CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	1.059E-08	4.612E-05	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	2.539E-08	7.899E-05	ADORA1, ADORA2A, ADORA3
BP	GO:0051179; localization	GO:0015860; purine nucleoside transmembrane transport	4.878E-07	9.657E-04	SLC28A2, SLC28A3
MF	GO:0005215; transporter activity	GO:0015389; pyrimidine- and adenine-specific:sodium symporter activity	4.878E-07	9.657E-04	SLC28A1, SLC28A3
MF	GO:0005215; transporter activity	GO:0015211; purine nucleoside transmembrane transporter activity	4.878E-07	9.657E-04	SLC28A2, SLC28A3
BP	GO:0051179; localization	GO:1904823; purine nucleobase transmembrane transport	1.463E-06	1.770E-03	SLC28A1, SLC28A3
BP	GO:0051179; localization	GO:0015855; pyrimidine nucleobase transport	1.463E-06	1.770E-03	SLC28A1, SLC28A3
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	1.463E-06	1.770E-03	ADORA1, ADORA2A
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	7.305E-06	6.964E-03	ALOX15, HPGD
BP	GO:0051179; localization	GO:0006909; phagocytosis	1.012E-05	8.904E-03	ADORA1, ADORA2A, ALOX15

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	8.543E-04	2.050E-02	ADORA2A; ADORA3; ADORA1
hsa04071	Sphingolipid signaling pathway_Homo sapiens_hsa04071	3.099E-03	3.719E-02	ADORA3; ADORA1
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	5.905E-03	3.751E-02	ADORA3; ADORA1
hsa03013	RNA transport_Homo sapiens_hsa03013	6.252E-03	3.751E-02	SMN2; SMN1
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	8.286E-03	3.977E-02	ADORA2A; ADORA1

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1
NA: NA	Hepatitis C virus infection	NA	ADORA3
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ADORA1
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA2A; ADORA1
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1; ADORA1
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1; ADORA1
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3
C00-D49: Neoplasms	Cancer	C00-C96	ADORA3
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA2A; ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3; ADORA2A; ADORA1
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ADORA2A; ADORA1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADK; TRPA1; ADORA2A
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ADK
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA2A; ADORA1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Elephantopus angustifolius

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases