Plant Name: Plantago uniflora
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Human Protein Targets
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 5.281E-07 | 3.068E-03 | CASP1, CASP7, LCK, XDH |
| MF | GO:0005488; binding | GO:0042610; CD8 receptor binding | 6.433E-07 | 3.068E-03 | FYN, LCK |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 3.627E-06 | 5.794E-03 | ALDH1A1, ALOX15, CYP2D6, HPGD, HSD17B10, KDM4E, XDH |
| BP | GO:0009987; cellular process | GO:0097194; execution phase of apoptosis | 3.865E-06 | 5.794E-03 | CASP1, CASP7, PRKCD |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 7.395E-06 | 7.668E-03 | EGFR, FYN, LCK |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 9.631E-06 | 8.388E-03 | ALOX15, HPGD |
| MF | GO:0003824; catalytic activity | GO:0004715; non-membrane spanning protein tyrosine kinase activity | 9.478E-06 | 8.388E-03 | FYN, LCK, PRKCD |
| BP | GO:0008152; metabolic process | GO:0032270; positive regulation of cellular protein metabolic process | 1.126E-05 | 8.754E-03 | ALOX15, CASP1, CASP7, EGFR, FYN, LCK, PRKCD, XDH |
| MF | GO:0005488; binding | GO:0042608; T cell receptor binding | 1.348E-05 | 9.417E-03 | FYN, LCK |
| MF | GO:0005488; binding | GO:0042609; CD4 receptor binding | 1.348E-05 | 9.417E-03 | FYN, LCK |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa05134 | Legionellosis_Homo sapiens_hsa05134 | 8.693E-04 | 2.829E-02 | CASP7; CASP1 |
| hsa05230 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 1.287E-03 | 2.829E-02 | HIF1A; EGFR |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 1.567E-03 | 2.829E-02 | FYN; EGFR |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 2.357E-03 | 2.829E-02 | PRKCD; EGFR |
| hsa05133 | Pertussis_Homo sapiens_hsa05133 | 1.609E-03 | 2.829E-02 | CASP7; CASP1 |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 2.782E-03 | 2.829E-02 | PRKCD; EGFR |
| hsa05231 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 2.893E-03 | 2.829E-02 | HIF1A; EGFR |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 3.007E-03 | 2.829E-02 | HIF1A; EGFR |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.064E-03 | 2.829E-02 | LCK; FYN |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 3.543E-03 | 2.829E-02 | CYP2D6; ALOX15 |
| hsa04919 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 3.924E-03 | 2.829E-02 | THRB; HIF1A |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 4.883E-03 | 3.097E-02 | LCK; FYN |
| hsa04650 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 5.101E-03 | 3.097E-02 | LCK; FYN |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 5.782E-03 | 3.277E-02 | FYN; EGFR |
| hsa05010 | Alzheimer's disease_Homo sapiens_hsa05010 | 7.791E-03 | 4.139E-02 | CASP7; HSD17B10 |
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.994E-03 | 2.829E-02 | XDH |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Autoimmune diabetes | E08-E13 | LCK |
| G00-G99: Diseases of the nervous system G00-G99 | Encephalopathy | G93.4 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricaemia in gout | E79.0, M10 | XDH |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperuricemia | E79.0 | XDH |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | EGFR |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; EGFR |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypothyroidism | E03 | THRB |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | THRB |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperthyroidism | E05 | THRB |
| I00-I99: Diseases of the circulatory system | Heart failure | I50 | XDH |
| C00-D49: Neoplasms | Gastric cancer | C16 | EGFR; EGFR |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | EGFR; EGFR |
| C00-D49: Neoplasms | Locally advanced head and neck cancer | C07-C14, C32, C33 | EGFR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Psoriasis | L40 | EGFR |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | CASP1 |
| G00-G99: Diseases of the nervous system G00-G99 | Epilepsy | G40 | CASP1 |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | THRB |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | EGFR; EGFR; EGFR |
| C00-D49: Neoplasms | Head and neck squamous cell carcinoma | C44 | EGFR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; EGFR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Fibrosis | L90.5 | CASP1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | XDH |
| C00-D49: Neoplasms | Inflammatory breast cancer | C50 | EGFR |
| I00-I99: Diseases of the circulatory system | Pulmonary arterial hypertension | I27.0, I27.2 | HIF1A |
| C00-D49: Neoplasms | Metastatic colorectal cancer | C18-C21 | EGFR |
| C00-D49: Neoplasms | Advanced cancers | C00-C96 | EGFR |
| C00-D49: Neoplasms | Colon cancer | C50 | EGFR |
| C00-D49: Neoplasms | Prostate cancer | C61 | EGFR |
| C00-D49: Neoplasms | Chronic lymphocytic leukaemia | C91 | EGFR |
| C00-D49: Neoplasms | Ovarian cancer | C56 | EGFR; EGFR |
| C00-D49: Neoplasms | Brain cancer | C71, D33 | EGFR; EGFR |
| NA: NA | Reperfusion injury and heart attacks | NA | PRKCD |
| C00-D49: Neoplasms | Malignant tumor | C00-C75, C7A, C7B | EGFR |
| C00-D49: Neoplasms | Melanoma | C43 | EGFR |
| C00-D49: Neoplasms | Urethral cancer | NA | EGFR |
| C00-D49: Neoplasms | Non-small-cell lung cancer | NA | EGFR |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | EGFR; EGFR |
| L00-L99: Diseases of the skin and subcutaneous tissue | Diabetic foot ulcer | L88-L89 | EGFR |
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| C00-D49: Neoplasms | Esophageal cancer | C15 | EGFR |
| K00-K95: Diseases of the digestive system | Gastrointestinal disease | K00-K93 | EGFR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Vulnerary | S00-T98 | EGFR |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Wound healing | T14.0-T14.1 | THRB |
| I00-I99: Diseases of the circulatory system | Acute myocardial infarction | I21-I22 | PRKCD |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | EGFR |
| E00-E89: Endocrine, nutritional and metabolic diseases | High cholesterol levels in blood | E78.0 | THRB |
| I00-I99: Diseases of the circulatory system | Cerebrovascular ischaemia | I61-I63 | EGFR |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| C00-D49: Neoplasms | Bladder cancer | C67 | EGFR |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6 |
| C00-D49: Neoplasms | Refractory breast cancer | C50 | EGFR |
| C00-D49: Neoplasms | Breast cancer | C50 | EGFR; EGFR; EGFR |
| C00-D49: Neoplasms | Glioma | C71 | EGFR; EGFR |
| C00-D49: Neoplasms | Glioblastoma multiforme | C71 | EGFR; EGFR |
| C00-D49: Neoplasms | Cancer | C00-C96 | HIF1A; EGFR |