Plant Name: Piper dilatatum
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| MGAM; | |
| TDP1; BLM; HSD17B1; AOX1; | |
| CHRNA7; | |
| ABL1; MAPK1; EGFR; ATM; ATR; | |
| ESR1; ESR2; | |
| ESRRB; ESRRA; | |
| MAOA; | |
| HIF1A; TP53; | |
| ABCG2; | |
| SLCO1B1; SLCO1B3; | |
| RAB9A; LMNA; NPC1; THPO; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| ATP-binding cassette | ABCG2 | ATP-binding cassette sub-family G member 2 | Q9UNQ0 | CHEMBL5393 |
| Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 5 | TBXAS1 | Thromboxane-A synthase | P24557 | CHEMBL1835 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | HSD17B1 | Estradiol 17-beta-dehydrogenase 1 | P14061 | CHEMBL3181 |
| Enzyme_unclassified | AOX1 | Aldehyde oxidase | Q06278 | CHEMBL3257 |
| Hydrolase | MGAM | Maltase-glucoamylase | O43451 | CHEMBL2074 |
| Nicotinic acetylcholine receptor | CHRNA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | P36544 | CHEMBL2492 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Nuclear hormone receptor subfamily 3 group B | ESRRB | Estrogen-related receptor beta | O95718 | CHEMBL3751 |
| Nuclear hormone receptor subfamily 3 group B | ESRRA | Estrogen-related receptor alpha | P11474 | CHEMBL3429 |
| Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Protein Kinase | ABL1 | Tyrosine-protein kinase ABL | P00519 | CHEMBL1862 |
| Protein Kinase | MAPK1 | MAP kinase ERK2 | P28482 | CHEMBL4040 |
| Protein Kinase | EGFR | Epidermal growth factor receptor erbB1 | P00533 | CHEMBL203 |
| Protein Kinase | ATM | Serine-protein kinase ATM | Q13315 | CHEMBL3797 |
| Protein Kinase | ATR | Serine-protein kinase ATR | Q13535 | CHEMBL5024 |
| SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
| SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
| Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0005496; steroid binding | 2.855E-09 | 6.217E-05 | ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NPC1 |
| BP | Unclassified; | GO:0032846; positive regulation of homeostatic process | 3.429E-08 | 3.734E-04 | ABL1, ATM, ATR, EGFR, HIF1A, MAPK1, NPC1 |
| BP | GO:0009987; cellular process | GO:0090399; replicative senescence | 6.633E-07 | 1.640E-03 | ATM, ATR, TP53 |
| BP | GO:0051179; localization | GO:0097695; establishment of macromolecular complex localization to telomere | 2.176E-06 | 2.290E-03 | ATM, ATR |
| BP | GO:0051179; localization | GO:0097694; establishment of RNA localization to telomere | 2.176E-06 | 2.290E-03 | ATM, ATR |
| BP | GO:0071840; cellular component organization or biogenesis | GO:1904884; positive regulation of telomerase catalytic core complex assembly | 2.176E-06 | 2.290E-03 | ATM, ATR |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 2.176E-06 | 2.290E-03 | ESR1, ESR2 |
| BP | GO:0022414; reproductive process | GO:0001892; embryonic placenta development | 3.409E-06 | 2.651E-03 | EGFR, ESRRB, HIF1A |
| BP | Unclassified; | GO:0032844; regulation of homeostatic process | 5.079E-06 | 3.098E-03 | ABL1, ATM, ATR, EGFR, HIF1A, MAPK1, NPC1 |
| BP | GO:0002376; immune system process | GO:0001922; B-1 B cell homeostasis | 6.523E-06 | 3.633E-03 | ABL1, HIF1A |
| BP | GO:0050896; response to stimulus | GO:0071480; cellular response to gamma radiation | 8.686E-06 | 4.299E-03 | ATM, ATR, TP53 |
| BP | GO:0009987; cellular process | GO:0071407; cellular response to organic cyclic compound | 1.151E-05 | 5.266E-03 | ABL1, BLM, EGFR, ESR1, MAPK1, NPC1 |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 1.303E-05 | 5.565E-03 | ESR1, ESR2 |
| MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 1.303E-05 | 5.565E-03 | CYP1A2, CYP2C9 |
| BP | GO:0009987; cellular process | GO:0071276; cellular response to cadmium ion | 1.329E-05 | 5.567E-03 | CYP1A2, EGFR, MAPK1 |
| BP | GO:0065007; biological regulation | GO:0030003; cellular cation homeostasis | 1.610E-05 | 6.262E-03 | ABCG2, ABL1, CHRNA7, ESR1, HIF1A, MAPK1, TP53 |
| BP | GO:0050896; response to stimulus | GO:0010165; response to X-ray | 1.610E-05 | 6.262E-03 | ATM, BLM, TP53 |
| BP | GO:0065007; biological regulation | GO:0032212; positive regulation of telomere maintenance via telomerase | 1.765E-05 | 6.625E-03 | ATM, ATR, MAPK1 |
| BP | GO:0050896; response to stimulus | GO:0034614; cellular response to reactive oxygen species | 1.971E-05 | 6.950E-03 | ABL1, EGFR, MAPK1, TP53 |
| BP | GO:0065007; biological regulation | GO:1900274; regulation of phospholipase C activity | 2.101E-05 | 6.950E-03 | ABL1, EGFR, ESR1 |
| MF | GO:0005488; binding | GO:0003690; double-stranded DNA binding | 2.119E-05 | 6.950E-03 | EGFR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, TDP1, TP53 |
| MF | GO:0005488; binding | GO:0008144; drug binding | 2.165E-05 | 6.950E-03 | ABCG2, ABL1, ATM, ATR, BLM, CHRNA7, CYP1A2, CYP2C9, EGFR, MAPK1, TP53 |
| BP | GO:0050896; response to stimulus | GO:0071417; cellular response to organonitrogen compound | 2.245E-05 | 7.085E-03 | ABL1, BLM, EGFR, MAPK1, TP53, TSHR |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 3.034E-05 | 8.927E-03 | CYP1A2, CYP2C9, ESR1, HSD17B1, NPC1 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 3.252E-05 | 9.325E-03 | CYP1A2, CYP2C9 |
| BP | GO:0050896; response to stimulus | GO:0032355; response to estradiol | 3.393E-05 | 9.596E-03 | CYP1A2, EGFR, ESR1, ESRRA |
| BP | GO:0008283; cell proliferation | GO:0008284; positive regulation of cell proliferation | 3.474E-05 | 9.642E-03 | ABL1, CHRNA7, EGFR, ESR1, HIF1A, MAPK1, THPO, TSHR |
| BP | GO:0032502; developmental process | GO:0048538; thymus development | 3.606E-05 | 9.694E-03 | ABL1, ATM, MAPK1 |
| BP | GO:0051179; localization | GO:0015850; organic hydroxy compound transport | 3.962E-05 | 9.958E-03 | ABCG2, NPC1, SLCO1B1, SLCO1B3 |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 4.083E-05 | 9.958E-03 | ESR1, ESR2, ESRRA, ESRRB |
| BP | GO:0008152; metabolic process | GO:0051053; negative regulation of DNA metabolic process | 4.083E-05 | 9.958E-03 | ATM, ATR, BLM, TP53 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 2.565E-06 | 2.122E-04 | MAPK1; TP53; HIF1A; EGFR |
| hsa00982 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.887E-06 | 2.122E-04 | CYP2C9; MAOA; CYP1A2; AOX1 |
| hsa05205 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 9.988E-06 | 4.483E-04 | MAPK1; TP53; HIF1A; ESR1; EGFR |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.220E-05 | 4.483E-04 | MAPK1; ESR1; EGFR; ESR2 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 2.440E-05 | 5.448E-04 | MAPK1; TP53; ESR1; HIF1A |
| hsa00380 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.612E-05 | 5.448E-04 | MAOA; CYP1A2; AOX1 |
| hsa04210 | Apoptosis_Homo sapiens_hsa04210 | 4.768E-05 | 7.788E-04 | LMNA; MAPK1; ATM; TP53 |
| hsa05219 | Bladder cancer_Homo sapiens_hsa05219 | 2.816E-05 | 5.448E-04 | MAPK1; TP53; EGFR |
| hsa04110 | Cell cycle_Homo sapiens_hsa04110 | 2.965E-05 | 5.448E-04 | ABL1; ATM; TP53; ATR |
| hsa05206 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 6.189E-05 | 8.271E-04 | ABL1; MAPK1; ATM; TP53; EGFR |
| hsa05213 | Endometrial cancer_Homo sapiens_hsa05213 | 5.775E-05 | 8.271E-04 | MAPK1; TP53; EGFR |
| hsa05223 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 7.215E-05 | 8.839E-04 | MAPK1; TP53; EGFR |
| hsa05214 | Glioma_Homo sapiens_hsa05214 | 1.127E-04 | 1.156E-03 | MAPK1; TP53; EGFR |
| hsa05212 | Pancreatic cancer_Homo sapiens_hsa05212 | 1.180E-04 | 1.156E-03 | MAPK1; TP53; EGFR |
| hsa05200 | Pathways in cancer_Homo sapiens_hsa05200 | 2.409E-04 | 1.610E-03 | ABL1; MAPK1; HIF1A; TP53; EGFR |
| hsa00830 | Retinol metabolism_Homo sapiens_hsa00830 | 1.127E-04 | 1.156E-03 | CYP2C9; CYP1A2; AOX1 |
| hsa05218 | Melanoma_Homo sapiens_hsa05218 | 1.466E-04 | 1.170E-03 | MAPK1; TP53; EGFR |
| hsa04917 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 1.528E-04 | 1.170E-03 | MAPK1; ESR1; ESR2 |
| hsa05220 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 1.592E-04 | 1.170E-03 | ABL1; MAPK1; TP53 |
| hsa04115 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.347E-04 | 1.170E-03 | ATM; TP53; ATR |
| hsa04976 | Bile secretion_Homo sapiens_hsa04976 | 1.466E-04 | 1.170E-03 | SLCO1B1; SLCO1B3; ABCG2 |
| hsa05215 | Prostate cancer_Homo sapiens_hsa05215 | 2.862E-04 | 1.753E-03 | MAPK1; TP53; EGFR |
| hsa04012 | ErbB signaling pathway_Homo sapiens_hsa04012 | 2.677E-04 | 1.711E-03 | ABL1; MAPK1; EGFR |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 4.152E-04 | 2.441E-03 | MAPK1; HIF1A; EGFR |
| hsa05204 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 2.247E-04 | 1.573E-03 | CYP2C9; CHRNA7; CYP1A2 |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 4.397E-04 | 2.486E-03 | MAPK1; HIF1A; EGFR |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 5.618E-04 | 3.059E-03 | CYP2C9; MAOA; MAPK1 |
| hsa04722 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 6.868E-04 | 3.532E-03 | ABL1; MAPK1; TP53 |
| hsa01100 | Metabolic pathways_Homo sapiens_hsa01100 | 1.608E-03 | 6.756E-03 | CYP2C9; MGAM; MAOA; HSD17B1; TBXAS1; CYP1A2; AOX1 |
| hsa04068 | FoxO signaling pathway_Homo sapiens_hsa04068 | 9.257E-04 | 4.123E-03 | MAPK1; ATM; EGFR |
| hsa05160 | Hepatitis C_Homo sapiens_hsa05160 | 9.257E-04 | 4.123E-03 | MAPK1; TP53; EGFR |
| hsa04014 | Ras signaling pathway_Homo sapiens_hsa04014 | 4.241E-03 | 1.450E-02 | ABL1; MAPK1; EGFR |
| hsa04010 | MAPK signaling pathway_Homo sapiens_hsa04010 | 5.859E-03 | 1.872E-02 | MAPK1; TP53; EGFR |
| hsa05166 | HTLV-I infection_Homo sapiens_hsa05166 | 6.052E-03 | 1.893E-02 | ATM; TP53; ATR |
| hsa04150 | mTOR signaling pathway_Homo sapiens_hsa04150 | 3.411E-03 | 1.319E-02 | MAPK1; HIF1A |
| hsa04151 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 1.293E-02 | 3.550E-02 | MAPK1; TP53; EGFR |
| hsa05210 | Colorectal cancer_Homo sapiens_hsa05210 | 3.637E-03 | 1.337E-02 | MAPK1; TP53 |
| hsa04725 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.124E-02 | 3.177E-02 | CHRNA7; MAPK1 |
| hsa05211 | Renal cell carcinoma_Homo sapiens_hsa05211 | 4.111E-03 | 1.439E-02 | MAPK1; HIF1A |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 7.675E-03 | 2.256E-02 | MAPK1; EGFR |
| hsa04611 | Platelet activation_Homo sapiens_hsa04611 | 1.346E-02 | 3.596E-02 | TBXAS1; MAPK1 |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 5.140E-03 | 1.679E-02 | MAPK1; EGFR |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 5.006E-03 | 1.672E-02 | CYP2C9; CYP1A2 |
| hsa00590 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 3.637E-03 | 1.337E-02 | CYP2C9; TBXAS1 |
| hsa04540 | Gap junction_Homo sapiens_hsa04540 | 7.194E-03 | 2.169E-02 | MAPK1; EGFR |
| hsa00140 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 3.191E-03 | 1.268E-02 | HSD17B1; CYP1A2 |
| hsa05162 | Measles_Homo sapiens_hsa05162 | 1.653E-02 | 4.263E-02 | RAB9A; TP53 |
| hsa04071 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 1.304E-02 | 3.550E-02 | MAPK1; TP53 |
| hsa05161 | Hepatitis B_Homo sapiens_hsa05161 | 1.889E-02 | 4.628E-02 | MAPK1; TP53 |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.841E-02 | 4.586E-02 | MAPK1; EGFR |
| hsa05131 | Shigellosis_Homo sapiens_hsa05131 | 3.990E-03 | 1.431E-02 | ABL1; MAPK1 |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.793E-02 | 4.544E-02 | ESRRB; MAPK1 |
| hsa04360 | Axon guidance_Homo sapiens_hsa04360 | 1.452E-02 | 3.812E-02 | ABL1; MAPK1 |
| hsa03460 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.672E-03 | 1.091E-02 | BLM; ATR |
| hsa05216 | Thyroid cancer_Homo sapiens_hsa05216 | 8.044E-04 | 3.815E-03 | MAPK1; TP53 |
| hsa04320 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 6.967E-04 | 3.532E-03 | MAPK1; EGFR |
| hsa00350 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.173E-03 | 5.070E-03 | MAOA; AOX1 |
| hsa00591 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 8.044E-04 | 3.815E-03 | CYP2C9; CYP1A2 |
| hsa00750 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 8.670E-03 | 2.499E-02 | AOX1 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 7.230E-03 | 2.169E-02 | CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| C00-D49: Neoplasms | Advanced cancers | C00-C96 | EGFR |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MAPK1 |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | EGFR; ATR |
| C00-D49: Neoplasms | Chronic myelogenous leukaemia | C92.1 | ABL1; ABL1 |
| C00-D49: Neoplasms | Glioma | C71 | ABL1; EGFR; EGFR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Vulnerary | S00-T98 | EGFR |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | EGFR; EGFR; ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthralgia | M25.5 | ESR1 |
| C00-D49: Neoplasms | Esophageal cancer | C15 | EGFR |
| G00-G99: Diseases of the nervous system G00-G99 | Mild to moderate alzheimer disease | G30 | CHRNA7 |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | CHRNA7 |
| C00-D49: Neoplasms | Adrenocortical carcinoma | C74.0 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Infertility | N97.0 | ESR1 |
| C00-D49: Neoplasms | Advanced prostate cancer | C61 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypogonadism | E23.0, E28.3, E29.1 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | MGAM |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Osteopetrosis | Q78.2 | ESR1 |
| H00-H59: Diseases of the eye and adnexa | Eye disorders | H00-H59 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Female hypogonadism | E23, E28 | ESR1 |
| C00-D49: Neoplasms | Breast cancer | C50 | EGFR; EGFR; EGFR; ESR1; ESR1 |
| Z00-Z99: Factors influencing health status and contact with health services | Contraception | Z30 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dietary shortage | E40-E46 | ABL1 |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | ABL1 |
| A00-B99: Certain infectious and parasitic diseases | Fungal infections | B35-B49 | RAB9A |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Female sexual dysfunction | F52 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Female infertility due to anovulation | N97.0 | ESR1 |
| C00-D49: Neoplasms | Gastric cancer | C16 | EGFR; EGFR |
| C00-D49: Neoplasms | Prostate cancer | C61 | ABL1; EGFR; ESR1 |
| C00-D49: Neoplasms | Colon cancer | C50 | EGFR |
| K00-K95: Diseases of the digestive system | Gastrointestinal disease | K00-K93 | EGFR; ESRRA |
| C00-D49: Neoplasms | Thyroid cancer | C73 | TSHR |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Anesthesia | R20.0 | CHRNA7 |
| N00-N99: Diseases of the genitourinary system | Female infertility | N97.0 | ESR1; ESR1 |
| C00-D49: Neoplasms | Hormone refractory prostate cancer | C61 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hormone deficiency | E00-E90 | ESR1; ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Pompe's disease | E74.02 | MGAM |
| N00-N99: Diseases of the genitourinary system | Post-menopausal vaginal atrophy | N95.2 | ESR1 |
| NA: NA | Postmenopausal disorder | NA | ESR1 |
| H00-H59: Diseases of the eye and adnexa | Choroidal neovascularisation | H35 | ESRRA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | MAOA |
| I00-I99: Diseases of the circulatory system | Angina pectoris | I20 | TBXAS1 |
| C00-D49: Neoplasms | Hematological malignancies | C81-C86 | TP53 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Alcohol use disorders | F10.2 | MAOA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | ESR1 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mood disorder | F30-F39 | MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | CHRNA7; MAOA |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | EGFR |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ESR1 |
| J00-J99: Diseases of the respiratory system | Allergic rhinitis | J00, J30, J31.0, T78.4 | ESRRA |
| Z00-Z99: Factors influencing health status and contact with health services | Hormone replacement therapy | Z79.890 | ESR1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Hyperglycemia | R73.9 | MGAM |
| G00-G99: Diseases of the nervous system G00-G99 | Multiple scierosis | G35 | ESR1; ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Muscle disease | M60-M63 | MGAM |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | EGFR; EGFR |
| C00-D49: Neoplasms | Ovarian cancer | C56 | EGFR; EGFR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Diabetic foot ulcer | L88-L89 | EGFR |
| NA: NA | Gonorrheal vaginitis | NA | ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Osteoporosis | M80-M81, Z79.890 | ESR1 |
| Z00-Z99: Factors influencing health status and contact with health services | Oral contraceptive | Z30 | ESR1 |
| C00-D49: Neoplasms | Oral cavity cancer | C00-C08 | TP53 |
| W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure | Diagnostic test to differentiate primary and secondary hypothyroidism | W88 | TSHR |
| C00-D49: Neoplasms | Myeloid leukemia | C92 | ABL1 |
| C00-D49: Neoplasms | Acute myeloid leukemia | C92.0 | TP53; TP53 |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | TP53; EGFR; EGFR; EGFR |
| C00-D49: Neoplasms | Head and neck squamous cell carcinoma | C44 | EGFR |
| H60-H95: Diseases of the ear and mastoid process | Hearing disorder | H90.5 | TP53 |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Major depressive disorder | F32, F33, M32 | MAOA; MAOA |
| E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | ESRRA |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | EGFR; EGFR; ATM |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | EGFR |
| A00-B99: Certain infectious and parasitic diseases | Acquired immune deficiency syndrome | B20 | MGAM |
| L00-L99: Diseases of the skin and subcutaneous tissue | Acne vulgaris | L70.0 | ESR1; ESRRA |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatitis | L20-L30 | ESRRA |
| A00-B99: Certain infectious and parasitic diseases | Dengue fever | A90 | MGAM |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Depression | F30-F39 | MAOA |
| N00-N99: Diseases of the genitourinary system | Dysmenorrhea | N94.4-N94.6 | ESR1 |
| C00-D49: Neoplasms | Malignant tumor | C00-C75, C7A, C7B | EGFR |
| C00-D49: Neoplasms | Melanoma | C43 | EGFR |
| NA: NA | Menopausal disorder | NA | ESR1 |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | CHRNA7; CHRNA7; MAOA |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | ESR1; CHRNA7 |
| G00-G99: Diseases of the nervous system G00-G99 | Neuropathic pain | G64, G90.0 | MAOA |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | MAOA |
