Plant Name: Eria rigida
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | 2.121E-06 | 5.774E-03 | ADRA2A, ADRA2C |
| BP | GO:0009987; cellular process | GO:0032811; negative regulation of epinephrine secretion | 2.121E-06 | 5.774E-03 | ADRA2A, ADRA2C |
| BP | GO:0009987; cellular process | GO:0038171; cannabinoid signaling pathway | 2.121E-06 | 5.774E-03 | CNR1, CNR2 |
| BP | GO:0032501; multicellular organismal process | GO:0019233; sensory perception of pain | 4.217E-06 | 7.063E-03 | CNR1, CNR2, MAPK1 |
| MF | GO:0060089; molecular transducer activity | GO:0004949; cannabinoid receptor activity | 1.061E-06 | 5.774E-03 | CNR1, CNR2 |
| MF | GO:0060089; molecular transducer activity | GO:0004938; alpha2-adrenergic receptor activity | 1.061E-06 | 5.774E-03 | ADRA2A, ADRA2C |
Showing 1 to 6 of 6 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 6.820E-03 | 3.902E-02 | CNR1; MAPK1 |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.190E-04 | 4.559E-03 | MAPK1; ADRA2C; ADRA2A |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 3.596E-07 | 3.704E-05 | CNR2; CNR1; NMUR2; ADRA2C; ADRA2A |
| hsa04723 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.612E-03 | 1.612E-02 | CNR1; MAPK1 |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.943E-03 | 1.612E-02 | ACHE; MAPK1 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.978E-03 | 1.612E-02 | ALOX5; MAPK1 |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.312E-03 | 1.612E-02 | MMP2; MAPK1 |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.550E-03 | 1.612E-02 | MMP2; MAPK1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.192E-03 | 1.612E-02 | RXRA; MAPK1 |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 1.612E-03 | 1.612E-02 | MMP2; MAPK1 |
Showing 1 to 10 of 18 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Postherpetic neuralgia | B02.2, G44.847, G53.0 | CNR1 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MMP2 |
| C00-D49: Neoplasms | Cutaneous T-cell lymphoma | C84.0, C84.1 | RXRA |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2 |
| C00-D49: Neoplasms | Cancer | C00-C96 | MMP2; MAPK1; ACHE |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | MMP2 |
Showing 1 to 10 of 88 entries