Plant Name: Dysoxylum lenticellatum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; HTR7; HTR5A; HTR1F; ADRA1A; ADRA2C; ADRB2; ADRB3; ADRA1D; ADRA2A; ADRA2B; DRD2; HTR4; HTR1D; HTR1B; HTR1E; DRD3; HTR2B; HTR2A; HTR1A; HTR2C; HTR6; | |
| OPRK1; OPRD1; OPRM1; | |
| GABBR1; | |
| TDP1; BLM; HSD17B10; MPO; | |
| HTR3A; | |
| GABRR1; | |
| MAPK1; | |
| KDM4E; | |
| HIF1A; | |
| KMT2A; | |
| ABCB1; | |
| SLC6A1; SLC6A11; SLC6A4; | |
| LMNA; RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| 5HT3 receptor | HTR3A | Serotonin 3a (5-HT3a) receptor | P46098 | CHEMBL1899 |
| ATP-binding cassette | ABCB1 | P-glycoprotein 1 | P08183 | CHEMBL4302 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | MPO | Myeloperoxidase | P05164 | CHEMBL2439 |
| GABA-A receptor | GABRR1 | GABA receptor rho-1 subunit | P24046 | CHEMBL3561 |
Showing 1 to 10 of 46 entries
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0009987; cellular process | GO:0007198; adenylate cyclase-inhibiting serotonin receptor signaling pathway | 2.814E-11 | 9.146E-09 | HTR1A, HTR1B, HTR5A, HTR7 |
| BP | GO:0009987; cellular process | GO:0014059; regulation of dopamine secretion | 5.775E-09 | 1.245E-06 | DRD2, DRD3, HTR1B, HTR2A, OPRK1 |
| BP | GO:0009987; cellular process | GO:0002031; G-protein coupled receptor internalization | 9.174E-09 | 1.885E-06 | DRD2, DRD3, HTR1B, HTR2B |
| BP | GO:0065007; biological regulation | GO:0007194; negative regulation of adenylate cyclase activity | 1.175E-08 | 2.284E-06 | ADRA2A, DRD2, DRD3, GABBR1, OPRM1 |
| BP | GO:0065007; biological regulation | GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | 5.047E-08 | 8.326E-06 | ADRA2A, ADRA2B, ADRA2C |
| BP | GO:0009987; cellular process | GO:0032811; negative regulation of epinephrine secretion | 5.047E-08 | 8.326E-06 | ADRA2A, ADRA2B, ADRA2C |
| BP | GO:0008152; metabolic process | GO:0010513; positive regulation of phosphatidylinositol biosynthetic process | 1.260E-07 | 1.905E-05 | HTR2A, HTR2B, HTR2C |
| BP | GO:0007610; behavior | GO:0048148; behavioral response to cocaine | 1.326E-07 | 1.991E-05 | DRD2, DRD3, HTR2A, OPRK1 |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 1.356E-07 | 2.023E-05 | ADRA2A, DRD2, DRD3, HIF1A, HTR2A, HTR2B, HTR2C, MAPK1, NPC1, OPRK1 |
| BP | GO:0009987; cellular process | GO:0014062; regulation of serotonin secretion | 4.394E-07 | 5.730E-05 | HTR1A, HTR1B, SLC6A4 |
Showing 1 to 10 of 74 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 5.153E-05 | 6.427E-04 | CYP2A6; CYP1A2 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 6.327E-04 | 6.035E-03 | CYP2A6; CYP2D6; CYP1A2 |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 5.364E-04 | 5.543E-03 | CYP2A6; CYP2D6; CYP1A2 |
| hsa04020 | Calcium signaling pathway_Homo sapiens_hsa04020 | 2.341E-13 | 9.677E-12 | HTR6; HTR7; ADRB3; HTR2B; HTR2C; ADRA1D; ADRB2; HTR2A; HTR5A; HTR4; ADRA1A |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 3.952E-12 | 9.801E-11 | OPRD1; ADRB3; ADORA3; MAPK1; ADRA1D; ADRB2; ADRA2C; ADRA2B; ADRA1A; ADRA2A |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 7.057E-13 | 2.188E-11 | HTR6; GABBR1; HTR1E; HTR1F; HTR1D; HTR1A; HTR1B; MAPK1; ADRB2; HTR4; DRD2 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 2.650E-03 | 1.825E-02 | OPRD1; ADORA3; MAPK1 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 5.974E-39 | 7.408E-37 | OPRD1; HTR2B; HTR2C; ADRA1D; ADRB2; HTR2A; HTR4; ADRA1A; HTR6; GABRR1; HTR7; ADORA3; DRD2; DRD3; GABBR1; HTR1E; HTR1F; HTR1D; HTR1A; HTR1B; OPRK1; OPRM1; HTR5A; ADRA2C; ADRA2B; ADRA2A; ADRB3 |
| hsa04261 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 3.690E-04 | 4.160E-03 | MAPK1; ADRA1D; ADRB2; ADRA1A |
| hsa04270 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 2.650E-03 | 1.825E-02 | MAPK1; ADRA1D; ADRA1A |
Showing 1 to 10 of 19 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | ADORA3; CYP2D6 |
| A00-B99: Certain infectious and parasitic diseases | Infections disease | A00-B99 | MPO |
| A00-B99: Certain infectious and parasitic diseases | Irritable bowel syndrome | A09, K58, K59.1 | HTR3A; ADRB3; HTR2B |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | ABCB1; DRD2 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| A00-B99: Certain infectious and parasitic diseases | Diarrhea | A09, K59.1 | OPRM1 |
| C00-D49: Neoplasms | Aggressive non-hodgkin's lymphoma | C81, C81-C86, C82-C85, C91-C95 | HTR2C |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | ABCB1; OPRM1; DRD2 |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | ABCB1; MAPK1; HIF1A |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A |
Showing 1 to 10 of 197 entries