CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.930E-11	1.073E-06	CA1, CA12, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.116E-09	2.304E-05	CA1, CA12, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.868E-09	3.533E-05	CA1, CA12, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	9.914E-07	2.906E-03	CA1, CA12, CA7, CA9, NR1H4, PTPN1
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	1.447E-06	3.485E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0046626; regulation of insulin receptor signaling pathway	1.818E-06	3.599E-03	NR1H4, PTPN1, PTPN2
CC	GO:0044464; cell part	GO:0005641; nuclear envelope lumen	6.743E-06	9.789E-03	ALOX5, PTGES

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa00910	Nitrogen metabolism_Homo sapiens_hsa00910	7.476E-11	8.971E-10	CA12; CA1; CA7; CA9
hsa00590	Arachidonic acid metabolism_Homo sapiens_hsa00590	4.187E-04	2.512E-03	ALOX5; PTGES
hsa04614	Renin-angiotensin system_Homo sapiens_hsa04614	1.144E-02	4.577E-02	PREP

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
NA: NA	Colour dead tissues	NA	PTPN1
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	PREP
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA1
C00-D49: Neoplasms	Renal cancer	C64	CA9
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5
C00-D49: Neoplasms	Breast cancer	C50	CA9
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5
K00-K95: Diseases of the digestive system	Celiac disease	K90.0	PREP
C00-D49: Neoplasms	Cancer	C00-C96	CA1; CA9
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGES
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	PREP
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1; PTPN1
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1; CA1
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PREP
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	PREP
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5; ALOX5
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Boswellia papyrifera

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Human Protein Targets

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases