Plant ID: NPO7805
Plant Latin Name: Vallisneria Spiralis
Taxonomy Genus: Vallisneria
Taxonomy Family: Hydrocharitaceae
NCBI TaxonomyDB:
55324
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC318696
Ingredient ID: NPC272998
Ingredient ID: NPC2724
Ingredient ID: NPC192040
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 70 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT03640507 | Vaginal Preparation With Chlorhexidine-alcohol vs. Povidine-iodine vs. Saline | infection | Alcohol (NPC2724) | NP level |
NCT03216954 | Influence of n-Acetylcysteine Maintenance on Alcohol Effects | alcohol dependence | Alcohol (NPC2724) | NP level |
NCT03964350 | Behavior Brain Responses | alcohol drinking | Alcohol (NPC2724) | NP level |
NCT02411175 | The Efficacy of Individualised Homeopathic Treatment on Constipation | Constipation | Alcohol (NPC2724) | NP level |
NCT00247585 | Hangover, Congeners, Sleep and Occupational Performance | neurobehavioral manifestations | Alcohol (NPC2724) | NP level |
NCT00001925 | Effect of Alcohol on Tremors | Tremor | Alcohol (NPC2724) | NP level |
NCT02709954 | Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study I | cannabis dependence | Alcohol (NPC2724) | NP level |
NCT00563342 | Catheters Dysfunction Rate After Instillation of Ethanol 60% Lock Solution in Tunneled Silicone Catheter of Chronic Hemodialysis Patients | chronic kidney disease | Alcohol (NPC2724) | NP level |
NCT03257930 | Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules | thyroid nodule | Alcohol (NPC2724) | NP level |
NCT01375556 | Genetics of the Acute Response to Alcohol in Social Drinkers | alcohol dependence | Alcohol (NPC2724) | NP level |
NCT02577718 | Safety and Effectiveness of Novel Nitroglycerin Based Catheter Lock Solution | infection | Alcohol (NPC2724) | NP level |
NCT05268419 | Efficacy and Safety of Ethanol Inhalation on COVID-19 Treatment (a Clinical Trial Study) | infection | Alcohol (NPC2724) | NP level |
NCT01985321 | Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold Sores | Herpes Labialis | Alcohol (NPC2724) | NP level |
NCT03192306 | Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for Episodic Treatment of Cold Sores | Herpes Labialis | Alcohol (NPC2724) | NP level |
NCT01186172 | Ethanol Lock for the Salvage of Infected Long-term Vascular Access | bacteriemia | Alcohol (NPC2724) | NP level |
NCT00471679 | Ethanol-Lock Treatment in Preventing Central Venous Catheter Infections in Patients With High-Risk Neuroblastoma | neuroblastoma | Alcohol (NPC2724) | NP level |
NCT00006656 | Carmustine in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme | Central Nervous System Neoplasm | Alcohol (NPC2724) | NP level |
NCT03838575 | ROSSINI 2 - Reduction of Surgical Site Infection Using Several Novel Interventions | infection | Alcohol (NPC2724) | NP level |
NCT04584684 | Mouth Rinses for Inactivation of COVID-19 | COVID-19 | Alcohol (NPC2724) | NP level |
NCT02710097 | Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study II | cannabis dependence | Alcohol (NPC2724) | NP level |
NCT02414581 | Mouthwash With Chlorhexidine 0.12%/Ethyl Alcohol 7% Compared to Ethyl Alcohol 7% | neutropenia | Alcohol (NPC2724) | NP level |
NCT00295334 | Moderate Alcohol Intake Among Patients With Type 2 Diabetes | type 2 diabetes mellitus | Alcohol (NPC2724) | NP level |
NCT01289561 | Combined Effects of Alcohol and Caffeine | alcohol dependence | Alcohol (NPC2724) | NP level |
NCT05470972 | Relation Between Ethanol Sclerotherapy for Endometrioma Systemic Immune Milieu | endometriosis | Alcohol (NPC2724) | NP level |
NCT02227329 | Prophylactic Ethanol Lock Therapy (ELT) in Patients on Home Parenteral Nutrition | infection | Alcohol (NPC2724) | NP level |
NCT00784433 | The CArdiovasCulAr Diabetes & Ethanol (CASCADE) Trial | prediabetes syndrome | Alcohol (NPC2724) | NP level |
NCT02158039 | Endoscopic Ultrasound-guided Ethanol Injection of Pancreatic Cystic Neoplasms | cystic, mucinous, and serous neoplasm | Alcohol (NPC2724) | NP level |
NCT02771587 | Interaction of Alcohol With Energy Drinks | alcohol-related disorders | Alcohol (NPC2724) | NP level |
NCT03757143 | Chlorhexidine-Alcohol Versus Povidone Iodine-Alcohol, Combined or Not With Use of a Bundle of New Devices, for Prevention of Intravascular-catheter Colonization and Catheter Failure | infection | Alcohol (NPC2724) | NP level |
NCT03294460 | Nicotinic Receptor Genetic Variation and Alcohol Reward | alcohol drinking | Alcohol (NPC2724) | NP level |
NCT00801086 | Efficacy Study of Tempol to Prevent Hair Loss From Radiotherapy to the Brain | alopecia | Alcohol (NPC2724) | NP level |
NCT02919579 | A Study to Evaluate the Effects of a Single-Dose and Repeat-Administration of Intranasal Esketamine on On-Road Driving in Participants With Major Depressive Disorder | major depressive disorder | Alcohol (NPC2724) | NP level |
NCT04999631 | SADBE for Congenital Melanocytic Nevi | large congenital melanocytic nevus | Alcohol (NPC2724) | NP level |
NCT04554433 | New Treatment for COVID-19 Using Ethanol Vapor Inhalation . | COVID-19 | Alcohol (NPC2724) | NP level |
NCT03083184 | Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN to Prevent Tunnelled Catheter Infections in Chronic Hemodialysis Patients | infection | Alcohol (NPC2724) | NP level |
NCT01380691 | A Study of LY2216684 in Healthy Participants | major depressive disorder | Alcohol (NPC2724) | NP level |
NCT02419235 | The Effect of a Homoeopathic Complex on Blood Pressure in Refractory Hypertension | essential hypertension | Alcohol (NPC2724) | NP level |
NCT03253887 | Ethanol-lock Therapy for the Prevention of Non-tunneled Catheter-related Infection in Pediatric Patients | infection | Alcohol (NPC2724) | NP level |
NCT01160848 | Photoactive Porphyrins (PAP) Levels After Topical Visonac Application in Acne Patients | acne | Alcohol (NPC2724) | NP level |
NCT03361384 | Alcohol and Implicit Process in Sexual Risk Behavior in MSM | alcohol drinking | Alcohol (NPC2724) | NP level |
NCT04669392 | The Effect of Using 70% Ethanol Alcohol as a Root Canal Irrigant on Increasing the Success Rate of Metapex in Pulpectomy Compared to Normal Saline in Primary Molars | pulpitis | Alcohol (NPC2724) | NP level |
NCT00680459 | Ethanol Locks for the Treatment of Central Venous Line Infections | infection | Alcohol (NPC2724) | NP level |
NCT04856566 | Examine the Feasibility of a Standardized Field Test for Marijuana and Alcohol Impairment: Laboratory Evaluations | alcohol dependence | Alcohol (NPC2724) | NP level |
NCT01205074 | ¹³C-Methacetin Breath Test (MBT) Methodology Study | cirrhosis of liver | Alcohol (NPC2724) | NP level |
NCT01898221 | Vein of Marshall Ethanol Infusion for Persistent Atrial Fibrillation | atrial fibrillation;ventricular tachycardia | Alcohol (NPC2724) | NP level |
NCT02710331 | Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Substudy III | cannabis dependence | Alcohol (NPC2724) | NP level |
NCT00887367 | EtOH Interaction Study | substance dependence | Alcohol (NPC2724) | NP level |
NCT01472965 | Ethanol Lock Therapy for Treatment and Secondary Prophylaxis of Central Line-Associated Bloodstream Infection | infection | Alcohol (NPC2724) | NP level |
NCT03131843 | Effectiveness of Alcohol Swabs for Preventing Infections During Vaccination | skin infection | Alcohol (NPC2724) | NP level |
NCT00437606 | A Study of the Pharmacokinetics/Pharmacodynamics of GK Activator (2) in Type 2 Diabetes Patients With Hepatic Impairment. | type 2 diabetes mellitus | Alcohol (NPC2724) | NP level |
NCT00037141 | Safety/Tolerability Study of Alcohol Injection for Treatment of BPH (Enlarged Prostate) | benign prostatic hyperplasia | Alcohol (NPC2724) | NP level |
NCT03010917 | Fish Oil vs. Placebo on Subjective Effects of Alcohol | alcohol dependence | Alcohol (NPC2724) | NP level |
NCT02910414 | TARGET BP I Clinical Trial | hypertension | Alcohol (NPC2724) | NP level |
NCT01241032 | Phase I Study to Investigate the Alcohol Interaction of DA8159 | erectile dysfunction | Alcohol (NPC2724) | NP level |
NCT01101412 | Antimicrobial Solution or Saline Solution in Maintaining Catheter Patency and Preventing Catheter-Related Blood Infections in Patients With Malignancies | infection | Alcohol (NPC2724) | NP level |
NCT03503773 | The TARGET BP OFF-MED Trial | hypertension | Alcohol (NPC2724) | NP level |
NCT02467543 | The Efficacy of Viburnum Opulus 3X in the Treatment of Primary Dysmenorrhea | Dysmenorrhea | Alcohol (NPC2724) | NP level |
NCT02213419 | Endoscopic Ultrasonography-guided Double Ethanol Lavage for Pancreatic Cysts: a Prospective Cohort Study | cystic, mucinous, and serous neoplasm | Alcohol (NPC2724) | NP level |
NCT03575403 | Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate) | alcohol dependence | Alcohol (NPC2724) | NP level |
NCT01475331 | The CHARM Trial: Chemotherapy for Ablation and Resolution of Mucinous Pancreatic Cysts | Pancreatic cysts | Alcohol (NPC2724) | NP level |
NCT02046200 | Development of Ivermectin for Alcohol Use Disorders | alcohol dependence | Alcohol (NPC2724) | NP level |
NCT00290290 | Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections | infection | Alcohol (NPC2724) | NP level |
NCT04251221 | Measuring the Neuroimmune Response to Alcohol | alcohol drinking | Alcohol (NPC2724) | NP level |
NCT00009854 | Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm | Central Nervous System Neoplasm | Alcohol (NPC2724) | NP level |
NCT03416348 | Hyperhidrosis, Developing a Treatment Approach Aims 1 & 2 | Hyperhidrosis | Alcohol (NPC2724) | NP level |
NCT03165942 | Neuroendocrine Response to Oral Alcohol Administration | alcohol abuse | Alcohol (NPC2724) | NP level |
NCT01054859 | A Phase I Crossover Study of the Hemodynamic Interactions of Avanafil & Alcohol in Healthy Male Subjects. | erectile dysfunction | Alcohol (NPC2724) | NP level |
NCT00806260 | A Study to Evaluate How VI-0521 Affect Psychomotor Performance in Healthy Overweight and Obese Subjects. | obesity | Alcohol (NPC2724) | NP level |
NCT00616746 | Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans | alcohol drinking | Alcohol (NPC2724) | NP level |
NCT03736343 | Impulsivity and Alcohol Response | alcohol dependence | Alcohol (NPC2724) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Alcohol dependenceDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40.2 |
NCT03010917,NCT03736343,NCT03575403,NCT04856566,NCT02046200,NCT01375556,NCT01289561,NCT03216954
|
Alcohol beverageDisease Category: X.Extension CodesDisease ICD-11 Code: XM1A61 |
NCT04251221,NCT03294460,NCT00616746,NCT03964350,NCT03361384
|
Cannabis use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C41 |
NCT02710331,NCT02710097,NCT02709954
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
NCT00887367,NCT03165942
|
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT02919579,NCT01380691
|
Herpes simplex labialisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00.01 |
NCT01985321,NCT03192306
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04584684,NCT04554433
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
NCT00295334,NCT00437606
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT03503773,NCT02910414
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
NCT00006656,NCT00009854
|
Male erectile dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA01.1 |
NCT01241032,NCT01054859
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT02213419,NCT02158039
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT01101412,NCT00290290,NCT05268419,NCT03253887,NCT03838575,NCT02227329,NCT01472965,NCT03640507,NCT03083184,NCT00680459,NCT02577718,NCT03757143
|
Hypo-thyroidismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A00 |
TSHR
|
Thyroid cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10 |
TSHR
|
ConstipationDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME05.0 |
NCT02411175
|
Other specified neuromusculoskeletal and movement-related functionsDisease Category: V.Supplementary section for functioning assessmentDisease ICD-11 Code: VV6Y |
NCT00001925
|
Hepatic fibrosis/cirrhosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB93 |
NCT01205074
|
Nontoxic single thyroid noduleDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A01.1 |
NCT03257930
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
NCT03131843
|
NeutropeniaDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4B00 |
NCT02414581
|
Neuroblastoma, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH85Z0 |
NCT00471679
|
AlopeciaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED70 |
NCT00801086
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT00806260
|
Cyst of pancreasDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC30.0 |
NCT01475331
|
Congenital melanocytic naevus, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH5YN0 |
NCT04999631
|
Acne vulgarisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED80 |
NCT01160848
|
Alcohol-related neurological disordersDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D44 |
NCT02771587
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
NCT00563342
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
NCT02419235
|
PulpitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA09.0 |
NCT04669392
|
Intermediate hyperglycaemia, unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.Z |
NCT00784433
|
Neurobehavioral disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00-8A0Z |
NCT00247585
|
Ventricular tachycardiaDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC71.0 |
NCT01898221
|
HyperhidrosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EE00 |
NCT03416348
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
NCT00037141
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
NCT01898221
|
BacteraemiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MA15.0 |
NCT01186172
|
DysmenorrhoeaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34.3 |
NCT02467543
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
NCT05470972
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
TSHR
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
TSHR
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
TSHR
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
TSHR
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
TSHR
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
TSHR
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
TSHR
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
TSHR
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
TSHR
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
TSHR
|