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Plant Name: Acer caudatifolium




Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
Target Class
Target Proteins


List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class Gene ID Protein Name Uniprot ID Target ChEMBL ID
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)


Detailed Information of Enriched Gene Ontolgy
GO Type GO Category Enriched GO Terms p-Value Adjusted p-Value Enriched Genes
BP GO:0008152; metabolic process GO:0006730; one-carbon metabolic process 1.240E-14 1.350E-10 CA1, CA12, CA5A, CA5B, CA6, CA9
BP GO:0051179; localization GO:0015701; bicarbonate transport 4.486E-14 3.256E-10 CA1, CA12, CA5A, CA5B, CA6, CA9
MF GO:0005488; binding GO:0008270; zinc ion binding 6.492E-08 1.571E-04 CA1, CA12, CA5A, CA5B, CA6, CA9, THRB
BP GO:0008152; metabolic process GO:0009822; alkaloid catabolic process 8.842E-07 1.605E-03 CYP2D6, CYP3A4
BP GO:0008152; metabolic process GO:0016098; monoterpenoid metabolic process 4.417E-06 5.658E-03 CYP2D6, CYP3A4
MF GO:0003824; catalytic activity GO:0004089; carbonate dehydratase activity 3.201E-17 6.971E-13 CA1, CA12, CA5A, CA5B, CA6, CA9
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways
Pathway ID Pathway Name p-Value Adjusted p-Value Enriched Genes
hsa00910 Nitrogen metabolism_Homo sapiens_hsa00910 6.422E-17 2.954E-15 CA12; CA1; CA5B; CA5A; CA6; CA9
hsa00982 Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 6.323E-04 1.085E-02 CYP2D6; CYP3A4
hsa00980 Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 7.075E-04 1.085E-02 CYP2D6; CYP3A4
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases
ICD10 Disease Category Disease Name ICD10 Code Linked Targets
C00-D49: Neoplasms Glioma C71 EGFR; EGFR
C00-D49: Neoplasms Glioblastoma multiforme C71 EGFR; EGFR
C00-D49: Neoplasms Clear cell renal cell carcinoma C64 CA9
K00-K95: Diseases of the digestive system Gastrointestinal disease K00-K93 EGFR
C00-D49: Neoplasms Ovarian cancer C56 EGFR; EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Anxiety disorder F32, F40-F42 CYP3A4
A00-B99: Certain infectious and parasitic diseases Cryptosporidium infection A07.2 EGFR
C00-D49: Neoplasms Head and neck cancer C07-C14, C32-C33 EGFR; EGFR; EGFR
C00-D49: Neoplasms Head and neck squamous cell carcinoma C44 EGFR
H00-H59: Diseases of the eye and adnexa Chronic glaucoma H40-H42 CA1
I00-I99: Diseases of the circulatory system Cerebrovascular ischaemia I61-I63 EGFR
C00-D49: Neoplasms Bladder cancer C67 EGFR
C00-D49: Neoplasms Esophageal cancer C15 EGFR
C00-D49: Neoplasms Chronic lymphocytic leukaemia C91 EGFR
C00-D49: Neoplasms Gastric cancer C16 EGFR; EGFR
C00-D49: Neoplasms Non-small-cell lung cancer NA EGFR
C00-D49: Neoplasms Malignant tumor C00-C75, C7A, C7B EGFR
C00-D49: Neoplasms Melanoma C43 EGFR
G00-G99: Diseases of the nervous system G00-G99 Migraine G43 CYP2D6
C00-D49: Neoplasms Metastatic colorectal cancer C18-C21 EGFR
H00-H59: Diseases of the eye and adnexa Glaucoma H40-H42 CA1; CA1
E00-E89: Endocrine, nutritional and metabolic diseases Hypothyroidism E03 THRB
C00-D49: Neoplasms Inflammatory breast cancer C50 EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders Insomnia F51.0, G47.0 CYP2D6
C00-D49: Neoplasms Pancreatic cancer C25 EGFR
K00-K95: Diseases of the digestive system Duodenal ulcers K25-K27 CA1
C00-D49: Neoplasms Renal cancer C64 CA9
E00-E89: Endocrine, nutritional and metabolic diseases Lipid metabolism disorder E75-E78 THRB
C00-D49: Neoplasms Non-small cell lung cancer C33-C34 EGFR; EGFR
C00-D49: Neoplasms Lymphoma C81-C86 CA9; EGFR
C00-D49: Neoplasms Lung cancer C33-C34 EGFR
C00-D49: Neoplasms Locally advanced head and neck cancer C07-C14, C32, C33 EGFR
C00-D49: Neoplasms Urethral cancer NA EGFR
S00-T88: Injury, poisoning and certain other consequences of external causes Wound healing T14.0-T14.1 THRB
S00-T88: Injury, poisoning and certain other consequences of external causes Vulnerary S00-T98 EGFR
C00-D49: Neoplasms Colorectal cancer C18-C21 EGFR; EGFR
C00-D49: Neoplasms Colon cancer C50 EGFR
A00-B99: Certain infectious and parasitic diseases Malaria B54 CYP2D6
C00-D49: Neoplasms Solid tumours C00-D48 CA9; EGFR
E00-E89: Endocrine, nutritional and metabolic diseases Hyperlipidaemia E78 THRB
E00-E89: Endocrine, nutritional and metabolic diseases High cholesterol levels in blood E78.0 THRB
C00-D49: Neoplasms Refractory breast cancer C50 EGFR
C00-D49: Neoplasms Cancer C00-C96 CA1; CA9; EGFR
C00-D49: Neoplasms Advanced cancers C00-C96 EGFR
L00-L99: Diseases of the skin and subcutaneous tissue Diabetic foot ulcer L88-L89 EGFR
E00-E89: Endocrine, nutritional and metabolic diseases Hyperthyroidism E05 THRB
C00-D49: Neoplasms Breast cancer C50 CA9; EGFR; EGFR; EGFR
C00-D49: Neoplasms Brain cancer C71, D33 EGFR; EGFR
C00-D49: Neoplasms Prostate cancer C61 EGFR
L00-L99: Diseases of the skin and subcutaneous tissue Psoriasis L40 EGFR
Data Section
Select to Download
1. General Info & Plant Usage & Geographical Distribution  
2. Human Target Proteins  
3. Target Gene Ontology  
4. Target KEGG Pathway  
5. Related Human Diseases  
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The CMAUP database is developed by the Bioinformatics & Drug Design group (BIDD), which is based in the Department of Pharmacy, National University of Singapore, Singapore.

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Principle Investigator:
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Developer & Maintainer:
Dr. Zeng Xian
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