Access Plants That Show Activities on Each Target Protein

Target Class L1 Target Class L2 Target Class L3 Target Gene Symbol Target Name No. of Plants No. of Medicinal Plants No. of Food Plants No. of Human Edible Plants No. of Agricultural Plants No. of Garden Plants
Unclassified GMNN Geminin 142 81 5 34 0 5
Ion channel Ligand-gated ion channel GABA-A receptor GABRR1 GABA receptor rho-1 subunit 56 35 5 19 0 4
Unclassified CXCL8 Interleukin-8 3 3 0 3 0 0
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group F RORC Nuclear receptor ROR-gamma 696 330 14 204 0 19
Epigenetic regulator Reader Plant homeodomain KMT2A Histone-lysine N-methyltransferase MLL 120 73 11 44 0 6
Enzyme Isomerase TOP2A DNA topoisomerase II alpha 322 165 15 99 0 10
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C PPARD Peroxisome proliferator-activated receptor delta 993 537 49 315 1 28
Enzyme Lyase CA4 Carbonic anhydrase IV 2584 1260 96 738 3 61
Enzyme Lyase CA6 Carbonic anhydrase VI 2580 1256 94 727 2 61
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) NMUR2 Neuromedin-U receptor 2 983 495 37 291 0 22
Enzyme IDO1 Indoleamine 2,3-dioxygenase 32 26 6 13 0 3
Epigenetic regulator Reader Bromodomain EP300 Histone acetyltransferase p300 45 25 5 14 1 4
Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group A ESR1 Estrogen receptor alpha 1084 564 41 326 1 21
Epigenetic regulator Reader Bromodomain KAT2B Histone acetyltransferase PCAF 18 14 0 8 1 1
Enzyme Protease Metallo protease MMP12 Matrix metalloproteinase 12 717 372 27 226 1 20
Enzyme Cytochrome P450 Cytochrome P450 family 3 CYP3A4 Cytochrome P450 3A4 2740 1378 104 797 0 60
Enzyme Protease Metallo protease MMP13 Matrix metalloproteinase 13 1236 613 43 376 0 30
Membrane receptor Frizzled family G protein-coupled receptor Smoothened receptor (frizzled family GPCR) SMO Smoothened homolog 4 2 0 2 0 0
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2D6 Cytochrome P450 2D6 728 398 38 210 0 15
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) APLNR Apelin receptor 1 1 0 1 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) CCR6 C-C chemokine receptor type 6 2 2 0 1 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) CXCR5 C-X-C chemokine receptor type 5 1 1 0 1 0 0
Enzyme ALOX12 Arachidonate 12-lipoxygenase 1637 809 55 491 1 43
Enzyme MAN1B1 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 2 1 1 0 0 0
Enzyme HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 734 347 17 210 0 18
Enzyme HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 14 9 1 3 0 0
Enzyme Lyase CA5A Carbonic anhydrase VA 2388 1170 88 686 2 55
Enzyme Lyase CA5B Carbonic anhydrase VB 1516 787 74 456 1 38
Enzyme Lyase CA3 Carbonic anhydrase III 2142 1054 78 621 2 50
Enzyme Phosphatase Protein Phosphatase ACP1 Low molecular weight phosphotyrosine protein phosphatase 685 322 14 200 0 18
Unclassified HTT Huntingtin 886 463 37 271 0 19
Enzyme Phosphatase Protein Phosphatase PTPN2 T-cell protein-tyrosine phosphatase 1020 471 31 279 0 27
Enzyme Phosphatase Protein Phosphatase DUSP3 Dual specificity protein phosphatase 3 286 146 13 90 0 6
Enzyme SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 24 12 1 4 0 0
Enzyme GAPDH Glyceraldehyde-3-phosphate dehydrogenase liver 5 4 1 2 0 1
Enzyme Protease Cysteine protease CASP7 Caspase-7 662 340 27 213 0 22
Enzyme MIF Macrophage migration inhibitory factor 76 43 10 24 0 3
Enzyme SENP8 Sentrin-specific protease 8 8 7 2 2 0 0
Enzyme SENP7 Sentrin-specific protease 7 26 15 3 6 0 0
Enzyme SENP6 Sentrin-specific protease 6 26 15 3 6 0 0
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM1 Metabotropic glutamate receptor 1 21 16 3 10 0 1
Enzyme Kinase Protein Kinase PIM1 Serine/threonine-protein kinase PIM1 1439 716 48 432 0 34
Enzyme AKR1B10 Aldo-keto reductase family 1 member B10 1351 688 54 397 0 36
Unclassified RAD52 DNA repair protein RAD52 homolog 37 22 1 13 0 0
Unclassified MITF Microphthalmia-associated transcription factor 38 19 3 13 0 0
Unclassified PAX8 Paired box protein Pax-8 117 57 8 30 0 4
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CNR2 Cannabinoid CB2 receptor 189 81 5 51 0 1
Enzyme HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 5 2 1 1 0 1
Enzyme PNP Purine nucleoside phosphorylase 14 11 1 4 0 1
Enzyme Kinase Protein Kinase LCK Tyrosine-protein kinase LCK 53 29 4 10 0 0
Ion channel Ligand-gated ion channel GABA-A receptor GABRR2 GABA receptor rho-2 subunit 13 6 2 5 0 1
Enzyme PGD 6-phosphogluconate dehydrogenase 183 89 7 49 0 8
Enzyme Kinase Protein Kinase MET Hepatocyte growth factor receptor 1486 726 49 438 1 36
Enzyme P4HB Protein disulfide-isomerase 431 218 22 123 0 14
Enzyme Kinase Protein Kinase CDK2 Cyclin-dependent kinase 2 84 40 3 19 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) P2RY6 Pyrimidinergic receptor P2Y6 1 1 0 0 0 0
Enzyme Kinase Protein Kinase FYN Tyrosine-protein kinase FYN 65 40 4 19 0 1
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GABBR1 GABA-B receptor 1 56 35 5 19 0 4
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) NPSR1 Neuropeptide S receptor 1389 703 53 423 0 34
Enzyme FAAH Anandamide amidohydrolase 458 235 27 154 1 12
Unclassified FABP4 Fatty acid binding protein adipocyte 533 326 39 192 0 21
Transporter Primary active transporter ATP-binding cassette ABCG2 ATP-binding cassette sub-family G member 2 2094 1008 69 607 3 52
Enzyme Kinase Protein Kinase CDK1 Cyclin-dependent kinase 1 1264 627 43 386 0 31
Enzyme Kinase Protein Kinase MAPK8 c-Jun N-terminal kinase 1 1 1 0 1 0 0
Enzyme Kinase Protein Kinase MAPK9 c-Jun N-terminal kinase 2 14 3 0 5 0 0
Enzyme Isomerase TOP1 DNA topoisomerase I 33 25 0 14 0 1
Enzyme Kinase Protein Kinase AURKA Serine/threonine-protein kinase Aurora-A 396 196 16 112 0 8
Enzyme Kinase Protein Kinase AURKB Serine/threonine-protein kinase Aurora-B 1502 733 52 434 0 35
Enzyme Kinase Protein Kinase BRAF Serine/threonine-protein kinase B-raf 285 145 12 90 0 5
Enzyme Kinase Protein Kinase ERBB4 Receptor protein-tyrosine kinase erbB-4 3 2 0 2 0 0
Enzyme Kinase Protein Kinase PTK2 Focal adhesion kinase 1 1398 686 48 413 0 33
Enzyme Kinase Protein Kinase FES Tyrosine-protein kinase FES 1 1 0 1 0 0
Enzyme Kinase Protein Kinase IGF1R Insulin-like growth factor I receptor 1395 686 48 414 0 33
Enzyme TERT Telomerase reverse transcriptase 575 307 33 192 1 16
Enzyme Kinase Protein Kinase JAK3 Tyrosine-protein kinase JAK3 7 4 0 3 0 0
Enzyme Kinase Protein Kinase MAPKAPK2 MAP kinase-activated protein kinase 2 11 5 0 2 0 0
Enzyme PIK3CA PI3-kinase p110-alpha subunit 140 74 7 39 0 1
Enzyme PIK3CG PI3-kinase p110-gamma subunit 321 164 15 98 0 10
Enzyme Kinase Protein Kinase SYK Tyrosine-protein kinase SYK 946 486 34 287 0 22
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) OPRM1 Mu opioid receptor 26 13 2 5 0 3
Enzyme CYP2J2 Cytochrome P450 2J2 3 2 0 1 0 0
Enzyme Phosphodiesterase Phosphodiesterase 4 PDE4D Phosphodiesterase 4D 39 24 2 14 0 0
Enzyme Kinase Protein Kinase KDR Vascular endothelial growth factor receptor 2 1496 732 52 433 0 35
Enzyme Kinase Protein Kinase KIT Stem cell growth factor receptor 66 32 2 15 0 3
Enzyme Kinase Protein Kinase FGFR1 Fibroblast growth factor receptor 1 8 5 0 3 0 0
Enzyme HSD17B10 Endoplasmic reticulum-associated amyloid beta-peptide-binding protein 2574 1262 86 749 1 66
Enzyme HPGD 15-hydroxyprostaglandin dehydrogenase [NAD+] 1542 792 65 477 1 44
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC1A1 Excitatory amino acid transporter 3 19 14 3 9 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC1A2 Excitatory amino acid transporter 2 2 1 0 1 0 0
Unclassified NFE2L2 Nuclear factor erythroid 2-related factor 2 11 6 2 4 0 1
Enzyme PNMT Phenylethanolamine N-methyltransferase 1 1 1 0 0 1
Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C AR Androgen Receptor 1302 634 53 377 2 30
Unclassified SMAD3 Mothers against decapentaplegic homolog 3 285 145 12 90 0 5
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A2 Solute carrier family 22 member 2 14 8 2 3 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A3 Solute carrier family 22 member 3 22 13 2 8 0 0
Enzyme Protease Aspartic protease CTSD Cathepsin D 35 15 0 9 0 0
Unclassified AHR Aryl hydrocarbon receptor 803 390 38 231 1 21
Enzyme GLO1 Glyoxalase I 1533 752 53 458 1 39
Enzyme Protease Serine protease CTRC Chymotrypsin C 1 1 0 1 0 1
Enzyme BRCA1 Breast cancer type 1 susceptibility protein 50 36 12 20 0 4
Enzyme Kinase Protein Kinase CDK6 Cyclin-dependent kinase 6 816 397 25 243 0 17
Enzyme PIK3R1 PI3-kinase p85-alpha subunit 1236 613 43 376 0 30
Enzyme AMY1A;AMY1B;AMY1C Salivary alpha-amylase 168 80 2 54 0 4
Enzyme CBR1 Carbonyl reductase [NADPH] 1 167 75 2 50 0 4
Unclassified HSF1 Heat shock factor protein 1 13 9 1 6 0 0
Enzyme HSD17B1 Estradiol 17-beta-dehydrogenase 1 1388 686 56 409 2 35
Enzyme HSD17B2 Estradiol 17-beta-dehydrogenase 2 1410 691 51 421 1 38
Enzyme Protease Serine protease PREP Prolyl endopeptidase 5 2 0 2 0 0
Enzyme Protease Serine protease DPP4 Dipeptidyl peptidase IV 3 3 0 3 0 0
Transporter Primary active transporter ATP-binding cassette ABCC1 Multidrug resistance-associated protein 1 1822 875 67 524 1 47
Enzyme Kinase Protein Kinase CSNK2A1 Casein kinase II alpha 1772 871 57 520 0 41
Enzyme Cytochrome P450 Cytochrome P450 family 1 CYP1A1 Cytochrome P450 1A1 2230 1067 81 639 2 56
Enzyme Cytochrome P450 Cytochrome P450 family 1 CYP1B1 Cytochrome P450 1B1 2255 1084 82 648 2 57
Enzyme NOX4 NADPH oxidase 4 1796 861 62 520 2 46
Enzyme Kinase Protein Kinase CHEK1 Serine/threonine-protein kinase Chk1 7 6 0 3 0 1
Enzyme Kinase Protein Kinase RPS6KB1 Ribosomal protein S6 kinase 1 1 1 0 1 0 0
Enzyme Kinase Protein Kinase MAPKAPK5 MAP kinase-activated protein kinase 5 11 5 0 2 0 0
Enzyme Kinase Protein Kinase MAPK11 MAP kinase p38 beta 1 1 0 1 0 0
Enzyme GALK1 Galactokinase 7 7 2 3 0 1
Unclassified STAT6 Signal transducer and activator of transcription 6 1428 723 49 437 0 33
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) GPR35 G-protein coupled receptor 35 524 271 25 162 0 15
Unclassified NFKB1 Nuclear factor NF-kappa-B p105 subunit 2063 1034 78 611 2 51
Enzyme Kinase Protein Kinase CAMK2B CaM kinase II beta 1237 614 43 377 0 30
Enzyme MPO Myeloperoxidase 1261 625 47 381 0 32
Enzyme Kinase Protein Kinase FLT3 Tyrosine-protein kinase receptor FLT3 1801 872 62 528 2 46
Enzyme Kinase Protein Kinase PKN1 Protein kinase N1 1269 626 44 380 0 31
Enzyme Kinase Protein Kinase NEK6 Serine/threonine-protein kinase NEK6 1269 626 44 380 0 31
Enzyme Kinase Protein Kinase NEK2 Serine/threonine-protein kinase NEK2 1270 627 44 381 0 31
Enzyme Kinase Protein Kinase AXL Tyrosine-protein kinase receptor UFO 1270 627 44 381 0 31
Enzyme CES1 Acyl coenzyme A:cholesterol acyltransferase 42 25 1 8 0 0
Enzyme Kinase Protein Kinase NUAK1 NUAK family SNF1-like kinase 1 1394 685 48 413 0 33
Enzyme Kinase Protein Kinase ALK ALK tyrosine kinase receptor 1273 627 44 380 0 31
Enzyme PYGL Liver glycogen phosphorylase 1238 613 43 376 0 30
Unclassified MPG DNA-3-methyladenine glycosylase 2 2 0 2 0 0
Enzyme Kinase Protein Kinase CAMK1D CaM kinase I delta 6 3 0 2 0 0
Enzyme Kinase Protein Kinase CAMK2A CaM kinase II alpha 6 3 0 2 0 0
Enzyme Kinase Protein Kinase CAMK2D CaM kinase II delta 3 2 0 2 0 0
Enzyme Kinase Protein Kinase CAMK2G CaM kinase II gamma 3 2 0 2 0 0
Enzyme Kinase Protein Kinase CAMKK2 CaM-kinase kinase beta 6 3 0 2 0 0
Enzyme Kinase Protein Kinase CHEK2 Serine/threonine-protein kinase Chk2 5 3 0 2 0 0
Enzyme Kinase Protein Kinase CLK1 Dual specificty protein kinase CLK1 4 3 0 3 0 0
Enzyme Kinase Protein Kinase CLK2 Dual specificity protein kinase CLK2 7 4 0 3 0 0
Enzyme Kinase Protein Kinase CSNK1G2 Casein kinase I gamma 2 1 1 0 1 0 0
Enzyme Kinase Protein Kinase CSNK1G3 Casein kinase I isoform gamma-3 1 1 0 1 0 0
Enzyme Kinase Protein Kinase DAPK3 Death-associated protein kinase 3 1 1 0 1 0 0
Enzyme Kinase Protein Kinase PDPK1 3-phosphoinositide dependent protein kinase-1 56 26 1 17 0 0
Enzyme Kinase Protein Kinase PIM2 Serine/threonine-protein kinase PIM2 1 1 0 1 0 0
Enzyme Kinase Protein Kinase PIM3 Serine/threonine-protein kinase PIM3 7 5 0 5 0 0
Enzyme Kinase Protein Kinase PLK4 Serine/threonine-protein kinase PLK4 286 146 12 91 0 5
Enzyme Kinase Protein Kinase PRKACA cAMP-dependent protein kinase alpha-catalytic subunit 7 4 0 3 0 0
Enzyme Kinase Protein Kinase RPS6KA3 Ribosomal protein S6 kinase alpha 3 9 5 0 5 0 0
Enzyme Kinase Protein Kinase SLK Serine/threonine-protein kinase 2 3 2 0 2 0 0
Enzyme Kinase Protein Kinase STK17A Serine/threonine-protein kinase 17A 1 1 0 1 0 0
Enzyme Kinase Protein Kinase PBK PDZ-binding kinase 1 1 0 1 0 0
Enzyme Protease Serine protease PLG Plasminogen 12 5 0 2 0 0
Enzyme Kinase Protein Kinase DAPK1 Death-associated protein kinase 1 1379 675 48 418 1 36
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group H NR1H2 LXR-beta 1 0 0 0 0 0
Enzyme TK1 Thymidine kinase, cytosolic 79 39 6 20 0 2
Enzyme Phosphatase Protein Phosphatase PTPN1 Protein-tyrosine phosphatase 1B 1533 762 62 438 0 40
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR5A Serotonin 5a (5-HT5a) receptor 84 37 1 26 0 4
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR7 Serotonin 7 (5-HT7) receptor 99 48 3 32 0 5
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA1A Alpha-1a adrenergic receptor 35 20 3 11 0 3
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA1B Alpha-1b adrenergic receptor 5 5 1 2 0 0
Unclassified NISCH Nischarin 4 3 0 3 0 0
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group H NR1H3 LXR-alpha 95 51 4 35 0 3
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD5 Dopamine D5 receptor 17 8 0 8 0 0
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) GCGR Glucagon receptor 2 2 0 1 0 0
Enzyme Kinase Protein Kinase PRKCA Protein kinase C alpha 157 84 5 55 0 6
Epigenetic regulator Reader Bromodomain CREBBP CREB-binding protein 58 30 1 20 0 2
Enzyme Phosphatase Protein Phosphatase PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) 685 322 14 200 0 18
Enzyme ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 1 1 1 0 0 0
Unclassified GLI1 Zinc finger protein GLI1 40 15 4 12 0 1
Unclassified SHH Sonic hedgehog protein 9 7 1 4 0 0
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group I VDR Vitamin D receptor 2 1 0 0 0 0
Enzyme CES2 Carboxylesterase 2 53 33 2 13 0 0
Enzyme Hydrolase ACHE Acetylcholinesterase 1905 967 70 547 0 43
Enzyme Phosphatase Protein Phosphatase PTPN6 Protein-tyrosine phosphatase 1C 37 20 0 6 0 0
Enzyme Phosphatase Protein Phosphatase PTPN11 Protein-tyrosine phosphatase 2C 56 34 3 14 0 1
Enzyme Cytochrome P450 Cytochrome P450 family 1 CYP1A2 Cytochrome P450 1A2 2896 1420 103 833 3 67
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) TSHR Thyroid stimulating hormone receptor 2163 1130 106 644 2 52
Unclassified HIF1A Hypoxia-inducible factor 1 alpha 2642 1308 103 760 3 63
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2C9 Cytochrome P450 2C9 1896 927 79 554 2 35
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2C19 Cytochrome P450 2C19 2089 1031 84 617 2 43
Enzyme Protease Cysteine protease CTSB Cathepsin B 8 6 2 5 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADORA1 Adenosine A1 receptor 228 136 10 80 0 4
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADORA2A Adenosine A2a receptor 229 137 11 79 0 4
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADORA3 Adenosine A3 receptor 460 253 22 145 0 10
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA1D Alpha-1d adrenergic receptor 24 12 2 5 0 2
Enzyme Kinase Protein Kinase CDK4 Cyclin-dependent kinase 4 7 2 0 1 0 0
Enzyme Transferase POLA1 DNA polymerase alpha subunit 11 7 2 5 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA2A Alpha-2a adrenergic receptor 1037 526 39 306 0 24
Unclassified NPC1L1 Niemann-Pick C1-like protein 1 6 2 0 4 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA2B Alpha-2b adrenergic receptor 102 69 13 34 0 6
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRA2C Alpha-2c adrenergic receptor 1109 553 40 319 0 24
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRB1 Beta-1 adrenergic receptor 4 3 2 1 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRB2 Beta-2 adrenergic receptor 22 10 3 4 0 2
Enzyme FBP1 Fructose-1,6-bisphosphatase 2 0 0 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADRB3 Beta-3 adrenergic receptor 26 14 4 7 0 2
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A2 Norepinephrine transporter 202 107 12 55 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CNR1 Cannabinoid CB1 receptor 136 64 3 41 0 1
Enzyme Lyase CA2 Carbonic anhydrase II 2981 1446 110 838 3 68
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) CCR2 C-C chemokine receptor type 2 2 1 0 1 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) CXCR1 Interleukin-8 receptor A 1236 613 43 376 0 30
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2A6 Cytochrome P450 2A6 357 214 32 110 1 14
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD1 Dopamine D1 receptor 152 87 4 51 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD2 Dopamine D2 receptor 132 71 6 36 0 4
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD3 Dopamine D3 receptor 154 76 7 39 0 9
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) DRD4 Dopamine D4 receptor 1258 623 43 383 0 30
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A3 Dopamine transporter 46 25 7 11 0 1
Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group A ESR2 Estrogen receptor beta 1200 645 63 379 1 32
Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C NR3C1 Glucocorticoid receptor 86 38 5 25 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HRH1 Histamine H1 receptor 20 13 4 10 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HRH2 Histamine H2 receptor 20 13 5 9 0 1
Enzyme Protease Metallo protease LTA4H Leukotriene A4 hydrolase 1 1 0 1 0 0
Enzyme Oxidoreductase HMGCR HMG-CoA reductase 45 28 8 14 0 1
Enzyme Protease Serine protease F10 Coagulation factor X 146 70 5 46 0 5
Unclassified ITGAL Leukocyte adhesion glycoprotein LFA-1 alpha 21 13 2 10 0 2
Enzyme Protease Metallo protease ANPEP Aminopeptidase N 11 6 2 4 0 1
Enzyme PARP1 Poly [ADP-ribose] polymerase-1 654 337 28 206 1 17
Enzyme TNKS2 Tankyrase-2 908 461 37 274 1 22
Enzyme Kinase Protein Kinase MAP3K8 Mitogen-activated protein kinase kinase kinase 8 285 145 12 90 0 5
Enzyme Kinase Protein Kinase EPHB4 Ephrin type-B receptor 4 287 146 12 91 0 5
Enzyme Kinase Protein Kinase FLT4 Vascular endothelial growth factor receptor 3 288 147 12 92 0 5
Enzyme Kinase Protein Kinase INSR Insulin receptor 499 257 22 155 0 13
Enzyme Kinase Protein Kinase PDGFRB Platelet-derived growth factor receptor beta 285 145 12 90 0 5
Enzyme Kinase Protein Kinase TEK Tyrosine-protein kinase TIE-2 285 145 12 90 0 5
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) MC4R Melanocortin receptor 4 2 1 0 1 0 0
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2A13 Cytochrome P450 2A13 73 43 6 23 0 2
Enzyme ADK Adenosine kinase 224 134 10 78 0 4
Enzyme Oxidoreductase MAOA Monoamine oxidase A 1831 908 64 539 2 46
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM1 Muscarinic acetylcholine receptor M1 39 32 6 10 0 1
Enzyme Kinase Protein Kinase MYLK Myosin light chain kinase, smooth muscle 323 165 15 99 0 10
Enzyme GFER FAD-linked sulfhydryl oxidase ALR 846 435 22 264 0 21
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM2 Muscarinic acetylcholine receptor M2 30 24 6 8 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM3 Muscarinic acetylcholine receptor M3 31 25 5 8 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM4 Muscarinic acetylcholine receptor M4 19 14 4 6 0 1
Unclassified SAE1 SUMO-activating enzyme subunit 1 11 5 3 1 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) CHRM5 Muscarinic acetylcholine receptor M5 30 25 5 8 0 1
Ion channel Ligand-gated ion channel P2X receptor P2RX1 P2X purinoceptor 1 2 2 2 0 0 1
Enzyme Lyase ODC1 Ornithine decarboxylase 24 11 0 4 0 0
Ion channel Voltage-gated ion channel Voltage-gated calcium channel CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit 9 8 1 5 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) OPRD1 Delta opioid receptor 281 133 12 68 0 16
