NPASS Compound

Structure

CID316325 OpenBabel06191716132D 41 42 0 0 1 0 0 0 0 0999 V2000 1.5357 -0.8719 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.2463 4.6511 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.7533 3.6724 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.9448 3.4262 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8513 2.8858 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.5360 4.7135 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -3.0219 1.8880 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.5495 5.2002 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.0936 0.8036 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.6942 0.3601 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3363 1.3489 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.5327 3.4424 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.7068 3.3251 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -2.2773 1.2428 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.4113 -0.2572 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 1.1773 0.0617 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 0.9874 3.6852 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 1.9762 3.0431 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.1061 2.8815 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -2.2773 0.2428 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.4113 1.7428 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -0.5452 0.2428 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3987 1.9424 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.1899 3.6235 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 -0.5452 1.2428 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 -1.3489 2.3363 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 0.3939 3.7476 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0 2.2746 2.5262 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0 0.5936 -0.0624 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.3646 3.8723 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.5875 4.5016 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 0.0000 0.0000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 -3.1433 -0.2572 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.3208 1.7428 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.6459 -1.0610 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 4.2982 4.2306 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.3973 1.9948 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -0.5483 4.5570 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 -2.3148 2.5951 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 0.3415 4.7462 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.2082 2.8846 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 1 16 1 0 0 0 0 3 18 1 0 0 0 0 5 37 1 0 0 0 0 6 38 1 0 0 0 0 7 39 1 0 0 0 0 8 40 1 0 0 0 0 9 10 1 0 0 0 0 9 11 2 0 0 0 0 10 16 2 0 0 0 0 11 23 1 0 0 0 0 12 17 1 0 0 0 0 12 18 2 0 0 0 0 13 19 1 0 0 0 0 13 24 1 0 0 0 0 14 20 1 0 0 0 0 14 21 2 0 0 0 0 15 20 1 0 0 0 0 15 22 2 0 0 0 0 16 29 1 0 0 0 0 17 2 1 1 0 0 0 17 27 1 0 0 0 0 18 28 1 0 0 0 0 19 4 1 1 0 0 0 19 26 1 0 0 0 0 20 33 2 0 0 0 0 21 25 1 0 0 0 0 21 26 1 0 0 0 0 22 25 1 0 0 0 0 22 32 1 0 0 0 0 23 28 1 0 0 0 0 23 37 1 1 0 0 0 24 27 1 0 0 0 0 24 38 1 6 0 0 0 25 34 2 0 0 0 0 26 39 1 6 0 0 0 27 40 1 6 0 0 0 28 41 1 6 0 0 0 29 32 2 3 0 0 0 29 35 1 0 0 0 0 30 31 2 0 0 0 0 30 36 1 0 0 0 0 30 41 1 0 0 0 0 M END $$$$

Physi-Chem Properties

Molecular Weight:	574.29
Volume:	587.701
LogP:	3.523
LogD:	3.031
LogS:	-3.679
# Rotatable Bonds:	6
TPSA:	158.8
# H-Bond Aceptor:	11
# H-Bond Donor:	5
# Rings:	2
# Heavy Atoms:	11

MedChem Properties

QED Drug-Likeness Score:	0.227
Synthetic Accessibility Score:	5.936
Fsp3:	0.467
Lipinski Rule-of-5:	Rejected
Pfizer Rule:	Accepted
GSK Rule:	Rejected
BMS Rule:	1
Golden Triangle Rule:	Rejected
Chelating Alert:	0
PAINS Alert:	0

ADMET Properties (ADMETlab2.0)

ADMET: Absorption

Caco-2 Permeability:	-4.936
MDCK Permeability:	1.5439456547028385e-05
Pgp-inhibitor:	0.937
Pgp-substrate:	0.999
Human Intestinal Absorption (HIA):	0.954
20% Bioavailability (F20%):	0.067
30% Bioavailability (F30%):	0.995

ADMET: Distribution

Blood-Brain-Barrier Penetration (BBB):	0.04
Plasma Protein Binding (PPB):	97.02812957763672%
Volume Distribution (VD):	0.58
Pgp-substrate:	4.50147819519043%

ADMET: Metabolism

CYP1A2-inhibitor:	0.062
CYP1A2-substrate:	0.125
CYP2C19-inhibitor:	0.023
CYP2C19-substrate:	0.177
CYP2C9-inhibitor:	0.114
CYP2C9-substrate:	0.069
CYP2D6-inhibitor:	0.187
CYP2D6-substrate:	0.239
CYP3A4-inhibitor:	0.32
CYP3A4-substrate:	0.477

ADMET: Excretion

Clearance (CL):	9.77
Half-life (T1/2):	0.149

ADMET: Toxicity

hERG Blockers:	0.461
Human Hepatotoxicity (H-HT):	0.773
Drug-inuced Liver Injury (DILI):	0.913
AMES Toxicity:	0.247
Rat Oral Acute Toxicity:	0.733
Maximum Recommended Daily Dose:	0.922
Skin Sensitization:	0.821
Carcinogencity:	0.052
Eye Corrosion:	0.003
Eye Irritation:	0.006
Respiratory Toxicity:	0.714

Download Data

Data Type	Select
General Info & Identifiers & Properties
Structure MOL file
Source Organisms
Biological Activities
Similar NPs/Drugs

Natural Product: NPC316325

Natural Product ID:	NPC316325
*Common Name:**	Herbimycin
IUPAC Name:	[(2R,3S,5S,6R,7S,8E,10S,11S,12E,14E)-2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Synonyms:	Herbimycin A
Standard InCHIKey:	MCAHMSDENAOJFZ-GDYSMBPZSA-N
Standard InCHI:	InChI=1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9+,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
SMILES:	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C=C(C1OC)C2=O)C)OC)OC(=O)N)C)C)OC)OC
Synthetic Gene Cluster:	n.a.
ChEMBL Identifier:	CHEMBL479533
PubChem CID:	6436247
Chemical Classification:**	CHEMONTID:0000000 [Organic compounds] [CHEMONTID:0000261] Phenylpropanoids and polyketides [CHEMONTID:0000064] Macrolactams

*Note: the InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
**Note: the Chemical Classification was calculated by NPClassifier Version 1.5. Reference: PMID:34662515.

Species Source

Organism ID	Organism Name	Taxonomy Level	Family	SuperKingdom	Isolation Part	Collection Location	Collection Time	Reference
NPO32789	Streptomyces sp. RM-7-15	Species	Streptomycetaceae	Bacteria	n.a.	n.a.	n.a.	PMID[23947794]

☑ Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

NP Quantity Composition/Concentration

Organism ID	NP ID	Organism Material Preparation	Organism Part	NP Quantity (Standard)	NP Quantity (Minimum)	NP Quantity (Maximum)	Quantity Unit	Reference

☑ Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].

Biological Activity

Activity Type	# Activity
ED50	2
IC50	9
Others	475

Activity Type	# Activity
Cell Line	9
Individual Protein	444
NON-MOLECULAR	4
Others	5
Protein Complex	24

Target ID	Target Type	Target Name	Target Organism	Activity Type	Activity Relation	Value	Unit	Reference
NPT168	Cell Line	P388	Mus musculus	ED50	=	0.0051	ug ml-1	PMID[485087]
NPT91	Cell Line	KB	Homo sapiens	ED50	=	0.12	ug ml-1	PMID[485087]
NPT385	Cell Line	SR	Homo sapiens	IC50	>	1000.0	nM	PMID[485088]
NPT389	Cell Line	RPMI-8226	Homo sapiens	IC50	>	1000.0	nM	PMID[485088]
NPT112	Cell Line	MOLT-4	Homo sapiens	IC50	>	1000.0	nM	PMID[485088]
NPT111	Cell Line	K562	Homo sapiens	IC50	=	95.0	nM	PMID[485088]
NPT116	Cell Line	HL-60	Homo sapiens	IC50	>	1000.0	nM	PMID[485088]
NPT404	Cell Line	CCRF-CEM	Homo sapiens	IC50	>	1000.0	nM	PMID[485088]
NPT3317	Individual Protein	Serine/threonine-protein kinase MARK1	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3317	Individual Protein	Serine/threonine-protein kinase MARK1	Homo sapiens	Residual Activity	=	82.0	%	PMID[485090]
NPT3419	Individual Protein	Serine/threonine-protein kinase SRPK3	Homo sapiens	Residual Activity	=	116.0	%	PMID[485090]
NPT3419	Individual Protein	Serine/threonine-protein kinase SRPK3	Homo sapiens	Residual Activity	=	84.0	%	PMID[485090]
NPT3284	Individual Protein	Serine/threonine-protein kinase NEK7	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT3214	Individual Protein	Tyrosine-protein kinase ABL2	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT1686	Individual Protein	Casein kinase I isoform gamma-3	Homo sapiens	Residual Activity	=	68.0	%	PMID[485090]
NPT3266	Individual Protein	Casein kinase I delta	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT1672	Individual Protein	CaM kinase I delta	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT1721	Individual Protein	Death-associated protein kinase 1	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3218	Individual Protein	Ephrin type-A receptor 4	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT3219	Individual Protein	Ephrin type-A receptor 5	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT3227	Individual Protein	Fibroblast growth factor receptor 3	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT3372	Individual Protein	Fibroblast growth factor receptor 4	Homo sapiens	Residual Activity	=	109.0	%	PMID[485090]
NPT14	Individual Protein	Tyrosine-protein kinase FYN	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	103.0	%	PMID[485090]
NPT3207	Individual Protein	c-Jun N-terminal kinase 3	Homo sapiens	Residual Activity	=	113.0	%	PMID[485090]
NPT3207	Individual Protein	c-Jun N-terminal kinase 3	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT491	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT1711	Individual Protein	Serine/threonine-protein kinase MST1	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT3284	Individual Protein	Serine/threonine-protein kinase NEK7	Homo sapiens	Residual Activity	=	76.0	%	PMID[485090]
NPT3285	Individual Protein	Serine/threonine protein kinase NLK	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT1432	Individual Protein	Serine/threonine-protein kinase Aurora-A	Homo sapiens	Residual Activity	=	77.0	%	PMID[485090]
NPT1432	Individual Protein	Serine/threonine-protein kinase Aurora-A	Homo sapiens	Residual Activity	=	86.0	%	PMID[485090]
NPT3266	Individual Protein	Casein kinase I delta	Homo sapiens	Residual Activity	=	81.0	%	PMID[485090]
NPT1721	Individual Protein	Death-associated protein kinase 1	Homo sapiens	Residual Activity	=	78.0	%	PMID[485090]
NPT3219	Individual Protein	Ephrin type-A receptor 5	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3372	Individual Protein	Fibroblast growth factor receptor 4	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT3406	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3406	Individual Protein	Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens	Residual Activity	=	81.0	%	PMID[485090]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	137.0	%	PMID[485090]
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT491	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3282	Individual Protein	Maternal embryonic leucine zipper kinase	Homo sapiens	Residual Activity	=	60.0	%	PMID[485090]
NPT1711	Individual Protein	Serine/threonine-protein kinase MST1	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT3331	Individual Protein	Serine/threonine-protein kinase MST2	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT3285	Individual Protein	Serine/threonine protein kinase NLK	Homo sapiens	Residual Activity	=	83.0	%	PMID[485090]
NPT1433	Individual Protein	Serine/threonine-protein kinase Aurora-B	Homo sapiens	Residual Activity	=	72.0	%	PMID[485090]
NPT3236	Individual Protein	Death-associated protein kinase 2	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3236	Individual Protein	Death-associated protein kinase 2	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT3211	Individual Protein	Ephrin type-A receptor 7	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3211	Individual Protein	Ephrin type-A receptor 7	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3244	Individual Protein	Tyrosine-protein kinase FER	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT3244	Individual Protein	Tyrosine-protein kinase FER	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3457	Individual Protein	G protein-coupled receptor kinase 5	Homo sapiens	Residual Activity	=	70.0	%	PMID[485090]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	113.0	%	PMID[485090]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	109.0	%	PMID[485090]
NPT1478	Individual Protein	Vascular endothelial growth factor receptor 2	Homo sapiens	Residual Activity	=	87.0	%	PMID[485090]
NPT3242	Individual Protein	LIM domain kinase 1	Homo sapiens	Residual Activity	=	109.0	%	PMID[485090]
NPT3282	Individual Protein	Maternal embryonic leucine zipper kinase	Homo sapiens	Residual Activity	=	63.0	%	PMID[485090]
NPT3331	Individual Protein	Serine/threonine-protein kinase MST2	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT1442	Individual Protein	Serine/threonine-protein kinase PAK 2	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT1442	Individual Protein	Serine/threonine-protein kinase PAK 2	Homo sapiens	Residual Activity	=	83.0	%	PMID[485090]
NPT1433	Individual Protein	Serine/threonine-protein kinase Aurora-B	Homo sapiens	Residual Activity	=	68.0	%	PMID[485090]
NPT3206	Individual Protein	Serine/threonine-protein kinase Aurora-C	Homo sapiens	Residual Activity	=	76.0	%	PMID[485090]
NPT3273	Individual Protein	Casein kinase II alpha (prime)	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3336	Individual Protein	Serine/threonine-protein kinase DCLK2	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT3216	Individual Protein	Ephrin type-A receptor 8	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3457	Individual Protein	G protein-coupled receptor kinase 5	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT4088	Individual Protein	G protein-coupled receptor kinase 6	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	117.0	%	PMID[485090]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT3242	Individual Protein	LIM domain kinase 1	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT3381	Individual Protein	Misshapen-like kinase 1	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3381	Individual Protein	Misshapen-like kinase 1	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3332	Individual Protein	Serine/threonine-protein kinase 24	Homo sapiens	Residual Activity	=	68.0	%	PMID[485090]
NPT3332	Individual Protein	Serine/threonine-protein kinase 24	Homo sapiens	Residual Activity	=	72.0	%	PMID[485090]
NPT3247	Individual Protein	Serine/threonine-protein kinase PAK 3	Homo sapiens	Residual Activity	=	68.0	%	PMID[485090]
NPT3206	Individual Protein	Serine/threonine-protein kinase Aurora-C	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT1682	Individual Protein	Dual specificity protein kinase CLK2	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT3336	Individual Protein	Serine/threonine-protein kinase DCLK2	Homo sapiens	Residual Activity	=	75.0	%	PMID[485090]
NPT3303	Individual Protein	Discoidin domain-containing receptor 2	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT3216	Individual Protein	Ephrin type-A receptor 8	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT3212	Individual Protein	Ephrin type-B receptor 1	Homo sapiens	Residual Activity	=	109.0	%	PMID[485090]
NPT4088	Individual Protein	G protein-coupled receptor kinase 6	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT2574	Individual Protein	Insulin receptor	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT3279	Individual Protein	Serine/threonine-protein kinase 11	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT3279	Individual Protein	Serine/threonine-protein kinase 11	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT1691	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens	Residual Activity	=	72.0	%	PMID[485090]
NPT3320	Individual Protein	Proto-oncogene tyrosine-protein kinase MER	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT3245	Individual Protein	Tyrosine kinase non-receptor protein 2	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3245	Individual Protein	Tyrosine kinase non-receptor protein 2	Homo sapiens	Residual Activity	=	72.0	%	PMID[485090]
NPT1659	Individual Protein	Tyrosine-protein kinase receptor UFO	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT1659	Individual Protein	Tyrosine-protein kinase receptor UFO	Homo sapiens	Residual Activity	=	77.0	%	PMID[485090]
NPT1682	Individual Protein	Dual specificity protein kinase CLK2	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT3303	Individual Protein	Discoidin domain-containing receptor 2	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT1688	Individual Protein	Myotonin-protein kinase	Homo sapiens	Residual Activity	=	147.0	%	PMID[485090]
NPT3212	Individual Protein	Ephrin type-B receptor 1	Homo sapiens	Residual Activity	=	103.0	%	PMID[485090]
NPT3438	Individual Protein	G protein-coupled receptor kinase 7	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT3438	Individual Protein	G protein-coupled receptor kinase 7	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3386	Individual Protein	Interleukin-1 receptor-associated kinase 1	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT3386	Individual Protein	Interleukin-1 receptor-associated kinase 1	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT1707	Individual Protein	Serine/threonine-protein kinase 10	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT1691	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3441	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3320	Individual Protein	Proto-oncogene tyrosine-protein kinase MER	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT1661	Individual Protein	ALK tyrosine kinase receptor	Homo sapiens	Residual Activity	=	71.0	%	PMID[485090]
NPT3215	Individual Protein	Tyrosine-protein kinase BRK	Homo sapiens	Residual Activity	=	109.0	%	PMID[485090]
NPT1683	Individual Protein	Dual specificity protein kinase CLK3	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT1683	Individual Protein	Dual specificity protein kinase CLK3	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT1688	Individual Protein	Myotonin-protein kinase	Homo sapiens	Residual Activity	=	127.0	%	PMID[485090]
NPT2941	Individual Protein	Ephrin type-B receptor 2	Homo sapiens	Residual Activity	=	115.0	%	PMID[485090]
NPT2941	Individual Protein	Ephrin type-B receptor 2	Homo sapiens	Residual Activity	=	128.0	%	PMID[485090]
NPT3425	Individual Protein	Interleukin-1 receptor-associated kinase 4	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT1707	Individual Protein	Serine/threonine-protein kinase 10	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	142.0	%	PMID[485090]
NPT3441	Individual Protein	Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT1337	Individual Protein	Hepatocyte growth factor receptor	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT1337	Individual Protein	Hepatocyte growth factor receptor	Homo sapiens	Residual Activity	=	82.0	%	PMID[485090]
NPT1661	Individual Protein	ALK tyrosine kinase receptor	Homo sapiens	Residual Activity	=	50.0	%	PMID[485090]
NPT3293	Individual Protein	Activin receptor type-1B	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT3215	Individual Protein	Tyrosine-protein kinase BRK	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT3113	Individual Protein	Tyrosine-protein kinase CSK	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT1709	Individual Protein	Serine/threonine-protein kinase 17A	Homo sapiens	Residual Activity	=	86.0	%	PMID[485090]
NPT3359	Individual Protein	Ephrin type-B receptor 3	Homo sapiens	Residual Activity	=	111.0	%	PMID[485090]
NPT1437	Individual Protein	Tyrosine-protein kinase FES	Homo sapiens	Residual Activity	=	111.0	%	PMID[485090]
NPT3425	Individual Protein	Interleukin-1 receptor-associated kinase 4	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3286	Individual Protein	Insulin receptor-related protein	Homo sapiens	Residual Activity	=	133.0	%	PMID[485090]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	86.0	%	PMID[485090]
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT2626	Individual Protein	Myosin light chain kinase, smooth muscle	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT3213	Individual Protein	MAP kinase signal-integrating kinase 2	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3113	Individual Protein	Tyrosine-protein kinase CSK	Homo sapiens	Residual Activity	=	118.0	%	PMID[485090]
NPT3232	Individual Protein	CaM kinase I alpha	Homo sapiens	Residual Activity	=	115.0	%	PMID[485090]
NPT1709	Individual Protein	Serine/threonine-protein kinase 17A	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT3399	Individual Protein	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3359	Individual Protein	Ephrin type-B receptor 3	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT2572	Individual Protein	Ephrin type-B receptor 4	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT1437	Individual Protein	Tyrosine-protein kinase FES	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT591	Individual Protein	Glycogen synthase kinase-3 beta	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3286	Individual Protein	Insulin receptor-related protein	Homo sapiens	Residual Activity	=	79.0	%	PMID[485090]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT13	Individual Protein	Tyrosine-protein kinase LCK	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT3326	Individual Protein	Mitogen-activated protein kinase kinase kinase 9	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3213	Individual Protein	MAP kinase signal-integrating kinase 2	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT3333	Individual Protein	Muscle, skeletal receptor tyrosine protein kinase	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3312	Individual Protein	Tyrosine-protein kinase BLK	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT3312	Individual Protein	Tyrosine-protein kinase BLK	Homo sapiens	Residual Activity	=	78.0	%	PMID[485090]
NPT3232	Individual Protein	CaM kinase I alpha	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT3399	Individual Protein	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT2572	Individual Protein	Ephrin type-B receptor 4	Homo sapiens	Residual Activity	=	113.0	%	PMID[485090]
NPT3112	Individual Protein	Tyrosine-protein kinase FGR	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3112	Individual Protein	Tyrosine-protein kinase FGR	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT3444	Individual Protein	Homeodomain-interacting protein kinase 1	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT1439	Individual Protein	Tyrosine-protein kinase ITK/TSK	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT1439	Individual Protein	Tyrosine-protein kinase ITK/TSK	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT3111	Individual Protein	Tyrosine-protein kinase Lyn	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT3326	Individual Protein	Mitogen-activated protein kinase kinase kinase 9	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3329	Individual Protein	Serine/threonine-protein kinase MRCK-A	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT3333	Individual Protein	Muscle, skeletal receptor tyrosine protein kinase	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT2750	Individual Protein	Tyrosine-protein kinase BMX	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT2750	Individual Protein	Tyrosine-protein kinase BMX	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT1608	Individual Protein	Serine/threonine-protein kinase Chk1	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT1608	Individual Protein	Serine/threonine-protein kinase Chk1	Homo sapiens	Residual Activity	=	87.0	%	PMID[485090]
NPT1630	Individual Protein	CaM kinase II beta	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT1630	Individual Protein	CaM kinase II beta	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT285	Individual Protein	Epidermal growth factor receptor erbB1	Homo sapiens	Residual Activity	=	115.0	%	PMID[485090]
NPT1435	Individual Protein	Receptor protein-tyrosine kinase erbB-4	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT1435	Individual Protein	Receptor protein-tyrosine kinase erbB-4	Homo sapiens	Residual Activity	=	67.0	%	PMID[485090]
NPT301	Individual Protein	Vascular endothelial growth factor receptor 1	Homo sapiens	Residual Activity	=	86.0	%	PMID[485090]
NPT3444	Individual Protein	Homeodomain-interacting protein kinase 1	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3432	Individual Protein	Homeodomain-interacting protein kinase 2	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT3246	Individual Protein	Tyrosine-protein kinase JAK2	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT3111	Individual Protein	Tyrosine-protein kinase Lyn	Homo sapiens	Residual Activity	=	57.0	%	PMID[485090]
NPT281	Individual Protein	MAP kinase ERK1	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT3329	Individual Protein	Serine/threonine-protein kinase MRCK-A	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3443	Individual Protein	Serine/threonine-protein kinase Nek11	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT1660	Individual Protein	NUAK family SNF1-like kinase 1	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT3315	Individual Protein	BR serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	76.0	%	PMID[485090]
NPT1680	Individual Protein	Serine/threonine-protein kinase Chk2	Homo sapiens	Residual Activity	=	91.0	%	PMID[485090]
NPT1676	Individual Protein	CaM kinase II gamma	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT3354	Individual Protein	Ephrin type-A receptor 1	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT1436	Individual Protein	Focal adhesion kinase 1	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT301	Individual Protein	Vascular endothelial growth factor receptor 1	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT1650	Individual Protein	Tyrosine-protein kinase receptor FLT3	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT3432	Individual Protein	Homeodomain-interacting protein kinase 2	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3246	Individual Protein	Tyrosine-protein kinase JAK2	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT1440	Individual Protein	Tyrosine-protein kinase JAK3	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT281	Individual Protein	MAP kinase ERK1	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT3330	Individual Protein	Serine/threonine-protein kinase MRCK beta	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT3330	Individual Protein	Serine/threonine-protein kinase MRCK beta	Homo sapiens	Residual Activity	=	77.0	%	PMID[485090]
NPT1658	Individual Protein	Serine/threonine-protein kinase NEK2	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT1660	Individual Protein	NUAK family SNF1-like kinase 1	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT3315	Individual Protein	BR serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	75.0	%	PMID[485090]
NPT3344	Individual Protein	BR serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT1680	Individual Protein	Serine/threonine-protein kinase Chk2	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT1684	Individual Protein	Casein kinase I gamma 1	Homo sapiens	Residual Activity	=	91.0	%	PMID[485090]
NPT1676	Individual Protein	CaM kinase II gamma	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT1675	Individual Protein	CaM kinase II delta	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT3354	Individual Protein	Ephrin type-A receptor 1	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT3225	Individual Protein	Ephrin type-A receptor 2	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT1436	Individual Protein	Focal adhesion kinase 1	Homo sapiens	Residual Activity	=	91.0	%	PMID[485090]
NPT1480	Individual Protein	Fibroblast growth factor receptor 1	Homo sapiens	Residual Activity	=	82.0	%	PMID[485090]
NPT1650	Individual Protein	Tyrosine-protein kinase receptor FLT3	Homo sapiens	Residual Activity	=	76.0	%	PMID[485090]
NPT3409	Individual Protein	Homeodomain-interacting protein kinase 3	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT3409	Individual Protein	Homeodomain-interacting protein kinase 3	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT1440	Individual Protein	Tyrosine-protein kinase JAK3	Homo sapiens	Residual Activity	=	63.0	%	PMID[485090]
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT282	Individual Protein	MAP kinase ERK2	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT1613	Individual Protein	Ribosomal protein S6 kinase alpha 5	Homo sapiens	Residual Activity	=	115.0	%	PMID[485090]
NPT1658	Individual Protein	Serine/threonine-protein kinase NEK2	Homo sapiens	Residual Activity	=	84.0	%	PMID[485090]
NPT3391	Individual Protein	Serine/threonine-protein kinase Nek3	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT1431	Individual Protein	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT1431	Individual Protein	Mitogen-activated protein kinase kinase kinase 5	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3344	Individual Protein	BR serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT1684	Individual Protein	Casein kinase I gamma 1	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT1675	Individual Protein	CaM kinase II delta	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT3225	Individual Protein	Ephrin type-A receptor 2	Homo sapiens	Residual Activity	=	113.0	%	PMID[485090]
NPT1480	Individual Protein	Fibroblast growth factor receptor 1	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT2573	Individual Protein	Vascular endothelial growth factor receptor 3	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT2573	Individual Protein	Vascular endothelial growth factor receptor 3	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT4093	Individual Protein	Serine/threonine-protein kinase haspin	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT1426	Individual Protein	c-Jun N-terminal kinase 1	Homo sapiens	Residual Activity	=	120.0	%	PMID[485090]
NPT1426	Individual Protein	c-Jun N-terminal kinase 1	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT1441	Individual Protein	MAP kinase-activated protein kinase 2	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT1613	Individual Protein	Ribosomal protein S6 kinase alpha 5	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT3374	Individual Protein	Ribosomal protein S6 kinase alpha 4	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3391	Individual Protein	Serine/threonine-protein kinase Nek3	Homo sapiens	Residual Activity	=	76.0	%	PMID[485090]
NPT2729	Individual Protein	Tyrosine-protein kinase ABL	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT1685	Individual Protein	Casein kinase I gamma 2	Homo sapiens	Residual Activity	=	73.0	%	PMID[485090]
NPT1685	Individual Protein	Casein kinase I gamma 2	Homo sapiens	Residual Activity	=	67.0	%	PMID[485090]
NPT1677	Individual Protein	CaM kinase IV	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT1677	Individual Protein	CaM kinase IV	Homo sapiens	Residual Activity	=	81.0	%	PMID[485090]
NPT3217	Individual Protein	Ephrin type-A receptor 3	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT3217	Individual Protein	Ephrin type-A receptor 3	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT1481	Individual Protein	Fibroblast growth factor receptor 2	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT1481	Individual Protein	Fibroblast growth factor receptor 2	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT3267	Individual Protein	Macrophage colony stimulating factor receptor	Homo sapiens	Residual Activity	=	131.0	%	PMID[485090]
NPT4093	Individual Protein	Serine/threonine-protein kinase haspin	Homo sapiens	Residual Activity	=	78.0	%	PMID[485090]
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	78.0	%	PMID[485090]
NPT1427	Individual Protein	c-Jun N-terminal kinase 2	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT1441	Individual Protein	MAP kinase-activated protein kinase 2	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT3461	Individual Protein	MAP kinase-activated protein kinase 3	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT3374	Individual Protein	Ribosomal protein S6 kinase alpha 4	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT1657	Individual Protein	Serine/threonine-protein kinase NEK6	Homo sapiens	Residual Activity	=	103.0	%	PMID[485090]
NPT1657	Individual Protein	Serine/threonine-protein kinase NEK6	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT2729	Individual Protein	Tyrosine-protein kinase ABL	Homo sapiens	Residual Activity	=	68.0	%	PMID[485090]
NPT3214	Individual Protein	Tyrosine-protein kinase ABL2	Homo sapiens	Residual Activity	=	111.0	%	PMID[485090]
NPT1686	Individual Protein	Casein kinase I isoform gamma-3	Homo sapiens	Residual Activity	=	87.0	%	PMID[485090]
NPT1672	Individual Protein	CaM kinase I delta	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT3218	Individual Protein	Ephrin type-A receptor 4	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT3227	Individual Protein	Fibroblast growth factor receptor 3	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT3267	Individual Protein	Macrophage colony stimulating factor receptor	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT14	Individual Protein	Tyrosine-protein kinase FYN	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT3205	Individual Protein	Tyrosine-protein kinase HCK	Homo sapiens	Residual Activity	=	76.0	%	PMID[485090]
NPT1438	Individual Protein	Insulin-like growth factor I receptor	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT1427	Individual Protein	c-Jun N-terminal kinase 2	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT3461	Individual Protein	MAP kinase-activated protein kinase 3	Homo sapiens	Residual Activity	=	81.0	%	PMID[485090]
NPT1703	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Homo sapiens	Residual Activity	=	79.0	%	PMID[485090]
NPT3124	Individual Protein	Protein kinase C eta	Homo sapiens	Residual Activity	=	83.0	%	PMID[485090]
NPT1700	Individual Protein	Serine/threonine-protein kinase PIM2	Homo sapiens	Residual Activity	=	129.0	%	PMID[485090]
NPT1701	Individual Protein	Serine/threonine-protein kinase PIM3	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT3277	Individual Protein	Tyrosine-protein kinase receptor TYRO3	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT3349	Individual Protein	Serine/threonine-protein kinase SIK1	Homo sapiens	Residual Activity	=	54.0	%	PMID[485090]
NPT3269	Individual Protein	Serine/threonine-protein kinase tousled-like 2	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT3269	Individual Protein	Serine/threonine-protein kinase tousled-like 2	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT4094	Individual Protein	Serine/threonine-protein kinase WNK3	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT4094	Individual Protein	Serine/threonine-protein kinase WNK3	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT1703	Individual Protein	cAMP-dependent protein kinase alpha-catalytic subunit	Homo sapiens	Residual Activity	=	70.0	%	PMID[485090]
NPT1701	Individual Protein	Serine/threonine-protein kinase PIM3	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3106	Individual Protein	Ribosomal protein S6 kinase alpha 1	Homo sapiens	Residual Activity	=	115.0	%	PMID[485090]
NPT3106	Individual Protein	Ribosomal protein S6 kinase alpha 1	Homo sapiens	Residual Activity	=	84.0	%	PMID[485090]
NPT3291	Individual Protein	Serine/threonine-protein kinase SRPK1	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3291	Individual Protein	Serine/threonine-protein kinase SRPK1	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT3299	Individual Protein	Testis-specific serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT1663	Individual Protein	Tyrosine-protein kinase YES	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT3394	Individual Protein	Protein kinase C iota	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3394	Individual Protein	Protein kinase C iota	Homo sapiens	Residual Activity	=	71.0	%	PMID[485090]
NPT1705	Individual Protein	Ribosomal protein S6 kinase alpha 3	Homo sapiens	Residual Activity	=	50.0	%	PMID[485090]
NPT3292	Individual Protein	Serine/threonine-protein kinase SRPK2	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3299	Individual Protein	Testis-specific serine/threonine-protein kinase 1	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT3462	Individual Protein	Testis-specific serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT1663	Individual Protein	Tyrosine-protein kinase YES	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT3259	Individual Protein	Tyrosine-protein kinase ZAP-70	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT1430	Individual Protein	Serine/threonine-protein kinase AKT2	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT1430	Individual Protein	Serine/threonine-protein kinase AKT2	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3364	Individual Protein	Protein kinase C mu	Homo sapiens	Residual Activity	=	119.0	%	PMID[485090]
NPT3358	Individual Protein	Serine/threonine-protein kinase PLK3	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT1705	Individual Protein	Ribosomal protein S6 kinase alpha 3	Homo sapiens	Residual Activity	=	36.0	%	PMID[485090]
NPT3234	Individual Protein	Ribosomal protein S6 kinase alpha 2	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT3292	Individual Protein	Serine/threonine-protein kinase SRPK2	Homo sapiens	Residual Activity	=	91.0	%	PMID[485090]
NPT3296	Individual Protein	Serine/threonine-protein kinase 33	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT3462	Individual Protein	Testis-specific serine/threonine-protein kinase 2	Homo sapiens	Residual Activity	=	75.0	%	PMID[485090]
NPT3259	Individual Protein	Tyrosine-protein kinase ZAP-70	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT2546	Individual Protein	Serine/threonine-protein kinase AKT3	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT3364	Individual Protein	Protein kinase C mu	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT3365	Individual Protein	Serine/threonine-protein kinase D2	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT3358	Individual Protein	Serine/threonine-protein kinase PLK3	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3234	Individual Protein	Ribosomal protein S6 kinase alpha 2	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3351	Individual Protein	Tyrosine-protein kinase TEC	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT3351	Individual Protein	Tyrosine-protein kinase TEC	Homo sapiens	Residual Activity	=	84.0	%	PMID[485090]
NPT1687	Individual Protein	Death-associated protein kinase 3	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT1687	Individual Protein	Death-associated protein kinase 3	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3247	Individual Protein	Serine/threonine-protein kinase PAK 3	Homo sapiens	Residual Activity	=	75.0	%	PMID[485090]
NPT1695	Individual Protein	Serine/threonine-protein kinase PAK 4	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT2546	Individual Protein	Serine/threonine-protein kinase AKT3	Homo sapiens	Residual Activity	=	75.0	%	PMID[485090]
NPT3365	Individual Protein	Serine/threonine-protein kinase D2	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT3262	Individual Protein	Serine/threonine-protein kinase PRKX	Homo sapiens	Residual Activity	=	80.0	%	PMID[485090]
NPT3262	Individual Protein	Serine/threonine-protein kinase PRKX	Homo sapiens	Residual Activity	=	72.0	%	PMID[485090]
NPT3254	Individual Protein	Ribosomal protein S6 kinase alpha 6	Homo sapiens	Residual Activity	=	113.0	%	PMID[485090]
NPT3254	Individual Protein	Ribosomal protein S6 kinase alpha 6	Homo sapiens	Residual Activity	=	91.0	%	PMID[485090]
NPT3414	Individual Protein	Serine/threonine-protein kinase PLK2	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT2576	Individual Protein	Tyrosine-protein kinase TIE-2	Homo sapiens	Residual Activity	=	84.0	%	PMID[485090]
NPT1424	Individual Protein	Serine/threonine-protein kinase RAF	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT1695	Individual Protein	Serine/threonine-protein kinase PAK 4	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT182	Individual Protein	Protein kinase C alpha	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT182	Individual Protein	Protein kinase C alpha	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT3263	Individual Protein	Protein tyrosine kinase 2 beta	Homo sapiens	Residual Activity	=	124.0	%	PMID[485090]
NPT283	Individual Protein	MAP kinase p38 alpha	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3414	Individual Protein	Serine/threonine-protein kinase PLK2	Homo sapiens	Residual Activity	=	91.0	%	PMID[485090]
NPT1449	Individual Protein	Tyrosine-protein kinase SYK	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT2576	Individual Protein	Tyrosine-protein kinase TIE-2	Homo sapiens	Residual Activity	=	76.0	%	PMID[485090]
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	Residual Activity	=	120.0	%	PMID[485090]
NPT1424	Individual Protein	Serine/threonine-protein kinase RAF	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT1696	Individual Protein	Serine/threonine-protein kinase PAK7	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT1696	Individual Protein	Serine/threonine-protein kinase PAK7	Homo sapiens	Residual Activity	=	64.0	%	PMID[485090]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT3263	Individual Protein	Protein tyrosine kinase 2 beta	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT1447	Individual Protein	Serine/threonine-protein kinase RIPK2	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT283	Individual Protein	MAP kinase p38 alpha	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT1616	Individual Protein	MAP kinase p38 beta	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT1449	Individual Protein	Tyrosine-protein kinase SYK	Homo sapiens	Residual Activity	=	87.0	%	PMID[485090]
NPT3239	Individual Protein	Nerve growth factor receptor Trk-A	Homo sapiens	Residual Activity	=	118.0	%	PMID[485090]
NPT1479	Individual Protein	Stem cell growth factor receptor	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT1697	Individual Protein	Serine/threonine-protein kinase PAK6	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3367	Individual Protein	cGMP-dependent protein kinase 1 beta	Homo sapiens	Residual Activity	=	81.0	%	PMID[485090]
NPT1612	Individual Protein	MAP kinase-activated protein kinase 5	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT1447	Individual Protein	Serine/threonine-protein kinase RIPK2	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT1616	Individual Protein	MAP kinase p38 beta	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT3442	Individual Protein	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3442	Individual Protein	Mitogen-activated protein kinase kinase kinase 7	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT3270	Individual Protein	Neurotrophic tyrosine kinase receptor type 2	Homo sapiens	Residual Activity	=	113.0	%	PMID[485090]
NPT3270	Individual Protein	Neurotrophic tyrosine kinase receptor type 2	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT36	Individual Protein	Tyrosine-protein kinase SRC	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT36	Individual Protein	Tyrosine-protein kinase SRC	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT1697	Individual Protein	Serine/threonine-protein kinase PAK6	Homo sapiens	Residual Activity	=	84.0	%	PMID[485090]
NPT3235	Individual Protein	MAP/microtubule affinity-regulating kinase 2	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT1612	Individual Protein	MAP kinase-activated protein kinase 5	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT592	Individual Protein	Rho-associated protein kinase 1	Homo sapiens	Residual Activity	=	121.0	%	PMID[485090]
NPT592	Individual Protein	Rho-associated protein kinase 1	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT1615	Individual Protein	MAP kinase p38 gamma	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT1615	Individual Protein	MAP kinase p38 gamma	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3431	Individual Protein	Serine/threonine-protein kinase TAO1	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT3272	Individual Protein	Tyrosine-protein kinase TXK	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT1344	Individual Protein	Serine/threonine-protein kinase EEF2K	Homo sapiens	Residual Activity	=	120.0	%	PMID[485090]
NPT3235	Individual Protein	MAP/microtubule affinity-regulating kinase 2	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT3357	Individual Protein	Protein kinase N2	Homo sapiens	Residual Activity	=	111.0	%	PMID[485090]
NPT3357	Individual Protein	Protein kinase N2	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3107	Individual Protein	Rho-associated protein kinase 2	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT1614	Individual Protein	MAP kinase p38 delta	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT3431	Individual Protein	Serine/threonine-protein kinase TAO1	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT3426	Individual Protein	Serine/threonine-protein kinase TAO2	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3272	Individual Protein	Tyrosine-protein kinase TXK	Homo sapiens	Residual Activity	=	103.0	%	PMID[485090]
NPT3422	Individual Protein	Serine/threonine-protein kinase ULK2	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT1344	Individual Protein	Serine/threonine-protein kinase EEF2K	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT3454	Individual Protein	PAS domain-containing serine/threonine-protein kinase	Homo sapiens	Residual Activity	=	125.0	%	PMID[485090]
NPT3454	Individual Protein	PAS domain-containing serine/threonine-protein kinase	Homo sapiens	Residual Activity	=	59.0	%	PMID[485090]
NPT3204	Individual Protein	Tyrosine-protein kinase FRK	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT3107	Individual Protein	Rho-associated protein kinase 2	Homo sapiens	Residual Activity	=	80.0	%	PMID[485090]
NPT3370	Individual Protein	Tyrosine-protein kinase receptor RET	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT1614	Individual Protein	MAP kinase p38 delta	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT1448	Individual Protein	Serine/threonine-protein kinase Sgk1	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT3426	Individual Protein	Serine/threonine-protein kinase TAO2	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT3422	Individual Protein	Serine/threonine-protein kinase ULK2	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3020	Individual Protein	Platelet-derived growth factor receptor alpha	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT3204	Individual Protein	Tyrosine-protein kinase FRK	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT3223	Individual Protein	Phosphorylase kinase gamma subunit 2	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT3370	Individual Protein	Tyrosine-protein kinase receptor RET	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT1448	Individual Protein	Serine/threonine-protein kinase Sgk1	Homo sapiens	Residual Activity	=	78.0	%	PMID[485090]
NPT3427	Individual Protein	Serine/threonine-protein kinase TAO3	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT3427	Individual Protein	Serine/threonine-protein kinase TAO3	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3382	Individual Protein	Serine/threonine-protein kinase ULK3	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT3382	Individual Protein	Serine/threonine-protein kinase ULK3	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3020	Individual Protein	Platelet-derived growth factor receptor alpha	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT2575	Individual Protein	Platelet-derived growth factor receptor beta	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT3223	Individual Protein	Phosphorylase kinase gamma subunit 2	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT3390	Individual Protein	Macrophage-stimulating protein receptor	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT3456	Individual Protein	Serine/threonine-protein kinase Sgk2	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT3456	Individual Protein	Serine/threonine-protein kinase Sgk2	Homo sapiens	Residual Activity	=	76.0	%	PMID[485090]
NPT3417	Individual Protein	Serine/threonine-protein kinase TBK1	Homo sapiens	Residual Activity	=	77.0	%	PMID[485090]
NPT1715	Individual Protein	Serine/threonine-protein kinase VRK2	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT1611	Individual Protein	Ribosomal protein S6 kinase 1	Homo sapiens	Residual Activity	=	75.0	%	PMID[485090]
NPT2575	Individual Protein	Platelet-derived growth factor receptor beta	Homo sapiens	Residual Activity	=	80.0	%	PMID[485090]
NPT3455	Individual Protein	Protein kinase C zeta	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT3455	Individual Protein	Protein kinase C zeta	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT1265	Individual Protein	Serine/threonine-protein kinase PIM1	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT1265	Individual Protein	Serine/threonine-protein kinase PIM1	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT3373	Individual Protein	Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT3418	Individual Protein	Serine/threonine-protein kinase Sgk3	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT3417	Individual Protein	Serine/threonine-protein kinase TBK1	Homo sapiens	Residual Activity	=	69.0	%	PMID[485090]
NPT3353	Individual Protein	TGF-beta receptor type I	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT1715	Individual Protein	Serine/threonine-protein kinase VRK2	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT4096	Individual Protein	Serine/threonine-protein kinase WNK2	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT1611	Individual Protein	Ribosomal protein S6 kinase 1	Homo sapiens	Residual Activity	=	43.0	%	PMID[485090]
NPT1699	Individual Protein	3-phosphoinositide dependent protein kinase-1	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT1699	Individual Protein	3-phosphoinositide dependent protein kinase-1	Homo sapiens	Residual Activity	=	96.0	%	PMID[485090]
NPT3124	Individual Protein	Protein kinase C eta	Homo sapiens	Residual Activity	=	118.0	%	PMID[485090]
NPT1700	Individual Protein	Serine/threonine-protein kinase PIM2	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT3373	Individual Protein	Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT3277	Individual Protein	Tyrosine-protein kinase receptor TYRO3	Homo sapiens	Residual Activity	=	86.0	%	PMID[485090]
NPT3418	Individual Protein	Serine/threonine-protein kinase Sgk3	Homo sapiens	Residual Activity	=	93.0	%	PMID[485090]
NPT3349	Individual Protein	Serine/threonine-protein kinase SIK1	Homo sapiens	Residual Activity	=	82.0	%	PMID[485090]
NPT3353	Individual Protein	TGF-beta receptor type I	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]
NPT4096	Individual Protein	Serine/threonine-protein kinase WNK2	Homo sapiens	Residual Activity	=	90.0	%	PMID[485090]
NPT81	Cell Line	A549	Homo sapiens	IC50	=	150.0	nM	PMID[485091]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	37.8	%	PMID[485086]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	Inhibition	=	50.7	%	PMID[485086]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	IC50	=	1.1	ug.mL-1	PMID[485086]
NPT20529	NON-MOLECULAR	NON-PROTEIN TARGET	n.a.	CC50	=	1.72	ug.mL-1	PMID[485086]
NPT2	Others	Unspecified		Inhibition	=	48.0	%	PMID[485089]
NPT27	Others	Unspecified		Activity	=	102.7	%	PMID[485089]
NPT2	Others	Unspecified		Inhibition	=	77.0	%	PMID[485089]
NPT27	Others	Unspecified		Activity	=	101.6	%	PMID[485089]
NPT2	Others	Unspecified		IC50	=	94.0	nM	PMID[485089]
NPT3814	Protein Complex	Cyclin-dependent kinase 2/cyclin A	Homo sapiens	Residual Activity	=	83.0	%	PMID[485090]
NPT2544	Protein Complex	Cyclin-dependent kinase 2/cyclin E	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT982	Individual Protein	Inhibitor of nuclear factor kappa B kinase alpha subunit	Homo sapiens	Residual Activity	=	113.0	%	PMID[485090]
NPT2544	Protein Complex	Cyclin-dependent kinase 2/cyclin E	Homo sapiens	Residual Activity	=	91.0	%	PMID[485090]
NPT981	Individual Protein	Inhibitor of nuclear factor kappa B kinase beta subunit	Homo sapiens	Residual Activity	=	111.0	%	PMID[485090]
NPT981	Individual Protein	Inhibitor of nuclear factor kappa B kinase beta subunit	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT4087	Protein Complex	CDK3/cyclin E	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT4087	Protein Complex	CDK3/cyclin E	Homo sapiens	Residual Activity	=	87.0	%	PMID[485090]
NPT1609	Protein Complex	Casein kinase II	Homo sapiens	Residual Activity	=	88.0	%	PMID[485090]
NPT1609	Protein Complex	Casein kinase II	Homo sapiens	Residual Activity	=	111.0	%	PMID[485090]
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	104.0	%	PMID[485090]
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	105.0	%	PMID[485090]
NPT1509	Protein Complex	Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Residual Activity	=	83.0	%	PMID[485090]
NPT4089	Protein Complex	CDK6/cyclin D3	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT4089	Protein Complex	CDK6/cyclin D3	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT676	Individual Protein	Glycogen synthase kinase-3 alpha	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT833	Individual Protein	Tyrosine-protein kinase BTK	Homo sapiens	Residual Activity	=	83.0	%	PMID[485090]
NPT4090	Protein Complex	Cyclin-dependent kinase 7/ cyclin H	Homo sapiens	Residual Activity	=	108.0	%	PMID[485090]
NPT676	Individual Protein	Glycogen synthase kinase-3 alpha	Homo sapiens	Residual Activity	=	109.0	%	PMID[485090]
NPT833	Individual Protein	Tyrosine-protein kinase BTK	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT4090	Protein Complex	Cyclin-dependent kinase 7/ cyclin H	Homo sapiens	Residual Activity	=	101.0	%	PMID[485090]
NPT4092	Protein Complex	CDK9/cyclin T1	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT4091	Protein Complex	AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1	Homo sapiens	Residual Activity	=	94.0	%	PMID[485090]
NPT4091	Protein Complex	AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1	Homo sapiens	Residual Activity	=	78.0	%	PMID[485090]
NPT4092	Protein Complex	CDK9/cyclin T1	Homo sapiens	Residual Activity	=	83.0	%	PMID[485090]
NPT1767	Protein Complex	AMP-activated protein kinase, AMPK	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT1767	Protein Complex	AMP-activated protein kinase, AMPK	Homo sapiens	Residual Activity	=	78.0	%	PMID[485090]
NPT1561	Protein Complex	Cyclin-dependent kinase 1/cyclin B1	Homo sapiens	Residual Activity	=	111.0	%	PMID[485090]
NPT1561	Protein Complex	Cyclin-dependent kinase 1/cyclin B1	Homo sapiens	Residual Activity	=	110.0	%	PMID[485090]
NPT3814	Protein Complex	Cyclin-dependent kinase 2/cyclin A	Homo sapiens	Residual Activity	=	138.0	%	PMID[485090]
NPT982	Individual Protein	Inhibitor of nuclear factor kappa B kinase alpha subunit	Homo sapiens	Residual Activity	=	85.0	%	PMID[485090]
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT728	Individual Protein	Serine/threonine-protein kinase AKT	Homo sapiens	Residual Activity	=	112.0	%	PMID[485090]
NPT887	Individual Protein	Protein kinase C theta	Homo sapiens	Residual Activity	=	98.0	%	PMID[485090]
NPT728	Individual Protein	Serine/threonine-protein kinase AKT	Homo sapiens	Residual Activity	=	114.0	%	PMID[485090]
NPT831	Individual Protein	Serine/threonine-protein kinase PLK1	Homo sapiens	Residual Activity	=	86.0	%	PMID[485090]
NPT831	Individual Protein	Serine/threonine-protein kinase PLK1	Homo sapiens	Residual Activity	=	70.0	%	PMID[485090]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	106.0	%	PMID[485090]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	121.0	%	PMID[485090]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	92.0	%	PMID[485090]
NPT760	Individual Protein	Protein kinase C beta	Homo sapiens	Residual Activity	=	97.0	%	PMID[485090]
NPT880	Individual Protein	Protein kinase C gamma	Homo sapiens	Residual Activity	=	111.0	%	PMID[485090]
NPT880	Individual Protein	Protein kinase C gamma	Homo sapiens	Residual Activity	=	99.0	%	PMID[485090]
NPT881	Individual Protein	Protein kinase C delta	Homo sapiens	Residual Activity	=	107.0	%	PMID[485090]
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	95.0	%	PMID[485090]
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	103.0	%	PMID[485090]
NPT761	Individual Protein	Protein kinase C epsilon	Homo sapiens	Residual Activity	=	100.0	%	PMID[485090]
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	77.0	%	PMID[485090]
NPT761	Individual Protein	Protein kinase C epsilon	Homo sapiens	Residual Activity	=	102.0	%	PMID[485090]
NPT940	Individual Protein	Serine/threonine-protein kinase mTOR	Homo sapiens	Residual Activity	=	89.0	%	PMID[485090]

☑ Note for Activity Records:
☉ The quantitative biological activities were primarily integrated from ChEMBL (Version-30) database and were also directly collected from PubMed literature. PubMed PMID was provided as the reference link for each activity record.

Chemically structural similarity: I. Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes 4,3285 NPs with experimentally-derived bioactivity available in NPASS)

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

● The left chart: Distribution of similarity level between NPC316325 and all remaining natural products in the NPASS database.
● The right table: Most similar natural products (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	89
0.1-0.2	516
0.2-0.3	2606
0.3-0.4	14976
0.4-0.5	18866
0.5-0.6	5268
0.6-0.7	352
0.7-0.8	10
0.8-0.85	8
0.85-0.9	4
0.9-0.95	0
0.95-1	2

Similarity Score	Similarity Level	Natural Product ID
0.8772	High Similarity	NPC271621
0.8772	High Similarity	NPC59751
0.8772	High Similarity	NPC27413
0.8632	High Similarity	NPC315915
0.8522	High Similarity	NPC315652
0.8522	High Similarity	NPC7905
0.8509	High Similarity	NPC5485
0.839	Intermediate Similarity	NPC473808
0.8376	Intermediate Similarity	NPC296361
0.8319	Intermediate Similarity	NPC133729
0.813	Intermediate Similarity	NPC473249
0.7807	Intermediate Similarity	NPC472616
0.7739	Intermediate Similarity	NPC472615
0.7674	Intermediate Similarity	NPC314361
0.7377	Intermediate Similarity	NPC471645
0.7373	Intermediate Similarity	NPC251330
0.7355	Intermediate Similarity	NPC469865
0.7185	Intermediate Similarity	NPC230889
0.7165	Intermediate Similarity	NPC469515
0.7143	Intermediate Similarity	NPC271269
0.7143	Intermediate Similarity	NPC316249
0.7132	Intermediate Similarity	NPC469494
0.712	Intermediate Similarity	NPC475642
0.7107	Intermediate Similarity	NPC473578
0.7099	Intermediate Similarity	NPC329919
0.7099	Intermediate Similarity	NPC477793
0.709	Intermediate Similarity	NPC78189
0.7045	Intermediate Similarity	NPC110294
0.7025	Intermediate Similarity	NPC475150
0.7018	Intermediate Similarity	NPC5418
0.7	Intermediate Similarity	NPC154601
0.6992	Remote Similarity	NPC170375
0.6949	Remote Similarity	NPC316250
0.6937	Remote Similarity	NPC472614
0.6923	Remote Similarity	NPC161855
0.6911	Remote Similarity	NPC477997
0.6899	Remote Similarity	NPC156379
0.6899	Remote Similarity	NPC475383
0.6897	Remote Similarity	NPC165332
0.6897	Remote Similarity	NPC195645
0.6897	Remote Similarity	NPC180722
0.6885	Remote Similarity	NPC307903
0.6885	Remote Similarity	NPC140251
0.6875	Remote Similarity	NPC241050
0.6855	Remote Similarity	NPC21713
0.6855	Remote Similarity	NPC475608
0.6829	Remote Similarity	NPC24389
0.6807	Remote Similarity	NPC175531
0.6794	Remote Similarity	NPC315783
0.6794	Remote Similarity	NPC16709
0.6752	Remote Similarity	NPC473291
0.675	Remote Similarity	NPC469598
0.672	Remote Similarity	NPC29501
0.6719	Remote Similarity	NPC476190
0.6695	Remote Similarity	NPC266842
0.6694	Remote Similarity	NPC474563
0.6667	Remote Similarity	NPC205546
0.6667	Remote Similarity	NPC233273
0.6667	Remote Similarity	NPC189764
0.6667	Remote Similarity	NPC315531
0.6667	Remote Similarity	NPC313234
0.6667	Remote Similarity	NPC50902
0.6639	Remote Similarity	NPC203627
0.6638	Remote Similarity	NPC472613
0.6615	Remote Similarity	NPC313802
0.6615	Remote Similarity	NPC67917
0.6615	Remote Similarity	NPC314268
0.6615	Remote Similarity	NPC477515
0.6613	Remote Similarity	NPC193765
0.661	Remote Similarity	NPC175614
0.6609	Remote Similarity	NPC477866
0.6609	Remote Similarity	NPC477865
0.6589	Remote Similarity	NPC6531
0.6585	Remote Similarity	NPC201128
0.6555	Remote Similarity	NPC265662
0.6555	Remote Similarity	NPC40812
0.6552	Remote Similarity	NPC314500
0.6549	Remote Similarity	NPC315395
0.6549	Remote Similarity	NPC316426
0.6514	Remote Similarity	NPC313911
0.6514	Remote Similarity	NPC314854
0.6512	Remote Similarity	NPC30196
0.6504	Remote Similarity	NPC74035
0.65	Remote Similarity	NPC234542
0.65	Remote Similarity	NPC255592
0.65	Remote Similarity	NPC308567
0.65	Remote Similarity	NPC261377
0.6493	Remote Similarity	NPC204639
0.648	Remote Similarity	NPC473807
0.6479	Remote Similarity	NPC471672
0.6475	Remote Similarity	NPC473596
0.6475	Remote Similarity	NPC128501
0.6471	Remote Similarity	NPC475503
0.6466	Remote Similarity	NPC313670
0.6452	Remote Similarity	NPC476738
0.6452	Remote Similarity	NPC476740
0.6446	Remote Similarity	NPC473224
0.6441	Remote Similarity	NPC116930
0.6429	Remote Similarity	NPC133625
0.6429	Remote Similarity	NPC16488
0.6423	Remote Similarity	NPC474581
0.6423	Remote Similarity	NPC309398
0.6423	Remote Similarity	NPC475367
0.6423	Remote Similarity	NPC473816
0.6418	Remote Similarity	NPC316133
0.6418	Remote Similarity	NPC314629
0.6418	Remote Similarity	NPC318445
0.6417	Remote Similarity	NPC471462
0.6417	Remote Similarity	NPC167380
0.6406	Remote Similarity	NPC476269
0.6406	Remote Similarity	NPC66108
0.6406	Remote Similarity	NPC60432
0.6406	Remote Similarity	NPC1111
0.6406	Remote Similarity	NPC261750
0.6404	Remote Similarity	NPC469483
0.6404	Remote Similarity	NPC164393
0.6397	Remote Similarity	NPC204556
0.6391	Remote Similarity	NPC314293
0.6387	Remote Similarity	NPC272050
0.6383	Remote Similarity	NPC472430
0.6378	Remote Similarity	NPC122926
0.6378	Remote Similarity	NPC476290
0.6378	Remote Similarity	NPC113012
0.6378	Remote Similarity	NPC89408
0.6371	Remote Similarity	NPC469869
0.6371	Remote Similarity	NPC14537
0.6364	Remote Similarity	NPC83895
0.6364	Remote Similarity	NPC187761
0.6356	Remote Similarity	NPC472196
0.6356	Remote Similarity	NPC238090
0.6356	Remote Similarity	NPC476049
0.6356	Remote Similarity	NPC472195
0.6348	Remote Similarity	NPC477959
0.6348	Remote Similarity	NPC313658
0.6348	Remote Similarity	NPC316138
0.6341	Remote Similarity	NPC149371
0.6336	Remote Similarity	NPC471145
0.6333	Remote Similarity	NPC288350
0.6333	Remote Similarity	NPC173329
0.6333	Remote Similarity	NPC121857
0.6325	Remote Similarity	NPC473311
0.632	Remote Similarity	NPC472751
0.632	Remote Similarity	NPC473252
0.632	Remote Similarity	NPC472749
0.6316	Remote Similarity	NPC471494
0.6316	Remote Similarity	NPC314482
0.6316	Remote Similarity	NPC473353
0.6312	Remote Similarity	NPC472428
0.6311	Remote Similarity	NPC475053
0.6303	Remote Similarity	NPC159698
0.6299	Remote Similarity	NPC474725
0.629	Remote Similarity	NPC472755
0.6284	Remote Similarity	NPC471674
0.6284	Remote Similarity	NPC201899
0.6283	Remote Similarity	NPC69469
0.6281	Remote Similarity	NPC245521
0.6281	Remote Similarity	NPC475646
0.6271	Remote Similarity	NPC472199
0.6271	Remote Similarity	NPC472010
0.627	Remote Similarity	NPC469853
0.627	Remote Similarity	NPC266514
0.6269	Remote Similarity	NPC470829
0.6269	Remote Similarity	NPC473228
0.6261	Remote Similarity	NPC122502
0.6261	Remote Similarity	NPC311163
0.626	Remote Similarity	NPC47880
0.625	Remote Similarity	NPC471141
0.625	Remote Similarity	NPC36954
0.625	Remote Similarity	NPC471142
0.624	Remote Similarity	NPC472748
0.624	Remote Similarity	NPC220964
0.624	Remote Similarity	NPC475676
0.6231	Remote Similarity	NPC106395
0.6231	Remote Similarity	NPC46269
0.623	Remote Similarity	NPC475653
0.623	Remote Similarity	NPC187268
0.6228	Remote Similarity	NPC161670
0.622	Remote Similarity	NPC151393
0.6218	Remote Similarity	NPC478036
0.6218	Remote Similarity	NPC476300
0.6218	Remote Similarity	NPC478037
0.6216	Remote Similarity	NPC77481
0.6216	Remote Similarity	NPC233770
0.6214	Remote Similarity	NPC316401
0.621	Remote Similarity	NPC472754
0.6207	Remote Similarity	NPC86005
0.6198	Remote Similarity	NPC93271
0.6198	Remote Similarity	NPC476315
0.6198	Remote Similarity	NPC279621
0.6198	Remote Similarity	NPC255410
0.6198	Remote Similarity	NPC230800
0.6198	Remote Similarity	NPC135576
0.6195	Remote Similarity	NPC85772
0.619	Remote Similarity	NPC475918
0.619	Remote Similarity	NPC475802
0.6187	Remote Similarity	NPC315387
0.6187	Remote Similarity	NPC316205
0.6186	Remote Similarity	NPC51004
0.6186	Remote Similarity	NPC179394
0.6186	Remote Similarity	NPC475879

Chemically structural similarity: II. Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

● The left chart: Distribution of similarity level between NPC316325 and all drugs/candidates.
● The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

range	Tanimoto Coefficient
0-0.1	90
0.1-0.2	405
0.2-0.3	2399
0.3-0.4	4334
0.4-0.5	1758
0.5-0.6	137
0.6-0.7	19
0.7-0.8	1
0.8-0.85	5
0.85-0.9	0
0.9-0.95	1
0.95-1	1

Similarity Score	Similarity Level	Drug ID	Developmental Stage
1.0	High Similarity	NPD7500	Approved
0.9174	High Similarity	NPD7116	Clinical (unspecified phase)
0.8403	Intermediate Similarity	NPD7623	Phase 3
0.8403	Intermediate Similarity	NPD7624	Clinical (unspecified phase)
0.8319	Intermediate Similarity	NPD7739	Clinical (unspecified phase)
0.813	Intermediate Similarity	NPD7746	Phase 1
0.813	Intermediate Similarity	NPD7747	Phase 1
0.7787	Intermediate Similarity	NPD7299	Clinical (unspecified phase)
0.6992	Remote Similarity	NPD7601	Clinical (unspecified phase)
0.6897	Remote Similarity	NPD7839	Suspended
0.6794	Remote Similarity	NPD7829	Approved
0.6794	Remote Similarity	NPD7830	Approved
0.6642	Remote Similarity	NPD8074	Phase 3
0.6641	Remote Similarity	NPD8444	Approved
0.664	Remote Similarity	NPD6421	Discontinued
0.6639	Remote Similarity	NPD8029	Clinical (unspecified phase)
0.6618	Remote Similarity	NPD6914	Discontinued
0.6589	Remote Similarity	NPD7505	Discontinued
0.6552	Remote Similarity	NPD7983	Approved
0.6466	Remote Similarity	NPD6698	Approved
0.6466	Remote Similarity	NPD46	Approved
0.6444	Remote Similarity	NPD8273	Phase 1
0.6429	Remote Similarity	NPD6413	Approved
0.6418	Remote Similarity	NPD7642	Approved
0.6412	Remote Similarity	NPD7641	Discontinued
0.6325	Remote Similarity	NPD7838	Discovery
0.6259	Remote Similarity	NPD8391	Approved
0.6259	Remote Similarity	NPD8390	Approved
0.6259	Remote Similarity	NPD8392	Approved
0.6214	Remote Similarity	NPD7260	Phase 2
0.6204	Remote Similarity	NPD8451	Approved
0.6159	Remote Similarity	NPD8448	Approved
0.6131	Remote Similarity	NPD8342	Approved
0.6131	Remote Similarity	NPD8340	Approved
0.6131	Remote Similarity	NPD8341	Approved
0.6131	Remote Similarity	NPD8299	Approved
0.6083	Remote Similarity	NPD5778	Approved
0.6083	Remote Similarity	NPD5779	Approved
0.605	Remote Similarity	NPD5785	Approved
0.6029	Remote Similarity	NPD8513	Phase 3
0.6029	Remote Similarity	NPD8516	Approved
0.6029	Remote Similarity	NPD8517	Approved
0.6029	Remote Similarity	NPD8515	Approved
0.6016	Remote Similarity	NPD7899	Clinical (unspecified phase)
0.6	Remote Similarity	NPD6371	Approved
0.5969	Remote Similarity	NPD6686	Approved
0.5954	Remote Similarity	NPD1719	Phase 1
0.5944	Remote Similarity	NPD6845	Suspended
0.5931	Remote Similarity	NPD8387	Clinical (unspecified phase)
0.5912	Remote Similarity	NPD8267	Approved
0.5912	Remote Similarity	NPD8269	Approved
0.5912	Remote Similarity	NPD8268	Approved
0.5912	Remote Similarity	NPD8266	Approved
0.5906	Remote Similarity	NPD2258	Approved
0.5906	Remote Similarity	NPD2259	Approved
0.5897	Remote Similarity	NPD5363	Approved
0.5878	Remote Similarity	NPD6420	Discontinued
0.5862	Remote Similarity	NPD8415	Approved
0.5833	Remote Similarity	NPD8413	Clinical (unspecified phase)
0.5814	Remote Similarity	NPD4211	Phase 1
0.5814	Remote Similarity	NPD5357	Phase 1
0.5794	Remote Similarity	NPD6648	Approved
0.5794	Remote Similarity	NPD6404	Discontinued
0.5702	Remote Similarity	NPD3732	Approved
0.568	Remote Similarity	NPD4228	Discovery
0.5664	Remote Similarity	NPD8336	Approved
0.5664	Remote Similarity	NPD8337	Approved
0.5656	Remote Similarity	NPD8522	Clinical (unspecified phase)
0.5645	Remote Similarity	NPD5282	Discontinued
0.5643	Remote Similarity	NPD8080	Discontinued
0.5641	Remote Similarity	NPD4270	Approved
0.5641	Remote Similarity	NPD4269	Approved
0.5638	Remote Similarity	NPD6334	Approved
0.5638	Remote Similarity	NPD6333	Approved
0.5634	Remote Similarity	NPD5108	Clinical (unspecified phase)
0.563	Remote Similarity	NPD1376	Discontinued
0.5625	Remote Similarity	NPD5344	Discontinued
0.562	Remote Similarity	NPD7115	Discovery
0.5616	Remote Similarity	NPD8338	Approved
0.5614	Remote Similarity	NPD4756	Discovery
0.56	Remote Similarity	NPD1698	Clinical (unspecified phase)

Bioactivity similarity: Similar Natural Products in NPASS

Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.

Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity

B: biological targets similarity

C: networks similarity

D: cell-based bioactivity similarity

E: similarity based on clinical data