CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.893E-08	3.748E-05	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.742E-31	2.121E-26	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.435E-06	5.365E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.376E-24	5.853E-20	CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.465E-22	1.342E-18	CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	6.016E-30	2.767E-28	CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14
hsa04964	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	3.438E-04	7.908E-03	CA2; CA4
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	5.493E-04	8.423E-03	CYP1A2; ALOX15
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	2.741E-03	2.677E-02	CYP1A2; ALDH1A1
hsa05230	Central carbon metabolism in cancer_Homo sapiens_hsa05230	2.909E-03	2.677E-02	PKM; HIF1A
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	5.986E-03	4.589E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Refractory renal cell carcinoma	C64	PKM
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
J00-J99: Diseases of the respiratory system	Pulmonary emphysema	J43	ELANE
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
J00-J99: Diseases of the respiratory system	Pulmonary disease	J00-J99	ELANE
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ELANE; ELANE
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
J00-J99: Diseases of the respiratory system	Asthma	J45	ELANE
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	ELANE; ELANE; ELANE
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
NA: NA	Edema	NA	CA2
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ELANE
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; CA9
NA: NA	Acute respiratory distress syndrome	NA	ELANE; ELANE; ELANE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ELANE
J00-J99: Diseases of the respiratory system	Mucolytic	J00-J99	ELANE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PKM
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
NA: NA	Myocardial ischaemia-reperfusion injury	NA	ELANE
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; CA9; PKM
C00-D49: Neoplasms	Breast cancer	C50	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	ELANE; ELANE
J00-J99: Diseases of the respiratory system	Bronchiectasis	J47, Q33.4	ELANE
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; CA4
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	ELANE
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ELANE
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; CA1; CA9
C00-D49: Neoplasms	Renal cancer	C64	CA9

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Rheum australe

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases