CMAUP Plant Collective Molecular Activities

Plant Name: Teucrium betonicum

Collective Molecular Activities at 10μM Activity Cutoff

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Hydrolase	GAA; MGAM;
Enzyme_unclassified	TDP1; BLM; HSD17B1; AKR1B1; ALDH1A1; AOX1;
Protein Kinase	ABL1; MAPK1; EGFR;
Lyase	CA12; CA7; CA4;
Nuclear hormone receptor subfamily 3 group A	ESR1; ESR2;
Nuclear hormone receptor subfamily 3 group B	ESRRB; ESRRA;
Oxidoreductase	MAOA; ALDH2;
Transcription Factor	HIF1A; TP53; NFKB1;
ATP-binding cassette	ABCG2;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;
Unclassified	LMNA; RAB9A; NPC1; MAPT; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	TBXAS1; CYP2C19; CYP2C9; CYP19A1; CYP3A4; CYP1A2; CYP1B1;

Detailed Information of Human Protein Targets

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Cytochrome P450 family 5	TBXAS1	Thromboxane-A synthase	P24557	CHEMBL1835
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	AOX1	Aldehyde oxidase	Q06278	CHEMBL3257
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	MGAM	Maltase-glucoamylase	O43451	CHEMBL2074
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Nuclear hormone receptor subfamily 3 group A	ESR1	Estrogen receptor alpha	P03372	CHEMBL206
Nuclear hormone receptor subfamily 3 group A	ESR2	Estrogen receptor beta	Q92731	CHEMBL242
Nuclear hormone receptor subfamily 3 group B	ESRRB	Estrogen-related receptor beta	O95718	CHEMBL3751
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Oxidoreductase	ALDH2	Aldehyde dehydrogenase	P05091	CHEMBL1935
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	ABL1	Tyrosine-protein kinase ABL	P00519	CHEMBL1862
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	EGFR	Epidermal growth factor receptor erbB1	P00533	CHEMBL203
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.122E-10	1.155E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.482E-10	1.345E-06	CYP19A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0005488; binding	GO:0005496; steroid binding	3.706E-10	1.345E-06	CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NPC1
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.196E-10	2.208E-06	AOX1, CYP19A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, TBXAS1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.953E-09	4.593E-06	CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	6.133E-09	7.419E-06	CYP19A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4, TBXAS1
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	6.940E-09	7.954E-06	CYP1A2, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	3.040E-08	2.758E-05	CYP1A2, CYP2C9, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	8.283E-08	6.012E-05	CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.222E-07	8.063E-05	CYP19A1, CYP1A2, CYP1B1, CYP3A4
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	4.132E-07	2.368E-04	ABL1, BLM, CYP1B1, EGFR, ESR1, MAPK1, NFKB1, NPC1
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	6.298E-07	3.366E-04	CYP19A1, CYP2C19, CYP2C9, CYP3A4
BP	GO:0050896; response to stimulus	GO:0071417; cellular response to organonitrogen compound	1.006E-06	5.097E-04	ABL1, AKR1B1, BLM, EGFR, MAPK1, NFKB1, TP53, TSHR
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.653E-06	7.331E-04	CYP1A2, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0016903; oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.817E-06	7.393E-04	AKR1B1, ALDH1A1, ALDH2, AOX1
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	2.463E-06	9.248E-04	AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006805; xenobiotic metabolic process	3.216E-06	1.129E-03	CYP1A2, CYP1B1, CYP2C19, CYP2C9, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	3.405E-06	1.177E-03	CA12, CA4, CA7
MF	GO:0060089; molecular transducer activity	GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	3.972E-06	1.351E-03	ESR1, ESR2
BP	GO:0065007; biological regulation	GO:0098771; inorganic ion homeostasis	4.111E-06	1.365E-03	ABCG2, ABL1, CA12, CA7, EGFR, ESR1, HIF1A, MAPK1, TP53
BP	Unclassified;	GO:0032846; positive regulation of homeostatic process	5.672E-06	1.760E-03	ABL1, CA7, EGFR, HIF1A, MAPK1, NPC1
BP	GO:0022414; reproductive process	GO:0001892; embryonic placenta development	8.471E-06	2.396E-03	EGFR, ESRRB, HIF1A
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	9.923E-06	2.770E-03	AKR1B1, HIF1A, MAPK1, MAPT
BP	GO:0008152; metabolic process	GO:0000023; maltose metabolic process	1.190E-05	3.160E-03	GAA, MGAM
BP	GO:0002376; immune system process	GO:0001922; B-1 B cell homeostasis	1.190E-05	3.160E-03	ABL1, HIF1A
MF	GO:0003824; catalytic activity	GO:0032450; maltose alpha-glucosidase activity	1.190E-05	3.160E-03	GAA, MGAM
BP	GO:0008152; metabolic process	GO:0022900; electron transport chain	1.783E-05	4.413E-03	AKR1B1, ALDH2, AOX1, CYP19A1, CYP1A2
BP	GO:0008152; metabolic process	GO:0006706; steroid catabolic process	1.916E-05	4.639E-03	CYP19A1, CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	2.187E-05	5.176E-03	CYP1B1, EGFR, HIF1A, MAPT, TP53
MF	GO:0005488; binding	GO:0034056; estrogen response element binding	2.377E-05	5.449E-03	ESR1, ESR2
MF	GO:0003824; catalytic activity	GO:0004558; alpha-1,4-glucosidase activity	2.377E-05	5.449E-03	GAA, MGAM
BP	GO:0008152; metabolic process	GO:0008209; androgen metabolic process	2.407E-05	5.460E-03	CYP19A1, CYP3A4, ESR1
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.693E-05	6.046E-03	BLM, CA12, CA4, CA7, ESR1, ESR2, ESRRA, ESRRB, TP53
MF	GO:0005488; binding	GO:0003690; double-stranded DNA binding	3.110E-05	6.574E-03	EGFR, ESR1, ESR2, ESRRA, ESRRB, HIF1A, NFKB1, TDP1, TP53
BP	GO:0009987; cellular process	GO:0071276; cellular response to cadmium ion	3.289E-05	6.887E-03	CYP1A2, EGFR, MAPK1
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.463E-05	7.182E-03	CA4, EGFR, SLCO1B1, SLCO1B3, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10, ordered by adjusted p-value

Detailed Information of Enriched KEGG Pathways

Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes

Human Diseases Associated with the Target Proteins of the Plant (Activity≤10μM)

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Linked Targets
C00-D49: Neoplasms	Locally advanced head and neck cancer	C07-C14, C32, C33	EGFR
C00-D49: Neoplasms	Lymphoma	C81-C86	HIF1A; EGFR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ESRRA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatological disease	L00-L99	ESRRA
C00-D49: Neoplasms	Glioma	C71	ABL1; EGFR; EGFR
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	ALDH2
C00-D49: Neoplasms	Chronic myelogenous leukaemia	C92.1	ABL1; ABL1
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	EGFR
K00-K95: Diseases of the digestive system	Gastrointestinal disease	K00-K93	EGFR; ESRRA
N00-N99: Diseases of the genitourinary system	Irregularities	N92.6	ESR1
C00-D49: Neoplasms	Intestinal cancer	NA	ABL1
NA: NA	Postmenopausal disorder	NA	ESR1
C00-D49: Neoplasms	Brain cancer	C71, D33	EGFR; EGFR; ESR1
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1; EGFR; EGFR; EGFR; ESR1; ESR1
A00-B99: Certain infectious and parasitic diseases	Cryptosporidium infection	A07.2	EGFR
NA: NA	Gonorrheal vaginitis	NA	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA; MAOA
Z00-Z99: Factors influencing health status and contact with health services	Hormone replacement therapy	Z79.890	ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Hyperglycemia	R73.9	MGAM
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	TBXAS1
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	MGAM
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic cataract	E10.36, E11.36	AKR1B1
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	ESR1; ESR1
C00-D49: Neoplasms	Hormone refractory prostate cancer	C61	ESR1
C00-D49: Neoplasms	Glioblastoma multiforme	C71	EGFR; EGFR
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	AKR1B1
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	AKR1B1
C00-D49: Neoplasms	Carcinoma	D00-D09	ESR1
C00-D49: Neoplasms	Cancer	C00-C96	HIF1A; TP53; ABL1; MAPK1; NFKB1; EGFR; ESR1; ESR1
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Cachexia	R64	ESRRA
E00-E89: Endocrine, nutritional and metabolic diseases	Dietary shortage	E40-E46	ABL1
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR
S00-T88: Injury, poisoning and certain other consequences of external causes	Vulnerary	S00-T98	EGFR
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	TBXAS1
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ESR1
A00-B99: Certain infectious and parasitic diseases	Acquired immune deficiency syndrome	B20	MGAM
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic complication	E08-E13	AKR1B1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	AKR1B1; ESRRA
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	ESR1
N00-N99: Diseases of the genitourinary system	Dyspareunia	N94.1	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	ESRRA
N00-N99: Diseases of the genitourinary system	Vagina disease	N76.0	ESR1
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA; MAPT
C00-D49: Neoplasms	Refractory breast cancer	C50	EGFR
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA
C00-D49: Neoplasms	Esophageal cancer	C15	EGFR
C00-D49: Neoplasms	Urethral cancer	NA	EGFR
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	TBXAS1
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ESRRA
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	AKR1B1; MGAM
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	ESRRA
C00-D49: Neoplasms	Solid tumours	C00-D48	HIF1A; TP53; ABL1; MAPK1; EGFR
E00-E89: Endocrine, nutritional and metabolic diseases	Estrogen deficiency	E28.39	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; TBXAS1; MGAM
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR
A00-B99: Certain infectious and parasitic diseases	Trematode infection	B66.9	ESR1
N00-N99: Diseases of the genitourinary system	Nephritis	N00-N19, N25-N29	TBXAS1
Z00-Z99: Factors influencing health status and contact with health services	Contraception	Z30	ESR1
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	EGFR
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	ABL1
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53; TP53
E00-E89: Endocrine, nutritional and metabolic diseases	Female hypogonadism	E23, E28	ESR1
C00-D49: Neoplasms	Myeloid leukemia	C92	ABL1
C00-D49: Neoplasms	Colon cancer	C50	EGFR
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53; EGFR; EGFR
I00-I99: Diseases of the circulatory system	Pulmonary arterial hypertension	I27.0, I27.2	HIF1A
C00-D49: Neoplasms	Adrenocortical carcinoma	C74.0	ESR1
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	EGFR; ALDH2
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	EGFR; EGFR
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	EGFR
C00-D49: Neoplasms	Pancreatic cancer	C25	EGFR
C00-D49: Neoplasms	Advanced prostate cancer	C61	ESR1
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ESR1
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT
C00-D49: Neoplasms	Advanced cancers	C00-C96	EGFR
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1
A00-B99: Certain infectious and parasitic diseases	Dengue fever	A90	MGAM
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1
C00-D49: Neoplasms	Lung cancer	C33-C34	ABL1; EGFR
N00-N99: Diseases of the genitourinary system	Menorrhagia	N92.0	ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA; ALDH2
Z00-Z99: Factors influencing health status and contact with health services	Oral contraceptive	Z30	ESR1
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Osteopetrosis	Q78.2	ESR1
N00-N99: Diseases of the genitourinary system	Infertility	N97.0	ESR1
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53
C00-D49: Neoplasms	Prostate cancer	C61	ABL1; EGFR; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ESRRA
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4; CA4
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4
E00-E89: Endocrine, nutritional and metabolic diseases	Hypogonadism	E23.0, E28.3, E29.1	ESR1
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Muscle disease	M60-M63	MGAM
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ESR1; ESR1
H00-H59: Diseases of the eye and adnexa	Eye disorders	H00-H59	ESR1
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ESR1
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53
N00-N99: Diseases of the genitourinary system	Menopause symptoms	N95.0	ESR1; ESR1
L00-L99: Diseases of the skin and subcutaneous tissue	Acne vulgaris	L70.0	ESR1; ESRRA
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	TBXAS1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	CYP3A4; MAOA
N00-N99: Diseases of the genitourinary system	Female infertility due to anovulation	N97.0	ESR1
N00-N99: Diseases of the genitourinary system	Female infertility	N97.0	ESR1; ESR1
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Female sexual dysfunction	F52	ESR1
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A
C00-D49: Neoplasms	Gastric cancer	C16	EGFR; EGFR
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	EGFR
C00-D49: Neoplasms	Ovarian cancer	C56	EGFR; EGFR
J00-J99: Diseases of the respiratory system	Asthma	J45	TBXAS1; ESRRA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthralgia	M25.5	ESR1
N00-N99: Diseases of the genitourinary system	Post-menopausal vaginal atrophy	N95.2	ESR1
E00-E89: Endocrine, nutritional and metabolic diseases	Pompe's disease	E74.02	GAA; MGAM
N00-N99: Diseases of the genitourinary system	Atrophic vaginitis	N95.2	ESR1
M00-M99: Diseases of the musculoskeletal system and connective tissue	Atrophy	M62.571	ESR1
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	TBXAS1
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR
NA: NA	Menopausal disorder	NA	ESR1
C00-D49: Neoplasms	Melanoma	C43	EGFR
C00-D49: Neoplasms	Malignant tumor	C00-C75, C7A, C7B	EGFR
H00-H59: Diseases of the eye and adnexa	Choroidal neovascularisation	H35	ESRRA
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoporosis	M80-M81, Z79.890	ESR1
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53
C00-D49: Neoplasms	Head and neck squamous cell carcinoma	C44	EGFR
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53; EGFR; EGFR; EGFR; AKR1B1
C00-D49: Neoplasms	Leukemia	C90-C95	ABL1; ESR1
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53
C00-D49: Neoplasms	Inflammatory breast cancer	C50	EGFR
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1; EGFR
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic neuropathy	E11.40	AKR1B1

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases