CMAUP Plant Collective Molecular Activities

Plant Name: Trapa japonica

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	6.595E-09	3.590E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0032501; multicellular organismal process	GO:0050968; detection of chemical stimulus involved in sensory perception of pain	2.459E-06	1.983E-03	TRPA1, TRPV1
BP	GO:0032501; multicellular organismal process	GO:0050955; thermoception	2.459E-06	1.983E-03	TRPA1, TRPV1
MF	GO:0005215; transporter activity	GO:0097603; temperature-gated ion channel activity	2.459E-06	1.983E-03	TRPA1, TRPV1
MF	GO:0060089; molecular transducer activity	GO:0004949; cannabinoid receptor activity	2.459E-06	1.983E-03	CNR1, CNR2
BP	GO:0050896; response to stimulus	GO:0043434; response to peptide hormone	4.378E-06	3.178E-03	FABP3, PPARA, TLR2, TRPV1, TSHR
BP	GO:0009987; cellular process	GO:0038171; cannabinoid signaling pathway	4.916E-06	3.453E-03	CNR1, CNR2
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.228E-05	7.425E-03	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0051001; negative regulation of nitric-oxide synthase activity	1.718E-05	8.698E-03	CNR1, CNR2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa03320	PPAR signaling pathway_Homo sapiens_hsa03320	2.425E-11	1.213E-09	FABP2; FABP3; FABP4; FABP5; PPARA; PPARD
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	2.204E-06	5.510E-05	CYP1A2; ALOX15; CYP2C19
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	9.454E-05	1.576E-03	CNR2; CNR1; TRPV1; TSHR
hsa04923	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	1.145E-03	1.401E-02	FABP4; TSHR
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.401E-03	1.401E-02	ALOX15; CYP2C19
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.732E-03	1.443E-02	CYP1A2; CYP2C19
hsa04750	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	3.455E-03	2.159E-02	TRPA1; TRPV1
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	2.435E-03	1.739E-02	CYP1A2; CYP2C19
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	4.485E-03	2.246E-02	ALOX15; CYP2C19
hsa03013	RNA transport_Homo sapiens_hsa03013	1.028E-02	4.672E-02	SMN2; SMN1
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	4.492E-03	2.246E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	CNR2; TRPV1
A00-B99: Certain infectious and parasitic diseases	Postherpetic neuralgia	B02.2, G44.847, G53.0	CNR1; TRPV1
C00-D49: Neoplasms	Solid tumours	C00-D48	TLR2
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CNR2
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	TRPV1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CNR1
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
C00-D49: Neoplasms	Cancer	C00-C96	TLR2
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD
C00-D49: Neoplasms	Prostate cancer	C61	TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	TRPV1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CNR1; TRPA1; CNR2; TRPV1; TRPV1
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Drug abuse	F10-F19	CNR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	CNR2
C00-D49: Neoplasms	Ovarian cancer	C56	CNR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pathological pain	R52, G89	TRPV1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cough	R05	TRPV1
E00-E89: Endocrine, nutritional and metabolic diseases	Endocrine disease	E00-E35	CNR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chemotherapy-induced nausea	R11	CNR1
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	CNR1; PPARD
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	CNR1
NA: NA	Esophagus sensitivity	NA	TRPV1
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	CNR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CNR1
J00-J99: Diseases of the respiratory system	Asthma	J45	TRPV1
K00-K95: Diseases of the digestive system	Non-alcoholic fatty liver disease	K76.0	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	CNR1; CNR1; CNR1; CNR1; CNR1; CNR1; PPARD; PPARD
K00-K95: Diseases of the digestive system	Gastroesophageal reflux disease	K21	TRPV1
C00-D49: Neoplasms	Melanoma	C43	TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Nicotine dependence	F17	CNR1
G00-G99: Diseases of the nervous system G00-G99	Acute migraine	G43	TRPV1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Acute or chronic pain	R52, G89	TRPV1
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD; PPARD
NA: NA	Dyslipidemia	NA	PPARD
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	CNR1; CNR1
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	TRPV1; TRPV1
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	CNR1; CNR1; CNR1
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anorexia	F50.0-F50.1	CNR1
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	TRPV1
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Immune disorder	D80-D89	CNR2
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	CNR2
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	CNR1
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	CNR1
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CNR1; CNR2; TRPV1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	CNR1; PPARD
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	PPARD
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
J00-J99: Diseases of the respiratory system	Throat irritation	J39.2	TRPA1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases