CMAUP Plant Collective Molecular Activities

Plant Name: Baeckea frutescens

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.569E-10	6.064E-06	CA12, CA2, CA5A, CA5B
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.131E-08	6.155E-05	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.376E-08	1.035E-04	CA12, CA2, CA5A, CA5B
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	5.453E-08	1.979E-04	CA12, CA2, CA5A, CA5B
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.240E-07	3.707E-04	CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	7.290E-07	1.588E-03	ACHE, BCHE
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.919E-07	1.964E-03	CYP1A2, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0046914; transition metal ion binding	1.350E-06	2.435E-03	CA12, CA2, CA5A, CA5B, CYP1A2, CYP2D6, CYP3A4, PTPN1
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	2.186E-06	3.173E-03	CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	2.581E-06	3.306E-03	BCHE, CYP1A2, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	4.370E-06	4.758E-03	CYP1A2, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	7.853E-06	8.143E-03	CYP1A2, CYP2D6, CYP3A4

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	8.442E-10	3.714E-08	CA12; CA5B; CA2; CA5A
hsa00982	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.581E-05	4.485E-04	CYP2D6; CYP1A2; CYP3A4
hsa00980	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.058E-05	4.485E-04	CYP2D6; CYP1A2; CYP3A4
hsa00591	Linoleic acid metabolism_Homo sapiens_hsa00591	2.724E-04	2.996E-03	CYP1A2; CYP3A4
hsa00140	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.093E-03	9.619E-03	CYP1A2; CYP3A4
hsa00830	Retinol metabolism_Homo sapiens_hsa00830	1.371E-03	1.005E-02	CYP1A2; CYP3A4
hsa04976	Bile secretion_Homo sapiens_hsa04976	1.633E-03	1.026E-02	CA2; CYP3A4
hsa04726	Serotonergic synapse_Homo sapiens_hsa04726	4.001E-03	1.867E-02	CYP2D6; HTR1A
hsa05204	Chemical carcinogenesis_Homo sapiens_hsa05204	2.170E-03	1.193E-02	CYP1A2; CYP3A4
hsa03013	RNA transport_Homo sapiens_hsa03013	9.187E-03	3.675E-02	SMN2; SMN1
hsa00232	Caffeine metabolism_Homo sapiens_hsa00232	4.243E-03	1.867E-02	CYP1A2

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Hypoactive sexual desire disorder	F52.0	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2; CYP2D6
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE
NA: NA	Episode	NA	HTR1A
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	HTR1A; HTR1A; ACHE; ACHE; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	HTR1A
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE
NA: NA	Anxiety disorders	NA	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HTR1A; CYP3A4; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HTR1A; ACHE
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	HTR1A; ACHE
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	HTR1A; ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1
NA: NA	Cervical dystonia	NA	HTR1A
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
NA: NA	Social phobia	NA	HTR1A
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	HTR1A
NA: NA	Bulimia nervosa	NA	HTR1A
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Generalized anxiety disorder	F32, F40-F42, F41.1	HTR1A; HTR1A
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	HTR1A
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	HTR1A
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
NA: NA	Upper abdominal bloating	NA	ACHE
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Severe mood disorders	F30-F39	HTR1A; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HTR1A; HTR1A
NA: NA	Schizoaffective disorder	NA	HTR1A
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	HTR1A
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2; ACHE
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE
NA: NA	Peripheral sensory neuropathies	NA	HTR1A
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Premature ejaculation	F52.4	HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	HTR1A
NA: NA	Colour dead tissues	NA	PTPN1
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HTR1A; HTR1A
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	HTR1A
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6; HTR1A
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Lateral sclerosis	G12.2	HTR1A
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Spasm	R25.2	HTR1A
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HTR1A

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases