Plant Name: Convolvulus scammonia
Collective Molecular Activities at 10μM Activity Cutoff
List of Human Proteins Collectively Targeted by the Plant
Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target
| Target Class |
Target Proteins |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Human Protein Targets
| Protein Class |
Gene ID |
Protein Name |
Uniprot ID |
Target ChEMBL ID |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type |
GO Category |
Enriched GO Terms |
p-Value |
Adjusted p-Value |
Enriched Genes |
| MF |
GO:0003824; catalytic activity
|
GO:0004089; carbonate dehydratase activity |
8.300E-08 |
1.807E-03 |
CA12, CA7, CA9 |
| BP |
GO:0009987; cellular process
|
GO:0038183; bile acid signaling pathway |
1.061E-06 |
6.022E-03 |
GPBAR1, NR1H4 |
| BP |
GO:0008152; metabolic process
|
GO:0006730; one-carbon metabolic process |
1.293E-06 |
6.022E-03 |
CA12, CA7, CA9 |
| MF |
GO:0060089; molecular transducer activity
|
GO:0038181; bile acid receptor activity |
1.061E-06 |
6.022E-03 |
GPBAR1, NR1H4 |
| BP |
GO:0051179; localization
|
GO:0015701; bicarbonate transport |
2.392E-06 |
8.679E-03 |
CA12, CA7, CA9 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10, ordered by adjusted p-value
Detailed Information of Enriched KEGG Pathways
| Pathway ID |
Pathway Name |
p-Value |
Adjusted p-Value |
Enriched Genes |
| hsa00910 |
Nitrogen metabolism_Homo sapiens_hsa00910 |
1.117E-07 |
3.016E-06 |
CA12; CA7; CA9 |
| hsa05134 |
Legionellosis_Homo sapiens_hsa05134 |
4.815E-04 |
6.033E-03 |
CASP7; CASP1 |
| hsa00830 |
Retinol metabolism_Homo sapiens_hsa00830 |
6.722E-04 |
6.033E-03 |
CYP1A2; ALDH1A1 |
| hsa05133 |
Pertussis_Homo sapiens_hsa05133 |
8.938E-04 |
6.033E-03 |
CASP7; CASP1 |
| hsa01100 |
Metabolic pathways_Homo sapiens_hsa01100 |
4.854E-03 |
1.872E-02 |
AKR1B10; CYP1A2; ALDH1A1; HSD17B10 |
| hsa05010 |
Alzheimer's disease_Homo sapiens_hsa05010 |
4.380E-03 |
1.872E-02 |
CASP7; HSD17B10 |
| hsa00232 |
Caffeine metabolism_Homo sapiens_hsa00232 |
2.997E-03 |
1.618E-02 |
CYP1A2 |
Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)
Detailed Information of Human Diseases
| ICD10 Disease Category |
Disease Name |
ICD10 Code |
Linked Targets |
| C00-D49: Neoplasms |
Clear cell renal cell carcinoma |
C64 |
CA9 |
| C00-D49: Neoplasms |
Renal cancer |
C64 |
CA9 |
| C00-D49: Neoplasms |
Cancer |
C00-C96 |
CA9 |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Metabolic disorders |
E70-E89 |
GPBAR1 |
| C00-D49: Neoplasms |
Breast cancer |
C50 |
CA9 |
| E00-E89: Endocrine, nutritional and metabolic diseases |
Type 2 diabetes |
E11 |
GPBAR1 |
| C00-D49: Neoplasms |
Solid tumours |
C00-D48 |
CA9 |
| G00-G99: Diseases of the nervous system G00-G99 |
Epilepsy |
G40 |
CASP1 |
| C00-D49: Neoplasms |
Lymphoma |
C81-C86 |
CA9 |
| L00-L99: Diseases of the skin and subcutaneous tissue |
Fibrosis |
L90.5 |
CASP1 |
| M00-M99: Diseases of the musculoskeletal system and connective tissue |
Rheumatoid arthritis |
M05-M06 |
CASP1 |