Plant Name: Sinapis semen
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| FFAR1; FFAR4; | |
| FAAH; TDP1; MIF; TERT; HPGD; ALOX15; ALDH1A1; | |
| TRPA1; | |
| CA2; CA12; CA1; CA9; CA14; CA7; | |
| PPARA; PPARD; PPARG; | |
| NR1I2; | |
| ESR2; | |
| PTGS1; | |
| TLR2; | |
| LMNA; FABP3; FABP5; FABP2; FABP4; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Cytochrome P450 family 2 | CYP2A13 | Cytochrome P450 2A13 | Q16696 | CHEMBL3542436 |
| Enzyme_unclassified | FAAH | Anandamide amidohydrolase | O00519 | CHEMBL2243 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | MIF | Macrophage migration inhibitory factor | P14174 | CHEMBL2085 |
| Enzyme_unclassified | TERT | Telomerase reverse transcriptase | O14746 | CHEMBL2916 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Showing 1 to 10 of 31 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 6.912E-11 | 1.672E-07 | CA1, CA12, CA14, CA2, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.762E-09 | 3.538E-06 | CA1, CA12, CA2, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0019369; arachidonic acid metabolic process | 2.271E-08 | 1.831E-05 | ALOX15, CYP2A13, CYP2A6, FAAH, PTGS1 |
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 6.705E-08 | 5.034E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 1.887E-06 | 9.339E-04 | ESR2, NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0051179; localization | GO:0015908; fatty acid transport | 3.876E-06 | 1.655E-03 | FABP3, PPARA, PPARD, PPARG |
| BP | GO:0008152; metabolic process | GO:0006367; transcription initiation from RNA polymerase II promoter | 5.229E-06 | 2.148E-03 | ESR2, NR1I2, PPARA, PPARD, PPARG |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 7.471E-06 | 2.905E-03 | CA2, CA7 |
| BP | GO:0050896; response to stimulus | GO:0070542; response to fatty acid | 7.883E-06 | 3.011E-03 | FABP3, FFAR1, PPARG, TLR2 |
| BP | GO:0009987; cellular process | GO:0030522; intracellular receptor signaling pathway | 8.092E-06 | 3.038E-03 | ESR2, NR1I2, PPARA, PPARD, PPARG |
Showing 1 to 10 of 17 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.014E-13 | 6.691E-12 | CA12; CA1; CA2; CA7; CA9; CA14 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.048E-11 | 3.457E-10 | FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 8.841E-05 | 1.945E-03 | FABP4; TSHR; PTGS1 |
Showing 1 to 3 of 3 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TERT |
| C00-D49: Neoplasms | Liver cancer | C22 | TERT |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2; TERT |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2 |
| C00-D49: Neoplasms | Melanoma | C43 | TLR2; TERT |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MIF; PTGS1; FAAH |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | PTGS1 |
| C00-D49: Neoplasms | Ovarian cancer | C56 | TERT |
Showing 1 to 10 of 69 entries