| I00-I99: Diseases of the circulatory system | Cardiac arrhythmias | I47-I49 | TBXAS1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | ESRRA |
| N00-N99: Diseases of the genitourinary system | Menorrhagia | N92.0 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Menopause symptoms | N95.0 | ESR1; ESR1 |
| N00-N99: Diseases of the genitourinary system | Nephritis | N00-N19, N25-N29 | TBXAS1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Estrogen deficiency | E28.39 | ESR1 |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | TP53; EGFR; EGFR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | CHRNA7; CHRNA7; CHRNA7; ESRRA |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | EGFR |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | EGFR |
| N00-N99: Diseases of the genitourinary system | Dyspareunia | N94.1 | ESR1 |
| I00-I99: Diseases of the circulatory system | Cardiovascular disorder | I00-I99 | MGAM |
| I00-I99: Diseases of the circulatory system | Thrombosis | I80-I82 | TBXAS1 |
| I00-I99: Diseases of the circulatory system | Thromboembolism | I80-I82 | TBXAS1 |
| C00-D49: Neoplasms | Refractory breast cancer | C50 | EGFR |
| C00-D49: Neoplasms | Urethral cancer | NA | EGFR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Dermatological disease | L00-L99 | ESRRA |
| C00-D49: Neoplasms | Inflammatory breast cancer | C50 | EGFR |
| K00-K95: Diseases of the digestive system | Inflammatory bowel disease | K50, K51 | TBXAS1 |
| C00-D49: Neoplasms | Carcinoma | D00-D09 | ESR1 |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Cachexia | R64 | ESRRA |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; TP53; ABL1; MAPK1; EGFR; ESR1; ESR1; ATR |
| I00-I99: Diseases of the circulatory system | Renal artery disease | I70.1 | TP53 |
| C00-D49: Neoplasms | Thyroid cancer diagnosis | C73 | TSHR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Toxicity | T36-T50, T51-T65 | TP53 |
| A00-B99: Certain infectious and parasitic diseases | Trematode infection | B66.9 | ESR1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | TBXAS1; MGAM |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Arthritis | M00-M25 | ESRRA |
| J00-J99: Diseases of the respiratory system | Asthma | J45 | TBXAS1; CHRNA7; ESRRA |
| C00-D49: Neoplasms | Intestinal cancer | NA | ABL1 |
| N00-N99: Diseases of the genitourinary system | Irregularities | N92.6 | ESR1 |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | EGFR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Vitiligo | L80 | MAOA |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Attention deficit hyperactivity disorder | F90 | CHRNA7 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | ESR1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Atrophy | M62.571 | ESR1 |
| N00-N99: Diseases of the genitourinary system | Atrophic vaginitis | N95.2 | ESR1 |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9 |
| C00-D49: Neoplasms | Late-stage solid tumors | C00-C75, C7A, C7B, D10-D36, D3A | TP53 |
| C00-D49: Neoplasms | Leukemia | C90-C95 | ABL1; ESR1 |
| C00-D49: Neoplasms | Bladder cancer | C67 | EGFR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Psychiatric disorder | F01-F99 | CHRNA7 |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| N00-N99: Diseases of the genitourinary system | Vagina disease | N76.0 | ESR1 |
| C00-D49: Neoplasms | Locally advanced head and neck cancer | C07-C14, C32, C33 | EGFR |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | ABL1; EGFR |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; EGFR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; TP53; ABL1; MAPK1; EGFR; ATR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | CHRNA7 |