Enzyme Phosphatase Protein Phosphatase PTPRS Receptor-type tyrosine-protein phosphatase S 49 31 2 19 0 2
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) OPRK1 Kappa opioid receptor 39 23 2 11 0 2
Epigenetic regulator Reader Plant homeodomain KDM2A Lysine-specific demethylase 2A 4 2 0 0 0 0
Epigenetic regulator Reader Methyl-lysine/arginine binding protein KDM4C Lysine-specific demethylase 4C 9 2 0 1 0 1
Enzyme Kinase Protein Kinase ABL1 Tyrosine-protein kinase ABL 112 59 6 32 1 3
Enzyme Phosphodiesterase Phosphodiesterase 5 PDE5A Phosphodiesterase 5A 55 38 7 15 0 1
Enzyme Oxidoreductase ALDH2 Aldehyde dehydrogenase 108 62 6 30 1 2
Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group B ESRRA Estrogen-related receptor alpha 855 425 41 252 2 23
Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group B ESRRB Estrogen-related receptor beta 115 61 7 33 1 3
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) PTAFR Platelet activating factor receptor 9 7 1 2 0 1
Enzyme AOX1 Aldehyde oxidase 119 65 8 35 1 4
Epigenetic regulator Writer DNA methyltransferase DNMT1 DNA (cytosine-5)-methyltransferase 1 93 47 4 27 0 5
Enzyme Protease Cysteine protease CASP1 Caspase-1 665 339 26 213 0 21
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1E Serotonin 1e (5-HT1e) receptor 21 8 0 4 0 2
Enzyme Protease Serine protease CTSG Cathepsin G 4 2 0 3 0 0
Enzyme Protease Serine protease ELANE Leukocyte elastase 156 78 0 49 0 1
Ion channel Other ion channel Miscellaneous ion channel BCL2L1 Apoptosis regulator Bcl-X 2 2 0 2 0 0
Enzyme Protease Metallo protease MMP9 Matrix metalloproteinase 9 1696 850 67 503 1 45
Enzyme UBE2N Ubiquitin-conjugating enzyme E2 N 75 48 6 26 0 3
Enzyme Kinase Protein Kinase MAPK3 MAP kinase ERK1 17 11 4 3 0 0
Epigenetic regulator Reader Bromodomain BRD4 Bromodomain-containing protein 4 1 1 0 1 0 0
Enzyme Oxidoreductase DHFR Dihydrofolate reductase 5 5 1 3 0 1
Enzyme Kinase Protein Kinase MAPK1 MAP kinase ERK2 1499 805 76 439 1 42
Enzyme Kinase Protein Kinase MAPK14 MAP kinase p38 alpha 200 100 10 54 0 8
Enzyme Kinase Protein Kinase EGFR Epidermal growth factor receptor erbB1 506 260 22 151 1 12
Unclassified PRNP Prion protein 1 1 0 0 0 0
Ion channel Voltage-gated ion channel Potassium channels KCNA3 Voltage-gated potassium channel subunit Kv1.3 43 17 1 11 0 1
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN5A Sodium channel protein type V alpha subunit 3 3 1 2 0 0
Enzyme Kinase Protein Kinase ERBB2 Receptor protein-tyrosine kinase erbB-2 300 152 12 92 0 5
Enzyme CDA Cytidine deaminase 124 74 8 45 0 3
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC28A3 Solute carrier family 28 member 3 305 171 16 102 0 6
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC28A2 Sodium/nucleoside cotransporter 2 224 134 10 78 0 4
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC28A1 Sodium/nucleoside cotransporter 1 305 171 16 102 0 6
Epigenetic regulator Reader Plant homeodomain KDM7A Lysine-specific demethylase 7 4 2 0 0 0 0
Epigenetic regulator Reader Plant homeodomain PHF8 Histone lysine demethylase PHF8 4 2 0 0 0 0
Unclassified XBP1 X-box-binding protein 1 72 23 3 15 1 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR2A Serotonin 2a (5-HT2a) receptor 53 34 9 15 0 4
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR2B Serotonin 2b (5-HT2b) receptor 110 62 5 37 0 5
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR2C Serotonin 2c (5-HT2c) receptor 121 74 15 35 0 8
Unclassified HBB Hemoglobin beta chain 307 161 13 101 0 6
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR6 Serotonin 6 (5-HT6) receptor 119 64 8 35 0 4
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A4 Serotonin transporter 60 33 7 20 0 5
Unclassified SIGMAR1 Sigma opioid receptor 39 29 3 16 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) TACR2 Neurokinin 2 receptor 9 7 2 4 0 2
Enzyme Oxidoreductase PTGS1 Cyclooxygenase-1 728 388 51 222 0 24
Enzyme Cytochrome P450 Cytochrome P450 family 5 TBXAS1 Thromboxane-A synthase 126 68 9 35 1 3
Enzyme MGLL Monoglyceride lipase 1 1 0 1 0 0
Enzyme Kinase Protein Kinase FLT1 Vascular endothelial growth factor receptor 1 8 5 0 3 0 0
Enzyme Kinase Protein Kinase PDGFRA Platelet-derived growth factor receptor alpha 6 3 0 2 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) AVPR1A Vasopressin V1a receptor 1 1 0 1 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) GPER1 G-protein coupled estrogen receptor 1 6 4 1 3 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) LTB4R Leukotriene B4 receptor 1 1 1 1 0 0 0
Enzyme Oxidoreductase PTGS2 Cyclooxygenase-2 884 454 37 257 0 20
Enzyme Lyase CA13 Carbonic anhydrase XIII 770 379 31 222 0 18
Enzyme Kinase Protein Kinase ROCK2 Rho-associated protein kinase 2 7 4 0 3 0 0
Enzyme Kinase Protein Kinase MAP4K5 Mitogen-activated protein kinase kinase kinase kinase 5 2 1 0 1 0 0
Enzyme Kinase Protein Kinase LYN Tyrosine-protein kinase Lyn 3 2 0 2 0 0
Enzyme Kinase Protein Kinase DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A 105 53 4 33 0 5
Ion channel Other ion channel Chloride channel CFTR Cystic fibrosis transmembrane conductance regulator 648 330 21 197 0 13
Enzyme Kinase Protein Kinase PRKCH Protein kinase C eta 2 2 0 2 0 1
Unclassified MPEG1 Macrophage-expressed gene 1 protein 13 13 1 8 0 1
Enzyme Kinase Protein Kinase CSNK1A1 Casein kinase I alpha 7 4 0 3 0 0
Enzyme PLA2G2A Phospholipase A2 group IIA 12 3 0 3 0 0
Enzyme SPHK1 Sphingosine kinase 1 1 1 0 1 0 0
Enzyme SPHK2 Sphingosine kinase 2 1 1 0 1 0 0
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group B RARA Retinoic acid receptor alpha 1 1 0 1 0 0
Enzyme Kinase Protein Kinase FRK Tyrosine-protein kinase FRK 3 2 0 2 0 0
Enzyme Kinase Protein Kinase HCK Tyrosine-protein kinase HCK 8 4 0 3 0 0
Enzyme Kinase Protein Kinase MAPK10 c-Jun N-terminal kinase 3 9 5 0 4 0 0
Enzyme Kinase Protein Kinase MKNK2 MAP kinase signal-integrating kinase 2 3 2 0 2 0 0
Enzyme Kinase Protein Kinase PHKG2 Phosphorylase kinase gamma subunit 2 3 2 0 2 0 0
Enzyme Kinase Protein Kinase FGFR3 Fibroblast growth factor receptor 3 1 1 0 1 0 0
Enzyme Kinase Protein Kinase CLK4 Dual specificity protein kinase CLK4 1 1 0 1 0 0
Enzyme Kinase Protein Kinase TTK Dual specificity protein kinase TTK 1 1 0 1 0 0
Enzyme Kinase Protein Kinase NTRK1 Nerve growth factor receptor Trk-A 1 1 0 1 0 0
Enzyme Kinase Protein Kinase CDK5 Cyclin-dependent kinase 5 1 1 0 1 0 0
Enzyme Kinase Protein Kinase LIMK1 LIM domain kinase 1 12 6 1 2 0 0
Enzyme Kinase Protein Kinase FER Tyrosine-protein kinase FER 1 1 0 1 0 0
Enzyme Kinase Protein Kinase TNK2 Tyrosine kinase non-receptor protein 2 6 3 0 2 0 0
Enzyme Kinase Protein Kinase JAK2 Tyrosine-protein kinase JAK2 8 4 0 3 0 0
Enzyme Kinase Protein Kinase MAP3K20 Mixed lineage kinase 7 1 1 0 1 0 0
Enzyme Kinase Protein Kinase PRKX Serine/threonine-protein kinase PRKX 6 3 0 2 0 0
Enzyme Kinase Protein Kinase PTK2B Protein tyrosine kinase 2 beta 16 10 1 8 0 0
Enzyme Kinase Protein Kinase CSNK1D Casein kinase I delta 7 5 0 5 0 0
Enzyme Kinase Protein Kinase CSF1R Macrophage colony stimulating factor receptor 1 1 0 1 0 0
Enzyme Kinase Protein Kinase NTRK2 Neurotrophic tyrosine kinase receptor type 2 1 1 0 1 0 0
Enzyme Kinase Protein Kinase NTRK3 NT-3 growth factor receptor 1 1 0 1 0 0
Enzyme Kinase Protein Kinase DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B 10 6 0 5 0 0
Enzyme Kinase Protein Kinase IKBKE Inhibitor of nuclear factor kappa B kinase epsilon subunit 6 3 0 2 0 0
Enzyme Kinase Protein Kinase TYK2 Tyrosine-protein kinase TYK2 1 1 0 1 0 0
Enzyme Kinase Protein Kinase TYRO3 Tyrosine-protein kinase receptor TYRO3 7 4 0 3 0 0
Enzyme Kinase Protein Kinase MARK3 Serine/threonine-protein kinase c-TAK1 7 4 0 3 0 0
Enzyme Kinase Protein Kinase MELK Maternal embryonic leucine zipper kinase 7 4 0 3 0 0
Enzyme Kinase Protein Kinase ACVR1 Activin receptor type-1 6 3 0 2 0 0
Enzyme Kinase Protein Kinase SIK2 Serine/threonine-protein kinase SIK2 8 4 0 3 0 0
Enzyme Kinase Protein Kinase LTK Leukocyte tyrosine kinase receptor 6 3 0 2 0 0
Enzyme Kinase Protein Kinase BLK Tyrosine-protein kinase BLK 3 2 0 2 0 0
Enzyme Kinase Protein Kinase BRSK1 BR serine/threonine-protein kinase 1 3 2 0 2 0 0
Enzyme Kinase Protein Kinase MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 9 5 0 4 0 0
Enzyme Kinase Protein Kinase MARK4 MAP/microtubule affinity-regulating kinase 4 6 3 0 2 0 0
Enzyme Kinase Protein Kinase MERTK Proto-oncogene tyrosine-protein kinase MER 7 5 1 4 0 2
Enzyme Kinase Protein Kinase CDK8 Cell division protein kinase 8 129 62 6 35 0 5
Enzyme Kinase Protein Kinase MAP3K10 Mitogen-activated protein kinase kinase kinase 10 6 3 0 2 0 0
Enzyme Kinase Protein Kinase STK3 Serine/threonine-protein kinase MST2 7 4 0 3 0 0
Enzyme Kinase Protein Kinase CDK9 Cyclin-dependent kinase 9 123 59 6 33 0 5
Enzyme Kinase Protein Kinase PRKD2 Serine/threonine-protein kinase D2 3 2 0 2 0 0
Enzyme Kinase Protein Kinase PRKD3 Protein kinase C nu 3 2 0 2 0 0
Enzyme Kinase Protein Kinase EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 1 0 1 0 0
Enzyme Kinase Protein Kinase RET Tyrosine-protein kinase receptor RET 11 7 1 5 0 0
Enzyme Kinase Protein Kinase ROS1 Proto-oncogene tyrosine-protein kinase ROS 7 4 0 3 0 0
Enzyme PIK3CB PI3-kinase p110-beta subunit 140 74 7 39 0 1
Enzyme Kinase Protein Kinase MINK1 Misshapen-like kinase 1 3 2 0 2 0 0
Enzyme Kinase Protein Kinase IRAK1 Interleukin-1 receptor-associated kinase 1 2 1 0 1 0 0
Enzyme Kinase Protein Kinase MATK Tyrosine-protein kinase CTK 1 1 0 1 0 0
Enzyme Kinase Protein Kinase NEK4 Serine/threonine-protein kinase Nek4 1 1 0 1 0 0
Enzyme Kinase Protein Kinase DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 8 6 3 3 0 1
Enzyme Kinase Protein Kinase MAP4K2 Mitogen-activated protein kinase kinase kinase kinase 2 1 1 0 1 0 0
Enzyme Kinase Protein Kinase TBK1 Serine/threonine-protein kinase TBK1 6 3 0 2 0 0
Enzyme Kinase Protein Kinase IRAK4 Interleukin-1 receptor-associated kinase 4 3 2 0 2 0 0
Enzyme Kinase Protein Kinase TAOK1 Serine/threonine-protein kinase TAO1 7 4 0 3 0 0
Enzyme Kinase Protein Kinase HIPK2 Homeodomain-interacting protein kinase 2 1 1 0 1 0 0
Enzyme Kinase Protein Kinase HIPK4 Homeodomain-interacting protein kinase 4 3 2 0 2 0 0
Enzyme Kinase Protein Kinase MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 2 2 0 2 0 0
Enzyme Kinase Protein Kinase MAP3K7 Mitogen-activated protein kinase kinase kinase 7 2 2 0 2 0 0
Enzyme Kinase Protein Kinase LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2 6 3 0 2 0 0
Enzyme Kinase Protein Kinase SGK2 Serine/threonine-protein kinase Sgk2 7 4 0 3 0 0
Enzyme Kinase Protein Kinase GRK5 G protein-coupled receptor kinase 5 6 3 0 2 0 0
Enzyme Kinase Protein Kinase CDC7 Cell division cycle 7-related protein kinase 1 1 0 1 0 0
Ion channel Voltage-gated ion channel Transient receptor potential channel TRPA1 Transient receptor potential cation channel subfamily A member 1 316 183 37 101 0 12
Enzyme Kinase Protein Kinase DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 5 4 0 4 0 0
Enzyme AKR1C3 Aldo-keto-reductase family 1 member C3 15 7 0 1 0 0
Enzyme AKR1C4 Aldo-keto reductase family 1 member C4 12 5 0 0 0 0
Enzyme AKR1C2 Aldo-keto reductase family 1 member C2 12 5 0 0 0 0
Enzyme NOS2 Nitric oxide synthase, inducible 12 7 2 5 0 1
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM5 Metabotropic glutamate receptor 5 21 16 3 10 0 1
Enzyme NOS1 Nitric-oxide synthase, brain 1 1 0 1 0 0
Enzyme Protease Cysteine protease CAPN1 Calpain 1 19 5 0 1 0 0
Enzyme Protease Cysteine protease CTSK Cathepsin K 2 1 0 1 0 0
Enzyme Kinase Protein Kinase SRC Tyrosine-protein kinase SRC 1398 687 48 414 0 33
Enzyme NQO2 Quinone reductase 2 155 85 10 43 0 2
Unclassified STAT1 Signal transducer and activator of transcription 1-alpha/beta 17 9 0 5 0 1
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN9A Sodium channel protein type IX alpha subunit 2 1 0 1 0 0
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN11A Sodium channel protein type XI alpha subunit 2 1 0 1 0 0
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN8A Sodium channel protein type VIII alpha subunit 2 1 0 1 0 0
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN4A Sodium channel protein type IV alpha subunit 2 1 0 1 0 0
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN3A Sodium channel protein type III alpha subunit 2 1 0 1 0 0
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN2A Sodium channel protein type II alpha subunit 2 1 0 1 0 0
Ion channel Voltage-gated ion channel Voltage-gated sodium channel SCN1A Sodium channel protein type I alpha subunit 2 1 0 1 0 0
Enzyme LDHB L-lactate dehydrogenase B chain 2 2 0 2 0 0
Unclassified MDM2 p53-binding protein Mdm-2 6 3 0 2 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) NTSR1 Neurotensin receptor 1 2 2 1 1 0 0
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIK2 Glutamate receptor ionotropic kainate 2 36 23 3 15 0 1
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIA1 Glutamate receptor ionotropic, AMPA 1 18 9 0 6 0 0
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIA2 Glutamate receptor ionotropic, AMPA 2 20 14 3 9 0 1
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIA4 Glutamate receptor ionotropic, AMPA 4 37 23 3 15 0 1
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIK1 Glutamate receptor ionotropic kainate 1 36 23 3 15 0 1
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIK5 Glutamate receptor ionotropic kainate 5 36 23 3 15 0 1
Ion channel Ligand-gated ion channel Ionotropic glutamate receptor GRIK3 Glutamate receptor ionotropic kainate 3 36 23 3 15 0 1
Unclassified STAT3 Signal transducer and activator of transcription 3 47 25 2 10 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLCO4C1 Solute carrier organic anion transporter family member 4C1 13 8 0 5 0 1
Enzyme EIF4A1 Eukaryotic initiation factor 4A-I 14 4 1 3 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) P2RY1 Purinergic receptor P2Y1 2 0 0 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) P2RY2 Purinergic receptor P2Y2 3 1 0 0 0 0
Enzyme Hydrolase ADA Adenosine deaminase 7 6 1 3 0 0
Ion channel Voltage-gated ion channel Potassium channels KCNA5 Voltage-gated potassium channel subunit Kv1.5 3 2 0 1 0 0
Enzyme CTDSP1 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 789 382 36 228 1 21
Unclassified SERPINE1 Plasminogen activator inhibitor-1 3 2 0 2 0 1
Enzyme Kinase Protein Kinase BCR Bcr/Abl fusion protein 43 24 3 10 0 1
Enzyme Hydrolase ATP12A Potassium-transporting ATPase alpha chain 2 30 16 3 6 0 3
Unclassified KLF5 Kruppel-like factor 5 3 3 0 1 0 0
Membrane receptor Taste family G protein-coupled receptor Taste receptor (taste family GPCR) TAS2R31 Taste receptor type 2 member 31 125 58 2 39 0 1
Enzyme Phosphatase Protein Phosphatase PTPN22 Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP 1 1 0 1 0 1
Unclassified FABP3 Fatty acid binding protein muscle 726 422 43 248 1 25
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) FFAR4 G-protein coupled receptor 120 533 301 37 175 1 19
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR4 Serotonin 4 (5-HT4) receptor 21 8 0 4 0 2
Enzyme Protease Metallo protease MMP14 Matrix metalloproteinase 14 92 46 4 26 0 5
Enzyme SCD Acyl-CoA desaturase 11 8 0 5 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) OXER1 Oxoeicosanoid receptor 1 7 7 2 4 0 1
Enzyme HKDC1 Putative hexokinase HKDC1 113 56 3 37 0 3
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47A2 Multidrug and toxin extrusion protein 2 2 1 0 1 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47A1 Multidrug and toxin extrusion protein 1 5 3 0 2 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) MTNR1A Melatonin receptor 1A 7 7 2 2 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) MTNR1B Melatonin receptor 1B 7 7 2 2 0 1
Unclassified HRAS Transforming protein p21/H-Ras-1 1 1 0 1 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) ADORA2B Adenosine A2b receptor 4 4 2 1 0 1
Enzyme Kinase Protein Kinase GRK6 G protein-coupled receptor kinase 6 45 25 0 20 0 1
Enzyme Kinase Protein Kinase HASPIN Serine/threonine-protein kinase haspin 8 6 3 3 0 1
Enzyme AKR1B1 Aldose reductase 2409 1153 86 677 2 61
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit 25 14 2 7 0 0
Enzyme Protease Cysteine protease CASP2 Caspase-2 3 1 0 1 0 0
Enzyme AOC3 Amine oxidase, copper containing 1 1 0 0 0 0
Enzyme EBP 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase 4 4 0 2 0 0
Unclassified XPO1 Exportin-1 34 23 4 13 0 1
Membrane receptor Family A G protein-coupled receptor GPR18 N-arachidonyl glycine receptor 1 1 1 0 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) GPR55 G-protein coupled receptor 55 4 2 1 1 0 0
Enzyme PTPRCAP Protein tyrosine phosphatase receptor type C-associated protein 3 3 1 1 0 1
Enzyme Isomerase FKBP1A FK506-binding protein 1A 19 5 0 1 0 0
Enzyme Protease Metallo protease PEPD Xaa-Pro dipeptidase 7 2 0 2 0 1
Enzyme NT5E 5'-nucleotidase 11 6 2 2 0 0
Enzyme CHAT Choline acetylase 1 1 1 0 0 0
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 7 7 2 3 0 1
Ion channel Ligand-gated ion channel 5HT3 receptor HTR3A Serotonin 3a (5-HT3a) receptor 26 13 2 7 0 3
Membrane receptor Toll-like and Il-1 receptors TLR9 Toll-like receptor 9 14 9 3 4 0 1
Ion channel Ligand-gated ion channel Glycine receptor GLRA1 Glycine receptor subunit alpha-1 4 2 2 0 0 1
Enzyme Oxidoreductase MT-ND4 NADH-ubiquinone oxidoreductase chain 4 16 10 0 2 0 0
Enzyme Protease Serine protease EPHX1 Epoxide hydrolase 1 1 1 0 1 0 0
Ion channel Ligand-gated ion channel Nicotinic acetylcholine receptor CHRNA4 Neuronal acetylcholine receptor protein alpha-4 subunit 7 7 2 3 0 1
Unclassified XIAP Inhibitor of apoptosis protein 3 10 10 0 6 0 1
Ion channel Ligand-gated ion channel Glycine receptor GLRA2 Glycine receptor subunit alpha-2 2 1 1 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A15 Sodium-dependent neutral amino acid transporter B(0)AT2 1 1 0 1 0 0
Enzyme Hydrolase BCHE Butyrylcholinesterase 207 122 3 68 0 1
Unclassified PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 17 7 1 4 0 0
Enzyme Cytochrome P450 Cytochrome P450 family 19 CYP19A1 Cytochrome P450 19A1 2053 993 71 602 1 48
Enzyme ENPP2 Autotaxin 1 1 1 0 0 0
Enzyme USP2 Ubiquitin carboxyl-terminal hydrolase 2 1385 716 52 430 0 34
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) F2RL1 Proteinase-activated receptor 2 1 0 0 0 0 0
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM3 Metabotropic glutamate receptor 3 19 14 3 9 0 1
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM2 Metabotropic glutamate receptor 2 19 14 3 9 0 1
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM4 Metabotropic glutamate receptor 4 19 14 3 9 0 1
Membrane receptor Family C G protein-coupled receptor Small molecule receptor (family C GPCR) GRM8 Metabotropic glutamate receptor 8 19 14 3 9 0 1
Enzyme Protease Metallo protease FOLH1 Glutamate carboxypeptidase II 2 2 0 1 0 0
Enzyme PLCG1 Phospholipase C-gamma-1 1 1 0 0 0 0
Transporter Primary active transporter Endoplasmic reticular retrotranslocon family VCP Transitional endoplasmic reticulum ATPase 67 36 4 19 0 6
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group A THRB Thyroid hormone receptor beta-1 137 73 13 36 0 12
Unclassified APAF1 Apoptotic protease-activating factor 1 28 12 0 4 0 0
Enzyme TGM2 Protein-glutamine gamma-glutamyltransferase 7 5 0 2 0 0
Enzyme Protease Cysteine protease CTSL Cathepsin L 4 4 2 2 0 0
Enzyme PLD1 Phospholipase D1 1 1 0 0 0 0
Enzyme PLD2 Phospholipase D2 1 1 0 0 0 0
Enzyme RECQL ATP-dependent DNA helicase Q1 2398 1173 75 687 1 63
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) P2RY14 Purinergic receptor P2Y14 1 1 0 0 0 0
Ion channel Voltage-gated ion channel Transient receptor potential channel TRPV1 Vanilloid receptor 133 59 8 39 0 3
Enzyme Phosphodiesterase Phosphodiesterase 4 PDE4B Phosphodiesterase 4B 24 13 2 8 0 0
Enzyme APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G 321 164 15 98 0 10
Unclassified TXN2 Thioredoxin, mitochondrial 16 8 0 7 0 1
Unclassified TXN Thioredoxin 16 8 0 7 0 1
Epigenetic regulator Eraser Lysine demethylase KDM4E Lysine-specific demethylase 4D-like 2120 1039 79 616 1 58
Unclassified LMNA Prelamin-A/C 3336 1670 135 958 3 77
Unclassified HSPA1A Heat shock 70 kDa protein 1 285 145 12 90 0 5
Enzyme Kinase Protein Kinase ATR Serine-protein kinase ATR 7 7 2 4 0 0
Enzyme IDE Insulin-degrading enzyme 13 4 1 2 0 1
Enzyme APEX1 DNA-(apurinic or apyrimidinic site) lyase 877 480 42 284 0 26
Enzyme TDP2 Tyrosyl-DNA phosphodiesterase 2 2 2 0 1 0 0
Enzyme Kinase Protein Kinase MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 52 28 2 15 0 2
Enzyme Hydrolase ATP1A1 Sodium/potassium-transporting ATPase alpha-1 chain 12 8 0 5 0 1
Enzyme GSTK1 Glutathione S-transferase kappa 1 4 4 1 1 0 0
Enzyme Hydrolase MGAM Maltase-glucoamylase 117 61 7 34 1 3
Enzyme TDP1 Tyrosyl-DNA phosphodiesterase 1 2798 1385 100 790 3 68
Enzyme GSTP1 Glutathione S-transferase Pi 1 1 0 1 0 0
Enzyme GLA Alpha-galactosidase A 208 97 14 59 0 4
Enzyme Protease Serine protease CMA1 Chymase 1 0 0 0 0 0
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) OXTR Oxytocin receptor 1 1 0 1 0 0
Enzyme FUCA1 Alpha-L-fucosidase I 2 1 1 0 0 0
Enzyme RBBP9 Putative hydrolase RBBP9 3 2 0 0 0 0
Ion channel Voltage-gated ion channel Voltage-gated calcium channel CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit 2 1 0 1 0 0
Unclassified MAPT Microtubule-associated protein tau 2519 1264 105 724 0 59
Enzyme Transferase UGCG Ceramide glucosyltransferase 2 0 0 0 0 0
Enzyme Phosphodiesterase Phosphodiesterase 2 PDE2A Phosphodiesterase 2A 7 6 1 2 0 0
Enzyme Phosphodiesterase Phosphodiesterase 3 PDE3A Phosphodiesterase 3A 7 6 1 2 0 0
Enzyme Phosphodiesterase Phosphodiesterase 3 PDE3B Phosphodiesterase 3B 7 6 1 2 0 0
Enzyme Phosphodiesterase Phosphodiesterase 10 PDE10A Phosphodiesterase 10A 7 6 1 2 0 0
Unclassified GLI2 Zinc finger protein GLI2 5 3 2 1 0 0
Enzyme SI Sucrase-isomaltase 7 3 1 3 0 0
Unclassified TUBB1 Tubulin beta-1 chain 2 1 0 1 0 0
Enzyme AGL Glycogen debranching enzyme 15 7 2 5 0 0
Enzyme FUCA2 Alpha-L-fucosidase 2 1 1 1 0 0 0
Unclassified FABP2 Fatty acid binding protein intestinal 533 326 39 192 0 21
Unclassified TUBB3 Tubulin beta-3 chain 9 6 1 5 0 2
Enzyme PKM Pyruvate kinase isozymes M1/M2 869 472 35 264 0 22
Enzyme Hydrolase MALT1 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 2 2 0 1 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A12 Solute carrier family 22 member 12 19 13 2 6 0 2
Unclassified FABP5 Fatty acid binding protein epidermal 713 407 40 251 1 24
Membrane receptor Toll-like and Il-1 receptors TLR2 Toll-like receptor 2 638 363 39 220 0 22
Enzyme Kinase Protein Kinase ATM Serine-protein kinase ATM 28 21 4 13 0 0
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HCAR2 Hydroxycarboxylic acid receptor 2 165 101 15 61 0 7
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1F Serotonin 1f (5-HT1f) receptor 21 8 0 4 0 2
Unclassified IL1B Interleukin-1 beta 6 1 0 1 0 0
Enzyme Transferase FUT7 Alpha-(1,3)-fucosyltransferase 7 602 318 23 194 0 16
Membrane receptor Family B G protein-coupled receptor Peptide receptor (family B GPCR) CRHR1 Corticotropin releasing factor receptor 1 1 1 1 0 0 1
Epigenetic regulator Reader Methyl-lysine/arginine binding protein KDM4A Lysine-specific demethylase 4A 15 7 0 4 0 1
Unclassified RAB9A Ras-related protein Rab-9A 1169 568 58 308 2 31
Enzyme Protease Metallo protease METAP2 Methionine aminopeptidase 2 4 1 0 2 0 0
Unclassified NPC1 Niemann-Pick C1 protein 1630 794 69 448 2 40
Unclassified CREB1 Cyclic AMP-responsive element-binding protein 1 29 16 0 10 0 1
Unclassified TP53 Cellular tumor antigen p53 2262 1134 86 668 3 61
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group H NR1H4 Bile acid receptor FXR 1492 665 40 413 0 42
Unclassified NOD2 Nucleotide-binding oligomerization domain-containing protein 2 1 1 1 0 0 0
Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C NR3C2 Mineralocorticoid receptor 14 7 1 5 0 0
Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C PGR Progesterone receptor 15 8 2 5 0 0
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group I NR1I2 Pregnane X receptor 327 179 25 105 0 11
Enzyme PLA2G1B Phospholipase A2 group 1B 1651 810 56 478 0 42
Nuclear receptor Nuclear hormone receptor subfamily 2 Nuclear hormone receptor subfamily 2 group B RXRA Retinoid X receptor alpha 47 29 3 18 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC7A11 Cystine/glutamate transporter 2 2 0 1 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC5A4 Low affinity sodium-glucose cotransporter 51 23 4 12 0 1
Ion channel Voltage-gated ion channel Transient receptor potential channel MCOLN3 MCOLN3 protein 1 0 0 0 0 0
Epigenetic regulator Eraser Histone deacetylase HDAC10 Histone deacetylase 10 33 13 1 4 0 1
Enzyme Protease Metallo protease MMP3 Matrix metalloproteinase 3 1249 620 43 379 0 31
Enzyme Protease Metallo protease MMP2 Matrix metalloproteinase-2 1792 896 67 537 1 47
Enzyme GSTA1 Glutathione S-transferase A1 1 1 0 1 0 0
Unclassified MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 246 157 17 84 0 16
Enzyme Oxidoreductase ALOX5 Arachidonate 5-lipoxygenase 1711 842 66 515 2 46
Enzyme BLM Bloom syndrome protein 824 443 43 260 1 20
Enzyme Oxidoreductase MAOB Monoamine oxidase B 84 41 3 24 0 3
Nuclear receptor Nuclear hormone receptor subfamily 0 Nuclear hormone receptor subfamily 0 group B NR0B1 Nuclear receptor subfamily 0 group B member 1 51 20 4 11 0 0
Enzyme TNKS Tankyrase-1 909 462 37 274 1 22
Enzyme POLB DNA polymerase beta 2628 1267 85 742 1 63
Enzyme Kinase Protein Kinase GSK3B Glycogen synthase kinase-3 beta 1811 881 62 525 1 44
Enzyme Kinase Protein Kinase ROCK1 Rho-associated protein kinase 1 7 4 0 3 0 0
Enzyme Hydrolase GAA Lysosomal alpha-glucosidase 2261 1104 75 655 0 51
Enzyme Protease Cysteine protease CTSV Cathepsin L2 4 2 0 1 0 0
Enzyme Protease Serine protease PRSS1 Trypsin I 1 1 0 1 0 1
Enzyme LSS Lanosterol synthase 1 1 1 0 0 0
Enzyme GBA Beta-glucocerebrosidase 2 2 1 1 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A1 Solute carrier family 22 member 1 19 11 3 7 0 0
Transporter Transmembrane 1-electron transfer carriers NOX1 NADPH oxidase 1 1 1 0 1 0 0
Enzyme Protease Serine protease PCSK7 Subtilisin/kexin type 7 2 2 2 0 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLCO2B1 Solute carrier organic anion transporter family member 2B1 3 3 0 3 0 0
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2B6 Cytochrome P450 2B6 13 8 1 7 0 0
Enzyme Cytochrome P450 Cytochrome P450 family 2 CYP2C8 Cytochrome P450 2C8 1238 615 43 377 0 30
Epigenetic regulator Writer Histone acetyltransferase NCOA3 Nuclear receptor coactivator 3 1 0 0 0 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC5A1 Sodium/glucose cotransporter 1 51 23 4 12 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC5A2 Sodium/glucose cotransporter 2 93 43 4 24 0 1
Enzyme LDHA L-lactate dehydrogenase A chain 2 2 0 2 0 0
Enzyme DAO D-amino-acid oxidase 7 5 3 1 0 1
Enzyme Protease Metallo protease CPB1 Carboxypeptidase B 1 0 0 1 0 0
Unclassified EBPL Emopamil-binding protein-like 2 2 0 1 0 0
Epigenetic regulator Writer Histone acetyltransferase NCOA1 Nuclear receptor coactivator 1 1 0 0 0 0 0
Enzyme GANC Neutral alpha-glucosidase C 1 0 0 0 0 0
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A6 Solute carrier family 22 member 6 373 189 20 124 0 9
Transporter Primary active transporter ATP-binding cassette ABCB1 P-glycoprotein 1 343 168 16 95 0 15
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC22A8 Solute carrier family 22 member 8 50 34 8 21 0 4
Enzyme Protease Serine protease F2 Thrombin 87 50 4 31 0 4
Enzyme Kinase Protein Kinase GSK3A Glycogen synthase kinase-3 alpha 7 4 0 3 0 0
Unclassified F3 Coagulation factor III 97 51 2 39 0 3
Epigenetic regulator Eraser Histone deacetylase HDAC1 Histone deacetylase 1 34 13 1 4 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC2 Histone deacetylase 2 37 15 1 5 0 1
Epigenetic regulator Eraser Histone deacetylase HDAC3 Histone deacetylase 3 85 43 6 17 0 3
Epigenetic regulator Eraser Histone deacetylase HDAC8 Histone deacetylase 8 37 15 1 5 0 1
Enzyme Protease Metallo protease MMP1 Matrix metalloproteinase-1 435 280 38 149 0 17
Epigenetic regulator Eraser Histone deacetylase HDAC6 Histone deacetylase 6 33 13 1 4 0 1
Transporter Electrochemical transporter SLC superfamily of solute carriers SLCO1B3 Solute carrier organic anion transporter family member 1B3 773 363 38 218 1 18
Unclassified RELA Nuclear factor NF-kappa-B p65 subunit 31 12 1 12 0 0
Enzyme Kinase Protein Kinase AKT1 Serine/threonine-protein kinase AKT 1397 687 48 415 0 33
Transporter Electrochemical transporter SLC superfamily of solute carriers SLCO1B1 Solute carrier organic anion transporter family member 1B1 738 353 38 206 1 19
Unclassified JUN Proto-oncogene c-JUN 4 4 0 1 0 0
Enzyme Protease Aspartic protease BACE1 Beta-secretase 1 1590 786 53 476 0 42
Enzyme Oxidoreductase TYR Tyrosinase 795 386 37 229 1 21
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) GPBAR1 G-protein coupled bile acid receptor 1 1089 521 32 316 0 28
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC10A1 Bile acid transporter 4 3 1 1 0 0
Enzyme Kinase Protein Kinase PRKCB Protein kinase C beta 10 6 0 6 0 1
Enzyme Kinase Protein Kinase PRKCE Protein kinase C epsilon 21 12 2 10 0 2
Unclassified TTR Transthyretin 905 462 36 275 1 23
Unclassified APP Beta amyloid A4 protein 1069 547 41 326 1 28
Enzyme ALOX15 Arachidonate 15-lipoxygenase 2622 1303 101 768 2 68
Unclassified PMP22 Peripheral myelin protein 22 64 40 3 26 0 5
Enzyme ALPI Intestinal alkaline phosphatase 644 310 24 197 0 20
Enzyme ALPL Alkaline phosphatase, tissue-nonspecific isozyme 497 238 17 146 0 12
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A1 GABA transporter 1 56 35 5 19 0 4
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC6A11 GABA transporter 3 56 35 5 19 0 4
Enzyme Kinase Protein Kinase PLK1 Serine/threonine-protein kinase PLK1 322 160 13 96 0 6
Enzyme Kinase Protein Kinase BTK Tyrosine-protein kinase BTK 6 3 0 2 0 0
Enzyme IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 18 8 1 8 0 0
Enzyme Protease Serine protease EPHX2 Epoxide hydratase 3 3 0 1 0 0
Epigenetic regulator Reader Methyl-lysine/arginine binding protein L3MBTL1 Lethal(3)malignant brain tumor-like protein 1 724 368 31 215 1 24
Enzyme Transferase FASN Fatty acid synthase 25 11 2 10 1 1
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C PPARA Peroxisome proliferator-activated receptor alpha 1090 580 52 339 1 30
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) FFAR1 Free fatty acid receptor 1 559 315 40 181 1 20
Enzyme CD38 Lymphocyte differentiation antigen CD38 717 355 30 216 1 19
Enzyme GDA Guanine deaminase 15 15 4 7 0 2
Enzyme Kinase Protein Kinase PRKCG Protein kinase C gamma 11 7 0 7 0 1
Enzyme Kinase Protein Kinase PRKCD Protein kinase C delta 32 17 0 11 0 1
Enzyme Kinase Protein Kinase PRKCQ Protein kinase C theta 16 9 0 8 0 1
Unclassified SERPINA6 Corticosteroid binding globulin 135 70 7 44 0 3
Unclassified SHBG Testis-specific androgen-binding protein 23 10 2 8 0 1
Enzyme UGT1A1 UDP-glucuronosyltransferase 1-1 20 11 0 11 0 1
Enzyme Phosphatase Protein Phosphatase CDC25B Dual specificity phosphatase Cdc25B 606 311 25 171 0 18
Enzyme AHCY Adenosylhomocysteinase 1 1 0 1 0 0
Unclassified HSP90AA1 Heat shock protein HSP 90-alpha 57 27 2 11 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1A Serotonin 1a (5-HT1a) receptor 138 66 7 42 0 6
Epigenetic regulator Reader Methyl-lysine/arginine binding protein SMN1;SMN2 Survival motor neuron protein 1537 819 62 483 1 37
Enzyme NQO1 Quinone reductase 1) 2 2 2 0 0 1
Enzyme ALDH1A1 Aldehyde dehydrogenase 1A1 1953 1000 85 582 0 48
Enzyme MTOR Serine/threonine-protein kinase mTOR 100 65 3 34 0 4
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC2A1 Glucose transporter 22 7 0 1 0 0
Enzyme ACLY ATP-citrate synthase 1 1 0 0 0 0
Enzyme Lyase CA1 Carbonic anhydrase I 2786 1367 102 785 3 68
Enzyme Lyase CA9 Carbonic anhydrase IX 2922 1426 108 836 3 70
Enzyme Lyase CA12 Carbonic anhydrase XII 3337 1618 121 943 3 79
Enzyme Lyase CA14 Carbonic anhydrase XIV 2500 1222 92 705 2 57
Enzyme Lyase CA7 Carbonic anhydrase VII 3166 1544 115 891 3 77
Enzyme PTGES Prostaglandin E synthase 63 29 6 12 0 1
Enzyme HSD17B3 Estradiol 17-beta-dehydrogenase 3 43 22 4 14 0 1
Unclassified THPO Thrombopoietin 1219 661 54 386 1 31
Enzyme Oxidoreductase XDH Xanthine dehydrogenase 2076 1007 78 603 2 52
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1B Serotonin 1b (5-HT1b) receptor 31 17 4 7 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HTR1D Serotonin 1d (5-HT1d) receptor 31 17 4 7 0 2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) TAAR1 Trace amine-associated receptor 1 51 28 5 17 0 2
Enzyme Protease Cysteine protease CASP3 Caspase-3 8 6 2 1 0 0
Ion channel Voltage-gated ion channel Potassium channels KCNH2 HERG 84 51 8 20 0 3
Ion channel Other ion channel Miscellaneous ion channel BCL2 Apoptosis regulator Bcl-2 264 133 9 72 0 8
Enzyme Kinase Protein Kinase IKBKB Inhibitor of nuclear factor kappa B kinase beta subunit 21 11 0 9 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HRH3 Histamine H3 receptor 41 21 4 15 0 1
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) HRH4 Histamine H4 receptor 17 10 3 8 0 1
Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group C PPARG Peroxisome proliferator-activated receptor gamma 697 388 41 232 1 22