Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
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GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:0035335; peptidyl-tyrosine dephosphorylation | 2.084E-07 | 2.559E-03 | ACP1, PTPN1, PTPN2, PTPRF |
BP | GO:0009987; cellular process | GO:0038183; bile acid signaling pathway | 8.842E-07 | 4.814E-03 | GPBAR1, NR1H4 |
MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 8.842E-07 | 4.814E-03 | GPBAR1, NR1H4 |
BP | GO:0009987; cellular process | GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway | 1.768E-06 | 7.699E-03 | PTPN1, PTPN2 |
BP | GO:0050896; response to stimulus | GO:0046626; regulation of insulin receptor signaling pathway | 2.495E-06 | 7.762E-03 | NR1H4, PTPN1, PTPN2 |
Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|
hsa04520 | Adherens junction_Homo sapiens_hsa04520 | 7.854E-06 | 1.571E-04 | PTPN1; ACP1; PTPRF |
hsa04931 | Insulin resistance_Homo sapiens_hsa04931 | 1.568E-03 | 1.568E-02 | PTPN1; PTPRF |
hsa04910 | Insulin signaling pathway_Homo sapiens_hsa04910 | 2.531E-03 | 1.688E-02 | PTPN1; PTPRF |
ICD10 Disease Category | Disease Name | ICD10 Code | Linked Targets |
---|---|---|---|
E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic disorders | E70-E89 | GPBAR1; HSD11B1 |
A00-B99: Certain infectious and parasitic diseases | Infections | A00-B99 | PTPN1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Metabolic syndrome x | E88.81 | HSD11B1 |
H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | HSD11B1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PTPN1; PTPN1; GPBAR1; HSD11B1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Non-insulin dependent diabetes | E11.9 | HSD11B1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PTPN1; HSD11B1 |
J00-J99: Diseases of the respiratory system | Influenza virus | J11.1 | HSD11B1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | PTPN1; HSD11B1; HSD11B1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | HSD11B1 |
I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | HSD11B1 |
NA: NA | Colour dead tissues | NA | PTPN1 |
E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | HSD11B1 |