CMAUP Plant Collective Molecular Activities

Plant Name: Vincetoxicum stauntonii

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.254E-06	9.101E-03	ADRA2A, ADRA2C

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
hsa04080	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.333E-05	2.800E-03	HRH3; ADRA2C; ADRA2A; TSHR
hsa04022	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.538E-04	9.227E-03	MAPK1; ADRA2C; ADRA2A
hsa04024	cAMP signaling pathway_Homo sapiens_hsa04024	2.578E-04	1.031E-02	MAPK1; PPARA; TSHR
hsa05140	Leishmaniasis_Homo sapiens_hsa05140	9.986E-04	2.397E-02	MAPK1; TLR2
hsa04976	Bile secretion_Homo sapiens_hsa04976	9.450E-04	2.397E-02	CA2; CYP3A4
hsa04620	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	2.089E-03	3.582E-02	MAPK1; TLR2
hsa05142	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	2.012E-03	3.582E-02	MAPK1; TLR2
hsa05145	Toxoplasmosis_Homo sapiens_hsa05145	2.580E-03	3.870E-02	MAPK1; TLR2
hsa05161	Hepatitis B_Homo sapiens_hsa05161	3.916E-03	4.699E-02	MAPK1; TLR2
hsa05160	Hepatitis C_Homo sapiens_hsa05160	3.263E-03	4.351E-02	MAPK1; PPARA

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Melanoma	C43	TLR2
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Eating disorder	E66, F50, I10-I16, I50	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C
S00-T88: Injury, poisoning and certain other consequences of external causes	Radiation sickness	T66	TLR2
G00-G99: Diseases of the nervous system G00-G99	Mild to moderate alzheimer disease	G30	HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	HRH3
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C; HRH3; HRH3
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C; HRH3
C00-D49: Neoplasms	Prostate cancer	C61	TLR2
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C; HRH3
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Excessive daytime sleepiness	F51.1, G47.1	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C; HRH3
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TLR2
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C; HRH3
E00-E89: Endocrine, nutritional and metabolic diseases	Obese insulin-resistant disorders	E11	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	HRH3
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	HRH3; CYP3A4
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sleep disorders	F51, G47	HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	TLR2
NA: NA	Edema	NA	CA2
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	HRH3; HRH3
G00-G99: Diseases of the nervous system G00-G99	Narcolepsy	G47.4	HRH3
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2C; HRH3; HRH3; ADRA2A
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	HRH3
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	HRH3; HRH3
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C
C00-D49: Neoplasms	Pancreatic cancer	C25	TLR2
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Musculoskeletal pain	R52, G89	HRH3
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	TLR2
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	HRH3; ADRA2A
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	HRH3
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	HRH3

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases