CMAUP Plant Collective Molecular Activities

Plant Name: Flemingia prostrata roxb

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	2.165E-09	9.449E-06	FABP2, FABP3, FABP4, FABP5
BP	GO:0051179; localization	GO:0015908; fatty acid transport	1.289E-07	1.754E-04	FABP3, PPARA, PPARD, PPARG
BP	GO:0050896; response to stimulus	GO:0032868; response to insulin	2.431E-06	1.825E-03	FABP3, PPARA, PPARG, TLR2
BP	GO:0051179; localization	GO:0010891; negative regulation of sequestering of triglyceride	4.872E-06	3.419E-03	PPARA, PPARG
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	5.475E-06	3.419E-03	PPARA, PPARD, PPARG
BP	GO:0051179; localization	GO:0010887; negative regulation of cholesterol storage	7.305E-06	4.186E-03	PPARA, PPARG
BP	GO:0008152; metabolic process	GO:0010871; negative regulation of receptor biosynthetic process	7.305E-06	4.186E-03	PPARA, PPARG
MF	GO:0005488; binding	GO:0050543; icosatetraenoic acid binding	7.305E-06	4.186E-03	FABP3, PPARG
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	9.620E-06	5.371E-03	PPARA, PPARD, PPARG

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	1.432E-14	6.587E-13	FABP2; FABP3; FABP4; FABP5; PPARG; PPARA; PPARD
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	7.405E-06	1.703E-04	FABP4; TSHR; PTGS1
hsa04931	Insulin resistance_Homo sapiens_hsa04931	2.566E-03	3.935E-02	PTPN1; PPARA

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TERT
C00-D49: Neoplasms	Liver cancer	C22	TERT
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	PPARD
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
NA: NA	Colour dead tissues	NA	PTPN1
C00-D49: Neoplasms	Colorectal cancer	C18-C21	PTGS1
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	PTGS1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS1
H00-H59: Diseases of the eye and adnexa	Ocular inflammation	H16.229	TERT; PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	PTGS1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	FAAH; PTGS1; TRPA1
C00-D49: Neoplasms	Pancreatic cancer	C25	TERT; TLR2
K00-K95: Diseases of the digestive system	Ulcerative colitis	K51	PTGS1
C00-D49: Neoplasms	Ovarian cancer	C56	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1; PPARG; PPARG; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARG; PPARD
C00-D49: Neoplasms	Tumors	C00-D48	TERT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	FAAH
C00-D49: Neoplasms	Prostate cancer	C61	TERT; TLR2
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	FAAH
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1; PPARG; PPARD; PPARD
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARG; PPARD
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	PPARG
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS1
C00-D49: Neoplasms	Breast cancer	C50	TERT
C00-D49: Neoplasms	Brain cancer	C71, D33	TERT
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS1; PPARG
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS1
NA: NA	Dyslipidemia	NA	PPARD
NA: NA	Rheumatold arthritis	NA	PTGS1
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PPARG
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PPARG
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	FAAH; PTGS1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PPARG; PPARG
C00-D49: Neoplasms	Melanoma	C43	TERT; TLR2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	FAAH
S00-T88: Injury, poisoning and certain other consequences of external causes	Postoperative inflammation	T81	PTGS1
C00-D49: Neoplasms	Solid tumours	C00-D48	TLR2
C00-D49: Neoplasms	Multiple myeloma	C90	TERT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	FAAH
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1; PPARG
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
NA: NA	Miosis during ocular surgery	NA	PTGS1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	PTGS1
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TERT
C00-D49: Neoplasms	Cancer	C00-C96	TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	PTGS1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	PPARG

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases