Plant Name: Nitraria tangutorum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 1.331E-07 | 1.635E-03 | ACP1, PTPN1, PTPN2, PTPRF |
| BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 7.235E-07 | 3.938E-03 | GPBAR1, NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 7.235E-07 | 3.938E-03 | GPBAR1, NR1H4 |
| BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.447E-06 | 5.055E-03 | PTPN1, PTPN2 |
| BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 1.818E-06 | 5.055E-03 | NR1H4, PTPN1, PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 5.727E-06 | 9.163E-05 | PTPN1; ACP1; PTPRF |
| hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.287E-03 | 1.030E-02 | PTPN1; PTPRF |
| hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 2.081E-03 | 1.110E-02 | PTPN1; PTPRF |
| hsa04710 | Circadian rhythm_Homo sapiens_hsa04710 | 1.490E-02 | 4.082E-02 | RORC |
| hsa00040 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.786E-02 | 4.082E-02 | AKR1B10 |
| hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.490E-02 | 4.082E-02 | AKR1B10 |
| hsa00561 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 2.912E-02 | 4.789E-02 | AKR1B10 |
| hsa00051 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.589E-02 | 4.082E-02 | AKR1B10 |
| hsa05321 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 3.204E-02 | 4.789E-02 | RORC |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 2.863E-02 | 4.789E-02 | HSD11B1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 3.591E-02 | 4.789E-02 | HSD11B1 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 3.495E-02 | 4.789E-02 | NR1H4 |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 4.026E-02 | 4.955E-02 | HSD11B1 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |
| NA: NA | Colour dead tissues | NA | PTPN1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
| A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1 |
| J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |