Plant Name: Ichthyothere latifolia
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0042493; response to drug | 5.871E-07 | 8.522E-04 | ABCC1, ABCG2, APEX1, CA3, CA9, CDK2, CDK6, NFKB1, POLB |
| BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 2.026E-06 | 1.838E-03 | APEX1, POLB |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.026E-06 | 1.838E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.026E-06 | 1.838E-03 | ALOX12, ALOX15 |
| BP | GO:0065007; biological regulation | GO:0065008; regulation of biological quality | 2.393E-06 | 2.084E-03 | ABCC1, ABCG2, ACHE, ALOX12, ALOX15, APEX1, CA12, CA2, CA7, CDK6, CYP19A1, GAA, MAPT, NFKB1, POLB, XDH |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 6.074E-06 | 4.408E-03 | CA2, CA7 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 6.074E-06 | 4.408E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 6.074E-06 | 4.408E-03 | ALOX12, ALOX15 |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 1.193E-05 | 7.772E-03 | ABCC1, ALOX12, ALOX15 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.396E-05 | 8.686E-03 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 3.340E-23 | 7.272E-19 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 4.610E-18 | 3.346E-14 | CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.910E-16 | 8.317E-13 | CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.184E-22 | 1.042E-20 | CA12; CA1; CA3; CA2; CA5A; CA7; CA6; CA9; CA14 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 1.810E-04 | 6.825E-03 | POLB; CDK6; CDK2; NFKB1 |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 2.327E-04 | 6.825E-03 | CDK6; CDK2; NFKB1 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 8.896E-04 | 1.602E-02 | CDK6; CDK2; NFKB1 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.288E-03 | 1.620E-02 | GAA; ALOX15; ALPL; ALOX12; CYP19A1; HSD17B10; XDH |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 1.092E-03 | 1.602E-02 | CDK6; CDK2; NFKB1 |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 1.634E-03 | 1.686E-02 | BACE1; MAPT; HSD17B10 |
| hsa03410 | Base excision repair_Homo sapiens_hsa03410 | 9.715E-04 | 1.602E-02 | POLB; APEX1 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 3.393E-03 | 2.936E-02 | ALOX15; ALOX12 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 3.836E-03 | 2.936E-02 | CDK6; NFKB1 |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 1.724E-03 | 1.686E-02 | ABCC1; ABCG2 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 4.671E-03 | 2.936E-02 | CDK6; NFKB1 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 6.865E-03 | 3.840E-02 | CDK2; NFKB1 |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 4.184E-03 | 2.936E-02 | CDK6; CDK2 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 4.425E-03 | 2.936E-02 | CA2; ABCG2 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 8.070E-03 | 4.177E-02 | ABCC1; CDK6; NFKB1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 6.981E-03 | 3.840E-02 | XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| C00-D49: Neoplasms | Thymoma | C37, D15.0 | CDK2 |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; MAPT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | CDK2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | ABCC1 |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| NA: NA | Edema | NA | CA2 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; ACHE; ACHE; MAPT |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | CDK2 |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; MAPT |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| C00-D49: Neoplasms | Ocular cancer | C69 | APEX1 |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1; ACHE |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1 |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CDK2; CA9; NFKB1; CA1; ACHE |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | CA1; CA1; ACHE |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | XDH; ABCC1; ABCC1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CYP19A1; CA9 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1 |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CDK2; CA9 |
| NA: NA | Upper abdominal bloating | NA | ACHE |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA2; ACHE |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |