DRD4; FFAR1; FFAR4; ADRA1A; ADRA2C; ADRA2A; ADRA2B; HTR2C; ADRB3; DRD3; DRD2; | |
SMO; | |
OPRD1; TSHR; NPSR1; CXCR1; | |
TDP1; PLA2G1B; BLM; CDA; RECQL; CTDSP1; P4HB; PKM; PIK3R1; GLO1; HPGD; MPO; HSD17B1; AKR1B1; HSD17B10; ALOX15; ALDH1A1; HSD17B2; ALOX12; GFER; NOX4; USP2; TNKS; PARP1; TNKS2; PYGL; APEX1; POLB; CD38; | |
PTPN1; | |
ACHE; GAA; | |
CFTR; | |
AKT1; MET; CAMK2B; CSNK2A1; DAPK1; SYK; FLT3; PKN1; SRC; IGF1R; PTK2; AURKB; NEK6; GSK3B; KDR; CDK1; MAPK1; PIM1; NUAK1; ALK; AXL; NEK2; CDK6; | |
CA6; CA12; CA3; CA14; CA5B; CA5A; CA1; CA7; CA4; CA2; CA9; | |
AR; | |
ESRRA; | |
PPARA; PPARG; PPARD; | |
ESR1; ESR2; | |
KDM4E; | |
MAOA; PTGS2; ALOX5; TYR; XDH; | |
CASP7; CASP1; | |
MMP13; MMP12; MMP3; MMP2; MMP9; | |
BACE1; | |
TLR2; | |
AHR; STAT6; HIF1A; NFKB1; TP53; | |
FUT7; | |
VCP; | |
SLC28A1; SLC28A3; | |
ABCC1; ABCG2; | |
LMNA; FABP5; FABP2; FABP4; MCL1; MAPT; FABP3; SHH; THPO; NPC1; APP; TTR; | |
SMN1;SMN2; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
ATP-binding cassette | ABCC1 | Multidrug resistance-associated protein 1 | P33527 | CHEMBL3004 |
ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
Chloride channel | CFTR | Cystic fibrosis transmembrane conductance regulator | P13569 | CHEMBL4051 |
Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | Unclassified; | GO:0032844; regulation of homeostatic process | 5.273E-13 | 1.093E-10 | ADRA2A, AURKB, CA2, CA7, CD38, CDK6, CFTR, DRD2, DRD3, HIF1A, HTR2C, KDR, MAPK1, NEK2, NPC1, NPSR1, PARP1, PLA2G1B, PTGS2, SRC, SYK, TNKS, TNKS2 |
BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 8.582E-12 | 1.395E-09 | AURKB, CA2, CA7, CFTR, DRD2, DRD3, HIF1A, MAPK1, NEK2, NPC1, NPSR1, PLA2G1B, PTGS2, SYK, TNKS, TNKS2 |
BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 2.669E-11 | 4.064E-09 | CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C8, CYP2C9 |
BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 9.650E-11 | 1.356E-08 | CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2C8, CYP2C9 |
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.111E-10 | 1.540E-08 | CYP1A2, CYP2C19, CYP2C9, CYP2D6, CYP3A4 |
BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.160E-10 | 1.599E-08 | CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2C9, CYP3A4 |
BP | GO:0009987; cellular process | GO:0071880; adenylate cyclase-activating adrenergic receptor signaling pathway | 4.641E-09 | 4.657E-07 | ADRA1A, ADRA2A, ADRA2B, ADRA2C, ADRB3, DRD2 |
BP | GO:0008152; metabolic process | GO:0070989; oxidative demethylation | 1.415E-08 | 1.323E-06 | CYP1A2, CYP2C8, CYP2C9, CYP2D6, CYP3A4 |
BP | GO:0008152; metabolic process | GO:0018105; peptidyl-serine phosphorylation | 3.317E-08 | 2.767E-06 | AKT1, AURKB, CAMK2B, CDK1, GSK3B, MAPK1, NEK6, PKN1, SRC, SYK, TNKS |
BP | GO:0051179; localization | GO:0042307; positive regulation of protein import into nucleus | 3.882E-08 | 3.202E-06 | APP, CDK1, MAPK1, PARP1, PIK3R1, PTGS2, SHH, SMO, TLR2 |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|
hsa00052 | Galactose metabolism_Homo sapiens_hsa00052 | 1.862E-02 | 2.955E-02 | GAA; AKR1B1 |
hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.581E-07 | 1.860E-06 | HSD17B1; CYP1A2; HSD17B2; CYP1A1; CYP1B1; CYP3A4; CYP19A1 |
hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.323E-06 | 1.846E-05 | CYP2A6; CYP1A2; XDH |
hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 2.490E-02 | 3.860E-02 | MAOA; TYR |
hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.728E-04 | 5.667E-04 | MAOA; CYP1A2; CYP1A1; CYP1B1 |
hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 1.159E-08 | 2.897E-07 | CYP2C9; CYP2C8; PLA2G1B; ALOX5; ALOX15; ALOX12; CYP2C19; PTGS2 |
hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 9.718E-10 | 3.887E-08 | CYP2C9; CYP2C8; PLA2G1B; CYP1A2; ALOX15; CYP3A4; CYP2C19 |
hsa00620 | Pyruvate metabolism_Homo sapiens_hsa00620 | 3.191E-02 | 4.871E-02 | PKM; GLO1 |
hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 3.514E-07 | 3.347E-06 | CYP2C9; CYP2C8; CYP2A6; CYP1A2; ALDH1A1; CYP1A1; CYP3A4 |
hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.583E-20 | 3.165E-18 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
---|---|---|---|
A00-B99: Certain infectious and parasitic diseases | Human immunodeficiency virus infection | B20-B26 | FLT3 |
A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
A00-B99: Certain infectious and parasitic diseases | HIV-associated diarrhoea | A09 | CFTR |
A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | ALOX5 |
A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9; DRD2 |
A00-B99: Certain infectious and parasitic diseases | Irritable bowel syndrome | A09, K58, K59.1 | ADRB3 |
A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
A00-B99: Certain infectious and parasitic diseases | Visceral leishmaniasis | B55.0 | PLA2G1B |