Plant Name: Schefflera divaricata
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.477E-12 | 9.748E-08 | CA1, CA12, CA13, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 5.529E-10 | 6.020E-06 | CA1, CA12, CA13, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.583E-09 | 1.149E-05 | CA1, CA12, CA13, CA7, CA9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 2.656E-06 | 6.427E-03 | CA1, CA12, CA13, CA7, CA9, NR1H4, PTPN1, RORC |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 4.066E-06 | 8.048E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 4.066E-06 | 8.048E-03 | GPBAR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 5.334E-06 | 9.679E-03 | ACP1, PTPN1, PTPN2, PTPRF |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 7.742E-12 | 3.019E-10 | CA12; CA1; CA7; CA9; CA13 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 8.165E-05 | 1.592E-03 | PTPN1; ACP1; PTPRF |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 1.810E-03 | 1.859E-02 | CASP7; CASP1 |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.011E-03 | 1.859E-02 | HSD11B1; CYP1A2 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 2.518E-03 | 1.859E-02 | CYP1A2; ALDH1A1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 3.164E-03 | 1.859E-02 | HSD11B1; CYP1A2 |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 3.336E-03 | 1.859E-02 | CASP7; CASP1 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 3.973E-03 | 1.937E-02 | HSD11B1; CYP1A2 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 6.910E-03 | 2.695E-02 | PTPN1; PTPRF |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.194E-02 | 3.880E-02 | HSD11B1; AKR1B10; CYP1A2; ALDH1A1; HSD17B10 |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.103E-02 | 3.880E-02 | PTPN1; PTPRF |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 1.581E-02 | 4.742E-02 | CASP7; HSD17B10 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 5.737E-03 | 2.486E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1 |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA1; CA9 |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9 |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1 |