Plant Name: Cratystylis conocephala
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 6.595E-09 | 3.590E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | GO:0032501; multicellular organismal process | GO:0050968; detection of chemical stimulus involved in sensory perception of pain | 2.459E-06 | 1.983E-03 | TRPA1, TRPV1 |
| BP | GO:0032501; multicellular organismal process | GO:0050955; thermoception | 2.459E-06 | 1.983E-03 | TRPA1, TRPV1 |
| BP | GO:0050896; response to stimulus | GO:0043434; response to peptide hormone | 4.378E-06 | 3.178E-03 | FABP3, PPARA, TLR2, TRPV1, TSHR |
| BP | GO:0009987; cellular process | GO:0038171; cannabinoid signaling pathway | 4.916E-06 | 3.453E-03 | CNR1, CNR2 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.228E-05 | 7.425E-03 | CYP1A2, CYP2C19 |
| BP | GO:0008152; metabolic process | GO:0051001; negative regulation of nitric-oxide synthase activity | 1.718E-05 | 8.698E-03 | CNR1, CNR2 |
| MF | GO:0005215; transporter activity | GO:0097603; temperature-gated ion channel activity | 2.459E-06 | 1.983E-03 | TRPA1, TRPV1 |
| MF | GO:0060089; molecular transducer activity | GO:0004949; cannabinoid receptor activity | 2.459E-06 | 1.983E-03 | CNR1, CNR2 |
Showing 1 to 9 of 9 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 4.492E-03 | 2.246E-02 | CYP1A2 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.401E-03 | 1.401E-02 | ALOX15; CYP2C19 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 2.204E-06 | 5.510E-05 | CYP1A2; ALOX15; CYP2C19 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.732E-03 | 1.443E-02 | CYP1A2; CYP2C19 |
| hsa03013 | RNA transport_Homo sapiens_hsa03013 | 1.028E-02 | 4.672E-02 | SMN2; SMN1 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.425E-11 | 1.213E-09 | FABP2; FABP3; FABP4; FABP5; PPARA; PPARD |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 9.454E-05 | 1.576E-03 | CNR2; CNR1; TRPV1; TSHR |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 4.485E-03 | 2.246E-02 | ALOX15; CYP2C19 |
| hsa04750 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 3.455E-03 | 2.159E-02 | TRPA1; TRPV1 |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.145E-03 | 1.401E-02 | FABP4; TSHR |
Showing 1 to 10 of 11 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Postherpetic neuralgia | B02.2, G44.847, G53.0 | CNR1; TRPV1 |
| C00-D49: Neoplasms | Ovarian cancer | C56 | CNR1 |
| C00-D49: Neoplasms | Overactive bladder disorder | C67, N32.81 | TRPV1; TRPV1 |
| C00-D49: Neoplasms | Cancer | C00-C96 | TLR2 |
| C00-D49: Neoplasms | Myelodysplastic syndrome | D46 | TLR2 |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TLR2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | TLR2 |
Showing 1 to 10 of 57 entries