Plant ID: NPO6447
Plant Latin Name: Kopsia Teoi
Taxonomy Genus: Kopsia
Taxonomy Family: Apocynaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC97100
Ingredient ID: NPC85276
Ingredient ID: NPC60278
Ingredient ID: NPC483488
Ingredient ID: NPC483487
Ingredient ID: NPC483486
Ingredient ID: NPC483485
Ingredient ID: NPC483484
Ingredient ID: NPC46801
Ingredient ID: NPC38065
Ingredient ID: NPC317474
Ingredient ID: NPC302248
Ingredient ID: NPC294185
Ingredient ID: NPC271803
Ingredient ID: NPC254702
Ingredient ID: NPC243635
Ingredient ID: NPC239572
Ingredient ID: NPC222046
Ingredient ID: NPC197313
Ingredient ID: NPC194653
Ingredient ID: NPC179950
Ingredient ID: NPC151004
Ingredient ID: NPC139134
Ingredient ID: NPC125732
Ingredient ID: NPC118009
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Therapeutic Target | Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Therapeutic Target | Membrane receptor | SIGMAR1 | Sigma opioid receptor | Q99720 | CHEMBL287 |
Therapeutic Target | Other cytosolic protein | NISCH | Nischarin | Q9Y2I1 | CHEMBL3923 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1D | Alpha-1d adrenergic receptor | P25100 | CHEMBL223 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM2 | Muscarinic acetylcholine receptor M2 | P08172 | CHEMBL211 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2A | Alpha-2a adrenergic receptor | P08913 | CHEMBL1867 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1A | Alpha-1a adrenergic receptor | P35348 | CHEMBL229 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM5 | Muscarinic acetylcholine receptor M5 | P08912 | CHEMBL2035 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2C | Alpha-2c adrenergic receptor | P18825 | CHEMBL1916 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM3 | Muscarinic acetylcholine receptor M3 | P20309 | CHEMBL245 |
Therapeutic Target | Small molecule receptor (family A GPCR) | TAAR1 | Trace amine-associated receptor 1 | Q96RJ0 | CHEMBL5857 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA2B | Alpha-2b adrenergic receptor | P18089 | CHEMBL1942 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM1 | Muscarinic acetylcholine receptor M1 | P11229 | CHEMBL216 |
Therapeutic Target | Small molecule receptor (family A GPCR) | CHRM4 | Muscarinic acetylcholine receptor M4 | P08173 | CHEMBL1821 |
Therapeutic Target | Small molecule receptor (family A GPCR) | ADRA1B | Alpha-1b adrenergic receptor | P35368 | CHEMBL232 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 45 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT05006638 | Assessing The Role Of Intravenous Lipid Emulsion As A Life Saving Therapy In Pesticides Toxicity | poisoning | Atropine (NPC317474) | NP level |
NCT02870478 | The Effects of Low Concentration Atropine on Pupil Size and Accommodation | Myopia | Atropine (NPC317474) | NP level |
NCT00094692 | An Evaluation of Treatment of Amblyopia in Children 7 To <18 Years Old | amblyopia | Atropine (NPC317474) | NP level |
NCT00944710 | Augmenting Atropine Treatment for Amblyopia in Children 3 to < 8 Years Old | amblyopia | Atropine (NPC317474) | NP level |
NCT02446795 | Isoquercetin as an Adjunct Therapy in Patients With Kidney Cancer Receiving First-line Sunitinib: a Phase I/II Trial | renal cell carcinoma | Isoquercetin (NPC179950) | NP level |
NCT03942419 | Microdosed Atropine 0.1% and 0.01% Ophthalmic Solutions for Reduction of Pediatric Myopia Progression | Myopia | Atropine (NPC317474) | NP level |
NCT00315302 | Trial Comparing Atropine to Atropine Plus a Plano Lens for the Sound Eye for Amblyopia in Children 3 to <7 Years Old | amblyopia | Atropine (NPC317474) | NP level |
NCT04514510 | Fixed Dose Flavonoid Isoquercetin on Thrombo-Inflammatory Biomarkers in Subjects With Stable Sickle Cell Disease | sickle cell anemia | Isoquercetin (NPC179950) | NP level |
NCT02194088 | Combined Medication for Improved Analgesia in Superficial Pain | pain | Atropine (NPC317474) | NP level |
NCT02082054 | StahistRx Phase 2, Five-arm, Parallel Group, Active vs Active, Double-blind Study | seasonal allergic rhinitis | Atropine (NPC317474) | NP level |
NCT02839668 | The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC) | breast cancer | Atropine (NPC317474) | NP level |
NCT04173780 | Topical 0.01% Atropine for the Control of Fast Progressing Myopia | Myopia | Atropine (NPC317474) | NP level |
NCT00506675 | Combined Patching-Atropine for Residual Amblyopia | amblyopia | Atropine (NPC317474) | NP level |
NCT02704923 | Atropine for Preventing Ventilator-Associated Pneumonia | ventilator-associated pneumonia | Atropine (NPC317474) | NP level |
NCT02752308 | Effectiveness of Caudal Epidural Block on Intraoperative Blood Loss During Hypospadias Repair | hypospadias | Atropine (NPC317474) | NP level |
NCT04536090 | Study of Isoquercetin (IQC-950AN) Plus Standard of Care Versus Standard of Care Only for the Treatment of COVID-19 | COVID-19 | Isoquercetin (NPC179950) | NP level |
NCT00992901 | Role of Neural and Hormonal Regulation Factors on Insulin Secretion After Gastric Bypass Surgery | Hypoglycemia | Atropine (NPC317474) | NP level |
NCT02676011 | Brad Arrhythmia Induced by Repeated Succinylcholine During Gynecological Laparoscopic Surgery | Bradycardia | Atropine (NPC317474) | NP level |
NCT00689208 | Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity | insulin resistance | Atropine (NPC317474) | NP level |
NCT02823665 | The Effects of Bariatric Surgeries on Glucose Metabolism | Hypoglycemia | Atropine (NPC317474) | NP level |
NCT00371124 | Safety and Efficacy Study of 0.5%, 0.1% & 0.01% Atropine Treatment to Both Eyes In Treatment of Myopia In Children | Myopia | Atropine (NPC317474) | NP level |
NCT03699423 | Effects of Low Concentration Atropine on Pupillary Size and Accommodative Amplitude | Myopia | Atropine (NPC317474) | NP level |
NCT04910477 | Nebulized Dexmedetomidine Versus Neostigmine/Atropine in Postdural Puncture Headache | Headache | Atropine (NPC317474) | NP level |
NCT00121524 | Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome | cardiac arrest | Atropine (NPC317474) | NP level |
NCT03334253 | Low-Dose Atropine for Treatment of Myopia | Myopia | Atropine (NPC317474) | NP level |
NCT02622126 | Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia | blood coagulation disease;hemorrhage | Atropine (NPC317474) | NP level |
NCT05116930 | Neostigmine and Atropine for the Treatment of Headache After Dural Puncture | Headache | Atropine (NPC317474) | NP level |
NCT04622865 | Masitinib Combined With Isoquercetin and Best Supportive Care in Hospitalized Patients With Moderate and Severe COVID-19 | COVID-19 | Isoquercetin (NPC179950) | NP level |
NCT02552888 | Nitrite, Isoquercetin and Endothelial Dysfunction (NICE) Trial | chronic kidney disease | Isoquercetin (NPC179950) | NP level |
NCT03911271 | Low-dose Atropine for the Prevention of Myopia Progression in Danish Children | Myopia | Atropine (NPC317474) | NP level |
NCT00476385 | Practicability and Acceptability of Stylomax® in Children | pituitary dwarfism | Atropine (NPC317474) | NP level |
NCT04733651 | Study to Investigate the Clinical Efficacy of Isoquercetin in Patients With COVID-19 | COVID-19 | Isoquercetin (NPC179950) | NP level |
NCT00000170 | Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia | amblyopia | Atropine (NPC317474) | NP level |
NCT03593044 | Side Effects of Atropine (SEA) Study | Myopia | Atropine (NPC317474) | NP level |
NCT00001864 | Amblyopia (Lazy Eye) Treatment Study | amblyopia;Anisometropia;Strabismus | Atropine (NPC317474) | NP level |
NCT01951729 | The Role of Cholinergic Signaling for Mediating the Effects of GIP and/or Xenin-25 on Insulin Secretion | prediabetes syndrome | Atropine (NPC317474) | NP level |
NCT00748059 | The Pathophysiology of Orthostatic Hypotension | orthostatic hypotension;orthostatic intolerance | Atropine (NPC317474);Tyramine (NPC125732) | NP level |
NCT03328312 | Combined Use of Low-dose Sugammadex Plus Neostigmine Administered for Reversal of Rocuronium | post-operative sign or symptom | Atropine (NPC317474) | NP level |
NCT04474626 | Isoquercetin in Sickle Cell Anemia | sickle cell anemia | Isoquercetin (NPC179950) | NP level |
NCT00203125 | A Study to Evaluate the Effects of Tyramine in Patients Who Completed the PRESTO Study. | Parkinson disease | Tyramine (NPC125732) | NP level |
NCT00315328 | Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds | amblyopia | Atropine (NPC317474) | NP level |
NCT03865160 | Low-dose Atropine for Myopia Control in Children | Myopia | Atropine (NPC317474) | NP level |
NCT04391361 | The Safety and Effectiveness of Cholinergic Receptor Block Therapy in the Treatment of ALS | amyotrophic lateral sclerosis | Atropine (NPC317474) | NP level |
NCT00457717 | Myopia Control by Combining Auricular Acupoint and Atropine Eyedrops | Myopia | Atropine (NPC317474) | NP level |
NCT05199597 | The Response to Atropine Drops (RAD) Study | Myopia | Atropine (NPC317474) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ADRA1D,CHRM1,ADRA2C,CHRM2,CA2,CHRM5,CHRM3,CHRM4,CA4
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
ADRA1D,ADRA1B,CHRM5,ADRA2C,CA2,ADRA2B,CHRM4,CHRM1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
ADRA2A,HTR2C,CA4,CA7,CA12,CHRM2,ADRA2C,CHRM3
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CHRM1,ADRA1D,CA2,KDM1A,CA12,CHRM5,CA4
|
Impairment of binocular functionsDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9D46 |
NCT00001864,NCT00094692,NCT00315302,NCT00944710,NCT00000170,NCT00315328,NCT00506675
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
HTR2C,CA12,ADRA2C,CA2,SIGMAR1,CHRM4,CHRM1
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ADRA2A,CA4,CHRM2,CA2,CHRM3,CHRM4,CHRM1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ADRA2A,ADRA1B,CA12,ADRA2C,KDM1A,SIGMAR1,LMNA
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
ADRA1D,HTR2C,CA4,CA12,ADRA2C,CHRM3,CA12
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
TAAR1,HTR2C,SIGMAR1,CHRM5,CHRM1
NCT00203125 |
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HTR2C,CA7,CA2,KDM1A,CHRM4,CHRM1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
ADRA2A,CA7,CA12,SIGMAR1,CHRM4,LMNA
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
ADRA1D,CHRM5,ADRA1B,ADRA1A,ADRA2C
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
CHRM5,CHRM3,CHRM4,CA4,CHRM2
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
ADRA1D,CA4,CA12,ADRA2C,CHRM3
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ADRA1B,CA7,CA2,CHRM4,LMNA
|
Peptic ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA61 |
CHRM2,CHRM3,CHRM1,CHRM5
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA4,CA12,CA2
NCT02839668 |
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
SIGMAR1,ADRA2C,CHRM1,HTR2C
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
ADRA2A,HTR2C,TAAR1,ADRA1B
|
Chronic obstructive pulmonary diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA22 |
SIGMAR1,CHRM3,CHRM5,CHRM1
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
ADRA2A,SIGMAR1,TAAR1,HTR2C
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
ADRA1B,ADRA2C,HTR2C,CHRM1
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ADRA2A,ADRA2B,HTR2C,ADRA2C
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
HTR2C,TAAR1,CHRM1,SIGMAR1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
ADRA2A,CA4,ADRA2C,LMNA
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
HTR2C,CA7,CA12,ADRA2B
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ADRA2A,CA2,LMNA,CA4
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA7,CA12,ADRA2C,ADRA1B
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ADRA2A,HTR2C,CA7,CA12
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA,CHRM4,ADRA2B,ADRA1A
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
HTR2C,CA4,CA12,ADRA2C
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
CHRM1,ADRA2B,ADRA2C
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA2,CA4,CA12
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
SIGMAR1,CHRM1,ADRA1A
|
Sebaceous gland disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED91 |
CHRM2,CHRM3,CHRM1
|
Respiratory system diseaseDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB40-CB7Z |
CHRM3,CHRM4,CHRM2
|
Functional bladder disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GC50 |
CHRM3,CHRM1,CHRM5
|
Abnormal micturitionDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50 |
CHRM2,CHRM1,CHRM5
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA4,CA2,CA12
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
CHRM5,CHRM3,HTR2C
|
COVID-19Disease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D6Y |
NCT04622865,NCT04536090,NCT04733651
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
HTR2C,ADRA1B,CHRM5
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CA12,CA2,LMNA
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CA12,CA2,CHRM1
|
Prostate hyperplasiaDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA90 |
ADRA1D,ADRA1A
|
Intellectual development disorderDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD90 |
SIGMAR1,CHRM1
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
SIGMAR1,ADRA1D
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
CHRM1,CHRM5
|
CoughDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD12 |
CHRM5,SIGMAR1
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
ADRA2C
NCT02552888 |
Epileptic encephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A62 |
CHRM1,SIGMAR1
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
CA2,ADRA1D
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
KDM1A,HTR2C
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
CHRM3,CHRM4
|
Vasomotor/allergic rhinitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA08 |
ADRA2C
NCT02082054 |
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
SIGMAR1,HTR2C
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NCT05116930,NCT04910477
|
Sickle-cell disorderDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3A51 |
NCT04474626,NCT04514510
|
Hypoglycaemia without associated diabetesDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A41 |
NCT00992901,NCT02823665
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
HTR2C,ADRA1B
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CA12,HTR2C
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
HTR2C,CA2
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
ADRA2B,CHRM5
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
HTR2C,CA2
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
HTR2C,ADRA2C
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CA12,HTR2C
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
ADRA1B,ADRA2B
|
Degenerative high myopiaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B76 |
NCT00371124,NCT00457717,NCT05199597,NCT03911271,NCT03942419,NCT02870478,NCT04173780,NCT03334253,NCT03593044,NCT03865160,NCT03699423
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
HTR2C,ADRA1D,ADRA2A,CHRM5,ADRA2B,ADRA1B,ADRA1A,ADRA2C,SIGMAR1
NCT02194088 |
Chronic insomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00 |
HTR2C
|
DyslipidemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80-5C81 |
CHRM1
|
GastritisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA42 |
CHRM5
|
Mental/behavioural/neurodevelopmental disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6E20-6E8Z |
ADRA1B
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
ADRA1A
|
Myeloproliferative neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A20 |
KDM1A
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
SIGMAR1
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
CHRM1
|
SomnolenceDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG42 |
SIGMAR1
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
CHRM5
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CA2
|
NarcolepsyDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A20 |
TAAR1
|
Neurobehavioral disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00-8A0Z |
SIGMAR1
|
PolyuriaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF55 |
CHRM5
|
Infectious gastroenteritis/colitisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A40 |
CHRM5
|
Central and peripheral nervous diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8E7Z |
CHRM5
|
Gastric ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA60 |
CHRM1
|
Dissociative neurological symptom disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B60 |
ADRA2C
|
Ewing sarcomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B52 |
KDM1A
|
Brain diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70-8E61 |
CHRM5
|
Abdominal pelvic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD81 |
CHRM1
|
Anterior uveitisDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A96 |
CHRM5
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
CHRM1
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
HTR2C
|
Oesophagus motility disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA21 |
CHRM5
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
HTR2C
|
Immune system diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A01-4B41 |
SIGMAR1
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
KDM1A
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
CHRM1
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
ADRA2C
|
Psychoactive substances use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4G |
HTR2C
|
Sjogren syndromeDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A43 |
CHRM3
|
Eye anterior segment structural developmental anomalyDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA11 |
CHRM4
|
Sleep-wake disorderDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7B2Z |
HTR2C
|
Bulimia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B81 |
SIGMAR1
|
Appearance/behaviour symptomDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB23 |
CHRM5
|
UrgencyDisease Category: NADisease ICD-11 Code: N.A. |
CHRM5
|
HypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA20-BA21 |
ADRA2C
|
Female pelvic painDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA34 |
CHRM5
|
HyperhidrosisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EE00 |
CHRM1
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
KDM1A
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Chronic painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30 |
ADRA2C
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
KDM1A
|
General examinationDisease Category: 24.Factors influencing health status or contact with health servicesDisease ICD-11 Code: QA00 |
CHRM5
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
CA2
|
Muscle disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB32-FB3Z |
CHRM2
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
ADRA2A
|
Focal/segmental autonomic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D8A |
TAAR1
|
Dystonic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A02 |
CHRM1
|
Post-traumatic stress disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B40 |
ADRA2C
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
HTR2C
|
Corneal diseaseDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A76-9A78 |
CHRM1
|
Non-specific cutaneous vascular symptonDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME64 |
ADRA2C
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
KDM1A
|
NystagmusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C84 |
CHRM5
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
ADRA2C
|
Cystic fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA25 |
SIGMAR1
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
SIGMAR1
|
Cognition symptoms/signs/clinical symptonDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21 |
CHRM5
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HTR2C
|
PancreatitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DC31-DC34 |
CHRM5
|
Central nervous system diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A04-8D87 |
SIGMAR1
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
CA2
|
Digestive system diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DE2Z |
CHRM5
|
Ventilation associated with injury or harm in therapeutic useDisease Category: 23.External causes of morbidity or mortalityDisease ICD-11 Code: PK81.0 |
NCT02704923
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
NCT00748059
|
Renal cell carcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90 |
NCT02446795
|
Insulin-resistance syndromesDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A44 |
NCT00689208
|
Blood-forming organ diseaseDisease Category: 03.Diseases of the blood or blood-forming organsDisease ICD-11 Code: 3C0Z |
NCT02622126
|
Bradycardia, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MC81.1 |
NCT02676011
|
AnisometropiaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9D00.4 |
NCT00001864
|
Intermediate hyperglycaemia, unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.Z |
NCT01951729
|
Strabismus or ocular motility disorders, unspecifiedDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C8Z |
NCT00001864
|
HypopituitarismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A61.0 |
NCT00476385
|
NADisease Category: NADisease ICD-11 Code: NA |
NCT00748059
|
Retention of urineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF50.3 |
NCT03328312
|
Haemorrhage, not elsewhere classifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG27 |
NCT02622126
|
Amyotrophic lateral sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B60.0 |
NCT04391361
|
Cardiac arrestDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MC82 |
NCT00121524
|
HypospadiasDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LB53 |
NCT02752308
|
Harmful effects of unspecified substanceDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
NCT05006638
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
CHRM4
|
Myelodysplastic syndromes, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A3Z |
ADRA2B
|
Hypertrophic cardiomyopathyDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC43.1 |
CHRM3
|
Osteoarthritis, unspecifiedDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA0Z |
CA12
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
HTR2C
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
ADRA2A
|
KeratoconusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A78.50 |
CA4
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
CA4
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
CA4
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
HTR2C
|
Pneumonia due to PseudomonasaeruginosaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40.05 |
ADRA1B
|