Plant Name: Ficus sarmentosa var. thunbergii
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GPR35; ADRA2C; GPBAR1; DRD4; | |
| NPSR1; CXCR1; | |
| RECQL; PLA2G1B; TDP1; BLM; APOBEC3G; CTDSP1; PIK3CG; PIK3R1; GLO1; HPGD; HSD11B1; MPO; HSD17B1; AKR1B1; HSD17B10; ALOX15; AKR1B10; ALDH1A1; HSD17B2; ALOX12; NOX4; USP2; PYGL; APEX1; POLB; | |
| PTPRF; PTPN1; DUSP3; PTPN2; ACP1; | |
| ACHE; GAA; | |
| TOP2A; | |
| MET; CAMK2B; GSK3B; CSNK2A1; DAPK1; SYK; NEK2; FLT3; NEK6; MYLK; SRC; IGF1R; PTK2; BRAF; AURKB; AURKA; FLT4; EPHB4; MAP3K8; TEK; PDGFRB; INSR; PLK4; CDK1; EGFR; ERBB2; PIM1; NUAK1; ALK; AXL; KDR; AKT1; PLK1; PKN1; | |
| CA12; CA5B; CA3; CA14; CA7; CA1; CA9; CA13; CA4; CA6; CA2; CA5A; | |
| AR; | |
| NR1H4; | |
| ESRRA; | |
| RORC; | |
| KDM4E; | |
| MAOA; ALOX5; TYR; XDH; | |
| MMP13; MMP3; MMP2; MMP9; | |
| BACE1; | |
| AHR; STAT6; HIF1A; NFKB1; TP53; | |
| FUT7; | |
| ABCC1; ABCG2; | |
| SLC22A6; | |
| SMAD3; LMNA; MAPT; HBB; THPO; APP; HSPA1A; | |
| L3MBTL1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
Showing 1 to 10 of 124 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 2.094E-02 | 3.429E-02 | AKR1B10; AKR1B1 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.675E-02 | 2.842E-02 | AKR1B10; AKR1B1 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 8.357E-04 | 1.826E-03 | AKR1B10; GAA; AKR1B1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.570E-09 | 2.326E-08 | HSD11B1; HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.767E-04 | 9.295E-04 | CYP1A2; XDH |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.985E-02 | 3.309E-02 | MAOA; TYR |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.082E-04 | 3.069E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.101E-07 | 7.468E-07 | CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 4.137E-10 | 5.614E-09 | CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 3.080E-06 | 1.330E-05 | CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
Showing 1 to 10 of 120 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | PIK3CG; CYP2C9 |
Showing 1 to 10 of 258 entries