Plant Name: Phebalium dentatum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0019433; triglyceride catabolic process | 5.070E-08 | 5.810E-05 | FABP2, FABP3, FABP4, FABP5 |
| BP | Unclassified; | GO:0015758; glucose transport | 6.399E-07 | 5.806E-04 | PPARD, SLC5A1, SLC5A2, SLC5A4 |
| BP | Unclassified; | GO:0035428; hexose transmembrane transport | 4.596E-06 | 2.944E-03 | SLC5A1, SLC5A2, SLC5A4 |
| BP | GO:0051179; localization | GO:1904659; glucose transmembrane transport | 4.596E-06 | 2.944E-03 | SLC5A1, SLC5A2, SLC5A4 |
| BP | Unclassified; | GO:1905950; monosaccharide transmembrane transport | 4.596E-06 | 2.944E-03 | SLC5A1, SLC5A2, SLC5A4 |
| BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 6.523E-06 | 3.689E-03 | CA2, CA7 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 7.393E-23 | 8.049E-19 | CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.502E-21 | 1.362E-17 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 7.645E-10 | 1.110E-06 | CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, PPARA, PPARD |
| MF | GO:0005215; transporter activity | GO:0005412; glucose:sodium symporter activity | 6.067E-08 | 6.605E-05 | SLC5A1, SLC5A2, SLC5A4 |
Showing 1 to 10 of 11 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00910 | Nitrogen metabolism_Homo sapiens_hsa00910 | 8.327E-29 | 7.245E-27 | CA12; CA1; CA3; CA5B; CA2; CA5A; CA4; CA7; CA6; CA9; CA14 |
| hsa03320 | PPAR signaling pathway_Homo sapiens_hsa03320 | 6.024E-10 | 2.621E-08 | FABP2; FABP3; FABP4; FABP5; PPARA; PPARD |
| hsa04024 | cAMP signaling pathway_Homo sapiens_hsa04024 | 2.930E-03 | 3.354E-02 | PPARA; NFKB1; TSHR |
| hsa04920 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 4.612E-03 | 3.959E-02 | PPARA; NFKB1 |
| hsa04923 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 2.978E-03 | 3.354E-02 | FABP4; TSHR |
| hsa04964 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 5.040E-04 | 1.096E-02 | CA2; CA4 |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 1.466E-04 | 4.252E-03 | CA2; SLC5A1; CYP3A4 |
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 2.874E-03 | 3.354E-02 | NFKB1; TLR2 |
| hsa05140 | Leishmaniasis_Homo sapiens_hsa05140 | 5.006E-03 | 3.959E-02 | NFKB1; TLR2 |
| hsa05221 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 3.084E-03 | 3.354E-02 | NFKB1; PPARD |
Showing 1 to 10 of 11 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | TLR2 |
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | CA9 |
| C00-D49: Neoplasms | Melanoma | C43 | TLR2 |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| C00-D49: Neoplasms | Clear cell renal cell carcinoma | C64 | CA9 |
| C00-D49: Neoplasms | Renal cancer | C64 | CA9 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| C00-D49: Neoplasms | Prostate cancer | C61 | TLR2 |
Showing 1 to 10 of 42 entries