CMAUP Plant Collective Molecular Activities

Plant Name: Onobrychis ebenoides

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPER1;
Enzyme_unclassified	BLM; AOX1;
Nuclear hormone receptor subfamily 3 group C	AR;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
SLC superfamily of solute carriers	SLC22A1; SLC22A3;
Unclassified	SHBG; SERPINA6; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP2B6;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2B6	Cytochrome P450 2B6	P20813	CHEMBL4729
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
SLC superfamily of solute carriers	SLC22A1	Solute carrier family 22 member 1	O15245	CHEMBL5685
SLC superfamily of solute carriers	SLC22A3	Solute carrier family 22 member 3	O75751	CHEMBL2073673
Small molecule receptor (family A GPCR)	GPER1	G-protein coupled estrogen receptor 1	Q99527	CHEMBL5872
Unclassified	SHBG	Testis-specific androgen-binding protein	P04278	CHEMBL3305
Unclassified	SERPINA6	Corticosteroid binding globulin	P08185	CHEMBL2421
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006367; transcription initiation from RNA polymerase II promoter	2.091E-07	4.140E-04	AR, ESR1, ESR2, ESRRA, ESRRB
BP	GO:0009987; cellular process	GO:0030518; intracellular steroid hormone receptor signaling pathway	5.626E-07	1.021E-03	AR, ESR1, ESR2, GPER1
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	7.290E-07	1.134E-03	ESR1, ESR2
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	4.370E-06	5.947E-03	ESR1, ESR2
MF	GO:0005488; binding	GO:0005497; androgen binding	4.370E-06	5.947E-03	AR, SHBG
MF	GO:0005488; binding	GO:0005496; steroid binding	1.055E-17	2.297E-13	AR, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, GPER1, SERPINA6, SHBG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	2.157E-05	4.259E-04	CYP2B6; AOX1; CYP3A4
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.581E-05	4.259E-04	CYP2B6; AOX1; CYP3A4
hsa04915	Estrogen signaling pathway_Homo sapiens_hsa04915	7.607E-05	8.368E-04	GPER1; ESR1; ESR2
hsa04917	Prolactin signaling pathway_Homo sapiens_hsa04917	1.678E-03	9.487E-03	ESR1; ESR2
hsa04976	Bile secretion_Homo sapiens_hsa04976	1.633E-03	9.487E-03	SLC22A1; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.725E-03	9.487E-03	CYP2B6; CYP3A4
hsa05231	Choline metabolism in cancer_Homo sapiens_hsa05231	3.268E-03	1.541E-02	SLC22A3; SLC22A1
hsa03013	RNA transport_Homo sapiens_hsa03013	9.187E-03	3.369E-02	SMN2; SMN1
hsa00750	Vitamin B6 metabolism_Homo sapiens_hsa00750	5.090E-03	2.100E-02	AOX1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	AR; ESRRA
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
J00-J99: Diseases of the respiratory system	Asthma	J45	SERPINA6; ESRRA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ESRRA
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	ESRRA
C00-D49: Neoplasms	Breast cancer	C50	AR; ESR1; ESR1
C00-D49: Neoplasms	Prostate cancer	C61	AR; AR; ESR1
N00-N99: Diseases of the genitourinary system	Prostate hyperplasia	N40	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
C00-D49: Neoplasms	Bladder cancer	C67	AR
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	AR; AR; ESR1; ESRRA
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	SERPINA6
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic macular edema	E08-E13, E08.3, E09.3, E10.3, E11.3, E13.3, H35.8, R60.9	SERPINA6
NA: NA	Gonorrheal vaginitis	NA	ESR1
C00-D49: Neoplasms	Brain cancer	C71, D33	ESR1
C00-D49: Neoplasms	Cancer	C00-C96	AR; ESR1; ESR1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	AR; ESR1
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	ESRRA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis in post-menopausal women	M80-M81	AR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	AR; ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	AR
I00-I99: Diseases of the circulatory system	Heart failure	I50	AR
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
H00-H59: Diseases of the eye and adnexa	Choroidal neovascularisation	H35	ESRRA
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	AR; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ESRRA
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	AR; ESRRA
NA: NA	Obstructive airway diseases	NA	SERPINA6
NA: NA	Male hypogonadism	NA	AR
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
NA: NA	Menopausal disorder	NA	ESR1
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	AR
C00-D49: Neoplasms	Metastatic prostate cancer	C61	AR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	SERPINA6
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	AR; ESR1
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	AR
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Male hormonal deficiencies	E20-E35	AR
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
C00-D49: Neoplasms	Leukemia	C90-C95	ESR1
C00-D49: Neoplasms	Advanced prostate cancer	C61	AR; ESR1
C00-D49: Neoplasms	Female androgenresponsive recurrent mammary cancer	C50	AR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	ESRRA
E00-E89: Endocrine, nutritional and metabolic diseases	Testosterone deficiency	E29.1	AR
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
NA: NA	Postmenopausal disorder	NA	ESR1
K00-K95: Diseases of the digestive system	Alcoholic hepatitis	K70.1	AR
C00-D49: Neoplasms	Castration-resistant prostate cancer	C61	AR
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ESRRA
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ESRRA
L00-L99: Diseases of the skin and subcutaneous tissue	Alopecia	L65.9	AR
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle atrophy	M62.5	AR
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	AR; ESR1; ESR1
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	AR; ESR1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases