Unknown.
Australia; Vanuatu; Myanmar; Philippines; Indonesia; Cambodia; Vietnam; China; Papua New Guinea; Laos; Thailand; Fiji
Ingredient ID: NPC97202
Ingredient ID: NPC79034
Ingredient ID: NPC77174
Ingredient ID: NPC75694
Ingredient ID: NPC479466
Ingredient ID: NPC479465
Ingredient ID: NPC479464
Ingredient ID: NPC479463
Ingredient ID: NPC36765
Ingredient ID: NPC310822
Ingredient ID: NPC307063
Ingredient ID: NPC305392
Ingredient ID: NPC303485
Ingredient ID: NPC30315
Ingredient ID: NPC273444
Ingredient ID: NPC271985
Ingredient ID: NPC25938
Ingredient ID: NPC245468
Ingredient ID: NPC244101
Ingredient ID: NPC243728
Ingredient ID: NPC242904
Ingredient ID: NPC242580
Ingredient ID: NPC240889
Ingredient ID: NPC233651
Ingredient ID: NPC230320
Ingredient ID: NPC230301
Ingredient ID: NPC225665
Ingredient ID: NPC224164
Ingredient ID: NPC218168
Ingredient ID: NPC207824
Ingredient ID: NPC203719
Ingredient ID: NPC195749
Ingredient ID: NPC185796
Ingredient ID: NPC182555
Ingredient ID: NPC166088
Ingredient ID: NPC163649
Ingredient ID: NPC161557
Ingredient ID: NPC155224
Ingredient ID: NPC149203
Ingredient ID: NPC148416
Ingredient ID: NPC131192
Ingredient ID: NPC127299
Ingredient ID: NPC121649
Ingredient ID: NPC113733
Ingredient ID: NPC111112
Ingredient ID: NPC110958
Ingredient ID: NPC107991
Ingredient ID: NPC107914
Ingredient ID: NPC103695
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Aspartic protease | BACE1 | Beta-secretase 1 | P56817 | CHEMBL4822 |
Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Methyl-lysine/arginine binding protein | SMN1 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Therapeutic Target | Oxidoreductase | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1 | P20839 | CHEMBL1822 |
Therapeutic Target | Oxidoreductase | IMPDH2 | Inosine-5'-monophosphate dehydrogenase 2 | P12268 | CHEMBL2002 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Transferase | GSTP1 | Glutathione S-transferase Pi | P09211 | CHEMBL3902 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 23 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT03700424 | Inflammation Reduction by TREhalose AdminisTration | acute coronary syndrome | Trehalose (NPC107914) | NP level |
NCT02800161 | Trehalose as add-on Therapy in Bipolar Depression | bipolar disorder | Trehalose (NPC107914) | NP level |
NCT00298324 | Myfortic - Treatment for Extensive cGvHD | graft versus host disease | Mycophenolic Acid (NPC75694) | NP level |
NCT01092533 | Myfortic for the Treatment of Non-infectious Intermediate Uveitis | intermediate uveitis | Mycophenolic Acid (NPC75694) | NP level |
NCT00622895 | Allogeneic Hematopoietic Cell Transplantation for Severe Systemic Sclerosis | systemic scleroderma | Mycophenolic Acid (NPC75694) | NP level |
NCT00504244 | Myfortic Versus Azathioprine in Systemic Lupus Erythematosus | systemic lupus erythematosus | Mycophenolic Acid (NPC75694) | NP level |
NCT04226924 | Treatment of Oculopharyngeal Muscular Dystrophy With Trehalose | oculopharyngeal muscular dystrophy | Trehalose (NPC107914) | NP level |
NCT04663854 | Mycose AdminiStration for HealIng Alzheimer NEuropathy (MASHIANE) | Alzheimer disease | Trehalose (NPC107914) | NP level |
NCT00251004 | Efficacy and Safety Study of Everolimus Plus Reduced Cyclosporine Versus Mycophenolic Acid Plus Cyclosporine in Kidney Transplant Recipients | acute graft vs. host disease | Mycophenolic Acid (NPC75694) | NP level |
NCT01369082 | Extended Follow-Up After Islet Transplantation in T1D | type 1 diabetes mellitus | Mycophenolic Acid (NPC75694) | NP level |
NCT02147886 | Study To Assess Safety, Tolerability and Efficacy of Intravenous Cabaletta in Patients With Machado-Joseph Disease | Spinocerebellar ataxia type 3 | Trehalose (NPC107914) | NP level |
NCT00298883 | Desensitization of Renal Transplant Candidates | chronic kidney disease | Mycophenolic Acid (NPC75694) | NP level |
NCT01346085 | Calcineurin Inhibitor (CNI)-Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation | type 1 diabetes mellitus | Mycophenolic Acid (NPC75694) | NP level |
NCT02015481 | Safety Tolerability and Efficacy Study of Cabaletta to Treat Oculopharyngeal Muscular Dystrophy (OPMD) Patients | oculopharyngeal muscular dystrophy | Trehalose (NPC107914) | NP level |
NCT00890253 | Safety Study of Calcineurin-Inhibitor-Free Immunosuppression After Liver Transplantation | chronic kidney disease | Mycophenolic Acid (NPC75694) | NP level |
NCT03738358 | Clinical Study of 12-week Trehalose Intake in Patients With Fatty Liver Disease | non-alcoholic fatty liver | Trehalose (NPC107914) | NP level |
NCT04297683 | HEALEY ALS Platform Trial - Master Protocol | amyotrophic lateral sclerosis | Trehalose (NPC107914) | NP level |
NCT04734197 | A Research Study To See How Well an Eye Drop, SURF-100 (A Mycophenolic Acid/Betamethasone Sodium Phosphate Combination), Works and What Side Effects There Are in Subjects With Dry Eye Disease | dry eye syndrome | Mycophenolic Acid (NPC75694) | NP level |
NCT01299922 | Clinical Trial Treatment in Lupus Nephritis | lupus nephritis | Mycophenolic Acid (NPC75694) | NP level |
NCT01197040 | Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome | nephrotic syndrome | Mycophenolic Acid (NPC75694) | NP level |
NCT02550652 | A Study to Evaluate the Safety and Efficacy of Obinutuzumab Compared With Placebo in Participants With Lupus Nephritis (LN) | lupus nephritis | Mycophenolic Acid (NPC75694) | NP level |
NCT01570348 | Crohn's Allogeneic Transplant Study | Crohn's disease | Mycophenolic Acid (NPC75694) | NP level |
NCT02416388 | Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR | acute myeloid leukemia | Mycophenolic Acid (NPC75694) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CA7,IMPDH2,LMNA,CA12,SMN1,BACE1,GSTP1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
IMPDH2,LMNA,CA12,SMN1,TRIM24,GSTP1
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
IMPDH2,CA12,IMPDH1,TRIM24,GSTP1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA7,LMNA,GSTP1,F2
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
F2,SMN1,CA12,IMPDH2
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
GSTP1,IMPDH1,CA12
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
GSTP1,IMPDH1,CA7
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
IMPDH1,GSTP1,LMNA
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
F2,CA12,CA7
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA12,TRIM24,CA12
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
F2,CA12,CA7
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA12,IMPDH1
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
IMPDH1
NCT01570348 |
Muscular atrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B61 |
SMN1,SMN2
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
BACE1
NCT04663854 |
Transplant rejectionDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE84 |
IMPDH1,IMPDH2
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT00890253,NCT00298883
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
NCT02550652,NCT01299922
|
Graft-versus-host diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4B24 |
NCT00298324,NCT00251004
|
Type1diabetesmellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A10 |
NCT01346085,NCT01369082
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
NCT02015481,NCT04226924
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
GSTP1,CA12
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
GSTP1,LMNA
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA12,CA7
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA12,LMNA
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA12,CA7
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA12
|
Immune system diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01-4B41 |
IMPDH2
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
F2
|
Cerebral ischaemic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B11 |
F2
|
PemphigusDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EB40 |
IMPDH2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
F2
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
F2
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
IMPDH1
|
Coagulation defectDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B10 |
F2
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
GSTP1
|
Hepatitis virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E50-1E51 |
IMPDH1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
F2
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
F2
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
F2
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
GSTP1
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
IMPDH1
|
Coronary thrombosisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA43 |
F2
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
GSTP1
|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
F2
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA12
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
GSTP1
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
F2
|
Mature B-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A85 |
IMPDH1
|
ThrombocytopeniaDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3B64 |
F2
|
Nutritional deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B50-5B71 |
F2
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F2
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT02416388
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
NCT03738358
|
Spinocerebellar ataxiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A03.16 |
NCT02147886
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT02800161
|
Systemic sclerosisDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A42 |
NCT00622895
|
Nephritic syndromeDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB40 |
NCT01197040
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
NCT00504244
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT04297683
|
Acute ischaemic heart disease, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA4Z |
NCT03700424
|
Intermediate choroiditis, unspecifiedDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B66.Z |
NCT01092533
|
Diseases of the visual system, unspecifiedDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9E1Z |
NCT04734197
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
F2
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
F2
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
F2
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
F2
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
F2
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
GSTP1
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
F2
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
TRIM24
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA12
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA12
|