Plant Name: Achillea collina
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 1.760E-07 | 7.665E-04 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 5.384E-07 | 1.172E-03 | CYP1A2, KIT, MAPK1, NPC1 |
| BP | GO:0032501; multicellular organismal process | GO:0006940; regulation of smooth muscle contraction | 9.854E-07 | 1.533E-03 | ADRA2A, ADRA2C, KIT, NMUR2 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 1.934E-06 | 2.340E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0008152; metabolic process | GO:0009404; toxin metabolic process | 2.571E-06 | 2.947E-03 | CYP1A1, CYP1A2, CYP1B1 |
| BP | GO:0009987; cellular process | GO:0071310; cellular response to organic substance | 5.654E-06 | 4.767E-03 | ADRA2A, CYP1A1, CYP1B1, KDR, KIT, MAPK1, NPC1, OPRD1, TSHR |
| BP | GO:0050896; response to stimulus | GO:0009636; response to toxic substance | 5.854E-06 | 4.767E-03 | CYP1A1, CYP1B1, KDR, MAPK1, OPRD1, POLB |
| BP | GO:0065007; biological regulation | GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway | 8.126E-06 | 5.204E-03 | ADRA2A, ADRA2C |
| BP | GO:0009987; cellular process | GO:0032811; negative regulation of epinephrine secretion | 8.126E-06 | 5.204E-03 | ADRA2A, ADRA2C |
| BP | GO:0008152; metabolic process | GO:0018894; dibenzo-p-dioxin metabolic process | 8.126E-06 | 5.204E-03 | CYP1A1, CYP1A2 |
Showing 1 to 10 of 20 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 5.410E-07 | 6.222E-05 | CYP1A2; CYP1A1; CYP1B1; CYP19A1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 5.737E-03 | 3.956E-02 | CYP1A2 |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.277E-05 | 5.168E-04 | CYP1A2; CYP1A1; CYP1B1 |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 2.518E-03 | 2.196E-02 | CYP1A2; CYP1A1 |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 7.840E-05 | 1.503E-03 | CYP1A2; CYP1A1; CYP1B1 |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 2.161E-03 | 2.129E-02 | KIT; KDR; MAPK1 |
| hsa04015 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 1.754E-03 | 2.129E-02 | KIT; KDR; MAPK1 |
| hsa04022 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 3.668E-05 | 8.437E-04 | OPRD1; MAPK1; ADRA2C; ADRA2A |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 3.417E-04 | 4.913E-03 | OPRD1; ABCC1; MAPK1 |
| hsa04080 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.348E-05 | 5.168E-04 | OPRD1; NMUR2; ADRA2C; ADRA2A; TSHR |
Showing 1 to 10 of 21 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE |
| C00-D49: Neoplasms | Metastatic breast cancer | C50 | KDR |
| C00-D49: Neoplasms | Metastatic castration-resistant prostate cancer | C61 | KDR |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | KDR |
| C00-D49: Neoplasms | Hepatocellular carcinoma | C22.0 | KDR |
| C00-D49: Neoplasms | Hormonally-responsive breast cancer | C50 | CYP19A1 |
| C00-D49: Neoplasms | Gastric cancer | C16 | KDR; KDR |
| C00-D49: Neoplasms | Peritoneal cavity cancer | NA | KDR |
Showing 1 to 10 of 104 entries