CMAUP Plant Collective Molecular Activities

Plant Name: Bothriocline longipes

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	2.414E-11	2.168E-07	ACP1, CDC25B, PTPN1, PTPN11, PTPN2, PTPN6, PTPRF
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	9.399E-08	2.274E-04	ACP1, PTPN11, PTPN2
BP	GO:0009987; cellular process	GO:0060338; regulation of type I interferon-mediated signaling pathway	2.888E-07	5.717E-04	PTPN1, PTPN11, PTPN2, PTPN6
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	1.480E-06	2.301E-03	PTPN11, PTPN6
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	4.435E-06	4.599E-03	GPBAR1, NR1H4
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	4.435E-06	4.599E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0047374; methylumbelliferyl-acetate deacetylase activity	4.435E-06	4.599E-03	CES1, CES2
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	6.589E-06	6.238E-03	AKR1B1, APAF1, MAPT, POLB, PTPN1, PTPN11, PTPRF, RECQL, TDP1, TERT
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	8.864E-06	7.423E-03	PTPN1, PTPN2
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.144E-05	8.590E-03	AKR1B1, AKR1B10, CES1, HSD11B1, NR1H4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04520	Adherens junction_Homo sapiens_hsa04520	1.735E-06	1.214E-04	PTPN1; PTPN6; ACP1; PTPRF
hsa04931	Insulin resistance_Homo sapiens_hsa04931	8.155E-06	2.854E-04	PTPN1; STAT3; PTPN11; PTPRF
hsa04630	Jak-STAT signaling pathway_Homo sapiens_hsa04630	3.522E-05	8.219E-04	STAT3; PTPN6; PTPN11; PTPN2
hsa05205	Proteoglycans in cancer_Homo sapiens_hsa05205	1.782E-03	1.559E-02	STAT3; PTPN6; PTPN11
hsa00040	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	8.480E-04	9.894E-03	AKR1B10; AKR1B1
hsa00052	Galactose metabolism_Homo sapiens_hsa00052	5.881E-04	9.375E-03	AKR1B10; AKR1B1
hsa00983	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.383E-03	1.383E-02	CES2; CES1
hsa00051	Fructose and mannose metabolism_Homo sapiens_hsa00051	6.696E-04	9.375E-03	AKR1B10; AKR1B1
hsa00561	Glycerolipid metabolism_Homo sapiens_hsa00561	2.265E-03	1.761E-02	AKR1B10; AKR1B1
hsa05321	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.741E-03	1.919E-02	STAT3; RORC
hsa04920	Adipocytokine signaling pathway_Homo sapiens_hsa04920	3.171E-03	2.018E-02	STAT3; PTPN11
hsa00564	Glycerophospholipid metabolism_Homo sapiens_hsa00564	5.757E-03	3.358E-02	ACHE; PLA2G1B

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	PLA2G1B
A00-B99: Certain infectious and parasitic diseases	Visceral leishmaniasis	B55.0	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Contact dermatitis	L23, L24, L25	PLA2G1B
NA: NA	Colour dead tissues	NA	PTPN1
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	STAT3
C00-D49: Neoplasms	Liver cancer	C22	TERT
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CES1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	CES1
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	PLA2G1B; CES1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HSD11B1; CES1
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	GPBAR1; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE
C00-D49: Neoplasms	Multiple myeloma	C90	TERT; STAT3
C00-D49: Neoplasms	Ovarian cancer	C56	TERT
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; ACHE; ACHE; MAPT
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	PLA2G1B
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	AKR1B1; TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; HSD11B1; HSD11B1; AKR1B1
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HSD11B1; CES1
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT
I00-I99: Diseases of the circulatory system	Peripheral vascular disease	I73.9	CES1
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; HSD11B1
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	HSD11B1
C00-D49: Neoplasms	Solid tumours	C00-D48	STAT3
C00-D49: Neoplasms	Melanoma	C43	TERT
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE; MAPT
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PLA2G1B; AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic syndrome x	E88.81	HSD11B1
S00-T88: Injury, poisoning and certain other consequences of external causes	Nerve injury	T14.4	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
NA: NA	Upper abdominal bloating	NA	ACHE
J00-J99: Diseases of the respiratory system	Influenza virus	J11.1	HSD11B1
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp	L20-L30	PLA2G1B
L00-L99: Diseases of the skin and subcutaneous tissue	Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses	L20-L30	PLA2G1B
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; STAT3; CDC25B
C00-D49: Neoplasms	Tumors	C00-D48	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; GPBAR1; HSD11B1
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	STAT3
C00-D49: Neoplasms	Prostate cancer	C61	TERT
A00-B99: Certain infectious and parasitic diseases	Leishmaniasis	B55.0	PLA2G1B
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	HSD11B1
J00-J99: Diseases of the respiratory system	Asthma	J45	PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; MAPT
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	HSD11B1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PLA2G1B
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
C00-D49: Neoplasms	Breast cancer	C50	TERT
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	PLA2G1B

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases