Plant Name: Pyrola japonica
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NPSR1; CXCR1; | |
| GPBAR1; DRD4; | |
| PLA2G1B; TDP1; ALPI; RECQL; P4HB; PIK3R1; GLO1; MPO; AKR1B1; HSD17B2; HSD17B10; ALOX15; HSD11B1; AKR1B10; ALOX12; NOX4; PYGL; POLB; | |
| PTPN1; CDC25B; PTPRF; PTPN2; ACP1; | |
| GAA; | |
| AKT1; MET; CAMK2B; NEK6; CSNK2A1; DAPK1; AXL; NEK2; FLT3; PKN1; SRC; IGF1R; PTK2; AURKB; GSK3B; CDK1; PIM1; NUAK1; ALK; KDR; | |
| CA9; CA3; CA14; CA7; CA5A; CA12; CA4; CA6; CA2; CA1; | |
| PPARA; PPARD; | |
| NR1H4; | |
| RORC; | |
| KDM4E; | |
| MAOA; ALOX5; XDH; | |
| MMP13; MMP3; MMP2; MMP9; | |
| BACE1; | |
| TLR2; | |
| STAT6; HIF1A; NFKB1; TP53; | |
| ABCC1; ABCG2; | |
| FABP5; FABP2; FABP4; FABP3; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
| ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C8 | Cytochrome P450 2C8 | P10632 | CHEMBL3721 |
| Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
| Enzyme_unclassified | GLO1 | Glyoxalase I | Q04760 | CHEMBL2424 |
| Enzyme_unclassified | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | HSD17B2 | Estradiol 17-beta-dehydrogenase 2 | P37059 | CHEMBL2789 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | ALOX12 | Arachidonate 12-lipoxygenase | P18054 | CHEMBL3687 |
| Enzyme_unclassified | NOX4 | NADPH oxidase 4 | Q9NPH5 | CHEMBL1250375 |
| Enzyme_unclassified | PYGL | Liver glycogen phosphorylase | P06737 | CHEMBL2568 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Enzyme_unclassified | PLA2G1B | Phospholipase A2 group 1B | P04054 | CHEMBL4426 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | ALPI | Intestinal alkaline phosphatase | P09923 | CHEMBL5573 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | P4HB | Protein disulfide-isomerase | P07237 | CHEMBL5422 |
| Enzyme_unclassified | PIK3R1 | PI3-kinase p85-alpha subunit | P27986 | CHEMBL2506 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
| Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Metallo protease | MMP13 | Matrix metalloproteinase 13 | P45452 | CHEMBL280 |
| Metallo protease | MMP3 | Matrix metalloproteinase 3 | P08254 | CHEMBL283 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group F | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
| Peptide receptor (family A GPCR) | NPSR1 | Neuropeptide S receptor | Q6W5P4 | CHEMBL5162 |
| Peptide receptor (family A GPCR) | CXCR1 | Interleukin-8 receptor A | P25024 | CHEMBL4029 |
| Protein Kinase | AKT1 | Serine/threonine-protein kinase AKT | P31749 | CHEMBL4282 |
| Protein Kinase | MET | Hepatocyte growth factor receptor | P08581 | CHEMBL3717 |
| Protein Kinase | CAMK2B | CaM kinase II beta | Q13554 | CHEMBL4121 |
| Protein Kinase | NEK6 | Serine/threonine-protein kinase NEK6 | Q9HC98 | CHEMBL4309 |
| Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
| Protein Kinase | DAPK1 | Death-associated protein kinase 1 | P53355 | CHEMBL2558 |
| Protein Kinase | AXL | Tyrosine-protein kinase receptor UFO | P30530 | CHEMBL4895 |
| Protein Kinase | NEK2 | Serine/threonine-protein kinase NEK2 | P51955 | CHEMBL3835 |
| Protein Kinase | FLT3 | Tyrosine-protein kinase receptor FLT3 | P36888 | CHEMBL1974 |
| Protein Kinase | PKN1 | Protein kinase N1 | Q16512 | CHEMBL3384 |
| Protein Kinase | SRC | Tyrosine-protein kinase SRC | P12931 | CHEMBL267 |
| Protein Kinase | IGF1R | Insulin-like growth factor I receptor | P08069 | CHEMBL1957 |
| Protein Kinase | PTK2 | Focal adhesion kinase 1 | Q05397 | CHEMBL2695 |
| Protein Kinase | AURKB | Serine/threonine-protein kinase Aurora-B | Q96GD4 | CHEMBL2185 |
| Protein Kinase | GSK3B | Glycogen synthase kinase-3 beta | P49841 | CHEMBL262 |
| Protein Kinase | CDK1 | Cyclin-dependent kinase 1 | P06493 | CHEMBL308 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Protein Kinase | NUAK1 | NUAK family SNF1-like kinase 1 | O60285 | CHEMBL5784 |
| Protein Kinase | ALK | ALK tyrosine kinase receptor | Q9UM73 | CHEMBL4247 |
| Protein Kinase | KDR | Vascular endothelial growth factor receptor 2 | P35968 | CHEMBL279 |
| Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
| Protein Phosphatase | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | P10586 | CHEMBL3521 |
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
| Protein Phosphatase | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | P24666 | CHEMBL4903 |
| Small molecule receptor (family A GPCR) | GPBAR1 | G-protein coupled bile acid receptor 1 | Q8TDU6 | CHEMBL5409 |
| Small molecule receptor (family A GPCR) | DRD4 | Dopamine D4 receptor | P21917 | CHEMBL219 |
| Toll-like and Il-1 receptors | TLR2 | Toll-like receptor 2 | O60603 | CHEMBL4163 |
| Transcription Factor | STAT6 | Signal transducer and activator of transcription 6 | P42226 | CHEMBL5401 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | FABP5 | Fatty acid binding protein epidermal | Q01469 | CHEMBL3674 |
| Unclassified | FABP2 | Fatty acid binding protein intestinal | P12104 | CHEMBL4879 |
| Unclassified | FABP4 | Fatty acid binding protein adipocyte | P15090 | CHEMBL2083 |
| Unclassified | FABP3 | Fatty acid binding protein muscle | P05413 | CHEMBL3344 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.080E-10 | 4.356E-08 | ALPI, CA1, CA12, CA2, CA3, CA4, CA5A, CA6, CA7, CA9, GLO1, MMP13, MMP2, MMP3, MMP9, NR1H4, PPARA, PPARD, PTPN1, RORC, TP53 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 8.183E-10 | 2.659E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 1.478E-09 | 4.469E-07 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4, NOX4 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 3.713E-09 | 1.037E-06 | ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4, XDH |
| BP | GO:0008152; metabolic process | GO:0006691; leukotriene metabolic process | 5.793E-09 | 1.520E-06 | ABCC1, ALOX12, ALOX15, ALOX5, PLA2G1B, TLR2 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 8.334E-09 | 2.088E-06 | CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP3A4, MPO, NOX4, SRC |
| MF | GO:0005488; binding | GO:0005524; ATP binding | 9.007E-09 | 2.213E-06 | ABCC1, ABCG2, AKT1, ALK, AURKB, AXL, CAMK2B, CDK1, CSNK2A1, DAPK1, FLT3, GSK3B, IGF1R, KDR, MET, NEK2, NEK6, NUAK1, PIM1, PKN1, PTK2, PYGL, RECQL, SRC, TP53 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 9.058E-08 | 1.644E-05 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| MF | GO:0003824; catalytic activity | GO:0004674; protein serine/threonine kinase activity | 1.741E-07 | 2.917E-05 | AKT1, ALK, AURKB, CAMK2B, CDK1, CSNK2A1, DAPK1, GSK3B, NEK2, NEK6, NUAK1, PIM1, PKN1 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 3.900E-07 | 5.980E-05 | CYP1A2, CYP2C8, CYP3A4 |
| CC | GO:0016020; membrane | GO:0005886; plasma membrane | 7.583E-07 | 1.013E-04 | ABCC1, ABCG2, ACP1, AKT1, ALK, ALOX12, ALOX15, ALPI, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CAMK2B, CSNK2A1, CXCR1, DAPK1, DRD4, FABP5, FLT3, GAA, GLO1, GPBAR1, GSK3B, HSD17B10, IGF1R, KDR, MET, MMP2, NPSR1, PIK3R1, PIM1, PKN1, PTK2, PTPN1, PTPN2, PTPRF, SRC, TDP1, TLR2 |
| MF | GO:0003824; catalytic activity | GO:0101020; estrogen 16-alpha-hydroxylase activity | 9.716E-07 | 1.256E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 1.023E-06 | 1.295E-04 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, NEK6, PKN1, SRC |
| BP | GO:0008152; metabolic process | GO:0018107; peptidyl-threonine phosphorylation | 1.696E-06 | 1.985E-04 | AKT1, CAMK2B, CDK1, CSNK2A1, GSK3B, PKN1 |
| BP | GO:0008152; metabolic process | GO:0002933; lipid hydroxylation | 1.937E-06 | 2.185E-04 | CYP1A1, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 2.482E-06 | 2.730E-04 | CYP1A1, CYP1A2, CYP1B1, CYP2C8 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 3.184E-06 | 3.317E-04 | NR1H4, PIK3R1, PTPN1, PTPN2, SRC |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 5.172E-06 | 4.983E-04 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0051179; localization | GO:0046903; secretion | 5.736E-06 | 5.407E-04 | ALOX5, AXL, CA2, CA9, CXCR1, DRD4, FABP5, GAA, HIF1A, MMP9, MPO, NFKB1, NR1H4, PLA2G1B, PYGL, TLR2, XDH |
| MF | GO:0005488; binding | GO:0032052; bile acid binding | 8.052E-06 | 7.404E-04 | NR1H4, PLA2G1B, PYGL |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 9.094E-06 | 8.217E-04 | AKT1, HIF1A, P4HB, PPARD, SRC, TP53 |
| BP | GO:0065007; biological regulation | GO:0042593; glucose homeostasis | 9.454E-06 | 8.380E-04 | AKT1, HIF1A, NOX4, NR1H4, PIK3R1, PTPN2, PYGL |
| BP | GO:0009987; cellular process | GO:0070301; cellular response to hydrogen peroxide | 9.506E-06 | 8.380E-04 | AKR1B1, AXL, CDK1, CYP1B1, STAT6 |
| BP | GO:0008152; metabolic process | GO:0042446; hormone biosynthetic process | 9.506E-06 | 8.380E-04 | AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B2 |
| BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 1.015E-05 | 8.875E-04 | HIF1A, MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 1.055E-05 | 9.188E-04 | AURKB, CA2, CA7, HIF1A, NEK2, NPSR1, NR1H4, PLA2G1B |
| BP | GO:0032502; developmental process | GO:0007568; aging | 1.237E-05 | 1.046E-03 | AKT1, AURKB, CDK1, CYP1A1, MPO, NOX4, POLB, TP53 |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 1.510E-05 | 1.213E-03 | DRD4, FABP3, PLA2G1B, PPARA, PPARD |
| BP | GO:0050896; response to stimulus | GO:0050728; negative regulation of inflammatory response | 1.619E-05 | 1.274E-03 | CYP19A1, NFKB1, NR1H4, PPARA, PPARD, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 2.088E-05 | 1.584E-03 | CYP1A2, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 2.088E-05 | 1.584E-03 | CYP1A2, CYP2C8, CYP3A4 |
| BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 2.147E-05 | 1.596E-03 | ALOX12, ALOX15 |
| BP | GO:0009987; cellular process | GO:0048010; vascular endothelial growth factor receptor signaling pathway | 2.147E-05 | 1.596E-03 | AXL, KDR, PIK3R1, PTK2, SRC |
| MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 2.147E-05 | 1.596E-03 | ALOX12, ALOX15 |
| BP | Unclassified; | GO:0044243; multicellular organismal catabolic process | 2.297E-05 | 1.678E-03 | MMP13, MMP2, MMP3, MMP9, PLA2G1B |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 2.408E-05 | 1.748E-03 | ACP1, AKR1B1, AKR1B10, AKT1, ALOX12, ALOX15, ALOX5, AURKB, CA1, CA2, CA3, CA7, CAMK2B, CDC25B, CDK1, CSNK2A1, FABP2, FABP3, FABP4, FABP5, FLT3, GLO1, GSK3B, HIF1A, NEK2, NEK6, NFKB1, PIK3R1, PIM1, PKN1, PLA2G1B, PTK2, PTPN1, PTPN2, PYGL, SMN1, SMN2, SRC, STAT6, TP53, XDH |
| BP | GO:0009987; cellular process | GO:1900103; positive regulation of endoplasmic reticulum unfolded protein response | 2.705E-05 | 1.925E-03 | PIK3R1, PTPN1, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 3.583E-05 | 2.454E-03 | AKT1, FABP3, NR1H4, SRC, TLR2 |
| BP | GO:0009987; cellular process | GO:0071345; cellular response to cytokine stimulus | 4.123E-05 | 2.771E-03 | AKT1, ALOX15, AXL, DAPK1, FABP4, FLT3, GSK3B, HIF1A, NFKB1 |
| BP | Unclassified; | GO:0044259; multicellular organismal macromolecule metabolic process | 5.079E-05 | 3.287E-03 | HIF1A, MMP13, MMP2, MMP3, MMP9 |
| CC | GO:0043226; organelle | GO:0043227; membrane-bounded organelle | 5.067E-05 | 3.287E-03 | ABCC1, ABCG2, ACP1, AKR1B1, AKR1B10, AKT1, ALK, ALOX12, AURKB, AXL, BACE1, CA1, CA2, CA4, CA5A, CA6, CDK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FABP5, FLT3, GAA, GLO1, GSK3B, HIF1A, HSD17B10, IGF1R, KDM4E, KDR, MAOA, MMP2, MMP9, MPO, NEK6, NFKB1, NOX4, NUAK1, P4HB, PIK3R1, PIM1, PKN1, PLA2G1B, POLB, PPARA, PPARD, PTK2, PTPN1, PTPN2, PTPRF, PYGL, RECQL, RORC, SMN1, SMN2, SRC, TDP1, TLR2, TP53, XDH |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 5.242E-05 | 3.367E-03 | ALOX12, ALOX15, ALOX5 |
| BP | GO:0048511; rhythmic process | GO:0048511; rhythmic process | 5.407E-05 | 3.453E-03 | AXL, CSNK2A1, DRD4, GSK3B, PPARA, RORC, SRC, TP53 |
| BP | GO:0008152; metabolic process | GO:0016311; dephosphorylation | 5.407E-05 | 3.453E-03 | ACP1, ALPI, CA3, CDC25B, POLB, PTPN1, PTPN2, PTPRF |
| BP | GO:0065007; biological regulation | GO:0000187; activation of MAPK activity | 5.536E-05 | 3.515E-03 | ALK, CDK1, DRD4, PKN1, PLA2G1B, PTPN1 |
| BP | GO:0051179; localization | GO:0060341; regulation of cellular localization | 5.714E-05 | 3.606E-03 | AKT1, CDK1, CSNK2A1, DRD4, GSK3B, HIF1A, NPSR1, NR1H4, PIK3R1, PLA2G1B, PTPN1, SRC, TLR2, TP53 |
| BP | GO:0008152; metabolic process | GO:0046209; nitric oxide metabolic process | 6.344E-05 | 3.917E-03 | AKT1, CYP1B1, TLR2 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 6.421E-05 | 3.917E-03 | CA2, CA7 |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 6.421E-05 | 3.917E-03 | GPBAR1, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0035173; histone kinase activity | 6.344E-05 | 3.917E-03 | AURKB, CDK1, PKN1 |
| MF | GO:0003824; catalytic activity | GO:0070576; vitamin D 24-hydroxylase activity | 6.421E-05 | 3.917E-03 | CYP1A1, CYP3A4 |
| MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 6.421E-05 | 3.917E-03 | ALOX12, ALOX15 |
| MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 6.421E-05 | 3.917E-03 | ALOX12, ALOX15 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 6.421E-05 | 3.917E-03 | GPBAR1, NR1H4 |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 6.744E-05 | 4.053E-03 | IGF1R, KDR, PTK2, SRC |
| BP | Unclassified; | GO:1905953; negative regulation of lipid localization | 6.744E-05 | 4.053E-03 | AKT1, NFKB1, PPARA, PTPN2 |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 7.251E-05 | 4.302E-03 | AURKB, CA2, CA7, HIF1A, KDR, NEK2, NPSR1, NR1H4, PLA2G1B, SRC |
| MF | Unclassified; | GO:0032403; protein complex binding | 7.747E-05 | 4.584E-03 | FLT3, IGF1R, KDR, MMP13, MMP9, P4HB, PIK3R1, PPARA, PTPN1, PTPN2, PTPRF, SRC, TLR2 |
| BP | GO:0009987; cellular process | GO:0051897; positive regulation of protein kinase B signaling | 7.771E-05 | 4.586E-03 | AXL, MET, NOX4, PIK3R1, PTK2, SRC |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 7.954E-05 | 4.656E-03 | NR1H4, PPARA, PPARD, RORC |
| BP | GO:0009987; cellular process | GO:2001243; negative regulation of intrinsic apoptotic signaling pathway | 8.176E-05 | 4.760E-03 | AKT1, HIF1A, MMP9, PTPN1, SRC |
| BP | GO:0008152; metabolic process | GO:0031331; positive regulation of cellular catabolic process | 9.359E-05 | 5.391E-03 | AKT1, CDK1, DAPK1, GSK3B, HIF1A, KDR, PPARA, PTK2, PTPN1 |
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 9.946E-05 | 5.640E-03 | ACP1, CDC25B, PTPN1, PTPN2, PTPRF |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 1.006E-04 | 5.663E-03 | AKR1B1, AKT1, ALOX5, AURKB, CAMK2B, CDC25B, CDK1, CSNK2A1, FABP5, GSK3B, HIF1A, NEK2, NEK6, NFKB1, NR1H4, NUAK1, PIM1, PKN1, POLB, PPARA, PPARD, PTPN2, RECQL, RORC, SMN1, SMN2, SRC, STAT6, TP53 |
| BP | GO:0008152; metabolic process | GO:0005977; glycogen metabolic process | 1.166E-04 | 6.479E-03 | AKT1, GAA, GSK3B, PYGL |
| BP | GO:0022610; biological adhesion | GO:0001952; regulation of cell-matrix adhesion | 1.200E-04 | 6.647E-03 | GSK3B, KDR, PIK3R1, PTK2, SRC |
| BP | GO:0050896; response to stimulus | GO:0055093; response to hyperoxia | 1.224E-04 | 6.749E-03 | CYP1A1, POLB, TP53 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.280E-04 | 6.970E-03 | PTPN1, PTPN2 |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 1.280E-04 | 6.970E-03 | CYP1A1, CYP1A2 |
| MF | GO:0005488; binding | GO:0030971; receptor tyrosine kinase binding | 1.345E-04 | 7.216E-03 | PIK3R1, PTPN1, PTPN2, TP53 |
| MF | GO:0003824; catalytic activity | GO:0009055; electron transfer activity | 1.500E-04 | 7.908E-03 | AKR1B1, CYP19A1, CYP1A2, NOX4, XDH |
| MF | GO:0005488; binding | GO:0042802; identical protein binding | 1.535E-04 | 8.076E-03 | ABCG2, AKT1, ALK, CAMK2B, CSNK2A1, DAPK1, DRD4, FLT3, IGF1R, KDR, MET, MMP9, NFKB1, PYGL, SMN1, SMN2, STAT6, TP53, XDH |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 1.619E-04 | 8.476E-03 | CYP1A1, CYP1A2, CYP1B1 |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 1.649E-04 | 8.590E-03 | NR1H4, PPARA, PPARD, RORC |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 1.684E-04 | 8.751E-03 | NR1H4, PIM1, PPARA, PPARD, RORC, SRC |
| BP | GO:0008152; metabolic process | GO:0008210; estrogen metabolic process | 1.844E-04 | 9.530E-03 | CYP19A1, CYP1B1, HSD17B2 |
| BP | GO:0050896; response to stimulus | GO:1901654; response to ketone | 1.847E-04 | 9.530E-03 | AKR1B1, AKT1, CA9, CSNK2A1, SRC, TLR2 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 8.480E-21 | 4.616E-17 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA6, CA7, CA9 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.280E-15 | 1.368E-11 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 5.830E-14 | 7.468E-11 | CA1, CA12, CA2, CA3, CA4, CA5A, CA6, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 3.852E-20 | 6.895E-18 | CA12; CA1; CA3; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 6.833E-12 | 6.115E-10 | CAMK2B; SRC; MMP2; PIK3R1; HIF1A; MMP9; PTK2; IGF1R; KDR; AKT1; TP53; MET; TLR2 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 2.699E-09 | 1.610E-07 | GSK3B; FLT3; DAPK1; MMP2; PIK3R1; HIF1A; MMP9; NFKB1; PTK2; IGF1R; AKT1; MET; TP53; PPARD |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 7.355E-09 | 3.291E-07 | HSD11B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 3.212E-08 | 1.150E-06 | PTPN1; GSK3B; AKT1; PIK3R1; PYGL; PPARA; NFKB1; PTPRF |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 4.153E-08 | 1.239E-06 | PTPN1; CSNK2A1; SRC; ACP1; MET; PTPRF; IGF1R |
| hsa04913 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 9.505E-08 | 2.431E-06 | ALOX5; HSD17B2; CYP1A1; CYP1B1; CYP19A1; IGF1R |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 3.773E-07 | 5.629E-06 | GSK3B; KDR; AKT1; PIK3R1; PKN1; TP53; MET; PTK2; NFKB1; TLR2; IGF1R |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 2.117E-07 | 3.789E-06 | FLT3; PIM1; AKT1; PIK3R1; NFKB1; PPARD |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 1.197E-07 | 2.679E-06 | FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 3.111E-07 | 5.063E-06 | SRC; AKT1; STAT6; PIK3R1; TP53; MMP9; NFKB1; TLR2 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 5.615E-07 | 7.731E-06 | FLT3; AKT1; PIK3R1; TP53; MET; HIF1A |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 2.068E-06 | 2.177E-05 | PLA2G1B; MAOA; GAA; ALOX15; AKR1B1; ALOX12; PYGL; CYP3A4; CYP19A1; HSD17B10; HSD11B1; CYP2C8; AKR1B10; ALOX5; HSD17B2; CYP1A2; CYP1A1; ALPI; XDH |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.798E-07 | 3.577E-06 | CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 6.696E-07 | 8.562E-06 | FABP2; FABP3; FABP4; FABP5; PPARA; PPARD |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 2.689E-06 | 2.533E-05 | GSK3B; CSNK2A1; AKT1; PIK3R1; TP53; NFKB1; TLR2 |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 2.644E-06 | 2.533E-05 | CAMK2B; GSK3B; SRC; AKT1; PIK3R1; PTK2 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 3.021E-06 | 2.703E-05 | GSK3B; AKT1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa04510 | Focal adhesion_Homo sapiens_hsa04510 | 3.597E-06 | 3.066E-05 | GSK3B; SRC; KDR; AKT1; PIK3R1; MET; PTK2; IGF1R |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 1.088E-06 | 1.298E-05 | DAPK1; SRC; MMP2; MMP9; TP53 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.867E-06 | 2.088E-05 | HSD11B1; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 7.067E-06 | 5.750E-05 | CAMK2B; AKT1; PIK3R1; HIF1A; NFKB1; IGF1R |
| hsa04370 | VEGF signaling pathway_Homo sapiens_hsa04370 | 8.044E-06 | 6.261E-05 | SRC; KDR; AKT1; PIK3R1; PTK2 |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 1.101E-05 | 7.885E-05 | CAMK2B; AKT1; PIK3R1; TP53; IGF1R |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 1.543E-05 | 1.062E-04 | GSK3B; SRC; AKT1; PIK3R1; TP53; HIF1A |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.698E-05 | 1.086E-04 | CAMK2B; GSK3B; AKT1; PIK3R1; TP53; NFKB1 |
| hsa04062 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 2.168E-05 | 1.252E-04 | GSK3B; CXCR1; SRC; AKT1; PIK3R1; NFKB1; PTK2 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 8.719E-06 | 6.503E-05 | CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 3.554E-05 | 1.871E-04 | GSK3B; CSNK2A1; CDK1; AKT1; PIK3R1; TP53; NFKB1 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 1.699E-05 | 1.086E-04 | AKT1; PIK3R1; TP53; MET; IGF1R |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.820E-05 | 1.123E-04 | GSK3B; SRC; AKT1; PIK3R1; NFKB1 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 3.043E-05 | 1.679E-04 | GSK3B; AKT1; PIK3R1; PPARA; TP53; NFKB1 |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 5.812E-05 | 2.812E-04 | ABCC1; PIM1; CYP1B1; TP53; MMP9; MET; NFKB1; CDC25B |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 7.434E-05 | 3.412E-04 | PLA2G1B; KDR; AKT1; PIK3R1; MET; NFKB1; IGF1R |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 3.900E-05 | 1.995E-04 | PTPN1; GSK3B; AKT1; PIK3R1; PYGL; PTPRF |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.947E-05 | 1.162E-04 | HSD11B1; CYP1A2; CYP1A1; CYP1B1; CYP3A4 |
| hsa04211 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 6.605E-05 | 3.112E-04 | AKT1; PIK3R1; TP53; NFKB1; IGF1R |
| hsa04914 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 8.058E-05 | 3.606E-04 | CDK1; AKT1; PIK3R1; CDC25B; IGF1R |
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 9.299E-05 | 3.871E-04 | MMP2; PIM1; AKT1; PIK3R1; NFKB1 |
| hsa05222 | Small cell lung cancer_Homo sapiens_hsa05222 | 4.311E-05 | 2.143E-04 | AKT1; PIK3R1; TP53; NFKB1; PTK2 |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 8.456E-05 | 3.692E-04 | SRC; MMP2; AKT1; PIK3R1; MMP9 |
| hsa04668 | TNF signaling pathway_Homo sapiens_hsa04668 | 1.392E-04 | 5.537E-04 | MMP3; AKT1; PIK3R1; MMP9; NFKB1 |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.515E-04 | 5.896E-04 | CYP2C8; MAOA; ALOX5; ALOX15; ALOX12 |
| hsa05145 | Toxoplasmosis_Homo sapiens_hsa05145 | 1.935E-04 | 7.215E-04 | ALOX5; AKT1; PIK3R1; NFKB1; TLR2 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 2.092E-04 | 7.246E-04 | ABCC1; AKT1; PIK3R1; TP53; NFKB1 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 3.282E-04 | 9.506E-04 | POLB; SRC; CDK1; PIK3R1; TP53; NFKB1 |
| hsa04728 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.928E-04 | 9.133E-04 | CAMK2B; GSK3B; MAOA; AKT1; DRD4 |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 3.827E-04 | 1.087E-03 | SRC; KDR; AKT1; PIK3R1; MET; IGF1R |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 1.178E-04 | 4.791E-04 | ALK; AKT1; PIK3R1; TP53 |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 8.800E-05 | 3.751E-04 | GSK3B; AKT1; PIK3R1; TP53 |
| hsa04932 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 6.024E-04 | 1.634E-03 | GSK3B; AKT1; PIK3R1; PPARA; NFKB1 |
| hsa04310 | Wnt signaling pathway_Homo sapiens_hsa04310 | 4.553E-04 | 1.254E-03 | CAMK2B; GSK3B; CSNK2A1; TP53; PPARD |
| hsa04630 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 7.394E-04 | 1.975E-03 | PIM1; AKT1; STAT6; PIK3R1; PTPN2 |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 1.752E-04 | 6.674E-04 | GSK3B; AKT1; PIK3R1; TP53 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 3.096E-05 | 1.679E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 1.096E-03 | 2.802E-03 | POLB; GSK3B; AKT1; PIK3R1; TP53; NFKB1 |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 2.233E-04 | 7.402E-04 | AKT1; PIK3R1; TP53; NFKB1 |
| hsa04750 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.003E-03 | 2.641E-03 | CAMK2B; SRC; ALOX12; PIK3R1 |
| hsa05321 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 2.105E-04 | 7.246E-04 | RORC; STAT6; NFKB1; TLR2 |
| hsa05211 | Renal cell carcinoma_Homo sapiens_hsa05211 | 2.233E-04 | 7.402E-04 | AKT1; PIK3R1; MET; HIF1A |
| hsa05152 | Tuberculosis_Homo sapiens_hsa05152 | 1.260E-03 | 3.048E-03 | CAMK2B; SRC; AKT1; NFKB1; TLR2 |
| hsa05168 | Herpes simplex infection_Homo sapiens_hsa05168 | 1.494E-03 | 3.519E-03 | CSNK2A1; CDK1; TP53; NFKB1; TLR2 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 3.293E-04 | 9.506E-04 | AKT1; PIK3R1; TP53; NFKB1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 2.105E-04 | 7.246E-04 | CYP2C8; CYP1A2; CYP1A1; CYP3A4 |
| hsa05146 | Amoebiasis_Homo sapiens_hsa05146 | 1.082E-03 | 2.802E-03 | PIK3R1; NFKB1; PTK2; TLR2 |
| hsa04922 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.122E-03 | 2.830E-03 | CAMK2B; AKT1; PYGL; PPARA |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 2.506E-04 | 8.156E-04 | CXCR1; SRC; MET; NFKB1 |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 2.057E-03 | 4.660E-03 | CAMK2B; AKT1; PIK3R1; PPARA; NFKB1 |
| hsa04662 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 3.293E-04 | 9.506E-04 | GSK3B; AKT1; PIK3R1; NFKB1 |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.251E-03 | 3.048E-03 | GSK3B; AKT1; PIK3R1; NFKB1 |
| hsa04620 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 1.343E-03 | 3.204E-03 | AKT1; PIK3R1; NFKB1; TLR2 |
| hsa04144 | Endocytosis_Homo sapiens_hsa04144 | 6.302E-03 | 1.297E-02 | CXCR1; SRC; KDR; MET; IGF1R |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.651E-04 | 8.474E-04 | CYP2C8; MAOA; CYP1A2; CYP3A4 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.691E-03 | 7.959E-03 | AKT1; PIK3R1; TP53; NFKB1 |
| hsa05142 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 1.251E-03 | 3.048E-03 | AKT1; PIK3R1; NFKB1; TLR2 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 2.959E-04 | 9.133E-04 | CA2; NR1H4; CYP3A4; ABCG2 |
| hsa04670 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 1.991E-03 | 4.628E-03 | MMP2; PIK3R1; MMP9; PTK2 |
| hsa05100 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 4.242E-04 | 1.186E-03 | SRC; PIK3R1; MET; PTK2 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 3.882E-03 | 8.175E-03 | GSK3B; AKT1; PIK3R1; IGF1R |
| hsa05164 | Influenza A_Homo sapiens_hsa05164 | 8.073E-03 | 1.624E-02 | GSK3B; AKT1; PIK3R1; NFKB1 |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 2.385E-03 | 5.336E-03 | GSK3B; CDK1; TP53; CDC25B |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.378E-02 | 2.653E-02 | CAMK2B; AKT1; PIK3R1 |
| hsa04611 | Platelet activation_Homo sapiens_hsa04611 | 1.771E-02 | 3.268E-02 | SRC; AKT1; PIK3R1 |
| hsa04114 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.809E-02 | 3.296E-02 | CAMK2B; CDK1; IGF1R |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 1.069E-02 | 2.103E-02 | AKT1; PIK3R1; HIF1A |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 2.812E-02 | 4.534E-02 | AKT1; TP53; NFKB1; CDC25B |
| hsa04060 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 3.174E-02 | 4.985E-02 | CXCR1; FLT3; KDR; MET |
| hsa04152 | AMPK signaling pathway_Homo sapiens_hsa04152 | 1.848E-02 | 3.309E-02 | AKT1; PIK3R1; IGF1R |
| hsa04530 | Tight junction_Homo sapiens_hsa04530 | 2.489E-02 | 4.202E-02 | CSNK2A1; SRC; AKT1 |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 8.048E-03 | 1.624E-02 | CAMK2B; SRC; MMP2 |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 2.177E-02 | 3.747E-02 | AKT1; PIK3R1; NFKB1 |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 2.220E-02 | 3.784E-02 | AKT1; PIK3R1; IGF1R |
| hsa04360 | Axon guidance_Homo sapiens_hsa04360 | 1.968E-02 | 3.488E-02 | GSK3B; MET; PTK2 |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 2.725E-02 | 4.435E-02 | CXCR1; AKT1; PIK3R1 |
| hsa04261 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.923E-02 | 4.630E-02 | CAMK2B; AKT1; PIK3R1 |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 3.880E-03 | 8.175E-03 | AKT1; PPARA; NFKB1 |
| hsa04213 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 3.011E-03 | 6.573E-03 | AKT1; PIK3R1; IGF1R |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 2.505E-03 | 5.537E-03 | AKT1; PIK3R1; HIF1A |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 2.056E-03 | 4.660E-03 | FABP4; AKT1; PIK3R1 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 2.903E-02 | 4.630E-02 | AKR1B10; AKR1B1 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 2.549E-02 | 4.224E-02 | NFKB1; TLR2 |
| hsa05217 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.549E-02 | 4.224E-02 | GSK3B; TP53 |
| hsa00500 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 2.635E-02 | 4.328E-02 | GAA; PYGL |
| hsa05144 | Malaria_Homo sapiens_hsa05144 | 2.054E-02 | 3.569E-02 | MET; TLR2 |
| hsa05030 | Cocaine addiction_Homo sapiens_hsa05030 | 2.054E-02 | 3.569E-02 | MAOA; NFKB1 |
| hsa04973 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 1.749E-02 | 3.261E-02 | AKT1; PIK3R1 |
| hsa00983 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.823E-02 | 3.296E-02 | CYP3A4; XDH |
| hsa02010 | ABC transporters_Homo sapiens_hsa02010 | 1.676E-02 | 3.158E-02 | ABCC1; ABCG2 |
| hsa04975 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.465E-02 | 2.791E-02 | FABP2; PLA2G1B |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 3.276E-04 | 9.506E-04 | AKR1B10; GAA; AKR1B1 |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.142E-02 | 2.223E-02 | AKR1B10; AKR1B1 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 9.099E-03 | 1.810E-02 | AKR1B10; AKR1B1 |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 4.764E-03 | 9.917E-03 | CA2; CA4 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.985E-04 | 7.246E-04 | CYP1A2; XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| J00-J99: Diseases of the respiratory system | Rhinitis | J00, J30, J31.0 | ALOX5 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CAMK2B; AKR1B1; PLA2G1B; ALOX5; MMP3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| C00-D49: Neoplasms | Multiple myeloma | C90 | SRC; IGF1R |
| G00-G99: Diseases of the nervous system G00-G99 | Motor neurone disease | G12.2 | IGF1R |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | DRD4 |
| C00-D49: Neoplasms | Biliary cancer | C22, C24 | KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | IGF1R |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2 |
| C00-D49: Neoplasms | Advanced renal cell carcinoma | C64 | KDR; KDR |
| C00-D49: Neoplasms | Advanced malignancies | C00-C96 | KDR |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Radiation sickness | T66 | TLR2 |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | MET; IGF1R; KDR |
| C00-D49: Neoplasms | Hematologic malignancies | C81-C86 | AKT1 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | SRC; AURKB; TP53 |
| NA: NA | Hematopoietic stem cell transplantation | NA | FLT3 |
| A00-B99: Certain infectious and parasitic diseases | HCV infection | B17.1, B18.2 | MMP3 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Renal cell carcinoma | NA | MMP2; KDR; KDR |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9; KDR |
| J00-J99: Diseases of the respiratory system | Respiratory disease | J00-J99 | ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Pruritus | L29 | PLA2G1B; ALOX5 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD |
| L00-L99: Diseases of the skin and subcutaneous tissue | Contact dermatitis | L23, L24, L25 | PLA2G1B |
| A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | FLT3; FLT3; AURKB; TP53; TP53 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | FLT3 |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2; FLT3 |
| N00-N99: Diseases of the genitourinary system | Prostate disease | N42.9 | CYP19A1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | ALOX5 |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | SRC |
| NA: NA | Anaplastic mixed oligoastrocytoma | NA | FLT3 |
| C00-D49: Neoplasms | Bladder cancer | C67 | CYP19A1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriatic disorder | L40 | IGF1R |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychotic disorders | F20-F29 | DRD4 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1 |
| C00-D49: Neoplasms | Breast cancer | C50 | CA9; CYP19A1; FLT3; FLT3; IGF1R; CDK1; KDR; KDR; KDR |
| C00-D49: Neoplasms | Glioma | C71 | KDR |
| C00-D49: Neoplasms | Gliosarcoma | NA | FLT3 |
| C00-D49: Neoplasms | Glioblastoma | NA | FLT3 |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | SRC |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1; ABCC1; ABCC1; XDH |
| C00-D49: Neoplasms | Advanced breast cancer | C50 | CYP19A1; SRC |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | MPO; MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MMP13; IGF1R; CDK1 |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | AKT1; TLR2; FLT3; MMP2; KDR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CAMK2B; MAOA; CYP3A4 |
| I00-I99: Diseases of the circulatory system | Angiogenesis disorder | I00-I99 | KDR |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| NA: NA | Edema | NA | CA2 |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | MPO; ALOX5 |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | MPO |
| C00-D49: Neoplasms | Fallopian tube cancer | C57.0, D28.2 | KDR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | SRC |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA |
| C00-D49: Neoplasms | Advanced solid tumor | C00-C75, C7A, C7B | MET |
| J00-J99: Diseases of the respiratory system | Airway inflammation | J00-J99 | FLT3 |
| C00-D49: Neoplasms | Cutaneous Melanoma | C43-C44 | KDR |
| N00-N99: Diseases of the genitourinary system | Endometriosis | N80 | CYP19A1 |
| I00-I99: Diseases of the circulatory system | Heart disease | I00-I52 | MET |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1; TP53; KDR; KDR |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoarthritis | M15-M19, M47 | ALOX5; MMP13; MMP3; MMP2 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| A00-B99: Certain infectious and parasitic diseases | Leishmaniasis | B55.0 | PLA2G1B |
| C00-D49: Neoplasms | AML | NA | FLT3; KDR |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | PLA2G1B |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAOA; GSK3B |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | CA1 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Allergy | T78.4 | PLA2G1B; ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ALOX5 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | SRC |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Growth failure | R62.8 | IGF1R |
| H00-H59: Diseases of the eye and adnexa | Graves' ophthalmopathy | H06.2 | IGF1R |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4; CA2 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1; CA4; CA4 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA |
| C00-D49: Neoplasms | Malignant adrenal gland cancer | C74.0 | IGF1R |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | MMP2; KDR |
| C00-D49: Neoplasms | Melanoma | C43 | TLR2; KDR; KDR |
| C00-D49: Neoplasms | Medullary thyroid cancer | C73 | KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | NPSR1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1; ALOX5; PPARD |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | PLA2G1B |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | PLA2G1B; ALOX5; ALOX5 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | PLA2G1B; ABCC1; ALOX5 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; PPARD |
| NA: NA | Dyslipidemia | NA | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1 |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1; CA1; CA1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | PPARD |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
| C00-D49: Neoplasms | Metastasis | C00-C97 | AXL |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR |
| C00-D49: Neoplasms | Mesothelioma | C45 | PTK2 |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Nerve injury | T14.4 | PLA2G1B |
| I00-I99: Diseases of the circulatory system | Myocardial infarction | I21, I22 | MMP3 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Myocardial reperfusion injury | T86.4 | AKT1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | TLR2 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Atopic dermatitis | L00-L99 | ALOX5 |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2 |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| NA: NA | GIST | NA | FLT3 |
| C00-D49: Neoplasms | Metastatic HER2-negative gastric cancer | NA | MET |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | KDR |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | FLT3 |
| C00-D49: Neoplasms | Myelofibrosis | C94.4, D47.4 | FLT3 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2; KDR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | MMP2 |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp | L20-L30 | PLA2G1B |
| E00-E89: Endocrine, nutritional and metabolic diseases | Inflammation | E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 | ALOX5 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses | L20-L30 | PLA2G1B |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MPO; PLA2G1B; ALOX5; MMP13 |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Erectile dysfunction | F52.2, N48.4 | DRD4 |
| K00-K95: Diseases of the digestive system | Chemotherapy-induced mucositis | K12.3 | MET |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | HSD11B1; PTPN1; PTPN1; NFKB1; GPBAR1; PPARD |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD |
| C00-D49: Neoplasms | CLL | NA | FLT3 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| I00-I99: Diseases of the circulatory system | Ischemia | I99.8 | SRC |
| I00-I99: Diseases of the circulatory system | Ischemic stroke | I61-I63 | MMP3 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA |
| A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| C00-D49: Neoplasms | Liver cancer | C22 | IGF1R; KDR |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | PTK2; TP53 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | AKT1; FLT3 |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MET; AXL; IGF1R; IGF1R; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HSD11B1; PTPN1; PPARD; PPARD |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MMP9 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | MET |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9; AKT1; HIF1A |
| K00-K95: Diseases of the digestive system | Liver disease | K70-K77 | MET |
| A00-B99: Certain infectious and parasitic diseases | Lymphatic filariasis | B74 | ALOX5 |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | MMP2 |
| C00-D49: Neoplasms | Squamous cell cancer of head and neck | NA | KDR |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| H00-H59: Diseases of the eye and adnexa | Corneal ulcers | H16.0 | MMP3 |
| C00-D49: Neoplasms | Cancer | C00-C96 | CA9; AKT1; MET; TLR2; CSNK2A1; FLT3; FLT3; MMP2; SRC; IGF1R; PTK2; GSK3B; HIF1A; CDK1; MMP9; NFKB1; PIM1; CDC25B; TP53; CA1; KDR |
| C00-D49: Neoplasms | Gastrointestinal cancers | C15-C26 | KDR |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | FLT3; IGF1R; MMP9; TP53; KDR |
| C00-D49: Neoplasms | Colon cancer | C50 | FLT3 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | KDR |
| C00-D49: Neoplasms | Osteosarcoma | C40-C41 | SRC; GSK3B |
| C00-D49: Neoplasms | Ovarian cancer | C56 | MMP2; KDR; KDR; KDR; KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1; HSD11B1; HSD11B1; PTPN1; GSK3B |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | ALOX5; FLT3 |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | MMP9 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | CA9; AKT1; MET; TLR2; FLT3; MMP2; SRC; IGF1R; PTK2; AURKB; HIF1A; MMP9; TP53; KDR; KDR; KDR |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2 |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | GAA |