Plant Name: Plantago uniflora
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 5.281E-07 | 3.068E-03 | CASP1, CASP7, LCK, XDH |
| BP | GO:0008152; metabolic process | GO:0055114; oxidation-reduction process | 3.627E-06 | 5.794E-03 | ALDH1A1, ALOX15, CYP2D6, HPGD, HSD17B10, KDM4E, XDH |
| BP | GO:0009987; cellular process | GO:0097194; execution phase of apoptosis | 3.865E-06 | 5.794E-03 | CASP1, CASP7, PRKCD |
| BP | GO:0008152; metabolic process | GO:0038083; peptidyl-tyrosine autophosphorylation | 7.395E-06 | 7.668E-03 | EGFR, FYN, LCK |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 9.631E-06 | 8.388E-03 | ALOX15, HPGD |
| BP | GO:0008152; metabolic process | GO:0032270; positive regulation of cellular protein metabolic process | 1.126E-05 | 8.754E-03 | ALOX15, CASP1, CASP7, EGFR, FYN, LCK, PRKCD, XDH |
| MF | GO:0005488; binding | GO:0042610; CD8 receptor binding | 6.433E-07 | 3.068E-03 | FYN, LCK |
| MF | GO:0003824; catalytic activity | GO:0004715; non-membrane spanning protein tyrosine kinase activity | 9.478E-06 | 8.388E-03 | FYN, LCK, PRKCD |
| MF | GO:0005488; binding | GO:0042608; T cell receptor binding | 1.348E-05 | 9.417E-03 | FYN, LCK |
| MF | GO:0005488; binding | GO:0042609; CD4 receptor binding | 1.348E-05 | 9.417E-03 | FYN, LCK |
Showing 1 to 10 of 10 entries
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|
| hsa00232 | Caffeine metabolism_Homo sapiens_hsa00232 | 3.994E-03 | 2.829E-02 | XDH |
| hsa04066 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 3.007E-03 | 2.829E-02 | HIF1A; EGFR |
| hsa04072 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 5.782E-03 | 3.277E-02 | FYN; EGFR |
| hsa04380 | Osteoclast differentiation_Homo sapiens_hsa04380 | 4.883E-03 | 3.097E-02 | LCK; FYN |
| hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 1.567E-03 | 2.829E-02 | FYN; EGFR |
| hsa04650 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 5.101E-03 | 3.097E-02 | LCK; FYN |
| hsa04660 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 3.064E-03 | 2.829E-02 | LCK; FYN |
| hsa04726 | Serotonergic synapse_Homo sapiens_hsa04726 | 3.543E-03 | 2.829E-02 | CYP2D6; ALOX15 |
| hsa04912 | GnRH signaling pathway_Homo sapiens_hsa04912 | 2.357E-03 | 2.829E-02 | PRKCD; EGFR |
| hsa04915 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 2.782E-03 | 2.829E-02 | PRKCD; EGFR |
Showing 1 to 10 of 16 entries
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6 |
| A00-B99: Certain infectious and parasitic diseases | Cryptosporidium infection | A07.2 | EGFR |
| C00-D49: Neoplasms | Lung cancer | C33-C34 | EGFR |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | HIF1A; EGFR |
| C00-D49: Neoplasms | Gastric cancer | C16 | EGFR; EGFR |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | EGFR; EGFR |
| C00-D49: Neoplasms | Locally advanced head and neck cancer | C07-C14, C32, C33 | EGFR |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | EGFR; EGFR; EGFR |
| C00-D49: Neoplasms | Head and neck squamous cell carcinoma | C44 | EGFR |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | HIF1A; EGFR |
Showing 1 to 10 of 56 entries