CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
NA: NA	Myocardial ischaemia-reperfusion injury	NA	ELANE
J00-J99: Diseases of the respiratory system	Pulmonary emphysema	J43	ELANE
J00-J99: Diseases of the respiratory system	Pulmonary disease	J00-J99	ELANE
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
J00-J99: Diseases of the respiratory system	Mucolytic	J00-J99	ELANE
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
NA: NA	Acute respiratory distress syndrome	NA	ELANE; ELANE; ELANE
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	ELANE; ELANE; ELANE
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ELANE
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ELANE; ELANE
E00-E89: Endocrine, nutritional and metabolic diseases	Cystic fibrosis	E84	ELANE; ELANE
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ELANE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4
J00-J99: Diseases of the respiratory system	Bronchiectasis	J47, Q33.4	ELANE
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
A00-B99: Certain infectious and parasitic diseases	Septic shock	A41.9	ELANE
J00-J99: Diseases of the respiratory system	Asthma	J45	ELANE
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
I00-I99: Diseases of the circulatory system	Myocardial infarction	I21, I22	ELANE

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Senna occidentalis

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases