CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Cancer	C00-C96	TP53
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HMGCR
NA: NA	Cardiovascular disease	NA	HMGCR
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	HMGCR
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	HMGCR
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
NA: NA	Hyperlipidemia	NA	HMGCR
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HMGCR
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	HMGCR
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
A00-B99: Certain infectious and parasitic diseases	HBV infection	B16, B18.0, B18.1	HMGCR
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
C00-D49: Neoplasms	Multiple myeloma	C90	HMGCR
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Elevated CRP	E78.0	HMGCR
K00-K95: Diseases of the digestive system	Chemotherapy or radiotherapy-induced mucositis	K12.3, R52, G89	HMGCR
NA: NA	Dyslipidemia	NA	HMGCR
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	HMGCR
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HMGCR
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HMGCR
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	HMGCR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Garcinia oligantha

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases