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Plant Name: Thymus quinquecostatus




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins
Small molecule receptor (family A GPCR)
HRH1; HRH2; CHRM1; CHRM3; CHRM4; CHRM5; DRD4; ADRA2C; ADRA1D; ADRA2A; ADRA2B; HTR2B; HTR2A; HTR2C; HTR6; DRD3; DRD1; CHRM2;
Peptide receptor (family A GPCR)
TSHR; NPSR1; CXCR1; NMUR2;
Enzyme_unclassified
ALPL; TDP1; PLA2G1B; BLM; ALPI; RECQL; CTDSP1; PTGES; PKM; PIK3R1; GLO1; HPGD; MPO; HSD17B1; AKR1B1; HSD17B10; ALOX15; ALDH1A1; HSD17B2; ALOX12; AKR1B10; NOX4; USP2; PARP1; TNKS2; PYGL; TNKS; APEX1; POLB; CD38;
Protein Phosphatase
PTPN1;
Hydrolase
ACHE; GAA;
Chloride channel
CFTR;
Transient receptor potential channel
TRPA1;
Protein Kinase
AKT1; MET; CAMK2B; CSNK2A1; DAPK1; SYK; NEK2; FLT3; SRC; IGF1R; PTK2; AURKB; GSK3B; KDR; CDK1; MAPK1; PIM1; NUAK1; ALK; RET; AXL; NEK6; CDK6; PLK1; PKN1;
Lyase
CA12; CA14; CA7; CA3; CA5B; CA5A; CA1; CA9; CA4; CA6; CA2;
Nuclear hormone receptor subfamily 3 group C
AR;
Nuclear hormone receptor subfamily 3 group B
ESRRA;
Nuclear hormone receptor subfamily 1 group C
PPARA; PPARD;
Nuclear hormone receptor subfamily 3 group A
ESR1; ESR2;
Lysine demethylase
KDM4E;
Oxidoreductase
MAOA; ALOX5; PTGS1; PTGS2; TYR; XDH;
Metallo protease
MMP13; MMP12; MMP3; MMP2; MMP9; MMP1;
Aspartic protease
BACE1;
Toll-like and Il-1 receptors
TLR2;
Transcription Factor
AHR; STAT6; HIF1A; NFKB1; TP53;
Transferase
FUT7;
ATP-binding cassette
ABCC1; ABCG2;
SLC superfamily of solute carriers
SLC6A4; SLC6A2; SLC6A3;
Unclassified
FABP5; FABP4; MAPT; LMNA; FABP3; MCL1; THPO; HTT; RAB9A; NPC1; FABP2; APP; TTR;
Methyl-lysine/arginine binding protein
SMN1;SMN2;


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes: CYP2D6; CYP19A1; CYP1A2; CYP2C19; CYP2C9; CYP2C8; CYP3A4; CYP1B1; CYP1A1;

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Aspartic protease BACE1 Beta-secretase 1 P56817 CHEMBL4822
ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 P33527 CHEMBL3004
ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 Q9UNQ0 CHEMBL5393
Chloride channel CFTR Cystic fibrosis transmembrane conductance regulator P13569 CHEMBL4051
Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 Q16678 CHEMBL4878
Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 P04798 CHEMBL2231
Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 P05177 CHEMBL3356
Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 P11511 CHEMBL1978
Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 P10632 CHEMBL3721
Cytochrome P450 family 2 CYP2D6 Cytochrome P450 2D6 P10635 CHEMBL289
Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 P33261 CHEMBL3622
Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 P11712 CHEMBL3397
Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 P08684 CHEMBL340
Enzyme_unclassified HSD17B2 Estradiol 17-beta-dehydrogenase 2 P37059 CHEMBL2789
Enzyme_unclassified ALOX12 Arachidonate 12-lipoxygenase P18054 CHEMBL3687
Enzyme_unclassified AKR1B10 Aldo-keto reductase family 1 member B10 O60218 CHEMBL5983
Enzyme_unclassified NOX4 NADPH oxidase 4 Q9NPH5 CHEMBL1250375
Enzyme_unclassified USP2 Ubiquitin carboxyl-terminal hydrolase 2 O75604 CHEMBL1293227
Enzyme_unclassified PARP1 Poly [ADP-ribose] polymerase-1 P09874 CHEMBL3105
Enzyme_unclassified TNKS2 Tankyrase-2 Q9H2K2 CHEMBL6154
Enzyme_unclassified PYGL Liver glycogen phosphorylase P06737 CHEMBL2568
Enzyme_unclassified TNKS Tankyrase-1 O95271 CHEMBL6164
Enzyme_unclassified APEX1 DNA-(apurinic or apyrimidinic site) lyase P27695 CHEMBL5619
Enzyme_unclassified POLB DNA polymerase beta P06746 CHEMBL2392
Enzyme_unclassified CD38 Lymphocyte differentiation antigen CD38 P28907 CHEMBL4660
Enzyme_unclassified ALPL Alkaline phosphatase, tissue-nonspecific isozyme P05186 CHEMBL5979
Enzyme_unclassified TDP1 Tyrosyl-DNA phosphodiesterase 1 Q9NUW8 CHEMBL1075138
Enzyme_unclassified PLA2G1B Phospholipase A2 group 1B P04054 CHEMBL4426
Enzyme_unclassified BLM Bloom syndrome protein P54132 CHEMBL1293237
Enzyme_unclassified ALPI Intestinal alkaline phosphatase P09923 CHEMBL5573
Enzyme_unclassified RECQL ATP-dependent DNA helicase Q1 P46063 CHEMBL1293236
Enzyme_unclassified CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 Q9GZU7 CHEMBL1795098
Enzyme_unclassified PTGES Prostaglandin E synthase O14684 CHEMBL5658
Enzyme_unclassified PKM Pyruvate kinase isozymes M1/M2 P14618 CHEMBL1075189
Enzyme_unclassified PIK3R1 PI3-kinase p85-alpha subunit P27986 CHEMBL2506
Enzyme_unclassified GLO1 Glyoxalase I Q04760 CHEMBL2424
Enzyme_unclassified HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] P15428 CHEMBL1293255
Enzyme_unclassified MPO Myeloperoxidase P05164 CHEMBL2439
Enzyme_unclassified HSD17B1 Estradiol 17-beta-dehydrogenase 1 P14061 CHEMBL3181
Enzyme_unclassified AKR1B1 Aldose reductase P15121 CHEMBL1900
Enzyme_unclassified HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein Q99714 CHEMBL4159
Enzyme_unclassified ALOX15 Arachidonate 15-lipoxygenase P16050 CHEMBL2903
Enzyme_unclassified ALDH1A1 Aldehyde dehydrogenase 1A1 P00352 CHEMBL3577
Hydrolase ACHE Acetylcholinesterase P22303 CHEMBL220
Hydrolase GAA Lysosomal alpha-glucosidase P10253 CHEMBL2608
Lyase CA12 Carbonic anhydrase XII O43570 CHEMBL3242
Lyase CA14 Carbonic anhydrase XIV Q9ULX7 CHEMBL3510
Lyase CA7 Carbonic anhydrase VII P43166 CHEMBL2326
Lyase CA3 Carbonic anhydrase III P07451 CHEMBL2885
Lyase CA5B Carbonic anhydrase VB Q9Y2D0 CHEMBL3969
Lyase CA5A Carbonic anhydrase VA P35218 CHEMBL4789
Lyase CA1 Carbonic anhydrase I P00915 CHEMBL261
Lyase CA9 Carbonic anhydrase IX Q16790 CHEMBL3594
Lyase CA4 Carbonic anhydrase IV P22748 CHEMBL3729
Lyase CA6 Carbonic anhydrase VI P23280 CHEMBL3025
Lyase CA2 Carbonic anhydrase II P00918 CHEMBL205
Lysine demethylase KDM4E Lysine-specific demethylase 4D-like B2RXH2 CHEMBL1293226
Metallo protease MMP13 Matrix metalloproteinase 13 P45452 CHEMBL280
Metallo protease MMP12 Matrix metalloproteinase 12 P39900 CHEMBL4393
Metallo protease MMP3 Matrix metalloproteinase 3 P08254 CHEMBL283
Metallo protease MMP2 Matrix metalloproteinase-2 P08253 CHEMBL333
Metallo protease MMP9 Matrix metalloproteinase 9 P14780 CHEMBL321
Metallo protease MMP1 Matrix metalloproteinase-1 P03956 CHEMBL332
Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein Q16637 CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C PPARA Peroxisome proliferator-activated receptor alpha Q07869 CHEMBL239
Nuclear hormone receptor subfamily 1 group C PPARD Peroxisome proliferator-activated receptor delta Q03181 CHEMBL3979
Nuclear hormone receptor subfamily 3 group A ESR1 Estrogen receptor alpha P03372 CHEMBL206
Nuclear hormone receptor subfamily 3 group A ESR2 Estrogen receptor beta Q92731 CHEMBL242
Nuclear hormone receptor subfamily 3 group B ESRRA Estrogen-related receptor alpha P11474 CHEMBL3429
Nuclear hormone receptor subfamily 3 group C AR Androgen Receptor P10275 CHEMBL1871
Oxidoreductase TYR Tyrosinase P14679 CHEMBL1973
Oxidoreductase XDH Xanthine dehydrogenase P47989 CHEMBL1929
Oxidoreductase MAOA Monoamine oxidase A P21397 CHEMBL1951
Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase P09917 CHEMBL215
Oxidoreductase PTGS1 Cyclooxygenase-1 P23219 CHEMBL221
Oxidoreductase PTGS2 Cyclooxygenase-2 P35354 CHEMBL230
Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor P16473 CHEMBL1963
Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor Q6W5P4 CHEMBL5162
Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A P25024 CHEMBL4029
Peptide receptor (family A GPCR) NMUR2 Neuromedin-U receptor 2 Q9GZQ4 CHEMBL1075144
Protein Kinase AKT1 Serine/threonine-protein kinase AKT P31749 CHEMBL4282
Protein Kinase MET Hepatocyte growth factor receptor P08581 CHEMBL3717
Protein Kinase CAMK2B CaM kinase II beta Q13554 CHEMBL4121
Protein Kinase CSNK2A1 Casein kinase II alpha P68400 CHEMBL3629
Protein Kinase DAPK1 Death-associated protein kinase 1 P53355 CHEMBL2558
Protein Kinase SYK Tyrosine-protein kinase SYK P43405 CHEMBL2599
Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 P51955 CHEMBL3835
Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 P36888 CHEMBL1974
Protein Kinase SRC Tyrosine-protein kinase SRC P12931 CHEMBL267
Protein Kinase IGF1R Insulin-like growth factor I receptor P08069 CHEMBL1957
Protein Kinase PTK2 Focal adhesion kinase 1 Q05397 CHEMBL2695
Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B Q96GD4 CHEMBL2185
Protein Kinase GSK3B Glycogen synthase kinase-3 beta P49841 CHEMBL262
Protein Kinase KDR Vascular endothelial growth factor receptor 2 P35968 CHEMBL279
Protein Kinase CDK1 Cyclin-dependent kinase 1 P06493 CHEMBL308
Protein Kinase MAPK1 MAP kinase ERK2 P28482 CHEMBL4040
Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 P11309 CHEMBL2147
Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 O60285 CHEMBL5784
Protein Kinase ALK ALK tyrosine kinase receptor Q9UM73 CHEMBL4247
Protein Kinase RET Tyrosine-protein kinase receptor RET P07949 CHEMBL2041
Protein Kinase AXL Tyrosine-protein kinase receptor UFO P30530 CHEMBL4895
Protein Kinase NEK6 Serine/threonine-protein kinase NEK6 Q9HC98 CHEMBL4309
Protein Kinase CDK6 Cyclin-dependent kinase 6 Q00534 CHEMBL2508
Protein Kinase PLK1 Serine/threonine-protein kinase PLK1 P53350 CHEMBL3024
Protein Kinase PKN1 Protein kinase N1 Q16512 CHEMBL3384
Protein Phosphatase PTPN1 Protein-tyrosine phosphatase 1B P18031 CHEMBL335
SLC superfamily of solute carriers SLC6A4 Serotonin transporter P31645 CHEMBL228
SLC superfamily of solute carriers SLC6A2 Norepinephrine transporter P23975 CHEMBL222
SLC superfamily of solute carriers SLC6A3 Dopamine transporter Q01959 CHEMBL238
Small molecule receptor (family A GPCR) HRH1 Histamine H1 receptor P35367 CHEMBL231
Small molecule receptor (family A GPCR) HRH2 Histamine H2 receptor P25021 CHEMBL1941
Small molecule receptor (family A GPCR) CHRM1 Muscarinic acetylcholine receptor M1 P11229 CHEMBL216
Small molecule receptor (family A GPCR) CHRM3 Muscarinic acetylcholine receptor M3 P20309 CHEMBL245
Small molecule receptor (family A GPCR) CHRM4 Muscarinic acetylcholine receptor M4 P08173 CHEMBL1821
Small molecule receptor (family A GPCR) CHRM5 Muscarinic acetylcholine receptor M5 P08912 CHEMBL2035
Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor P21917 CHEMBL219
Small molecule receptor (family A GPCR) ADRA2C Alpha-2c adrenergic receptor P18825 CHEMBL1916
Small molecule receptor (family A GPCR) ADRA1D Alpha-1d adrenergic receptor P25100 CHEMBL223
Small molecule receptor (family A GPCR) ADRA2A Alpha-2a adrenergic receptor P08913 CHEMBL1867
Small molecule receptor (family A GPCR) ADRA2B Alpha-2b adrenergic receptor P18089 CHEMBL1942
Small molecule receptor (family A GPCR) HTR2B Serotonin 2b (5-HT2b) receptor P41595 CHEMBL1833
Small molecule receptor (family A GPCR) HTR2A Serotonin 2a (5-HT2a) receptor P28223 CHEMBL224
Small molecule receptor (family A GPCR) HTR2C Serotonin 2c (5-HT2c) receptor P28335 CHEMBL225
Small molecule receptor (family A GPCR) HTR6 Serotonin 6 (5-HT6) receptor P50406 CHEMBL3371
Small molecule receptor (family A GPCR) DRD3 Dopamine D3 receptor P35462 CHEMBL234
Small molecule receptor (family A GPCR) DRD1 Dopamine D1 receptor P21728 CHEMBL2056
Small molecule receptor (family A GPCR) CHRM2 Muscarinic acetylcholine receptor M2 P08172 CHEMBL211
Toll-like and Il-1 receptors TLR2 Toll-like receptor 2 O60603 CHEMBL4163
Transcription Factor AHR Aryl hydrocarbon receptor P35869 CHEMBL3201
Transcription Factor STAT6 Signal transducer and activator of transcription 6 P42226 CHEMBL5401
Transcription Factor HIF1A Hypoxia-inducible factor 1 alpha Q16665 CHEMBL4261
Transcription Factor NFKB1 Nuclear factor NF-kappa-B p105 subunit P19838 CHEMBL3251
Transcription Factor TP53 Cellular tumor antigen p53 P04637 CHEMBL4096
Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 Q11130 CHEMBL3596077
Transient receptor potential channel TRPA1 Transient receptor potential cation channel subfamily A member 1 O75762 CHEMBL6007
Unclassified FABP5 Fatty acid binding protein epidermal Q01469 CHEMBL3674
Unclassified FABP4 Fatty acid binding protein adipocyte P15090 CHEMBL2083
Unclassified MAPT Microtubule-associated protein tau P10636 CHEMBL1293224
Unclassified LMNA Prelamin-A/C P02545 CHEMBL1293235
Unclassified FABP3 Fatty acid binding protein muscle P05413 CHEMBL3344
Unclassified MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Q07820 CHEMBL4361
Unclassified THPO Thrombopoietin P40225 CHEMBL1293256
Unclassified HTT Huntingtin P42858 CHEMBL5514
Unclassified RAB9A Ras-related protein Rab-9A P51151 CHEMBL1293294
Unclassified NPC1 Niemann-Pick C1 protein O15118 CHEMBL1293277
Unclassified FABP2 Fatty acid binding protein intestinal P12104 CHEMBL4879
Unclassified APP Beta amyloid A4 protein P05067 CHEMBL2487
Unclassified TTR Transthyretin P02766 CHEMBL3194
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
MF GO:0005488; binding GO:0020037; heme binding 1.164E-12 2.640E-10 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, MPO, NOX4, PTGS1, PTGS2, SRC
MF GO:0005488; binding GO:0019825; oxygen binding 1.392E-12 3.062E-10 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, NOX4
BP Unclassified; GO:0032846; positive regulation of homeostatic process 1.930E-12 4.041E-10 AURKB, CA2, CA7, CFTR, DRD1, DRD3, HIF1A, HTT, MAPK1, NEK2, NPC1, NPSR1, PLA2G1B, PTGS2, SYK, TNKS, TNKS2
MF GO:0005488; binding GO:0008270; zinc ion binding 4.079E-12 7.536E-10 ALPI, AR, BLM, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, GLO1, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, PARP1, PPARA, PPARD, PTPN1, TNKS, TP53
MF Unclassified; GO:0004872; receptor activity 2.490E-11 3.900E-09 ADRA1D, ADRA2A, ADRA2B, ADRA2C, AHR, ALK, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CXCR1, DRD1, DRD3, DRD4, ESR1, ESR2, ESRRA, FLT3, HPGD, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, NMUR2, NPC1, NPSR1, PPARA, PPARD, RET, TLR2, TSHR
CC GO:0044425; membrane part GO:0005887; integral component of plasma membrane 2.479E-11 3.900E-09 ABCC1, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ALK, APP, AXL, BACE1, CFTR, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD3, DRD4, FLT3, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, NPC1, NPSR1, RET, SLC6A2, SLC6A3, SLC6A4, TLR2, TRPA1, TSHR
BP GO:0050896; response to stimulus GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway 2.553E-11 3.943E-09 CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF GO:0060089; molecular transducer activity GO:0016907; G-protein coupled acetylcholine receptor activity 2.553E-11 3.943E-09 CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP GO:0008152; metabolic process GO:0097267; omega-hydroxylase P450 pathway 3.898E-11 5.774E-09 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP Unclassified; GO:0045907; positive regulation of vasoconstriction 1.224E-10 1.655E-08 ADRA1D, ADRA2C, AKT1, CD38, HRH1, HRH2, HTR2A, PTGS2
BP GO:0050896; response to stimulus GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway 1.523E-10 2.009E-08 CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 1.523E-10 2.009E-08 CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4
MF GO:0003824; catalytic activity GO:0070330; aromatase activity 3.118E-10 3.814E-08 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C8, CYP2D6, CYP3A4
MF GO:0005488; binding GO:0005506; iron ion binding 3.347E-10 4.026E-08 ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, XDH
BP GO:0008152; metabolic process GO:0018105; peptidyl-serine phosphorylation 4.908E-10 5.715E-08 AKT1, AURKB, CAMK2B, CDK1, DRD1, GSK3B, MAPK1, NEK6, PKN1, PLK1, SRC, SYK, TNKS
BP Unclassified; GO:2000021; regulation of ion homeostasis 8.235E-10 9.291E-08 CA2, CA7, DRD1, DRD3, HTR2A, HTR2B, HTR2C, HTT, KDR, NPSR1, PARP1, PLA2G1B, SRC, TRPA1
MF GO:0003824; catalytic activity GO:0034875; caffeine oxidase activity 3.401E-09 3.381E-07 CYP1A2, CYP2C8, CYP2C9, CYP3A4
MF Unclassified; GO:0099600; transmembrane receptor activity 6.179E-09 5.901E-07 ADRA1D, ADRA2A, ADRA2B, ADRA2C, ALK, AXL, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CXCR1, DRD1, DRD3, DRD4, FLT3, HPGD, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, KDR, MET, NMUR2, NPC1, NPSR1, RET, TSHR
BP GO:0008152; metabolic process GO:0019373; epoxygenase P450 pathway 9.392E-09 8.675E-07 CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9
BP GO:0050896; response to stimulus GO:0042738; exogenous drug catabolic process 1.936E-08 1.634E-06 CYP1A2, CYP2C19, CYP2C8, CYP2C9, CYP3A4
BP GO:0008152; metabolic process GO:0070989; oxidative demethylation 1.936E-08 1.634E-06 CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4
MF GO:0005488; binding GO:0005524; ATP binding 2.123E-08 1.778E-06 ABCC1, ABCG2, AKT1, ALK, AURKB, AXL, BLM, CAMK2B, CDK1, CDK6, CFTR, CSNK2A1, DAPK1, FLT3, GSK3B, IGF1R, KDR, MAPK1, MET, NEK2, NEK6, NUAK1, PIM1, PKM, PKN1, PLK1, PTK2, PYGL, RECQL, RET, SRC, SYK, TP53
CC GO:0016020; membrane GO:0045121; membrane raft 6.509E-08 4.921E-06 APP, BACE1, HTR2A, KDR, MAPK1, NPC1, PTGS2, RET, SLC6A2, SLC6A3, SLC6A4, SRC, STAT6, TLR2
MF GO:0003824; catalytic activity GO:0004674; protein serine/threonine kinase activity 8.148E-08 6.017E-06 AKT1, ALK, AURKB, CAMK2B, CDK1, CDK6, CSNK2A1, DAPK1, GSK3B, MAPK1, NEK2, NEK6, NUAK1, PIM1, PKN1, PLK1, SYK
BP GO:0008152; metabolic process GO:0019372; lipoxygenase pathway 1.041E-07 7.509E-06 ALOX12, ALOX15, ALOX5, HPGD, PTGS2
BP GO:0065007; biological regulation GO:1904355; positive regulation of telomere capping 1.466E-07 1.027E-05 AURKB, MAPK1, NEK2, TNKS, TNKS2
BP Unclassified; GO:0032845; negative regulation of homeostatic process 1.749E-07 1.209E-05 ADRA2A, CD38, HTR2A, HTR2B, HTR2C, PARP1, SRC, TNKS, TNKS2, TRPA1
BP GO:0009987; cellular process GO:0030168; platelet activation 1.816E-07 1.252E-05 ADRA2A, ADRA2B, ADRA2C, AKT1, AXL, MAPK1, PIK3R1, SRC, SYK
CC GO:0044464; cell part GO:0042995; cell projection 2.187E-07 1.465E-05 ADRA2C, AKR1B1, APP, BACE1, CA2, CAMK2B, CDK6, CHRM1, CHRM2, CHRM3, DRD1, DRD3, HIF1A, HTR2A, HTR2B, HTR6, HTT, MAPK1, MAPT, PKM, PTGS2, PTK2, RET, SLC6A2, SLC6A3, SLC6A4, SMN1, SMN2, SRC, TLR2
MF GO:0005488; binding GO:0051379; epinephrine binding 2.324E-07 1.547E-05 ADRA2A, ADRA2B, ADRA2C, DRD4
BP GO:0032502; developmental process GO:0007568; aging 2.413E-07 1.597E-05 AKT1, APEX1, AURKB, CDK1, CYP1A1, HTR2A, MPO, NOX4, POLB, PTGS2, SLC6A3, TP53
MF GO:0060089; molecular transducer activity GO:0004938; alpha2-adrenergic receptor activity 4.499E-07 2.729E-05 ADRA2A, ADRA2B, ADRA2C
MF GO:0005215; transporter activity GO:0005330; dopamine:sodium symporter activity 4.499E-07 2.729E-05 SLC6A2, SLC6A3, SLC6A4
MF Unclassified; GO:0032403; protein complex binding 8.221E-07 4.625E-05 ACHE, ADRA2A, APEX1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP13, MMP9, PIK3R1, PKM, PLK1, PPARA, PTPN1, SLC6A3, SLC6A4, SRC, SYK, TLR2, TSHR
BP GO:0007610; behavior GO:0007626; locomotory behavior 1.305E-06 6.984E-05 ALK, APP, DRD1, DRD3, DRD4, GAA, HTR2C, NPC1, SLC6A3, USP2
BP Unclassified; GO:0044243; multicellular organismal catabolic process 1.502E-06 7.937E-05 MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP Unclassified; GO:0044236; multicellular organism metabolic process 1.654E-06 8.595E-05 HIF1A, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9, PLA2G1B
BP GO:0007610; behavior GO:0008542; visual learning 1.789E-06 9.188E-05 APP, DRD1, DRD3, HIF1A, HRH1, HRH2
BP GO:0065007; biological regulation GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway 1.789E-06 9.188E-05 ADRA2A, ADRA2B, ADRA2C
BP GO:0009987; cellular process GO:0032811; negative regulation of epinephrine secretion 1.789E-06 9.188E-05 ADRA2A, ADRA2B, ADRA2C
BP GO:0023052; signaling GO:0007271; synaptic transmission, cholinergic 1.798E-06 9.188E-05 CHRM1, CHRM2, CHRM3, CHRM4, CHRM5
MF GO:0005488; binding GO:0005504; fatty acid binding 1.798E-06 9.188E-05 FABP2, FABP3, FABP4, FABP5, PPARD
MF GO:0005488; binding GO:0051721; protein phosphatase 2A binding 2.175E-06 1.074E-04 AKT1, MAPT, PTPN1, SLC6A3, TP53
MF GO:0005488; binding GO:0035240; dopamine binding 2.303E-06 1.130E-04 DRD1, DRD3, DRD4, SLC6A3
CC GO:0044464; cell part GO:0005829; cytosol 3.954E-06 1.840E-04 AHR, AKR1B1, AKR1B10, AKT1, ALDH1A1, ALOX12, ALOX15, ALOX5, APP, AR, AURKB, BLM, CA1, CA2, CA3, CA7, CAMK2B, CDK1, CDK6, CFTR, CSNK2A1, FABP2, FABP3, FABP4, FABP5, FLT3, GLO1, GSK3B, HIF1A, HPGD, HRH1, HSD17B1, HTR2A, HTT, LMNA, MAPK1, MAPT, MCL1, NEK2, NEK6, NFKB1, PIK3R1, PIM1, PKM, PKN1, PLA2G1B, PLK1, PTK2, PTPN1, PYGL, RAB9A, RET, SLC6A4, SMN1, SMN2, SRC, STAT6, SYK, TNKS, TNKS2, TP53, TYR, XDH
MF GO:0005488; binding GO:0051879; Hsp90 protein binding 4.347E-06 2.014E-04 AHR, CSNK2A1, HIF1A, KDR, MAPT
BP GO:0008152; metabolic process GO:0010513; positive regulation of phosphatidylinositol biosynthetic process 4.448E-06 2.039E-04 HTR2A, HTR2B, HTR2C
MF GO:0003824; catalytic activity GO:0101020; estrogen 16-alpha-hydroxylase activity 4.448E-06 2.039E-04 CYP1A1, CYP2C8, CYP3A4
BP Unclassified; GO:0044259; multicellular organismal macromolecule metabolic process 4.555E-06 2.071E-04 HIF1A, MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
MF GO:0005488; binding GO:0005496; steroid binding 4.555E-06 2.071E-04 AR, CYP3A4, ESR1, ESR2, ESRRA, HSD17B1, NPC1
BP GO:0032501; multicellular organismal process GO:0048265; response to pain 5.758E-06 2.549E-04 NMUR2, RET, SLC6A2, TRPA1
BP GO:0065007; biological regulation GO:0032148; activation of protein kinase B activity 5.932E-06 2.615E-04 ADRA2A, ADRA2B, ADRA2C, AKT1, SRC
BP GO:0065007; biological regulation GO:0032212; positive regulation of telomere maintenance via telomerase 5.932E-06 2.615E-04 AURKB, MAPK1, NEK2, TNKS, TNKS2
BP GO:0051179; localization GO:0034502; protein localization to chromosome 6.127E-06 2.690E-04 AURKB, CDK1, ESR1, PLK1, TNKS, TNKS2
BP GO:0009987; cellular process GO:0070301; cellular response to hydrogen peroxide 7.455E-06 3.253E-04 AKR1B1, APEX1, AXL, CDK1, CYP1B1, STAT6
BP GO:0009987; cellular process GO:0030522; intracellular receptor signaling pathway 8.809E-06 3.718E-04 AHR, AR, ESR1, ESR2, ESRRA, PIM1, PPARA, PPARD, SRC
BP GO:0009987; cellular process GO:2001243; negative regulation of intrinsic apoptotic signaling pathway 8.842E-06 3.718E-04 AKT1, HIF1A, MCL1, MMP9, PTGS2, PTPN1, SRC
BP GO:0008152; metabolic process GO:0002933; lipid hydroxylation 8.845E-06 3.718E-04 CYP1A1, CYP2C8, CYP3A4
MF GO:0060089; molecular transducer activity GO:0004969; histamine receptor activity 8.845E-06 3.718E-04 HRH1, HRH2, HTR6
BP GO:0050896; response to stimulus GO:0032496; response to lipopolysaccharide 1.039E-05 4.254E-04 ALPL, AXL, CYP1A1, CYP1A2, HPGD, MPO, NFKB1, PPARD, PTGES, PTGS2, SRC
MF GO:0005488; binding GO:0019901; protein kinase binding 1.041E-05 4.254E-04 ADRA2A, AKT1, ESR1, GSK3B, HIF1A, MAPK1, NEK6, PARP1, PIK3R1, PKN1, PLK1, PTK2, PTPN1, SRC, SYK, TP53
BP GO:0008152; metabolic process GO:0030574; collagen catabolic process 1.081E-05 4.401E-04 MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP GO:0051179; localization GO:0042307; positive regulation of protein import into nucleus 1.086E-05 4.411E-04 APP, CDK1, MAPK1, PARP1, PIK3R1, PTGS2, TLR2
BP GO:0008152; metabolic process GO:0031331; positive regulation of cellular catabolic process 1.219E-05 4.925E-04 ADRA2A, AKT1, CDK1, DAPK1, GSK3B, HIF1A, HTR2A, HTT, KDR, PLK1, PPARA, PTK2, PTPN1
BP GO:0007610; behavior GO:0048148; behavioral response to cocaine 1.497E-05 5.925E-04 DRD1, DRD3, DRD4, HTR2A
BP GO:0009987; cellular process GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway 1.497E-05 5.925E-04 ADRA1D, ADRA2A, ADRA2B, ADRA2C
BP GO:0009987; cellular process GO:2001237; negative regulation of extrinsic apoptotic signaling pathway 1.506E-05 5.952E-04 AKT1, AR, DAPK1, HTT, LMNA, MCL1, SRC
BP GO:0009987; cellular process GO:0071456; cellular response to hypoxia 1.604E-05 6.283E-04 AKT1, HIF1A, LMNA, PPARD, PTGS2, SRC, TP53
BP GO:0051179; localization GO:0043270; positive regulation of ion transport 1.633E-05 6.374E-04 ADRA2A, AKT1, CFTR, CHRM1, DRD1, DRD4, HTT, NPSR1, PLA2G1B, SLC6A4
MF GO:0005488; binding GO:0002039; p53 binding 1.663E-05 6.477E-04 BLM, GSK3B, HIF1A, HTT, NUAK1, TP53
BP GO:0007610; behavior GO:0007613; memory 1.708E-05 6.618E-04 DRD1, HRH1, HRH2, HTR2A, MAPT, PTGS2, SLC6A4
BP GO:0009987; cellular process GO:0071216; cellular response to biotic stimulus 2.168E-05 8.282E-04 AXL, GSK3B, NFKB1, PPARD, SRC, SYK, TLR2, TP53
BP GO:0009987; cellular process GO:0070374; positive regulation of ERK1 and ERK2 cascade 2.269E-05 8.637E-04 ALOX15, APP, HTR2A, HTR2B, HTR2C, KDR, NOX4, SRC, THPO
BP GO:0009987; cellular process GO:1903376; regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 2.449E-05 9.220E-04 HIF1A, MCL1, PARP1
BP GO:0023052; signaling GO:0051584; regulation of dopamine uptake involved in synaptic transmission 2.449E-05 9.220E-04 DRD1, DRD3, DRD4
BP GO:0009987; cellular process GO:0010700; negative regulation of norepinephrine secretion 2.449E-05 9.220E-04 ADRA2A, ADRA2B, ADRA2C
CC GO:0044464; cell part GO:0005641; nuclear envelope lumen 2.449E-05 9.220E-04 ALOX5, APP, PTGES
BP GO:0065007; biological regulation GO:0048167; regulation of synaptic plasticity 2.621E-05 9.805E-04 APP, CAMK2B, CD38, DRD1, HRH1, HRH2, MAPK1, PTGS2
BP GO:0051179; localization GO:0050482; arachidonic acid secretion 2.686E-05 9.999E-04 DRD3, DRD4, NMUR2, PLA2G1B
BP GO:0008152; metabolic process GO:0042136; neurotransmitter biosynthetic process 2.713E-05 1.008E-03 ACHE, AKT1, CYP1B1, SLC6A3, SLC6A4
BP GO:0008152; metabolic process GO:0038083; peptidyl-tyrosine autophosphorylation 3.017E-05 1.104E-03 IGF1R, KDR, PTK2, SRC, SYK
CC GO:0044464; cell part GO:0030424; axon 3.154E-05 1.151E-03 ADRA2C, APP, BACE1, CA2, HTR2A, HTT, MAPK1, MAPT, RET, SLC6A3
BP GO:0009987; cellular process GO:0007210; serotonin receptor signaling pathway 3.204E-05 1.157E-03 HTR2A, HTR2B, HTR2C, HTR6
MF GO:0060089; molecular transducer activity GO:0004993; G-protein coupled serotonin receptor activity 3.204E-05 1.157E-03 HTR2A, HTR2B, HTR2C, HTR6
BP GO:0050896; response to stimulus GO:0045471; response to ethanol 3.261E-05 1.176E-03 CA3, CDK1, DRD3, HPGD, POLB, SLC6A3, TP53
BP GO:0009987; cellular process GO:0022617; extracellular matrix disassembly 3.330E-05 1.199E-03 MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP GO:0050896; response to stimulus GO:0006954; inflammatory response 3.344E-05 1.202E-03 AKT1, ALOX15, AXL, CXCR1, HRH1, NFKB1, NOX4, POLB, PTGES, PTGS1, PTGS2, SYK, TLR2
CC GO:0043226; organelle GO:0005654; nucleoplasm 3.633E-05 1.301E-03 AHR, AKR1B1, AKT1, ALOX5, APEX1, AR, AURKB, BLM, CAMK2B, CDK1, CDK6, CSNK2A1, CTDSP1, ESR1, ESR2, ESRRA, FABP5, GSK3B, HIF1A, HPGD, HTT, LMNA, MAPK1, MCL1, NEK2, NEK6, NFKB1, NUAK1, PARP1, PIM1, PKN1, PLK1, POLB, PPARA, PPARD, RECQL, SMN1, SMN2, SRC, STAT6, TNKS, TP53, USP2
BP GO:0009987; cellular process GO:0000733; DNA strand renaturation 3.652E-05 1.302E-03 BLM, RECQL, TP53
BP Unclassified; GO:0003056; regulation of vascular smooth muscle contraction 3.652E-05 1.302E-03 ADRA2B, CHRM1, CHRM3
BP GO:0008152; metabolic process GO:0019433; triglyceride catabolic process 3.792E-05 1.343E-03 FABP2, FABP3, FABP4, FABP5
BP GO:0023052; signaling GO:0050806; positive regulation of synaptic transmission 4.276E-05 1.492E-03 APP, CA2, CA7, DRD1, DRD4, MAPK1, PTGS2
BP GO:0050896; response to stimulus GO:0032355; response to estradiol 5.001E-05 1.718E-03 CD38, CYP1A2, ESR1, ESRRA, HPGD, PTGS2, SLC6A4
BP GO:0051179; localization GO:2001225; regulation of chloride transport 5.188E-05 1.774E-03 CA2, CA7, CFTR
BP GO:0065007; biological regulation GO:1904357; negative regulation of telomere maintenance via telomere lengthening 5.198E-05 1.774E-03 PARP1, SRC, TNKS, TNKS2
BP GO:0050896; response to stimulus GO:1904646; cellular response to amyloid-beta 5.198E-05 1.774E-03 APP, GSK3B, IGF1R, PARP1
BP GO:0009987; cellular process GO:0007208; phospholipase C-activating serotonin receptor signaling pathway 5.911E-05 1.962E-03 HTR2A, HTR2C
BP GO:0009987; cellular process GO:0006286; base-excision repair, base-free sugar-phosphate removal 5.911E-05 1.962E-03 APEX1, POLB
BP GO:0008152; metabolic process GO:2001303; lipoxin A4 biosynthetic process 5.911E-05 1.962E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0004666; prostaglandin-endoperoxide synthase activity 5.911E-05 1.962E-03 PTGS1, PTGS2
MF GO:0060089; molecular transducer activity GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding 5.911E-05 1.962E-03 ESR1, ESR2
MF GO:0003824; catalytic activity GO:0047977; hepoxilin-epoxide hydrolase activity 5.911E-05 1.962E-03 ALOX12, ALOX15
MF GO:0005488; binding GO:0071886; 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding 5.911E-05 1.962E-03 HTR2A, HTR2C
BP GO:0008152; metabolic process GO:0016572; histone phosphorylation 6.028E-05 1.998E-03 AURKB, CDK1, DRD1, PKN1
BP GO:0008152; metabolic process GO:0031623; receptor internalization 6.511E-05 2.138E-03 ACHE, CXCR1, DRD3, HTR2B, SYK
CC GO:0043226; organelle GO:0044454; nuclear chromosome part 6.589E-05 2.158E-03 APEX1, AR, AURKB, BLM, CDK1, CSNK2A1, ESR1, PARP1, PLK1, PPARD, STAT6, TNKS, TNKS2, TP53
BP GO:0009987; cellular process GO:0043401; steroid hormone mediated signaling pathway 6.753E-05 2.205E-03 AR, ESR1, ESR2, ESRRA, PPARA, PPARD, SRC
BP GO:0008152; metabolic process GO:2000379; positive regulation of reactive oxygen species metabolic process 6.958E-05 2.241E-03 AKT1, MAPT, NOX4, PTGS2, TP53, XDH
BP GO:0050896; response to stimulus GO:0034776; response to histamine 7.093E-05 2.265E-03 DRD3, DRD4, HRH1
BP GO:0032501; multicellular organismal process GO:0060736; prostate gland growth 7.093E-05 2.265E-03 AR, CYP19A1, ESR1
BP GO:0008152; metabolic process GO:0019371; cyclooxygenase pathway 7.093E-05 2.265E-03 PTGES, PTGS1, PTGS2
MF GO:0005488; binding GO:0051378; serotonin binding 7.093E-05 2.265E-03 HTR2A, HTR2B, HTR2C
MF GO:0005488; binding GO:0034452; dynactin binding 7.093E-05 2.265E-03 GSK3B, HTT, MAPT
BP GO:0008152; metabolic process GO:0016579; protein deubiquitination 7.303E-05 2.325E-03 AR, CDK1, CFTR, ESR1, HIF1A, POLB, TNKS, TNKS2, TP53, USP2
BP GO:0009987; cellular process GO:0043065; positive regulation of apoptotic process 7.422E-05 2.356E-03 AKT1, CYP1B1, DAPK1, GSK3B, HPGD, HTT, MAPT, MCL1, MMP9, NOX4, PTGS2, RET, SRC, TP53, XDH
CC GO:0016020; membrane GO:0005789; endoplasmic reticulum membrane 8.860E-05 2.784E-03 CAMK2B, CDK1, CFTR, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9, CYP2D6, CYP3A4, DRD1, HSD17B2, NOX4, PTGES, PTGS1, PTGS2, RAB9A
BP GO:0009987; cellular process GO:0071276; cellular response to cadmium ion 9.098E-05 2.830E-03 AKT1, CYP1A2, MAPK1, MMP9
BP GO:0009987; cellular process GO:0045600; positive regulation of fat cell differentiation 9.141E-05 2.835E-03 AKT1, HTR2A, HTR2C, PPARD, PTGS2
BP GO:0008283; cell proliferation GO:0033598; mammary gland epithelial cell proliferation 9.404E-05 2.894E-03 ESR1, MAPK1, STAT6
BP GO:0009987; cellular process GO:0051983; regulation of chromosome segregation 9.411E-05 2.894E-03 AURKB, CSNK2A1, NEK2, NEK6, PLK1, TNKS
CC GO:0016020; membrane GO:0016323; basolateral plasma membrane 9.965E-05 3.051E-03 ABCC1, ADRA2A, CA2, CA4, CA9, CHRM3, HPGD, TSHR
BP GO:0008152; metabolic process GO:1902893; regulation of pri-miRNA transcription from RNA polymerase II promoter 1.169E-04 3.507E-03 HIF1A, PPARA, PPARD, TP53
BP GO:0008152; metabolic process GO:0090407; organophosphate biosynthetic process 1.211E-04 3.606E-03 ACHE, ALOX15, ALPI, CSNK2A1, HTR2B, HTR2C, MAPK1, PIK3R1, PKM, PLA2G1B, PPARD, PTGS2, PYGL
BP GO:0008152; metabolic process GO:0006703; estrogen biosynthetic process 1.216E-04 3.606E-03 CYP19A1, HSD17B1, HSD17B2
BP GO:0050896; response to stimulus GO:0060134; prepulse inhibition 1.216E-04 3.606E-03 DRD1, DRD3, SLC6A3
MF GO:0005488; binding GO:0046982; protein heterodimerization activity 1.286E-04 3.798E-03 ADRA2A, ADRA2C, AHR, AXL, HIF1A, MCL1, NFKB1, PIK3R1, PPARD, TLR2, TP53, TTR, TYR
BP GO:0032501; multicellular organismal process GO:0045987; positive regulation of smooth muscle contraction 1.317E-04 3.872E-03 ADRA1D, ADRA2B, CHRM3, PTGS2
MF GO:0005488; binding GO:0042803; protein homodimerization activity 1.395E-04 4.060E-03 ABCG2, ACHE, ADRA2A, ADRA2C, AKT1, BLM, CAMK2B, FLT3, HPGD, MAPT, MCL1, NFKB1, PTGS2, PYGL, SLC6A4, TYR, XDH
BP GO:0009987; cellular process GO:0000226; microtubule cytoskeleton organization 1.461E-04 4.242E-03 AURKB, CDK1, HTT, LMNA, MAPT, NEK2, NEK6, PLK1, PTK2, TNKS
BP GO:0022610; biological adhesion GO:0001952; regulation of cell-matrix adhesion 1.472E-04 4.257E-03 CDK6, GSK3B, KDR, PIK3R1, PTK2, SRC
BP GO:0032502; developmental process GO:0060065; uterus development 1.538E-04 4.422E-03 CYP19A1, ESR1, SRC
BP GO:0065007; biological regulation GO:0045124; regulation of bone resorption 1.653E-04 4.719E-03 CA2, CD38, SRC, SYK
BP GO:0050896; response to stimulus GO:0009266; response to temperature stimulus 1.654E-04 4.719E-03 AKT1, HTR2A, HTR2B, MAPT, PTGS2, TP53, TRPA1
BP GO:0032501; multicellular organismal process GO:0014005; microglia development 1.764E-04 4.944E-03 APP, TLR2
BP GO:0008152; metabolic process GO:0009822; alkaloid catabolic process 1.764E-04 4.944E-03 CYP2D6, CYP3A4
BP GO:0009987; cellular process GO:0032849; positive regulation of cellular pH reduction 1.764E-04 4.944E-03 CA2, CA7
MF GO:0003824; catalytic activity GO:0050473; arachidonate 15-lipoxygenase activity 1.764E-04 4.944E-03 ALOX15, PTGS2
MF GO:0003824; catalytic activity GO:0070576; vitamin D 24-hydroxylase activity 1.764E-04 4.944E-03 CYP1A1, CYP3A4
MF GO:0003824; catalytic activity GO:0004052; arachidonate 12-lipoxygenase activity 1.764E-04 4.944E-03 ALOX12, ALOX15
MF GO:0003824; catalytic activity GO:0051120; hepoxilin A3 synthase activity 1.764E-04 4.944E-03 ALOX12, ALOX15
BP GO:0009987; cellular process GO:0051897; positive regulation of protein kinase B signaling 1.795E-04 5.025E-03 AXL, MET, NOX4, PIK3R1, PTK2, SRC, THPO
BP GO:0008152; metabolic process GO:0019318; hexose metabolic process 1.870E-04 5.206E-03 AKR1B1, AKT1, ALDH1A1, FUT7, GAA, PKM, PPARD
BP GO:0065007; biological regulation GO:0043393; regulation of protein binding 1.947E-04 5.414E-03 APP, AURKB, GSK3B, MET, MMP9, PLK1, PPARA, SRC
BP GO:0065007; biological regulation GO:0051100; negative regulation of binding 2.025E-04 5.610E-03 AURKB, CYP2D6, GSK3B, MET, NEK2, PPARA, TNKS
BP GO:0022414; reproductive process GO:0007566; embryo implantation 2.047E-04 5.656E-03 MMP2, MMP9, PPARD, PTGS2
BP GO:0008152; metabolic process GO:0010507; negative regulation of autophagy 2.207E-04 6.038E-03 AKT1, HTR2B, MCL1, MET, NPC1
BP GO:0009987; cellular process GO:2000811; negative regulation of anoikis 2.340E-04 6.338E-03 MCL1, PTK2, SRC
BP GO:0032501; multicellular organismal process GO:0032481; positive regulation of type I interferon production 2.358E-04 6.361E-03 MMP12, NFKB1, STAT6, SYK, TLR2
BP GO:0009987; cellular process GO:0048010; vascular endothelial growth factor receptor signaling pathway 2.358E-04 6.361E-03 AXL, KDR, PIK3R1, PTK2, SRC
BP GO:0008152; metabolic process GO:0006367; transcription initiation from RNA polymerase II promoter 2.460E-04 6.630E-03 AR, CDK1, ESR1, ESR2, ESRRA, PPARA, PPARD
BP GO:0022610; biological adhesion GO:0033628; regulation of cell adhesion mediated by integrin 2.504E-04 6.732E-03 CYP1B1, PTK2, RET, SYK
BP GO:0008152; metabolic process GO:0045862; positive regulation of proteolysis 2.524E-04 6.777E-03 ADRA2A, AKT1, APP, CDK1, DAPK1, GSK3B, MAPT, PLK1, PTK2, SRC, XDH
MF GO:0003824; catalytic activity GO:0004222; metalloendopeptidase activity 2.686E-04 7.176E-03 MMP1, MMP12, MMP13, MMP2, MMP3, MMP9
BP GO:0008152; metabolic process GO:0046209; nitric oxide metabolic process 2.826E-04 7.458E-03 AKT1, CYP1B1, TLR2
MF GO:0005488; binding GO:0001085; RNA polymerase II transcription factor binding 2.815E-04 7.458E-03 AHR, AR, ESR1, GSK3B, PPARA, TP53
MF GO:0003824; catalytic activity GO:0008392; arachidonic acid epoxygenase activity 2.826E-04 7.458E-03 CYP2C19, CYP2C8, CYP2C9
MF GO:0003824; catalytic activity GO:0035173; histone kinase activity 2.826E-04 7.458E-03 AURKB, CDK1, PKN1
BP GO:0032502; developmental process GO:0031214; biomineral tissue development 2.855E-04 7.526E-03 ALOX15, ALPL, MMP13, PPARA, PTGS2
BP GO:0002376; immune system process GO:0002684; positive regulation of immune system process 2.929E-04 7.703E-03 AKT1, APP, AXL, CA2, CD38, HIF1A, MAPK1, MMP12, MMP2, NFKB1, PIK3R1, PLA2G1B, PTK2, SRC, STAT6, SYK, THPO, TLR2, TP53
CC GO:0044464; cell part GO:0009986; cell surface 2.990E-04 7.855E-03 ACHE, APP, AXL, BACE1, CA4, CD38, CFTR, MET, PLA2G1B, SLC6A2, SLC6A3, TLR2, TSHR
BP GO:0032502; developmental process GO:0031100; animal organ regeneration 3.037E-04 7.958E-03 AXL, CDK1, CSNK2A1, FLT3, PKM
BP GO:0032501; multicellular organismal process GO:0050767; regulation of neurogenesis 3.179E-04 8.250E-03 ADRA2B, ADRA2C, AKT1, APP, CAMK2B, CDK1, CTDSP1, DRD3, GSK3B, HIF1A, MAPT, PTK2, RET, SLC6A4, TLR2
BP GO:0002376; immune system process GO:0048534; hematopoietic or lymphoid organ development 3.193E-04 8.267E-03 FLT3, HIF1A, KDR, MAPK1, PKN1, POLB, TYR
BP GO:0009987; cellular process GO:1901216; positive regulation of neuron death 3.228E-04 8.333E-03 GSK3B, MAPT, MCL1, PARP1, TP53
BP GO:0008152; metabolic process GO:0051000; positive regulation of nitric-oxide synthase activity 3.371E-04 8.647E-03 AKT1, HIF1A, HTR2B
BP GO:0065007; biological regulation GO:0032431; activation of phospholipase A2 activity 3.511E-04 8.909E-03 NMUR2, PLA2G1B
BP GO:0008152; metabolic process GO:0070213; protein auto-ADP-ribosylation 3.511E-04 8.909E-03 TNKS, TNKS2
BP GO:0032501; multicellular organismal process GO:0032640; tumor necrosis factor production 3.511E-04 8.909E-03 APP, TLR2
BP GO:0008152; metabolic process GO:0018894; dibenzo-p-dioxin metabolic process 3.511E-04 8.909E-03 CYP1A1, CYP1A2
MF GO:0005488; binding GO:0034056; estrogen response element binding 3.511E-04 8.909E-03 ESR1, ESR2
MF GO:0005488; binding GO:0005497; androgen binding 3.511E-04 8.909E-03 ALDH1A1, AR
BP GO:0032501; multicellular organismal process GO:0043536; positive regulation of blood vessel endothelial cell migration 3.632E-04 9.174E-03 AKT1, HIF1A, KDR, PTGS2
BP GO:0009987; cellular process GO:0007077; mitotic nuclear envelope disassembly 3.632E-04 9.174E-03 CDK1, LMNA, NEK6, PLK1
MF GO:0003824; catalytic activity GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors 3.632E-04 9.174E-03 AKR1B1, AKR1B10, ALDH1A1, XDH
BP GO:0008283; cell proliferation GO:0008285; negative regulation of cell proliferation 3.640E-04 9.185E-03 APP, AR, CDK6, CYP1B1, FABP3, LMNA, NOX4, PKN1, PPARD, PTGES, PTGS2, SLC6A4, TLR2, TP53, XDH
BP GO:0002376; immune system process GO:0043312; neutrophil degranulation 3.675E-04 9.262E-03 ALOX5, CXCR1, FABP5, GAA, MAPK1, MMP9, MPO, NFKB1, PKM, PYGL, TLR2, TTR
BP GO:0051179; localization GO:0051924; regulation of calcium ion transport 3.758E-04 9.446E-03 ADRA2A, CAMK2B, DRD1, DRD4, HTT, NPSR1, PLA2G1B, PTGS2
BP GO:0050896; response to stimulus GO:0070542; response to fatty acid 3.856E-04 9.650E-03 AKT1, FABP3, PTGS2, SRC, TLR2
BP GO:0051179; localization GO:1904062; regulation of cation transmembrane transport 3.962E-04 9.815E-03 ADRA2A, APP, DAPK1, DRD1, DRD3, DRD4, HTT, MMP9, NPSR1
BP GO:0009987; cellular process GO:0090199; regulation of release of cytochrome c from mitochondria 3.962E-04 9.815E-03 AKT1, LMNA, MMP9, TP53
BP GO:0051179; localization GO:0051209; release of sequestered calcium ion into cytosol 3.962E-04 9.815E-03 HTR2A, HTR2B, HTR2C, TRPA1
BP GO:0008152; metabolic process GO:0042053; regulation of dopamine metabolic process 3.981E-04 9.819E-03 DRD1, DRD4, SLC6A3
BP GO:0050896; response to stimulus GO:1901655; cellular response to ketone 4.084E-04 9.981E-03 AKR1B1, AKT1, AR, CFTR, SRC
CC GO:0044464; cell part GO:0005739; mitochondrion 4.082E-04 9.981E-03 AKT1, APEX1, CA5A, CA5B, CDK1, CYP1A1, CYP1B1, CYP2D6, ESR2, GSK3B, HSD17B10, MAOA, MAPK1, MCL1, MMP2, MPO, NFKB1, NOX4, PARP1, PKM, SRC, TP53
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 5.256E-21 9.538E-18 CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP Unclassified; GO:0032844; regulation of homeostatic process 3.798E-16 2.176E-13 ADRA2A, AURKB, CA2, CA7, CD38, CDK6, CFTR, DRD1, DRD3, HIF1A, HTR2A, HTR2B, HTR2C, HTT, KDR, MAPK1, NEK2, NPC1, NPSR1, PARP1, PLA2G1B, PTGS2, SRC, SYK, TNKS, TNKS2, TRPA1
BP GO:0051179; localization GO:0015701; bicarbonate transport 4.830E-16 2.697E-13 CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CFTR
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.177E-13 3.125E-11 CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa04726 Serotonergic synapse_Homo sapiens_hsa04726 7.753E-18 7.753E-16 APP; MAOA; ALOX15; HTR2B; HTR2C; ALOX12; HTR2A; CYP2C19; PTGS2; SLC6A4; PTGS1; CYP2C9; CYP2C8; HTR6; CYP2D6; ALOX5; MAPK1
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 3.212E-20 6.423E-18 CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04080 Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 2.160E-14 1.440E-12 CHRM2; CHRM3; CHRM1; CHRM4; CHRM5; HTR2B; HTR2C; ADRA1D; HTR2A; ADRA2C; ADRA2B; ADRA2A; TSHR; HTR6; HRH1; HRH2; NMUR2; DRD1; DRD3; DRD4
hsa05200 Pathways in cancer_Homo sapiens_hsa05200 1.697E-11 8.487E-10 RET; GSK3B; FLT3; MMP1; DAPK1; MMP2; PIK3R1; PTGS2; HIF1A; MMP9; NFKB1; PTK2; IGF1R; AR; CDK6; AKT1; MAPK1; MET; TP53; PPARD
hsa05205 Proteoglycans in cancer_Homo sapiens_hsa05205 3.296E-11 1.099E-09 CAMK2B; SRC; MMP2; PIK3R1; HIF1A; ESR1; MMP9; PTK2; IGF1R; KDR; AKT1; MAPK1; TP53; MET; TLR2
hsa00590 Arachidonic acid metabolism_Homo sapiens_hsa00590 2.998E-11 1.099E-09 CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19; PTGS2; PTGES; PTGS1
hsa04020 Calcium signaling pathway_Homo sapiens_hsa04020 7.764E-11 2.218E-09 CHRM2; CAMK2B; CHRM3; CHRM1; CHRM5; HTR2B; HTR2C; ADRA1D; HTR2A; HTR6; HRH1; HRH2; CD38; DRD1
hsa04151 PI3K-Akt signaling pathway_Homo sapiens_hsa04151 7.295E-10 1.824E-08 CHRM2; GSK3B; CHRM1; SYK; PIK3R1; PTK2; NFKB1; IGF1R; CDK6; KDR; AKT1; MAPK1; PKN1; TP53; MET; TLR2; MCL1
hsa01100 Metabolic pathways_Homo sapiens_hsa01100 8.185E-09 1.364E-07 PLA2G1B; MAOA; ALOX15; AKR1B1; ALOX12; PYGL; PTGS2; CYP2C19; CYP3A4; CYP19A1; HSD17B10; PTGS1; FUT7; HSD17B1; ALOX5; HSD17B2; CD38; XDH; GAA; TYR; CYP2C9; CYP2C8; PKM; AKR1B10; CYP1A2; ALDH1A1; CYP1A1; ALPL; ALPI; PTGES
hsa05230 Central carbon metabolism in cancer_Homo sapiens_hsa05230 1.641E-09 3.282E-08 RET; PKM; FLT3; AKT1; MAPK1; PIK3R1; TP53; MET; HIF1A
hsa04725 Cholinergic synapse_Homo sapiens_hsa04725 1.053E-08 1.621E-07 CHRM2; CAMK2B; CHRM3; ACHE; CHRM1; CHRM4; CHRM5; AKT1; MAPK1; PIK3R1
hsa04913 Ovarian steroidogenesis_Homo sapiens_hsa04913 3.237E-09 5.885E-08 HSD17B1; ALOX5; HSD17B2; CYP1A1; CYP1B1; PTGS2; CYP19A1; IGF1R
hsa04024 cAMP signaling pathway_Homo sapiens_hsa04024 3.259E-08 4.345E-07 CHRM2; CAMK2B; HTR6; CHRM1; AKT1; MAPK1; PIK3R1; DRD1; PPARA; CFTR; NFKB1; TSHR
hsa04750 Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 4.965E-08 6.207E-07 CAMK2B; HRH1; TRPA1; SRC; HTR2B; HTR2C; ALOX12; PIK3R1; HTR2A
hsa00591 Linoleic acid metabolism_Homo sapiens_hsa00591 1.504E-09 3.282E-08 CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19
hsa04917 Prolactin signaling pathway_Homo sapiens_hsa04917 6.285E-08 7.394E-07 GSK3B; SRC; AKT1; MAPK1; PIK3R1; ESR1; NFKB1; ESR2
hsa05161 Hepatitis B_Homo sapiens_hsa05161 1.449E-07 1.610E-06 CDK6; SRC; AKT1; MAPK1; STAT6; PIK3R1; TP53; MMP9; NFKB1; TLR2
hsa05219 Bladder cancer_Homo sapiens_hsa05219 2.010E-08 2.872E-07 MMP1; DAPK1; SRC; MMP2; MAPK1; MMP9; TP53
hsa05215 Prostate cancer_Homo sapiens_hsa05215 3.333E-07 2.996E-06 GSK3B; AR; AKT1; MAPK1; PIK3R1; TP53; NFKB1; IGF1R
hsa05221 Acute myeloid leukemia_Homo sapiens_hsa05221 2.140E-07 2.140E-06 FLT3; PIM1; AKT1; MAPK1; PIK3R1; NFKB1; PPARD
hsa05214 Glioma_Homo sapiens_hsa05214 5.363E-07 4.469E-06 CAMK2B; CDK6; AKT1; MAPK1; PIK3R1; TP53; IGF1R
hsa05204 Chemical carcinogenesis_Homo sapiens_hsa05204 1.758E-07 1.850E-06 CYP2C9; CYP2C8; CYP1A2; CYP1A1; CYP1B1; CYP3A4; CYP2C19; PTGS2
hsa04915 Estrogen signaling pathway_Homo sapiens_hsa04915 7.590E-07 5.936E-06 SRC; MMP2; AKT1; MAPK1; PIK3R1; ESR1; MMP9; ESR2
hsa04370 VEGF signaling pathway_Homo sapiens_hsa04370 3.445E-07 2.996E-06 SRC; KDR; AKT1; MAPK1; PIK3R1; PTGS2; PTK2
hsa05162 Measles_Homo sapiens_hsa05162 8.310E-07 5.936E-06 GSK3B; CDK6; CSNK2A1; AKT1; RAB9A; PIK3R1; TP53; NFKB1; TLR2
hsa05203 Viral carcinogenesis_Homo sapiens_hsa05203 3.258E-06 2.036E-05 POLB; CDK6; PKM; SYK; SRC; CDK1; MAPK1; PIK3R1; TP53; NFKB1
hsa00140 Steroid hormone biosynthesis_Homo sapiens_hsa00140 2.419E-07 2.304E-06 HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1
hsa05202 Transcriptional misregulation in cancer_Homo sapiens_hsa05202 1.007E-06 6.715E-06 HPGD; FLT3; MMP3; TP53; MPO; MMP9; MET; NFKB1; PTK2; IGF1R
hsa05218 Melanoma_Homo sapiens_hsa05218 9.869E-07 6.715E-06 CDK6; AKT1; MAPK1; PIK3R1; TP53; MET; IGF1R
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 8.107E-07 5.936E-06 CYP2C9; CYP2C8; MAOA; CYP2D6; CYP1A2; CYP3A4; CYP2C19
hsa04919 Thyroid hormone signaling pathway_Homo sapiens_hsa04919 2.879E-06 1.857E-05 GSK3B; SRC; AKT1; MAPK1; PIK3R1; TP53; ESR1; HIF1A
hsa03320 PPAR signaling pathway_Homo sapiens_hsa03320 8.107E-07 5.936E-06 FABP2; FABP3; FABP4; FABP5; MMP1; PPARA; PPARD
hsa05222 Small cell lung cancer_Homo sapiens_hsa05222 3.633E-06 2.109E-05 CDK6; AKT1; PIK3R1; PTGS2; TP53; NFKB1; PTK2
hsa04728 Dopaminergic synapse_Homo sapiens_hsa04728 5.600E-06 2.947E-05 CAMK2B; GSK3B; MAOA; AKT1; DRD1; DRD3; SLC6A3; DRD4
hsa04210 Apoptosis_Homo sapiens_hsa04210 1.024E-05 4.995E-05 PARP1; LMNA; AKT1; MAPK1; PIK3R1; TP53; NFKB1; MCL1
hsa04012 ErbB signaling pathway_Homo sapiens_hsa04012 3.926E-06 2.181E-05 CAMK2B; GSK3B; SRC; AKT1; MAPK1; PIK3R1; PTK2
hsa05206 MicroRNAs in cancer_Homo sapiens_hsa05206 1.446E-05 6.727E-05 ABCC1; CDK6; PIM1; CYP1B1; MAPK1; PTGS2; TP53; MMP9; MET; NFKB1; MCL1
hsa04540 Gap junction_Homo sapiens_hsa04540 4.239E-06 2.292E-05 SRC; CDK1; HTR2B; HTR2C; MAPK1; HTR2A; DRD1
hsa04066 HIF-1 signaling pathway_Homo sapiens_hsa04066 1.206E-05 5.741E-05 CAMK2B; AKT1; MAPK1; PIK3R1; HIF1A; NFKB1; IGF1R
hsa04923 Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 3.692E-06 2.109E-05 FABP4; AKT1; PIK3R1; PTGS2; TSHR; PTGS1
hsa05223 Non-small cell lung cancer_Homo sapiens_hsa05223 3.692E-06 2.109E-05 ALK; CDK6; AKT1; MAPK1; PIK3R1; TP53
hsa05169 Epstein-Barr virus infection_Homo sapiens_hsa05169 2.110E-05 8.275E-05 GSK3B; SYK; CSNK2A1; CDK1; AKT1; CD38; PIK3R1; TP53; NFKB1
hsa04510 Focal adhesion_Homo sapiens_hsa04510 2.110E-05 8.275E-05 GSK3B; SRC; KDR; AKT1; MAPK1; PIK3R1; MET; PTK2; IGF1R
hsa04668 TNF signaling pathway_Homo sapiens_hsa04668 1.854E-05 7.701E-05 MMP3; AKT1; MAPK1; PIK3R1; PTGS2; MMP9; NFKB1
hsa04931 Insulin resistance_Homo sapiens_hsa04931 1.747E-05 7.434E-05 PTPN1; GSK3B; AKT1; PIK3R1; PYGL; PPARA; NFKB1
hsa05212 Pancreatic cancer_Homo sapiens_hsa05212 9.717E-06 4.859E-05 CDK6; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04810 Regulation of actin cytoskeleton_Homo sapiens_hsa04810 3.323E-05 1.254E-04 CHRM2; CHRM3; CHRM1; SRC; CHRM4; CHRM5; MAPK1; PIK3R1; PTK2
hsa05220 Chronic myeloid leukemia_Homo sapiens_hsa05220 1.744E-05 7.434E-05 CDK6; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04662 B cell receptor signaling pathway_Homo sapiens_hsa04662 1.744E-05 7.434E-05 GSK3B; SYK; AKT1; MAPK1; PIK3R1; NFKB1
hsa04722 Neurotrophin signaling pathway_Homo sapiens_hsa04722 3.258E-05 1.253E-04 CAMK2B; GSK3B; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa00830 Retinol metabolism_Homo sapiens_hsa00830 8.888E-06 4.558E-05 CYP2C9; CYP2C8; CYP1A2; ALDH1A1; CYP1A1; CYP3A4
hsa04062 Chemokine signaling pathway_Homo sapiens_hsa04062 8.147E-05 2.910E-04 GSK3B; CXCR1; SRC; AKT1; MAPK1; PIK3R1; NFKB1; PTK2
hsa05160 Hepatitis C_Homo sapiens_hsa05160 6.286E-05 2.286E-04 GSK3B; AKT1; MAPK1; PIK3R1; PPARA; TP53; NFKB1
hsa04933 AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 1.095E-04 3.711E-04 MMP2; PIM1; AKT1; MAPK1; PIK3R1; NFKB1
hsa04914 Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 9.259E-05 3.249E-04 PLK1; CDK1; AKT1; MAPK1; PIK3R1; IGF1R
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 1.744E-05 7.434E-05 CYP2C9; CYP2D6; CYP1A2; CYP1A1; CYP1B1; CYP3A4
hsa04520 Adherens junction_Homo sapiens_hsa04520 1.887E-05 7.701E-05 PTPN1; CSNK2A1; SRC; MAPK1; MET; IGF1R
hsa04022 cGMP-PKG signaling pathway_Homo sapiens_hsa04022 2.592E-04 8.100E-04 AKT1; MAPK1; ADRA1D; PIK3R1; ADRA2C; ADRA2B; ADRA2A
hsa04014 Ras signaling pathway_Homo sapiens_hsa04014 3.075E-04 9.181E-04 PLA2G1B; KDR; AKT1; MAPK1; PIK3R1; MET; NFKB1; IGF1R
hsa05145 Toxoplasmosis_Homo sapiens_hsa05145 2.566E-04 8.100E-04 ALOX5; AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa04611 Platelet activation_Homo sapiens_hsa04611 3.072E-04 9.181E-04 SYK; SRC; AKT1; MAPK1; PIK3R1; PTGS1
hsa05152 Tuberculosis_Homo sapiens_hsa05152 3.816E-04 1.106E-03 CAMK2B; SYK; SRC; AKT1; MAPK1; NFKB1; TLR2
hsa04071 Sphingolipid signaling pathway_Homo sapiens_hsa04071 2.810E-04 8.647E-04 ABCC1; AKT1; MAPK1; PIK3R1; TP53; NFKB1
hsa04114 Oocyte meiosis_Homo sapiens_hsa04114 3.210E-04 9.442E-04 CAMK2B; AR; PLK1; CDK1; MAPK1; IGF1R
hsa04910 Insulin signaling pathway_Homo sapiens_hsa04910 6.155E-04 1.710E-03 PTPN1; GSK3B; AKT1; MAPK1; PIK3R1; PYGL
hsa04015 Rap1 signaling pathway_Homo sapiens_hsa04015 1.044E-03 2.676E-03 SRC; KDR; AKT1; MAPK1; PIK3R1; MET; IGF1R
hsa04971 Gastric acid secretion_Homo sapiens_hsa04971 2.286E-04 7.374E-04 CAMK2B; CHRM3; HRH2; CA2; CFTR
hsa04921 Oxytocin signaling pathway_Homo sapiens_hsa04921 1.199E-03 2.889E-03 CAMK2B; SRC; CD38; MAPK1; PIK3R1; PTGS2
hsa04630 Jak-STAT signaling pathway_Homo sapiens_hsa04630 1.199E-03 2.889E-03 THPO; PIM1; AKT1; STAT6; PIK3R1; MCL1
hsa04922 Glucagon signaling pathway_Homo sapiens_hsa04922 9.572E-04 2.519E-03 CAMK2B; PKM; AKT1; PYGL; PPARA
hsa04211 Longevity regulating pathway - mammal_Homo sapiens_hsa04211 6.915E-04 1.869E-03 AKT1; PIK3R1; TP53; NFKB1; IGF1R
hsa05211 Renal cell carcinoma_Homo sapiens_hsa05211 1.330E-04 4.434E-04 AKT1; MAPK1; PIK3R1; MET; HIF1A
hsa04620 Toll-like receptor signaling pathway_Homo sapiens_hsa04620 1.189E-03 2.889E-03 AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa05142 Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 1.092E-03 2.729E-03 AKT1; MAPK1; PIK3R1; NFKB1; TLR2
hsa05010 Alzheimer's disease_Homo sapiens_hsa05010 1.640E-03 3.741E-03 BACE1; APP; GSK3B; MAPK1; MAPT; HSD17B10
hsa04064 NF-kappa B signaling pathway_Homo sapiens_hsa04064 6.586E-04 1.804E-03 SYK; CSNK2A1; PARP1; PTGS2; NFKB1
hsa04660 T cell receptor signaling pathway_Homo sapiens_hsa04660 1.092E-03 2.729E-03 GSK3B; AKT1; MAPK1; PIK3R1; NFKB1
hsa05210 Colorectal cancer_Homo sapiens_hsa05210 9.864E-05 3.402E-04 GSK3B; AKT1; MAPK1; PIK3R1; TP53
hsa04972 Pancreatic secretion_Homo sapiens_hsa04972 7.609E-04 2.029E-03 CHRM3; CA2; PLA2G1B; CD38; CFTR
hsa05213 Endometrial cancer_Homo sapiens_hsa05213 4.206E-05 1.558E-04 GSK3B; AKT1; MAPK1; PIK3R1; TP53
hsa04310 Wnt signaling pathway_Homo sapiens_hsa04310 4.248E-03 8.670E-03 CAMK2B; GSK3B; CSNK2A1; TP53; PPARD
hsa04550 Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 4.248E-03 8.670E-03 GSK3B; AKT1; MAPK1; PIK3R1; IGF1R
hsa04380 Osteoclast differentiation_Homo sapiens_hsa04380 3.111E-03 6.549E-03 SYK; AKT1; MAPK1; PIK3R1; NFKB1
hsa04068 FoxO signaling pathway_Homo sapiens_hsa04068 3.213E-03 6.695E-03 PLK1; AKT1; MAPK1; PIK3R1; IGF1R
hsa04072 Phospholipase D signaling pathway_Homo sapiens_hsa04072 4.507E-03 9.014E-03 SYK; CXCR1; AKT1; MAPK1; PIK3R1
hsa04110 Cell cycle_Homo sapiens_hsa04110 2.374E-03 5.106E-03 GSK3B; CDK6; PLK1; CDK1; TP53
hsa04261 Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 5.058E-03 9.821E-03 CAMK2B; AKT1; MAPK1; ADRA1D; PIK3R1
hsa04932 Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 5.501E-03 1.038E-02 GSK3B; AKT1; PIK3R1; PPARA; NFKB1
hsa05164 Influenza A_Homo sapiens_hsa05164 1.008E-02 1.833E-02 GSK3B; AKT1; MAPK1; PIK3R1; NFKB1
hsa04144 Endocytosis_Homo sapiens_hsa04144 1.315E-02 2.229E-02 RET; CXCR1; SRC; KDR; MET; IGF1R
hsa05168 Herpes simplex infection_Homo sapiens_hsa05168 1.259E-02 2.179E-02 CSNK2A1; CDK1; TP53; NFKB1; TLR2
hsa05166 HTLV-I infection_Homo sapiens_hsa05166 1.293E-02 2.210E-02 POLB; GSK3B; AKT1; PIK3R1; TP53; NFKB1
hsa04670 Leukocyte transendothelial migration_Homo sapiens_hsa04670 1.179E-02 2.125E-02 MMP2; PIK3R1; MMP9; PTK2
hsa04152 AMPK signaling pathway_Homo sapiens_hsa04152 1.393E-02 2.342E-02 AKT1; PIK3R1; CFTR; IGF1R
hsa04916 Melanogenesis_Homo sapiens_hsa04916 6.675E-03 1.236E-02 CAMK2B; GSK3B; MAPK1; TYR
hsa04360 Axon guidance_Homo sapiens_hsa04360 1.509E-02 2.495E-02 GSK3B; MAPK1; MET; PTK2
hsa04912 GnRH signaling pathway_Homo sapiens_hsa04912 4.789E-03 9.390E-03 CAMK2B; SRC; MMP2; MAPK1
hsa05231 Choline metabolism in cancer_Homo sapiens_hsa05231 6.911E-03 1.268E-02 AKT1; MAPK1; PIK3R1; HIF1A
hsa04666 Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 5.172E-03 9.947E-03 SYK; AKT1; MAPK1; PIK3R1
hsa05146 Amoebiasis_Homo sapiens_hsa05146 6.675E-03 1.236E-02 PIK3R1; NFKB1; PTK2; TLR2
hsa04150 mTOR signaling pathway_Homo sapiens_hsa04150 1.044E-03 2.676E-03 AKT1; MAPK1; PIK3R1; HIF1A
hsa05100 Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 2.753E-03 5.858E-03 SRC; PIK3R1; MET; PTK2
hsa04664 Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 1.665E-03 3.741E-03 SYK; AKT1; MAPK1; PIK3R1
hsa05323 Rheumatoid arthritis_Homo sapiens_hsa05323 2.974E-02 4.610E-02 MMP1; MMP3; TLR2
hsa04640 Hematopoietic cell lineage_Homo sapiens_hsa04640 2.807E-02 4.456E-02 THPO; FLT3; CD38
hsa04970 Salivary secretion_Homo sapiens_hsa04970 2.890E-02 4.551E-02 CHRM3; CD38; ADRA1D
hsa05140 Leishmaniasis_Homo sapiens_hsa05140 2.162E-03 4.700E-03 MAPK1; PTGS2; NFKB1; TLR2
hsa05132 Salmonella infection_Homo sapiens_hsa05132 2.646E-02 4.268E-02 MAPK1; PKN1; NFKB1
hsa05031 Amphetamine addiction_Homo sapiens_hsa05031 1.576E-03 3.664E-03 CAMK2B; MAOA; DRD1; SLC6A3
hsa04976 Bile secretion_Homo sapiens_hsa04976 1.952E-03 4.290E-03 CA2; CYP3A4; CFTR; ABCG2
hsa05120 Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 1.665E-03 3.741E-03 CXCR1; SRC; MET; NFKB1
hsa04920 Adipocytokine signaling pathway_Homo sapiens_hsa04920 1.542E-02 2.528E-02 AKT1; PPARA; NFKB1
hsa04213 Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 1.212E-02 2.164E-02 AKT1; PIK3R1; IGF1R
hsa04115 p53 signaling pathway_Homo sapiens_hsa04115 1.484E-02 2.473E-02 CDK6; CDK1; TP53
hsa05030 Cocaine addiction_Homo sapiens_hsa05030 4.831E-04 1.380E-03 MAOA; DRD1; NFKB1; SLC6A3
hsa05131 Shigellosis_Homo sapiens_hsa05131 1.264E-02 2.179E-02 SRC; MAPK1; NFKB1
hsa05321 Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 1.264E-02 2.179E-02 STAT6; NFKB1; TLR2
hsa00380 Tryptophan metabolism_Homo sapiens_hsa00380 2.195E-04 7.196E-04 MAOA; CYP1A2; CYP1A1; CYP1B1
hsa04930 Type II diabetes mellitus_Homo sapiens_hsa04930 5.485E-03 1.038E-02 PKM; MAPK1; PIK3R1
hsa02010 ABC transporters_Homo sapiens_hsa02010 4.292E-03 8.670E-03 ABCC1; CFTR; ABCG2
hsa05216 Thyroid cancer_Homo sapiens_hsa05216 1.285E-03 3.059E-03 RET; MAPK1; TP53
hsa00052 Galactose metabolism_Homo sapiens_hsa00052 1.420E-03 3.340E-03 AKR1B10; GAA; AKR1B1
hsa00350 Tyrosine metabolism_Homo sapiens_hsa00350 2.794E-02 4.456E-02 MAOA; TYR
hsa00051 Fructose and mannose metabolism_Homo sapiens_hsa00051 2.363E-02 3.842E-02 AKR1B10; AKR1B1
hsa00040 Pentose and glucuronate interconversions_Homo sapiens_hsa00040 2.944E-02 4.600E-02 AKR1B10; AKR1B1
hsa03410 Base excision repair_Homo sapiens_hsa03410 1.877E-03 4.171E-03 POLB; PARP1; APEX1
hsa04964 Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 1.259E-02 2.179E-02 CA2; CA4
hsa00790 Folate biosynthesis_Homo sapiens_hsa00790 4.731E-03 9.368E-03 ALPL; ALPI
hsa00232 Caffeine metabolism_Homo sapiens_hsa00232 5.433E-04 1.530E-03 CYP1A2; XDH
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
K00-K95: Diseases of the digestive system Alcoholic hepatitis K70.1 AR
L00-L99: Diseases of the skin and subcutaneous tissue Seborrhea L21 CHRM3
G00-G99: Diseases of the nervous system G00-G99 Motor neurone disease G12.2 IGF1R
M00-M99: Diseases of the musculoskeletal system and connective tissue Muscle atrophy M62.5 AR
C00-D49: Neoplasms Multiple myeloma C90 AHR; SRC; IGF1R; CD38
G00-G99: Diseases of the nervous system G00-G99 Multiple scierosis G35 MPO; ESR1; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic nephropathy E11.21 ADRA2C; MMP1
J00-J99: Diseases of the respiratory system Seasonal and perennial allergic rhinitis and vasomotor rhinitis J30 HRH1
H00-H59: Diseases of the eye and adnexa Mydriasis diagnosis H57.0 CHRM4
A00-B99: Certain infectious and parasitic diseases Visceral leishmaniasis B55.0 PLA2G1B
NA: NA Vertigo's disease NA HRH1
H60-H95: Diseases of the ear and mastoid process Vertigo meniere's disease H81, H81.0, R42 HRH1
NA: NA Vomiting NA HRH1; CHRM4
L00-L99: Diseases of the skin and subcutaneous tissue Vitiligo L80 MAOA; TYR
J00-J99: Diseases of the respiratory system Rhinitis J00, J30, J31.0 HRH1; HRH1; ALOX5
NA: NA Morning sickness NA HRH1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mood disorder F30-F39 MAOA; HTR2C; HTR2A; SLC6A4
M00-M99: Diseases of the musculoskeletal system and connective tissue Moderate to severe rheumatoid arthritis M05-M06 PTGS2
NA: NA Miosis during ocular surgery NA PTGS1
NA: NA Moderate and severe psychomotor agitation NA CHRM4
M00-M99: Diseases of the musculoskeletal system and connective tissue Stabilize muscle contractions M00-M99 CHRM2
NA: NA Dyslipidemia NA PPARD
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Schizophrenia F20 CHRM1; CHRM1; CHRM1; CHRM5; ESRRA; HTR2C; HTR2A; HTR2A; SLC6A4; HTR6; DRD3; DRD4; DRD1
J00-J99: Diseases of the respiratory system Hay fever J30 HRH1; HRH1; HRH1
I00-I99: Diseases of the circulatory system Neurological disease I21, I22, R52, R52.1-R52.2, R60.9, G89 CHRM1; CHRM5; HTR2C; ADRA2C; NPSR1; HTR6; ESR1; APP
K00-K95: Diseases of the digestive system Xerostomia K11.7, R68.2 ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Attention deficit hyperactivity disorder F90 ADRA2A; SLC6A2; SLC6A2; SLC6A4
C00-D49: Neoplasms Peritoneal cavity cancer NA KDR
G00-G99: Diseases of the nervous system G00-G99 Permanent and transient stroke G45.9, I61-I63 PARP1
S00-T88: Injury, poisoning and certain other consequences of external causes Poison intoxication T36-T50 CHRM4; ACHE; ADRA2C
I00-I99: Diseases of the circulatory system Peripheral vascular disease I73.9 ADRA1D
S00-T88: Injury, poisoning and certain other consequences of external causes Poisoning due to pesticides and chemicals T36-T50 ACHE
L00-L99: Diseases of the skin and subcutaneous tissue Acne vulgaris L70.0 AR; AR; ESRRA; MMP2; PTGS1; ESR1
K00-K95: Diseases of the digestive system Acid-reflux disorders K21 HRH2
NA: NA Abdominal stomach pain NA CHRM1
H00-H59: Diseases of the eye and adnexa Acquired nystagmus H55 CHRM4
C00-D49: Neoplasms Late-stage solid tumors C00-C75, C7A, C7B, D10-D36, D3A PTK2; TP53
G00-G99: Diseases of the nervous system G00-G99 Alzheimer disease G30 MAOA; CHRM1; CHRM3; CHRM4; PTGES; MAPT; ACHE; ACHE; ACHE; PTGS2; GSK3B; ADRA2C; HTR6; HTR6; HTR6; CHRM2; APP
K00-K95: Diseases of the digestive system Chemotherapy-induced mucositis K12.3 MET
S00-T88: Injury, poisoning and certain other consequences of external causes Postoperative inflammation T81 PTGS1
N00-N99: Diseases of the genitourinary system Post-menopausal vaginal atrophy N95.2 ESR1
NA: NA Postmenopausal disorder NA ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Pompe's disease E74.02 GAA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Premature ejaculation F52.4 SLC6A4
C00-D49: Neoplasms Thyroid cancer C73 TSHR; RET; KDR
NA: NA Dysuria NA CHRM4
N00-N99: Diseases of the genitourinary system Dysmenorrhea N94.4-N94.6 CHRM5; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; ESR1
NA: NA Menopausal staging NA SLC6A4
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Osteopetrosis Q78.2 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Testosterone deficiency E29.1 AR
J00-J99: Diseases of the respiratory system Throat irritation J39.2 TRPA1
L00-L99: Diseases of the skin and subcutaneous tissue Melasma L81.1 TYR
NA: NA Meniere's disease NA HRH1
C00-D49: Neoplasms Medullary thyroid cancer C73 KDR
C00-D49: Neoplasms Melanoma C43 TLR2; PARP1; TYR; KDR; KDR
NA: NA Menopausal disorder NA ESR1
N00-N99: Diseases of the genitourinary system Prostate hyperplasia N40 AR; ADRA1D
N00-N99: Diseases of the genitourinary system Prostate disease N42.9 CYP19A1; ADRA1D
C00-D49: Neoplasms Colon cancer C50 ALPL; FLT3
K00-K95: Diseases of the digestive system Colon polyps K63.5 PTGS2
C00-D49: Neoplasms Colorectal cancer C18-C21 FLT3; PTGS1; IGF1R; MMP9; TP53; KDR
NA: NA Colour dead tissues NA PTPN1
NA: NA Common cold NA HRH1
I00-I99: Diseases of the circulatory system Congestive heart failure I50 ADRA1D; HTR2B
L00-L99: Diseases of the skin and subcutaneous tissue Contact dermatitis L23, L24, L25 PLA2G1B
H00-H59: Diseases of the eye and adnexa Ocular disease H00-H59 ADRA2C
C00-D49: Neoplasms Neuroendocrine cancer C7A SLC6A2
NA: NA Suprapubic pain NA CHRM4
I00-I99: Diseases of the circulatory system Stroke I61-I63, I80-I82 MMP9
K00-K95: Diseases of the digestive system Stomach ulcer K25-K27 HRH2; CHRM1; CHRM5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depressive disorder F32, F33, M32 MAOA; MAOA; HTR2C; HTR2C; SLC6A2; SLC6A4; SLC6A4
A00-B99: Certain infectious and parasitic diseases Malaria B54 CYP2D6
NA: NA Male hypogonadism NA AR
E00-E89: Endocrine, nutritional and metabolic diseases Male hormonal deficiencies E20-E35 AR
C00-D49: Neoplasms Malignant adrenal gland cancer C74.0 IGF1R
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Male sexual disorders F52 ADRA2C; DRD3
C00-D49: Neoplasms Brain cancer C71, D33 SRC; ESR1
H00-H59: Diseases of the eye and adnexa Corneal ulcers H16.0 MMP3
S00-T88: Injury, poisoning and certain other consequences of external causes Contusion S36.220S ADRA2C
Z00-Z99: Factors influencing health status and contact with health services Contraception Z30 AR; ESR1
I00-I99: Diseases of the circulatory system Coronary heart disease I25.1 HTR2B
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Visceral spasms R25.2 CHRM1
NA: NA Early satiation associated with functional dyspepsia NA ACHE
N00-N99: Diseases of the genitourinary system Dyspareunia N94.1 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Cystic fibrosis E84 AR; CFTR
E00-E89: Endocrine, nutritional and metabolic diseases Hypogonadism E23.0, E28.3, E29.1 AR; ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Postoperative nausea and vomiting R11 CHRM3
G00-G99: Diseases of the nervous system G00-G99 Mild to moderate alzheimer disease G30 APP
C00-D49: Neoplasms Metastatic prostate cancer C61 AR
G00-G99: Diseases of the nervous system G00-G99 Migraine G43 HTR2B; HTR2A; CYP2D6; SLC6A4
G00-G99: Diseases of the nervous system G00-G99 Migraine headaches G43 HTR2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Mild cognitive impairment F06.7 ACHE; APP
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 KDR
C00-D49: Neoplasms Metastatic HER2-negative gastric cancer NA MET
J00-J99: Diseases of the respiratory system Chronic obstructive pulmonary disease J40-J44, J47 MPO; CHRM1; CHRM3; CHRM4; CHRM5; ALOX5; MMP12; MMP12
C00-D49: Neoplasms Gastric cancer C16 KDR; KDR
K00-K95: Diseases of the digestive system Gastric motility disorder K22.4 CHRM4; DRD3
N00-N99: Diseases of the genitourinary system Female infertility N97.0 ESR1; ESR1
N00-N99: Diseases of the genitourinary system Female infertility due to anovulation N97.0 ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Female sexual dysfunction F52 ESR1; DRD3
M00-M99: Diseases of the musculoskeletal system and connective tissue Fibromyalgia M79.7 ADRA2C; SLC6A2; HTR2A; SLC6A4; SLC6A4
L00-L99: Diseases of the skin and subcutaneous tissue Fibrosis L90.5 MET
NA: NA Functional bowel syndrome NA CHRM1
A00-B99: Certain infectious and parasitic diseases Fungal infections B35-B49 ALOX5; RAB9A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Chronic pain R52.1-R52.2, G89 PTGS2; SLC6A4
C00-D49: Neoplasms Chronic myelogenous leukaemia C92.1 SRC
I00-I99: Diseases of the circulatory system Cardiovascular disorder I00-I99 AR; HTR2A; KDR; CHRM2
NA: NA Schizoaffective disorders NA CHRM1
M00-M99: Diseases of the musculoskeletal system and connective tissue Rheumatoid arthritis M05-M06 CAMK2B; AKR1B1; PLA2G1B; ESRRA; ALOX5; SYK; MMP3; PTGS2; PTGS2; PTGS2; PTGS2; TYR; MMP1
I00-I99: Diseases of the circulatory system Thrombosis I80-I82 ALOX5; SYK
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 ALOX5; FLT3
C00-D49: Neoplasms Metastatic castration-resistant prostate cancer C61 AR; KDR
C00-D49: Neoplasms Metastasis C00-C97 AXL
E00-E89: Endocrine, nutritional and metabolic diseases Metabolic disorders E70-E89 PPARD
C00-D49: Neoplasms Mesothelioma C45 PTK2
N00-N99: Diseases of the genitourinary system Menorrhagia N92.0 ESR1
N00-N99: Diseases of the genitourinary system Menopause symptoms N95.0 ESR1; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue Dermatitis L20-L30 ESRRA; ALOX5; PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases Female hypogonadism E23, E28 ESR1
C00-D49: Neoplasms Fallopian tube cancer C57.0, D28.2 KDR
H00-H59: Diseases of the eye and adnexa Eye disorders H00-H59 ESR1
C00-D49: Neoplasms Female androgenresponsive recurrent mammary cancer C50 AR
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Fecal incontinence R15 ADRA1D
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Fatigue R53 SLC6A2
C00-D49: Neoplasms Renal cancer C64 CA9; KDR
G00-G99: Diseases of the nervous system G00-G99 Neuropathic pain G64, G90.0 MAOA; CHRM1; PTGS1; PTGS2; PTGS2; ADRA2B; SLC6A4; SLC6A4
G00-G99: Diseases of the nervous system G00-G99 Neurodegenerative disease G30-G32 MAPT; ACHE; HTR6; RET
C00-D49: Neoplasms Neuroblastoma C74.1, C74.9, C75.4, C75.5, D35.0, D35.5, D35.6, D44.6, D44.7 SLC6A2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Nocturia R35 CHRM4
C00-D49: Neoplasms Biliary cancer C22, C24 KDR
NA: NA Itching NA HRH1
NA: NA Joint and muscular pain NA PTGS2
A00-B99: Certain infectious and parasitic diseases Irritable bowel syndrome A09, K58, K59.1 CHRM1; CHRM1; CHRM4; CHRM4; CHRM5; HTR2B
N00-N99: Diseases of the genitourinary system Irregularities N92.6 ESR1
I00-I99: Diseases of the circulatory system Ischemic stroke I61-I63 MMP3
I00-I99: Diseases of the circulatory system Ischemia I99.8 SRC
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricemia E79.0 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Hyperuricaemia in gout E79.0, M10 XDH
NA: NA Excessive sweating NA CHRM1
O00-O9A: Pregnancy, childbirth and the puerperium Excessive bleeding following childbirth and spontaneous or elective abortion O04 DRD1
E00-E89: Endocrine, nutritional and metabolic diseases Estrogen deficiency E28.39 ESR1
L00-L99: Diseases of the skin and subcutaneous tissue Atopic dermatitis L00-L99 ALOX5
A00-B99: Certain infectious and parasitic diseases Bacterial infections A00-B99 CYP2C9
I00-I99: Diseases of the circulatory system Hemorrhoids I84 HTR2A
C00-D49: Neoplasms Cutaneous Melanoma C43-C44 KDR
N00-N99: Diseases of the genitourinary system Vagina disease N76.0 ESR1
J00-J99: Diseases of the respiratory system Bronchodilator J45 CHRM4
C00-D49: Neoplasms Cancer C00-C96 AR; HRH1; AKT1; MET; TLR2; MCL1; CSNK2A1; SYK; CA1; FLT3; FLT3; CA9; MMP2; ACHE; PTGS2; SRC; IGF1R; PTK2; GSK3B; HIF1A; CDK1; MAPK1; MMP9; NFKB1; PIM1; PARP1; SLC6A4; CD38; TP53; RET; ESR1; ESR1; KDR; PLK1; APP
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cancer pain R52, G89 SLC6A2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Substance dependence F10-F19 DRD1
C00-D49: Neoplasms Inflammatory disease C11, C44, K75.9, M00-M25 MPO; PLA2G1B; ALOX5; MMP13; SYK; MMP12; PTGS1; PTGS2; SLC6A4
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory skin condition L00-L99 PARP1
E00-E89: Endocrine, nutritional and metabolic diseases Inflammation E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89 ALOX5; PTGS2
K00-K95: Diseases of the digestive system Inflammatory bowel disease K50, K51 PTGS1; PTGS2
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp L20-L30 PLA2G1B
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 HRH1; HRH1; CYP2D6; CA2
N00-N99: Diseases of the genitourinary system Infertility N97.0 ESR1
A00-B99: Certain infectious and parasitic diseases Infections disease A00-B99 MPO
E00-E89: Endocrine, nutritional and metabolic diseases Type 2 diabetes E11 PTPN1; PTPN1; PTGS2; NFKB1; PPARD; DRD1
C00-D49: Neoplasms Metastatic breast cancer C50 KDR
G00-G99: Diseases of the nervous system G00-G99 Epileptic seizures G40, P90, R56 ACHE
G00-G99: Diseases of the nervous system G00-G99 Epilepsy G40 MAOA
E00-E89: Endocrine, nutritional and metabolic diseases Erythropoietic porphyria E80.0 HTR2A
L00-L99: Diseases of the skin and subcutaneous tissue Erythema L51-L54 ADRA2C
M00-M99: Diseases of the musculoskeletal system and connective tissue Atrophy M62.571 ESR1
N00-N99: Diseases of the genitourinary system Atrophic vaginitis N95.2 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Autoimmune diabetes E08-E13 TLR2; SYK; ESR1
A00-B99: Certain infectious and parasitic diseases Diarrhea A09, K59.1 CFTR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Drug abuse F10-F19 HTR2C; DRD3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Major depression F32, F33 SLC6A4
C00-D49: Neoplasms Non-small-cell lung cancer NA MMP2; KDR
NA: NA Extrapyramidal disorders secondary to neuroleptic drug therapy NA CHRM1
C00-D49: Neoplasms Myelodysplastic syndrome D46 TLR2; KDR
C00-D49: Neoplasms Myeloid leukemia C92 FLT3
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis G70.0 CHRM5; ACHE
NA: NA Depressive disorders NA SLC6A4
K00-K95: Diseases of the digestive system Liver disease K70-K77 MET
A00-B99: Certain infectious and parasitic diseases Lymphatic filariasis B74 ALOX5
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Spasm R25.2 CHRM4; CHRM4
I00-I99: Diseases of the circulatory system Hypotension I95 ADRA2C
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Emesis R11 CHRM4; HTR6; DRD3
G00-G99: Diseases of the nervous system G00-G99 Encephalopathy G93.4 XDH
E00-E89: Endocrine, nutritional and metabolic diseases Endocrine disease E00-E35 AR
NA: NA Edema NA CA2
I00-I99: Diseases of the circulatory system Edema associated with congestive heart failure I50, R60.9 CA2
G00-G99: Diseases of the nervous system G00-G99 Ataxia telangiectasia G11.3 PARP1
I00-I99: Diseases of the circulatory system Atherosclerosis I70 ALOX5; MMP12; PPARD
I00-I99: Diseases of the circulatory system Arteriosclerosis I70 PLA2G1B
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthralgia M25.5 ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue Arthritis M00-M25 PLA2G1B; ABCC1; ESRRA; ALOX5; PTGS2; PTGS2; MMP1
J00-J99: Diseases of the respiratory system Asthma J45 HRH1; PLA2G1B; ESRRA; ALOX5; ALOX5; SYK; SYK; MMP12; PTGS2; ADRA2C; CHRM2
NA: NA Appetite suppressant NA SLC6A4
C00-D49: Neoplasms Solid tumours C00-D48 AKT1; MET; TLR2; CHRM4; PKM; SYK; FLT3; CA9; MMP2; SRC; IGF1R; PTK2; AURKB; HIF1A; MAPK1; MMP9; TP53; RET; KDR; KDR; KDR; PLK1; PLK1
C00-D49: Neoplasms Acute myeloid leukemia C92.0 FLT3; FLT3; AURKB; TP53; TP53; PLK1
C00-D49: Neoplasms Non-hodgkin's lymphoma C85 SYK; PLK1
K00-K95: Diseases of the digestive system Non-alcoholic fatty liver disease K76.0 PPARD
E00-E89: Endocrine, nutritional and metabolic diseases Non-insulin dependent diabetes E11.9 ESRRA
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 MET; PTGS2; IGF1R; IGF1R; AXL; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Obesity E66 SLC6A4
C00-D49: Neoplasms Lymphoma C81-C86 AKT1; CA9; HIF1A; PLK1
S00-T88: Injury, poisoning and certain other consequences of external causes Nerve injury T14.4 PLA2G1B
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Nausea R11 HRH1; HRH1; CHRM4; CHRM2
J00-J99: Diseases of the respiratory system Nasal congestion J34.89 HRH1
S00-T88: Injury, poisoning and certain other consequences of external causes Myocardial reperfusion injury T86.4 AKT1
I00-I99: Diseases of the circulatory system Myocardial infarction I21, I22 MMP3; PARP1
M00-M99: Diseases of the musculoskeletal system and connective tissue Knee osteoarthritis M15-M19, M47 PTGS2
C00-D49: Neoplasms Leukemia C90-C95 AKT1; FLT3; ESR1
C00-D49: Neoplasms Liver cancer C22 IGF1R; KDR
NA: NA Dystonia NA CHRM1
E00-E89: Endocrine, nutritional and metabolic diseases Dyslipidaemias E78 PPARD; PPARD
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 HRH2; CA1; CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Erectile dysfunction F52.2, N48.4 ADRA1D; DRD4
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 SYK
NA: NA Chronic low back pain NA SLC6A4
L00-L99: Diseases of the skin and subcutaneous tissue Inflammatory and pruritic manifestations of corticosteroid responsive dermatoses L20-L30 PLA2G1B
C00-D49: Neoplasms Overactive bladder disorder C67, N32.81 CHRM1; CHRM3; CHRM4
C00-D49: Neoplasms Osteosarcoma C40-C41 SRC; GSK3B
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis M80-M81, Z79.890 AR; SRC; ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoporosis in post-menopausal women M80-M81 AR
C00-D49: Neoplasms Ovarian cancer C56 MMP2; PARP1; KDR; KDR; KDR; KDR
N00-N99: Diseases of the genitourinary system Overactive bladder N32.81 CHRM3
A00-B99: Certain infectious and parasitic diseases Infections A00-B99 PTPN1
NA: NA Hematopoietic stem cell transplantation NA FLT3
C00-D49: Neoplasms Hematological malignancies C81-C86 SYK; SRC; AURKB; CD38; TP53
A00-B99: Certain infectious and parasitic diseases Helminth infection A00-B99 ACHE
C00-D49: Neoplasms Hematologic malignancies C81-C86 AKT1
C00-D49: Neoplasms Hepatocellular carcinoma C22.0 MET; IGF1R; KDR
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 CA1; ACHE
K00-K95: Diseases of the digestive system Colitis K50-K52 CHRM5
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cognitive disorders F01-F07, F04, F05, R41.3 CHRM1; CHRM5; MAPT; ACHE; HTR6; DRD1
C00-D49: Neoplasms CLL NA FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Cocaine addiction F14.2 DRD3; DRD1
C00-D49: Neoplasms Pediatric cancer C00-C96 ADRA1D
K00-K95: Diseases of the digestive system Peptic ulcer K25-K27 HRH2; CHRM1; CHRM4; CHRM4; CHRM4; ADRA2C; CHRM2
C00-D49: Neoplasms Pancreatic cancer C25 AKT1; TLR2; FLT3; MMP2; PTGS2; KDR; PLK1
G00-G99: Diseases of the nervous system G00-G99 Pain G64, G90.0, R52, G89 AR; HRH1; HRH2; CHRM3; PKM; MMP13; HTR2C; ACHE; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; IGF1R; CDK1; ADRA2C; ADRA2A; SLC6A2; TRPA1; SLC6A4; ESR1; DRD1
K00-K95: Diseases of the digestive system Pancreatitis K85, K86.0K86.1 CHRM4; HTR2A
NA: NA Peptic ulcer disease NA CHRM4
I00-I99: Diseases of the circulatory system High blood pressure I10-I16 CA2
A00-B99: Certain infectious and parasitic diseases HIV-associated diarrhoea A09 CFTR
C00-D49: Neoplasms Hormonally-responsive breast cancer C50 CYP19A1
C00-D49: Neoplasms Hormone refractory prostate cancer C61 AR; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases Hormone deficiency E00-E90 AR; IGF1R; ESR1; ESR1
A00-B99: Certain infectious and parasitic diseases Pediculus humanus capitis B85.0 ACHE
G00-G99: Diseases of the nervous system G00-G99 Parkinson's disease G20 HRH1; MPO; MAOA; CHRM1; CHRM1; CHRM4; ACHE; SLC6A4; DRD1; CHRM2
NA: NA Perennial and seasonal allergic rhinitis NA HRH1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic neuropathy E11.40 AKR1B1; PTGS1
G00-G99: Diseases of the nervous system G00-G99 Diagnostic imaging G30, I73.9 APP
L00-L99: Diseases of the skin and subcutaneous tissue Alopecia L65.9 AR
S00-T88: Injury, poisoning and certain other consequences of external causes Allergy T78.4 HRH1; HRH1; PLA2G1B; ALOX5; SYK
L00-L99: Diseases of the skin and subcutaneous tissue Allergic skin disorders L00-L99 HRH1
J00-J99: Diseases of the respiratory system Allergic rhinitis J00, J30, J31.0, T78.4 HRH1; HRH1; HRH1; HRH1; HRH1; CHRM5; PLA2G1B; ESRRA; ADRA2C
NA: NA Allergic disorders NA HRH1
C00-D49: Neoplasms Allergic conjunctivitis C91.0, H10, H10.45, T78.4 HRH1; HRH1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Amnesia F04 CHRM5
C00-D49: Neoplasms AML NA FLT3; KDR
E00-E89: Endocrine, nutritional and metabolic diseases Dietary shortage E40-E46 PTGS1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnostic test to differentiate primary and secondary hypothyroidism W88 TSHR
I00-I99: Diseases of the circulatory system Cerebral amyloid angiopathy I68.0 APP
I00-I99: Diseases of the circulatory system Cerebral infarction I63 HTR2B
I00-I99: Diseases of the circulatory system Cerebrovascular disorders I60-I69 PARP1
G00-G99: Diseases of the nervous system G00-G99 Central and peripheral nervous diseases G96.9 CHRM4; CHRM5
G00-G99: Diseases of the nervous system G00-G99 Central nervous system disease G00-G99 MAPT; HTR2A; PPARD
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 PARP1
H00-H59: Diseases of the eye and adnexa Ocular allergy H00-H59 HRH1
C00-D49: Neoplasms Ocular cancer C69 APEX1
H00-H59: Diseases of the eye and adnexa Ocular hypertension H40.0 ADRA2C; CA4; CA4
Z00-Z99: Factors influencing health status and contact with health services Hormone replacement therapy Z79.890 ESR1
A00-B99: Certain infectious and parasitic diseases Human immunodeficiency virus infection B20-B26 FLT3
L00-L99: Diseases of the skin and subcutaneous tissue Dermatological disease L00-L99 AR; ESRRA
E00-E89: Endocrine, nutritional and metabolic diseases Diabetes E23.2, N25.1 AKR1B1; PTPN1; HTR2C; GSK3B; ADRA1D; HTR2A
N00-N99: Diseases of the genitourinary system Benign prostatic hyperplasia N40 ADRA1D
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Bipolar disorder F31, F40-F42 SLC6A2
C00-D49: Neoplasms Bladder cancer C67 AR; CYP19A1
C00-D49: Neoplasms Advanced solid tumor C00-C75, C7A, C7B MET; PLK1
H00-H59: Diseases of the eye and adnexa Age related macular degeneration H35.3 APP
C00-D49: Neoplasms Aggressive non-hodgkin's lymphoma C81, C81-C86, C82-C85, C91-C95 HTR2C
J00-J99: Diseases of the respiratory system Airway inflammation J00-J99 FLT3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Alcohol use disorders F10.2 MAOA; HTR2C; ADRA2C; ADRA2B; HTR2A
C00-D49: Neoplasms Glioblastoma NA FLT3
NA: NA HIV infections NA AHR
C00-D49: Neoplasms Squamous cell cancer of head and neck NA KDR
H00-H59: Diseases of the eye and adnexa Choroidal neovascularisation H35 ESRRA
NA: NA Chemotherapyinduced emesis NA SLC6A4
C00-D49: Neoplasms Prostate cancer C61 AR; AR; TLR2; FLT3; ESR1; PLK1
Z00-Z99: Factors influencing health status and contact with health services Oral contraceptive Z30 ESR1
C00-D49: Neoplasms Oral cavity cancer C00-C08 TP53
M00-M99: Diseases of the musculoskeletal system and connective tissue Osteoarthritis M15-M19, M47 ALOX5; MMP13; MMP3; MMP2; PTGS1; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2; PTGS2
S00-T88: Injury, poisoning and certain other consequences of external causes Organophosphate poisoning T60.0 CHRM4
S00-T88: Injury, poisoning and certain other consequences of external causes Hyperthermia T68 PTGS2
I00-I99: Diseases of the circulatory system Hypertension I10-I16 CHRM4; ADRA2C; ADRA1D; DRD1
NA: NA Hypersensitivity reactions NA HRH1
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 PPARD; ESR1
NA: NA Coughs NA HRH1
I00-I99: Diseases of the circulatory system Aortic aneurysm I71 MMP12
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 HRH1; HRH1; HRH1; CAMK2B; MAOA; HTR2C; ACHE; SLC6A2; HTR2A; HTR6; HTR6; CYP3A4
A00-B99: Certain infectious and parasitic diseases Anthelmintic B89 ALPL
M00-M99: Diseases of the musculoskeletal system and connective tissue Ankylosing spondylitis M08.1, M45 PTGS2
I00-I99: Diseases of the circulatory system Angiogenesis disorder I00-I99 KDR
NA: NA Geographic retinal atrophy NA APP
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic complication E08-E13 AKR1B1
E00-E89: Endocrine, nutritional and metabolic diseases Diabetic cataract E10.36, E11.36 AKR1B1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure Diagnosing bronchial hyperreactivity W88 CHRM3
J00-J99: Diseases of the respiratory system Respiratory disease J00-J99 HRH1; CHRM3; ALOX5
I00-I99: Diseases of the circulatory system Restenosis I51.89 MAPK1
NA: NA Respiratory allergies NA HRH1; HRH1
C00-D49: Neoplasms Renal cell carcinoma NA MMP2; KDR; KDR
I00-I99: Diseases of the circulatory system Renal artery disease I70.1 TP53
C00-D49: Neoplasms Carcinoma D00-D09 ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Generalized anxiety disorder F32, F40-F42, F41.1 HTR2C
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities Genetic disease Q00-Q99 ALPL
NA: NA Gastritis NA CHRM4
K00-K95: Diseases of the digestive system Gastroesophageal reflux disease K21 HRH2
K00-K95: Diseases of the digestive system Gastric secretory disorders K30 HRH2
K00-K95: Diseases of the digestive system Gastric ulcer K25 HRH2
C00-D49: Neoplasms Gastrointestinal cancers C15-C26 KDR
K00-K95: Diseases of the digestive system Gastrointestinal disease K00-K93 CHRM4; CHRM4; ESRRA
NA: NA Sleep initiation and maintenance disorders NA HTR2C
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Anesthesia R20.0 HRH1; CHRM1
NA: NA Anaplastic mixed oligoastrocytoma NA FLT3
E00-E89: Endocrine, nutritional and metabolic diseases Amyloidosis E85 APP; TTR
C00-D49: Neoplasms Refractory renal cell carcinoma C64 PKM
S00-T88: Injury, poisoning and certain other consequences of external causes Radiation sickness T66 TLR2
C00-D49: Neoplasms Recurrent epithelial ovarian or primary peritoneal cancer C78 PARP1
C00-D49: Neoplasms Castration-resistant prostate cancer C61 AR
I00-I99: Diseases of the circulatory system Cardiomyopathy I42.0 TTR
C00-D49: Neoplasms Myelofibrosis C94.4, D47.4 FLT3
G00-G99: Diseases of the nervous system G00-G99 Myasthenia gravis diagnosis G70.0 ACHE
C00-D49: Neoplasms Glioblastoma multiforme C71 SRC
C00-D49: Neoplasms Gliosarcoma NA FLT3
C00-D49: Neoplasms Glioma C71 KDR; APP
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 AKR1B1; CHRM1; CHRM3; CHRM4; CA1; CA1; ACHE; ADRA2C; ADRA1D; HTR2A
NA: NA GIST NA FLT3
M00-M99: Diseases of the musculoskeletal system and connective tissue Gout M10 AKR1B1; ABCC1; ABCC1; PTGS2; XDH
NA: NA Gonorrheal vaginitis NA ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychotic disorders F20-F29 HTR2C; DRD3; DRD4; DRD1
L00-L99: Diseases of the skin and subcutaneous tissue Psoriatic disorder L40 IGF1R
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychiatric disorder F01-F99 HTR2A; DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Psychoses F20-F29 HTR2B
C00-D49: Neoplasms B-cell lymphoma C85.1 SYK
C00-D49: Neoplasms Lung cancer C33-C34 MMP2
H00-H59: Diseases of the eye and adnexa Macular degeneration H35.3 APP
C00-D49: Neoplasms Acute lymphoblastic leukemia C91.0 FLT3
H00-H59: Diseases of the eye and adnexa Graves' ophthalmopathy H06.2 IGF1R
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Growth failure R62.8 IGF1R
L00-L99: Diseases of the skin and subcutaneous tissue Pruritus L29 HRH1; HRH1; PLA2G1B; ALOX5
H00-H59: Diseases of the eye and adnexa Produce mydriasis and cycloplegia for diagnostic purposes H57.04 CHRM4
NA: NA Primary insomnia NA HTR2C
A00-B99: Certain infectious and parasitic diseases Leishmaniasis B55.0 PLA2G1B
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Dry cough R05 HRH1
C00-D49: Neoplasms Breast cancer C50 AR; CYP19A1; FLT3; FLT3; CA9; IGF1R; CDK1; ESR1; ESR1; KDR; KDR; KDR
S00-T88: Injury, poisoning and certain other consequences of external causes Brain injury S09.90 APP
G00-G99: Diseases of the nervous system G00-G99 Brain diseases G00-G99 CHRM5
G00-G99: Diseases of the nervous system G00-G99 Brain ischaemia G45.9, I67.8 PARP1
NA: NA Rheumatold arthritis NA PTGS1; PTGS2; PTGS2; PTGS2
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 AKR1B1; TP53; KDR; KDR
A00-B99: Certain infectious and parasitic diseases HCV infection B17.1, B18.2 MMP3
H60-H95: Diseases of the ear and mastoid process Hearing disorder H90.5 TP53
I00-I99: Diseases of the circulatory system Heart failure I50 SLC6A2
I00-I99: Diseases of the circulatory system Heart disease I00-I52 MET
J00-J99: Diseases of the respiratory system Obstructive lung diseases J40-J44, J47 CHRM3
H00-H59: Diseases of the eye and adnexa Open-angle glaucoma H40-H42 ACHE; CA4; CA2
C00-D49: Neoplasms Advanced malignancies C00-C96 KDR
C00-D49: Neoplasms Advanced prostate cancer C61 AR; ESR1
C00-D49: Neoplasms Advanced renal cell carcinoma C64 KDR; KDR
N00-N99: Diseases of the genitourinary system Endometriosis N80 CYP19A1; PTGS2
E00-E89: Endocrine, nutritional and metabolic diseases Type 1 diabetes E10 PPARD
A00-B99: Certain infectious and parasitic diseases Trematode infection B66.9 ESR1
E00-E89: Endocrine, nutritional and metabolic diseases TTR amyloidosis E85 TTR
S00-T88: Injury, poisoning and certain other consequences of external causes Toxicity T36-T50, T51-T65 TP53
C00-D49: Neoplasms Thyroid cancer diagnosis C73 TSHR
NA: NA Myalgia NA SLC6A4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Smoking cessation F17.2 SLC6A4
NA: NA Spasms NA CHRM3
G00-G99: Diseases of the nervous system G00-G99 Spinal muscular atrophy G00-G99 SMN1;SMN2
I00-I99: Diseases of the circulatory system Pulmonary arterial hypertension I27.0, I27.2 HIF1A; HTR2B
NA: NA Addiction NA HTR2A; CHRM2
C00-D49: Neoplasms Adrenocortical carcinoma C74.0 ESR1
C00-D49: Neoplasms Advanced breast cancer C50 CYP19A1; SRC
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cachexia R64 AR; ESRRA
NA: NA Urticaria NA HRH1; HRH1; HRH1
NA: NA Upper abdominal bloating NA ACHE
K00-K95: Diseases of the digestive system Ulcerative colitis K51 HRH2; PTGS1; MMP9
NA: NA Urgency NA CHRM4
N00-N99: Diseases of the genitourinary system Urinary incontinence N39.3, N39.4, R32 CHRM1; CHRM3; CHRM5; ADRA1D; CHRM2
N00-N99: Diseases of the genitourinary system Urinary dysfunction N39.3-N39.4 ACHE
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Urinary retention R33 CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Sleep maintenance insomnia F51.0, G47.0 HTR2A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Sleep disorders F51, G47 HRH1; HTR2A
M00-M99: Diseases of the musculoskeletal system and connective tissue Sjogren's syndrome M35.0 CHRM3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Sexual dysfunction F52 ADRA2A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified Cough R05 HRH1; CHRM4
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Dementia F01-F07 CHRM1; HTR6; DRD1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Depression F30-F39 HRH1; MAOA; CHRM4; HTR2C; ADRA2C; SLC6A2; SLC6A2; SLC6A2; SLC6A2; HTR2B; HTR2A; SLC6A4; SLC6A4; SLC6A4
NA: NA Vasomotor rhinitis NA HRH1
N00-N99: Diseases of the genitourinary system Vasomotor symptoms N95.1 SLC6A4
NA: NA Uveitis NA CHRM4
Data Section
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1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Developer & Maintainer:
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