.418E-07 SRC; BCL2; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1; TLR2
hsa03320 PPAR signaling pathway_Homo sapiens_hsa03320 3.247E-08 4.661E-07 FABP2; FABP3; FABP4; FABP5; MMP1; PPARG; PPARA; PPARD
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 7.130E-08 7.165E-07 HPGD; FLT3; MMP3; PPARG; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa04913 Ovarian steroidogenesis_Homo sapiens_hsa04913 6.367E-08 6.998E-07 HSD17B1; ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R
hsa04510 Focal adhesion_Homo sapiens_hsa04510 2.296E-07 1.775E-06 GSK3B; SRC; KDR; BCL2; AKT1; MAPK1; PIK3R1; MET; PTK2; EGFR; IGF1R
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 2.023E-07 1.626E-06 CAMK2B; GSK3B; ABL1; BCL2; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 2.023E-07 1.626E-06 ABCC1; ADORA3; ADORA1; BCL2; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 1.617E-07 1.413E-06 FLT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PPARD
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 1.280E-07 1.169E-06 HSD11B1; CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19
hsa05214 Glioma_Homo sapiens_hsa05214 4.059E-07 2.914E-06 CAMK2B; AKT1; MAPK1; PIK3R1; TP53; EGFR; IGF1R
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 1.550E-06 9.733E-06 ABCC1; PIM1; ABL1; BCL2; CYP1B1; MAPK1; TP53; MMP9; MET; EGFR; NFKB1; MCL1
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 1.720E-06 1.048E-05 HCAR2; CAMK2B; ADORA2A; ADORA1; AKT1; MAPK1; PIK3R1; PPARA; NFKB1; TSHR
hsa05218 Melanoma_Homo sapiens_hsa05218 7.482E-07 5.013E-06 AKT1; MAPK1; PIK3R1; TP53; MET; EGFR; IGF1R
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 4.059E-07 2.914E-06 CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; AOX1; CYP3A4
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 6.142E-07 4.257E-06 CYP2C9; CYP2C8; MAOA; CYP1A2; AOX1; CYP3A4; CYP2C19
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 2.117E-06 1.216E-05 GSK3B; SRC; AKT1; MAPK1; PIK3R1; TP53; ESR1; HIF1A
hsa04520 Adherens junction_Homo sapiens_hsa04520 9.945E-07 6.448E-06 PTPN1; CSNK2A1; SRC; MAPK1; MET; EGFR; IGF1R
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 5.575E-06 2.733E-05 PLA2G1B; KDR; ABL1; AKT1; MAPK1; PIK3R1; MET; EGFR; NFKB1; IGF1R
hsa05160 Hepatitis C_Homo sapiens_hsa05160 5.181E-06 2.670E-05 GSK3B; AKT1; MAPK1; PIK3R1; PPARA; TP53; EGFR; NFKB1
hsa05162 Measles_Homo sapiens_hsa05162 6.113E-06 2.925E-05 GSK3B; CSNK2A1; AKT1; RAB9A; PIK3R1; TP53; NFKB1; TLR2
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 8.096E-06 3.698E-05 MMP2; PIM1; BCL2; AKT1; MAPK1; PIK3R1; NFKB1
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 1.519E-05 6.108E-05 GSK3B; CSNK2A1; BCL2; CDK1; AKT1; CD38; PIK3R1; TP53; NFKB1
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 2.910E-06 1.581E-05 ALK; AKT1; MAPK1; PIK3R1; TP53; EGFR
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 1.868E-06 1.104E-05 GSK3B; AKT1; MAPK1; PIK3R1; TP53; EGFR
hsa04931 Insulin resistance_Homo sapiens_hsa04931 1.337E-05 5.782E-05 PTPN1; GSK3B; AKT1; PIK3R1; PYGL; PPARA; NFKB1
hsa04370 VEGF signaling pathway_Homo sapiens_hsa04370 4.832E-06 2.556E-05 SRC; KDR; AKT1; MAPK1; PIK3R1; PTK2
hsa04015 Rap1 signaling pathway_Homo sapiens_hsa04015 2.147E-05 8.300E-05 ADORA2A; SRC; KDR; AKT1; MAPK1; PIK3R1; MET; EGFR; IGF1R
hsa04630 Jak-STAT signaling pathway_Homo sapiens_hsa04630 1.832E-05 7.219E-05 THPO; PIM1; BCL2; AKT1; AOX1; STAT6; PIK3R1; MCL1
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 1.420E-05 5.824E-05 CASP7; MMP3; AKT1; MAPK1; PIK3R1; MMP9; NFKB1
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 2.910E-06 1.581E-05 FABP4; ADORA1; AKT1; PIK3R1; TSHR; PTGS1
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 5.318E-06 2.672E-05 GSK3B; BCL2; AKT1; MAPK1; PIK3R1; TP53
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 7.678E-06 3.589E-05 AKT1; MAPK1; PIK3R1; TP53; EGFR; NFKB1
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 2.243E-05 8.508E-05 ALOX5; BCL2; AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 6.099E-05 2.151E-04 GSK3B; CXCR1; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PTK2
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 1.381E-05 5.782E-05 ABL1; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 5.841E-05 2.133E-04 AKT1; PPARG; PIK3R1; TP53; NFKB1; IGF1R
hsa04725 Cholinergic synapse_Homo sapiens_hsa04725 1.471E-04 4.927E-04 CAMK2B; ACHE; BCL2; AKT1; MAPK1; PIK3R1
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 1.381E-05 5.782E-05 HSD11B1; CYP2C9; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 2.090E-04 6.667E-04 BACE1; APP; GSK3B; CASP7; MAPK1; MAPT; HSD17B10
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 3.534E-05 1.315E-04 BCL2; AKT1; PIK3R1; TP53; NFKB1; PTK2
hsa04611 Platelet activation_Homo sapiens_hsa04611 2.462E-04 7.733E-04 SRC; TBXAS1; AKT1; MAPK1; PIK3R1; PTGS1
hsa05152 Tuberculosis_Homo sapiens_hsa05152 2.974E-04 9.196E-04 CAMK2B; SRC; BCL2; AKT1; MAPK1; NFKB1; TLR2
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 6.924E-04 1.938E-03 POLB; SRC; CDK1; MAPK1; PIK3R1; TP53; NFKB1
hsa04910 Insulin signaling pathway_Homo sapiens_hsa04910 4.954E-04 1.480E-03 PTPN1; GSK3B; AKT1; MAPK1; PIK3R1; PYGL
hsa04550 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 5.547E-04 1.616E-03 GSK3B; ESRRB; AKT1; MAPK1; PIK3R1; IGF1R
hsa04932 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 7.661E-04 2.109E-03 GSK3B; CASP7; AKT1; PIK3R1; PPARA; NFKB1
hsa04912 GnRH signaling pathway_Homo sapiens_hsa04912 4.947E-04 1.480E-03 CAMK2B; SRC; MMP2; MAPK1; EGFR
hsa04921 Oxytocin signaling pathway_Homo sapiens_hsa04921 9.697E-04 2.499E-03 CAMK2B; SRC; CD38; MAPK1; PIK3R1; EGFR
hsa04914 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 6.941E-04 1.938E-03 CDK1; AKT1; MAPK1; PIK3R1; IGF1R
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 1.771E-04 5.740E-04 GSK3B; AKT1; MAPK1; PIK3R1; NFKB1
hsa05164 Influenza A_Homo sapiens_hsa05164 1.637E-03 4.014E-03 GSK3B; CASP1; AKT1; MAPK1; PIK3R1; NFKB1
hsa05231 Choline metabolism in cancer_Homo sapiens_hsa05231 7.958E-04 2.162E-03 AKT1; MAPK1; PIK3R1; HIF1A; EGFR
hsa05211 Renal cell carcinoma_Homo sapiens_hsa05211 1.097E-04 3.800E-04 AKT1; MAPK1; PIK3R1; MET; HIF1A
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 2.590E-03 5.886E-03 POLB; GSK3B; TERT; AKT1; PIK3R1; TP53; NFKB1
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 9.083E-04 2.371E-03 AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 9.896E-04 2.518E-03 AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 9.083E-04 2.371E-03 GSK3B; AKT1; MAPK1; PIK3R1; NFKB1
hsa05120 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 1.264E-04 4.308E-04 CXCR1; SRC; MET; EGFR; NFKB1
hsa04976 Bile secretion_Homo sapiens_hsa04976 1.552E-04 5.115E-04 SLCO1B1; CA2; SLCO1B3; CYP3A4; ABCG2
hsa04728 Dopaminergic synapse_Homo sapiens_hsa04728 2.359E-03 5.483E-03 CAMK2B; GSK3B; MAOA; AKT1; DRD4
hsa04360 Axon guidance_Homo sapiens_hsa04360 2.203E-03 5.211E-03 GSK3B; ABL1; MAPK1; MET; PTK2
hsa04310 Wnt signaling pathway_Homo sapiens_hsa04310 3.567E-03 7.794E-03 CAMK2B; GSK3B; CSNK2A1; TP53; PPARD
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 2.606E-03 5.886E-03 AKT1; MAPK1; PPARG; PIK3R1; NFKB1
hsa04068 FoxO signaling pathway_Homo sapiens_hsa04068 2.693E-03 6.013E-03 AKT1; MAPK1; PIK3R1; EGFR; IGF1R
hsa04072 Phospholipase D signaling pathway_Homo sapiens_hsa04072 3.786E-03 8.096E-03 CXCR1; AKT1; MAPK1; PIK3R1; EGFR
hsa04261 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 4.253E-03 8.905E-03 CAMK2B; BCL2; AKT1; MAPK1; PIK3R1
hsa04010 MAPK signaling pathway_Homo sapiens_hsa04010 1.015E-02 1.925E-02 AKT1; MAPK1; MAPT; TP53; EGFR; NFKB1
hsa04144 Endocytosis_Homo sapiens_hsa04144 1.090E-02 1.992E-02 CXCR1; SRC; KDR; MET; EGFR; IGF1R
hsa05168 Herpes simplex infection_Homo sapiens_hsa05168 1.068E-02 1.988E-02 CSNK2A1; CDK1; TP53; NFKB1; TLR2
hsa04022 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 7.044E-03 1.375E-02 ADORA3; ADORA1; AKT1; MAPK1; PIK3R1
hsa04060 Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 1.210E-02 2.103E-02 CXCR1; THPO; FLT3; KDR; MET; EGFR
hsa04810 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 1.895E-02 3.122E-02 SRC; MAPK1; PIK3R1; PTK2; EGFR
hsa04750 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 5.386E-03 1.093E-02 CAMK2B; SRC; ALOX12; PIK3R1
hsa04670 Leukocyte transendothelial migration_Homo sapiens_hsa04670 1.026E-02 1.927E-02 MMP2; PIK3R1; MMP9; PTK2
hsa04922 Glucagon signaling pathway_Homo sapiens_hsa04922 5.988E-03 1.180E-02 CAMK2B; AKT1; PYGL; PPARA
hsa05146 Amoebiasis_Homo sapiens_hsa05146 5.783E-03 1.154E-02 PIK3R1; NFKB1; PTK2; TLR2
hsa04114 Oocyte meiosis_Homo sapiens_hsa04114 1.181E-02 2.101E-02 CAMK2B; CDK1; MAPK1; IGF1R
hsa04110 Cell cycle_Homo sapiens_hsa04110 1.214E-02 2.103E-02 GSK3B; ABL1; CDK1; TP53
hsa04152 AMPK signaling pathway_Homo sapiens_hsa04152 1.214E-02 2.103E-02 AKT1; PPARG; PIK3R1; IGF1R
hsa04540 Gap junction_Homo sapiens_hsa04540 3.672E-03 7.937E-03 SRC; CDK1; MAPK1; EGFR
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 4.474E-03 9.176E-03 CSNK2A1; PARP1; BCL2; NFKB1
hsa05132 Salmonella infection_Homo sapiens_hsa05132 3.381E-03 7.468E-03 CASP1; MAPK1; PKN1; NFKB1
hsa05100 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 2.373E-03 5.483E-03 SRC; PIK3R1; MET; PTK2
hsa05133 Pertussis_Homo sapiens_hsa05133 2.056E-03 4.919E-03 CASP7; CASP1; MAPK1; NFKB1
hsa04150 mTOR signaling pathway_Homo sapiens_hsa04150 8.958E-04 2.371E-03 AKT1; MAPK1; PIK3R1; HIF1A
hsa04666 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 2.912E-02 4.573E-02 AKT1; MAPK1; PIK3R1
hsa04972 Pancreatic secretion_Homo sapiens_hsa04972 3.158E-02 4.895E-02 CA2; PLA2G1B; CD38
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 9.371E-06 4.186E-05 MAOA; CYP1A2; CYP1A1; AOX1; CYP1B1
hsa05323 Rheumatoid arthritis_Homo sapiens_hsa05323 2.677E-02 4.271E-02 MMP1; MMP3; TLR2
hsa04640 Hematopoietic cell lineage_Homo sapiens_hsa04640 2.526E-02 4.095E-02 THPO; FLT3; CD38
hsa05134 Legionellosis_Homo sapiens_hsa05134 6.440E-04 1.849E-03 CASP7; CASP1; NFKB1; TLR2
hsa05131 Shigellosis_Homo sapiens_hsa05131 1.210E-03 3.002E-03 SRC; ABL1; MAPK1; NFKB1
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 1.546E-02 2.612E-02 MAPK1; NFKB1; TLR2
hsa04664 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 1.279E-02 2.196E-02 AKT1; MAPK1; PIK3R1
hsa04920 Adipocytokine signaling pathway_Homo sapiens_hsa04920 1.382E-02 2.354E-02 AKT1; PPARA; NFKB1
hsa04213 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 1.085E-02 1.992E-02 AKT1; PIK3R1; IGF1R
hsa05321 Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 1.132E-02 2.049E-02 STAT6; NFKB1; TLR2
hsa04621 NOD-like receptor signaling pathway_Homo sapiens_hsa04621 7.901E-03 1.512E-02 CASP1; MAPK1; NFKB1
hsa00500 Starch and sucrose metabolism_Homo sapiens_hsa00500 7.524E-03 1.454E-02 MGAM; GAA; PYGL
hsa05014 Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 5.801E-03 1.154E-02 BCL2; CASP1; TP53
hsa04973 Carbohydrate digestion and absorption_Homo sapiens_hsa04973 4.078E-03 8.627E-03 MGAM; AKT1; PIK3R1
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 5.943E-05 2.133E-04 MGAM; AKR1B10; GAA; AKR1B1
hsa00983 Drug metabolism - other enzymes_Homo sapiens_hsa00983 4.339E-03 8.992E-03 TK1; CYP3A4; XDH
hsa04960 Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 3.166E-02 4.895E-02 MAPK1; PIK3R1
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 1.141E-03 2.867E-03 MAPK1; PPARG; TP53
hsa00350 Tyrosine metabolism_Homo sapiens_hsa00350 2.589E-02 4.164E-02 MAOA; AOX1
hsa03410 Base excision repair_Homo sapiens_hsa03410 1.669E-03 4.041E-03 POLB; PARP1; APEX1
hsa04320 Dorso-ventral axis formation_Homo sapiens_hsa04320 1.585E-02 2.655E-02 MAPK1; EGFR
hsa00051 Fructose and mannose metabolism_Homo sapiens_hsa00051 2.189E-02 3.577E-02 AKR1B10; AKR1B1
hsa00040 Pentose and glucuronate interconversions_Homo sapiens_hsa00040 2.729E-02 4.319E-02 AKR1B10; AKR1B1
hsa00760 Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 1.817E-02 3.018E-02 AOX1; CD38
hsa04964 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 1.164E-02 2.089E-02 CA2; CA4
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 5.006E-04 1.480E-03 CYP1A2; XDH
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
I00-I99: Diseases of the circulatory system Cardiac arrhythmias I47-I49 TBXAS1; ADORA1; ADORA1
I00-I99: Diseases of the circulatory system Cardiac disease I00-I99 ADORA1
I00-I99: Diseases of the circulatory system Cardiomyopathy I42.0 TTR
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 MGAM; HCAR2; KDR
N00-N99: Diseases of the genitourinary system Endometriosis N80 CYP19A1; PPARG
I00-I99: Diseases of the circulatory system Acute ischemic stroke I61-I63 HCAR2
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3; ABL1
C00-D49: Neoplasms Acute myeloid leukemia C92.0 TERT; TK1; FLT3; FLT3; AURKB; TP53; TP53
C00-D49: Neoplasms Cancer C00-C96 AKT1; MET; TLR2; TK1; MCL1; CSNK2A1; CA1; FLT3; FLT3; CA9; ABL1; MMP2; ACHE; SRC; IGF1R; PTK2; GSK3B; ADORA3; HIF1A; CDK1; MAPK1; MMP9; NFKB1; EGFR; PIM1; PARP1; CD38; BCL2; BCL2; TP53; ESR1; ESR1; KDR; APP
C00-D49: Neoplasms Ocular cancer C69 APEX1
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes Vulnerary S00-T98 EGFR
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 KDR
C00-D49: Neoplasms Metastasis C00-C97 AXL
C00-D49: Neoplasms Metastatic breast cancer C50 KDR
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic disorders E70-E89 PPARD
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic syndrome x E88.81 HSD11B1
N00-N99: Diseases of the genitourinary system Menopause symptoms N95.0 ESR1; ESR1
N00-N99: Diseases of the genitourinary system Menorrhagia N92.0 ESR1
C00-D49: Neoplasms Advanced breast cancer C50 CYP19A1; SRC
C00-D49: Neoplasms Adrenocortical carcinoma C74.0 ESR1
A00-B99: Certain infectious and parasitic diseases Adult varicella zoster virus infection B02 TK1
NA: NA Rheumatold arthritis NA PTGS1
J00-J99: Diseases of the respiratory system Rhinitis J00, J30, J31.0 ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 CAMK2B; AKR1B1; PLA2G1B; ESRRA; ALOX5; CASP1; MMP3; MMP1
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA
NA: NA Geographic retinal atrophy NA APP
NA: NA GIST NA FLT3
G00-G99: Diseases of the nervous system G00-G99 Mild to moderate alzheimer disease G30 APP
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 EGFR; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE; APP
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR; KDR
C00-D49: Neoplasms Advanced prostate cancer C61 ESR1
C00-D49: Neoplasms Advanced melanoma C43 BCL2
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR
C00-D49: Neoplasms Advanced cancers C00-C96 EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Female sexual dysfunction F52 ESR1
A00-B99: Certain infectious and parasitic diseases Sepsis A40, A41 ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases Inflammation E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 ALOX5; ADORA3
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory skin condition L00-L99 PARP1
A00-B99: Certain infectious and parasitic diseases Malaria B54 ADORA3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; MAOA; FAAH; HCAR2
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3
H00-H59: Diseases of the eye and adnexa Age related macular degeneration H35.3 APP
NA: NA Upper abdominal bloating NA ACHE
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE
C00-D49: Neoplasms Urethral cancer NA EGFR
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MPO; ALOX5; MMP12; MMP12; ADORA2A
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 PTPN1; HSD11B1; PPARG; PPARD; PPARD
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; IGF1R; IGF1R; EGFR; EGFR; AXL; KDR
K00-K95: Diseases of the digestive system Non-alcoholic fatty liver disease K76.0 PPARG; PPARD
C00-D49: Neoplasms Melanoma C43 TLR2; TERT; EGFR; PARP1; KDR; KDR
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR
C00-D49: Neoplasms Malignant tumor C00-C75, C7A, C7B EGFR
NA: NA Menopausal disorder NA ESR1
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 PLA2G1B; ALOX5; ADORA1
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAOA; MAPT; ACHE; ACHE; ACHE; GSK3B; PPARG; PPARG; APP
C00-D49: Neoplasms AML NA FLT3; KDR
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR
G00-G99: Diseases of the nervous system G00-G99 Spinal muscular atrophy G00-G99 SMN1;SMN2
C00-D49: Neoplasms Solid tumours C00-D48 AKT1; MET; TLR2; TK1; FLT3; CA9; ABL1; MMP2; SRC; IGF1R; PTK2; AURKB; HIF1A; MAPK1; MMP9; EGFR; TP53; KDR; KDR; KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
E00-E89: Endocrine, nutritional and metabolic diseases Type 1 diabetes E10 PPARG; PPARD
C00-D49: Neoplasms Tumors C00-D48 TERT
A00-B99: Certain infectious and parasitic diseases Trematode infection B66.9 ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Convulsions R56.0 ADK
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
C00-D49: Neoplasms Head and neck squamous cell carcinoma C44 EGFR
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1; TERT; EGFR; EGFR; EGFR; TP53; KDR; KDR
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
C00-D49: Neoplasms Leukemia C90-C95 AKT1; FLT3; ABL1; BCL2; ESR1
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A PTK2; TP53
E00-E89: Endocrine, nutritional and metabolic diseases Lipid metabolism disorder E75-E78 HSD11B1
C00-D49: Neoplasms Liver cancer C22 TERT; IGF1R; KDR
G00-G99: Diseases of the nervous system G00-G99 Amyotrophic lateral sclerosis G12.2 BCL2
E00-E89: Endocrine, nutritional and metabolic diseases Amyloidosis E85 APP; TTR
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Anesthesia R20.0 FAAH
S00-T88: Injury, poisoning and certain other consequences of external causes Myocardial reperfusion injury T86.4 AKT1
I00-I99: Diseases of the circulatory system Myocardial infarction I21, I22 MMP3; PARP1
N00-N99: Diseases of the genitourinary system Nephritis N00-N19, N25-N29 TBXAS1
S00-T88: Injury, poisoning and certain other consequences of external causes Nerve injury T14.4 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 PLA2G1B; ALOX5
C00-D49: Neoplasms Prostate cancer C61 TLR2; TERT; TK1; FLT3; ABL1; EGFR; BCL2; ESR1
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
C00-D49: Neoplasms Esophageal cancer C15 EGFR
S00-T88: Injury, poisoning and certain other consequences of external causes Graft-versus-host disease T86.0 TK1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R
C00-D49: Neoplasms Lymphoma C81-C86 AKT1; CA9; HIF1A; EGFR; BCL2
C00-D49: Neoplasms Lung cancer C33-C34 ABL1; MMP2; EGFR
C00-D49: Neoplasms Locally advanced head and neck cancer C07-C14, C32, C33 EGFR
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET; FAAH
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR
I00-I99: Diseases of the circulatory system Angina pectoris I20 TBXAS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CAMK2B; MAOA; ACHE; FAAH; CYP3A4
I00-I99: Diseases of the circulatory system Aortic aneurysm I71 MMP12
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 ACHE
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3
C00-D49: Neoplasms Myelodysplastic syndrome D46 TLR2; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 DRD4
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R
J00-J99: Diseases of the respiratory system Allergic rhinitis J00, J30, J31.0, T78.4 PLA2G1B; ESRRA; ADORA2A
C00-D49: Neoplasms Hematological malignancies C81-C86 SRC; AURKB; CD38; TP53
C00-D49: Neoplasms Glioblastoma NA FLT3
C00-D49: Neoplasms Glioblastoma multiforme C71 SRC; EGFR; EGFR
C00-D49: Neoplasms Gliosarcoma NA FLT3
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1; CA1; CA1; ACHE; ADORA3; ADORA2A; ADORA1
NA: NA Gonorrheal vaginitis NA ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1; ABCC1; ABCC1; XDH; PPARG
J00-J99: Diseases of the respiratory system Influenza virus J11.1 HSD11B1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CA2
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses L20-L30 PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp L20-L30 PLA2G1B
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 TBXAS1; PTGS1; PPARG
C00-D49: Neoplasms Inflammatory breast cancer C50 EGFR
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MPO; PLA2G1B; ALOX5; MMP13; MMP12; PTGS1; FAAH
C00-D49: Neoplasms Non-small-cell lung cancer NA MMP2; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 ESRRA; FFAR1; HSD11B1
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 CA1; ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes Radiation sickness T66 TLR2
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Radionuclide imaging W88 ADORA2A
C00-D49: Neoplasms Recurrent epithelial ovarian or primary peritoneal cancer C78 PARP1
C00-D49: Neoplasms Refractory breast cancer C50 EGFR
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Genetic disease Q00-Q99 ALPL
K00-K95: Diseases of the digestive system Gastrointestinal disease K00-K93 ESRRA; EGFR
I00-I99: Diseases of the circulatory system Ischemia I99.8 SRC; ADORA3
N00-N99: Diseases of the genitourinary system Irregularities N92.6 ESR1
C00-D49: Neoplasms Intestinal cancer NA ABL1
I00-I99: Diseases of the circulatory system Ischemic stroke I61-I63 MMP3
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT; ACHE
C00-D49: Neoplasms Renal cell carcinoma NA MMP2; KDR; KDR
C00-D49: Neoplasms Renal cancer C64 CA9; KDR
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
N00-N99: Diseases of the genitourinary system Renal failure N17, N18, N19 ADORA1
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
A00-B99: Certain infectious and parasitic diseases Cryptosporidium infection A07.2 EGFR
S00-T88: Injury, poisoning and certain other consequences of external causes Postoperative inflammation T81 PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 ADORA1; PPARD; ESR1; HCAR2
E00-E89: Endocrine, nutritional and metabolic diseases Hypertriglyceridemia E78.1, E78.2, E78.3, I47-I49 ADORA1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cachexia R64 ESRRA
C00-D49: Neoplasms Carcinoma D00-D09 ESR1
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Osteopetrosis Q78.2 ESR1
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
Z00-Z99: Factors influencing health status and contact with health services Oral contraceptive Z30 ESR1
I00-I99: Diseases of the circulatory system Orthostatic hypotension I95.1 ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases Dietary shortage E40-E46 ABL1; PTGS1
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR
E00-E89: Endocrine, nutritional and metabolic diseases TTR amyloidosis E85 TTR
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 TBXAS1; MGAM; PTPN1; PTPN1; FFAR1; HSD11B1; NFKB1; PPARG; PPARG; PPARD; HCAR2
C00-D49: Neoplasms Breast cancer C50 TERT; CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; EGFR; EGFR; EGFR; BCL2; ESR1; ESR1; KDR; KDR; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 AKR1B1; MGAM; PTPN1; FFAR1; HSD11B1; HSD11B1; GSK3B; ADORA1; PPARG
L00-L99: Diseases of the skin and subcutaneous tissue Dermatological disease L00-L99 ESRRA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 MAOA
A00-B99: Certain infectious and parasitic diseases Dengue fever A90 MGAM
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Hyperglycemia R73.9 MGAM
E00-E89: Endocrine, nutritional and metabolic diseases Hypercholesterolemia E78 HSD11B1
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
Z00-Z99: Factors influencing health status and contact with health services Hormone replacement therapy Z79.890 ESR1
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA; PTGS1; ADORA2A; ADORA1
Z00-Z99: Factors influencing health status and contact with health services Contraception Z30 ESR1
I00-I99: Diseases of the circulatory system Coronary disorder diagnosis I20-I25 ADORA2A
C00-D49: Neoplasms Mesothelioma C45 PTK2
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 HSD11B1; CA4; CA4
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 ACHE; CA4; CA2
H00-H59: Diseases of the eye and adnexa Ocular inflammation H16.229 TERT; PPARG
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 MMP1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1; PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
L00-L99: Diseases of the skin and subcutaneous tissue Diabetic foot ulcer L88-L89 ADORA2A; EGFR
G00-G99: Diseases of the nervous system G00-G99 Diagnostic imaging G30, I73.9 APP
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 IGF1R; ESR1; ESR1
C00-D49: Neoplasms Hormone refractory prostate cancer C61 ESR1
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1
H00-H59: Diseases of the eye and adnexa Corneal ulcers H16.0 MMP3
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
J00-J99: Diseases of the respiratory system Respiratory disease J00-J99 ALOX5
C00-D49: Neoplasms Glioma C71 ABL1; EGFR; EGFR; KDR; APP
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 MMP13; ADK; ACHE; PTGS1; IGF1R; ADORA2A; CDK1; FAAH; ESR1
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 MPO; MAOA; ACHE; ADORA2A; ADORA1
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET
I00-I99: Diseases of the circulatory system Heart failure I50 ADORA1; XDH
N00-N99: Diseases of the genitourinary system Vagina disease N76.0 ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Drug abuse F10-F19 PPARG
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; ADORA3; KDR
C00-D49: Neoplasms Hematologic malignancies C81-C86 AKT1
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
NA: NA Hepatitis C virus infection NA ADORA3
NA: NA Hematopoietic stem cell transplantation NA FLT3
C00-D49: Neoplasms Colon cancer C50 ALPL; FLT3; EGFR
NA: NA Colour dead tissues NA PTPN1
C00-D49: Neoplasms Colorectal cancer C18-C21 FLT3; PTGS1; IGF1R; MMP9; EGFR; EGFR; TP53; KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Nicotine dependence F17 PPARG
C00-D49: Neoplasms Osteosarcoma C40-C41 SRC; GSK3B
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 SRC; ESR1
I00-I99: Diseases of the circulatory system Atherosclerosis I70 NR1I2; ALOX5; MMP12; HSD11B1; PPARD; HCAR2
J00-J99: Diseases of the respiratory system Asthma J45 TBXAS1; PLA2G1B; ESRRA; ALOX5; ALOX5; MMP12; ADORA2A; ADORA1
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthralgia M25.5 ESR1
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 PLA2G1B; ADORA2A; HCAR2
NA: NA Dyslipidemia NA PPARD
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA1; CA2
N00-N99: Diseases of the genitourinary system Dysmenorrhea N94.4-N94.6 PTGS1; ESR1
N00-N99: Diseases of the genitourinary system Dyspareunia N94.1 ESR1
NA: NA Early satiation associated with functional dyspepsia NA ACHE
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR
I00-I99: Diseases of the circulatory system Acute and chronic heart failure I50 ADORA1
A00-B99: Certain infectious and parasitic diseases Acquired immune deficiency syndrome B20 MGAM
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 ESRRA; MMP2; PTGS1; ESR1
G00-G99: Diseases of the nervous system G00-G99 Ataxia telangiectasia G11.3 PARP1
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases Atrial fibrillation E78, I48 ADORA1; ADORA1
N00-N99: Diseases of the genitourinary system Atrophic vaginitis N95.2 ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue Atrophy M62.571 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Autoimmune diabetes E08-E13 TLR2; ADORA1; ESR1
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
NA: NA Edema NA CA2
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2
I00-I99: Diseases of the circulatory system Hypertension I10-I16 ADORA2A; ADORA1
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA; CASP1; ADK
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ADK; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 DRD4
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR
G00-G99: Diseases of the nervous system G00-G99 Permanent and transient stroke G45.9, I61-I63 PARP1
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 ACHE
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET
NA: NA Miosis during ocular surgery NA PTGS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 PLA2G1B; ABCC1; ESRRA; ALOX5; MMP1
C00-D49: Neoplasms Bladder cancer C67 CYP19A1; EGFR
E00-E89: Endocrine, nutritional and metabolic diseases Dyslipidaemias E78 PPARD; PPARD
C00-D49: Neoplasms Biliary cancer C22, C24 KDR
C00-D49: Neoplasms Ovarian cancer C56 TERT; MMP2; EGFR; EGFR; PARP1; KDR; KDR; KDR; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Estrogen deficiency E28.39 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Hypogonadism E23.0, E28.3, E29.1 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT; PPARD
I00-I99: Diseases of the circulatory system Cerebral amyloid angiopathy I68.0 APP
I00-I99: Diseases of the circulatory system Cerebrovascular disorders I60-I69 PARP1
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 ADORA3; EGFR; PARP1
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 ALOX5; MMP13; MMP3; MMP2; PTGS1
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R
M00-M99: Diseases of the musculoskeletal system and connective tissue Muscle disease M60-M63 MGAM
G00-G99: Diseases of the nervous system G00-G99 Multiple scierosis G35 MPO; ADORA1; ESR1; ESR1
C00-D49: Neoplasms Multiple myeloma C90 TERT; SRC; IGF1R; CD38; BCL2
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET
N00-N99: Diseases of the genitourinary system Infertility N97.0 ESR1
C00-D49: Neoplasms Gastric cancer C16 EGFR; EGFR; KDR; KDR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Fatigue R53 ADORA1
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 MAPT; ACHE; ADORA1
C00-D49: Neoplasms CLL NA FLT3
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
N00-N99: Diseases of the genitourinary system Female infertility due to anovulation N97.0 ESR1
N00-N99: Diseases of the genitourinary system Female infertility N97.0 ESR1; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET; CASP1
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5; RAB9A
H00-H59: Diseases of the eye and adnexa Eye disorders H00-H59 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Female hypogonadism E23, E28 ESR1
L00-L99: Diseases of the skin and subcutaneous tissue Contact dermatitis L23, L24, L25 PLA2G1B
C00-D49: Neoplasms Chronic myelogenous leukaemia C92.1 ABL1; ABL1; SRC
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 EGFR; BCL2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 ESRRA; DRD4
H00-H59: Diseases of the eye and adnexa Macular degeneration H35.3 APP
A00-B99: Certain infectious and parasitic diseases Anthelmintic B89 ALPL
NA: NA Postmenopausal disorder NA ESR1
N00-N99: Diseases of the genitourinary system Post-menopausal vaginal atrophy N95.2 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Pompe's disease E74.02 MGAM; GAA
G00-G99: Diseases of the nervous system G00-G99 Brain ischaemia G45.9, I67.8 PARP1
S00-T88: Injury, poisoning and certain other consequences of external causes Brain injury S09.90 APP
C00-D49: Neoplasms Brain cancer C71, D33 TERT; TK1; SRC; EGFR; EGFR; ESR1
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 ESRRA; ALOX5; PTGS1
K00-K95: Diseases of the digestive system Ulcerative colitis K51 PTGS1; MMP9
H00-H59: Diseases of the eye and adnexa Choroidal neovascularisation H35 ESRRA
C00-D49: Neoplasms Myeloid leukemia C92 FLT3; ABL1
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 ALOX5; FLT3; EGFR; BCL2
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE
C00-D49: Neoplasms Thyroid cancer C73 TSHR; KDR
I00-I99: Diseases of the circulatory system Thromboembolism I80-I82 TBXAS1
I00-I99: Diseases of the circulatory system Thrombosis I80-I82 TBXAS1; ALOX5
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 NPSR1; ESR1; APP
C00-D49: Neoplasms Pancreatic cancer C25 AKT1; TLR2; TERT; TK1; FLT3; MMP2; EGFR; KDR
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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Developer & Maintainer:
Dr. Zeng Xian
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