Plant Name: Cordyline fruticosa
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05162 | Measles_Homo sapiens_hsa05162 | 6.469E-05 | 4.528E-03 | STAT3; RAB9A; TP53 |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 1.328E-04 | 4.648E-03 | PAX8; TP53 |
| hsa05321 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 6.722E-04 | 9.350E-03 | STAT3; RORC |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 6.929E-04 | 9.350E-03 | STAT3; TP53 |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 1.495E-03 | 1.495E-02 | PAX8; STAT3; TP53 |
| hsa04918 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 8.014E-04 | 9.350E-03 | PAX8; ATP1A1 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 8.014E-04 | 9.350E-03 | SLCO1B1; ATP1A1 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.192E-03 | 1.918E-02 | ATP1A1; TP53 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 3.067E-03 | 2.119E-02 | LMNA; TP53 |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 2.773E-03 | 2.119E-02 | STAT3; TP53 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 3.330E-03 | 2.119E-02 | STAT3; TP53 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 6.328E-03 | 3.010E-02 | STAT3; TP53 |
| hsa05169 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 6.268E-03 | 3.010E-02 | STAT3; TP53 |
| hsa05203 | Viral carcinogenesis_Homo sapiens_hsa05203 | 6.449E-03 | 3.010E-02 | STAT3; TP53 |
| hsa05202 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 5.010E-03 | 2.923E-02 | PAX8; TP53 |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 9.824E-03 | 4.298E-02 | MAPT; TP53 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | STAT3 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| C00-D49: Neoplasms | Cancer | C00-C96 | ATP1A1; STAT3; TP53 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT |
| C00-D49: Neoplasms | Multiple myeloma | C90 | STAT3 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | ATP1A1 |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | ATP1A1; ATP1A1; ATP1A1 |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53 |
| NA: NA | Congestive cardiac insufficiency | NA | ATP1A1; ATP1A1 |
| I00-I99: Diseases of the circulatory system | Congestive heart failure | I50 | ATP1A1 |
| J00-J99: Diseases of the respiratory system | Chronic obstructive pulmonary disease | J40-J44, J47 | ATP1A1 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT |
| E00-E89: Endocrine, nutritional and metabolic diseases | Atrial fibrillation | E78, I48 | ATP1A1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Hyperhidrosis | R61 | ATP1A1 |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ATP1A1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | STAT3 |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | STAT3; TP53 |
| NA: NA | Arrhythmias | NA | ATP1A1; ATP1A1 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |