Plant ID: NPO5305
Plant Latin Name: Corydalis Mucronifera
Taxonomy Genus: Corydalis
Taxonomy Family: Papaveraceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC78540
Ingredient ID: NPC78359
Ingredient ID: NPC481449
Ingredient ID: NPC481448
Ingredient ID: NPC481447
Ingredient ID: NPC481446
Ingredient ID: NPC481445
Ingredient ID: NPC481444
Ingredient ID: NPC481443
Ingredient ID: NPC481442
Ingredient ID: NPC481441
Ingredient ID: NPC481440
Ingredient ID: NPC481439
Ingredient ID: NPC481438
Ingredient ID: NPC481437
Ingredient ID: NPC4247
Ingredient ID: NPC300365
Ingredient ID: NPC290525
Ingredient ID: NPC276944
Ingredient ID: NPC226652
Ingredient ID: NPC219113
Ingredient ID: NPC206625
Ingredient ID: NPC206442
Ingredient ID: NPC188813
Ingredient ID: NPC166616
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A1 | Cytochrome P450 1A1 | P04798 | CHEMBL2231 |
Cytochrome P450 | Cytochrome P450 family 1 | CYP1A2 | Cytochrome P450 1A2 | P05177 | CHEMBL3356 |
Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 | Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
Cytochrome P450 | Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
Therapeutic Target | Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
Therapeutic Target | Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Therapeutic Target | Oxidoreductase | CBR1 | Carbonyl reductase [NADPH] 1 | P16152 | CHEMBL5586 |
Therapeutic Target | Oxidoreductase | XDH | Xanthine dehydrogenase | P47989 | CHEMBL1929 |
Therapeutic Target | Surface antigen | F3 | Coagulation factor III | P13726 | CHEMBL4081 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 32 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01677754 | A Study of RO4602522 in Participants With Moderate Severity Alzheimer Disease on Background Alzheimer Disease Therapy | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00082602 | Safety and Tolerability Study of Extended Release (ER) Galantamine in Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT02365285 | Racial Differences in Vagal Control of Glucose Homeostasis | obesity | Galantamine (NPC78359) | NP level |
NCT00252603 | Galantamine Versus Placebo in Childhood Autism | autism | Galantamine (NPC78359) | NP level |
NCT00301574 | An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease. | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT01372306 | Galantamine Bioequivalence Study of Dr. Reddy's Under Fed Condition | Fish-eye disease | Galantamine (NPC78359) | NP level |
NCT02248636 | Cholinesterase Inhibitor Discontinuation | Dementia | Galantamine (NPC78359) | NP level |
NCT00035191 | A Placebo-controlled Trial to Evaluate the Safety and Efficacy of Galantamine in the Treatment of Vascular Dementia | vascular dementia | Galantamine (NPC78359) | NP level |
NCT01669538 | Effect of Galantamine on Short-term Abstinence | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT03384784 | Effect of Galantamine on Inflammation and Cognition | HIV infection | Galantamine (NPC78359) | NP level |
NCT02234752 | Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia | schizoaffective disorder;schizophrenia | Galantamine (NPC78359) | NP level |
NCT00750529 | Alzheimer and Sleep | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT01012167 | Oxytocin or Galantamine Versus Placebo for the Treatment of Negative Symptoms and Cognitive Impairments in Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT01417429 | Galantamine Effects on Nicotine Responses in Smokers | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT00679627 | A Study of Galantamine Used to Treat Patients With Mild to Moderate Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00809835 | Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse | cocaine dependence | Galantamine (NPC78359) | NP level |
NCT00309725 | A Cardiac Safety Study of Galantamine in the Treatment of Alzheimer's Disease. | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00230997 | Safety and Efficacy of Galantamine in Patients With Dementia With Lewy Bodies | Lewy body dementia | Galantamine (NPC78359) | NP level |
NCT00304629 | Long-term Safety and Efficacy of Galantamine in Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00814801 | An Efficacy and Safety Study of Galantamine for the Treatment of Patients With Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT01548638 | Effect of Galantamine on Smoking Abstinence | nicotine dependence | Galantamine (NPC78359) | NP level |
NCT02374567 | Pharmacovigilance in Gerontopsychiatric Patients | anxiety;depressive disorder;schizophrenia;Dementia | Galantamine (NPC78359) | NP level |
NCT01039194 | Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER) | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT01100775 | Effects of Galantamine on Cognition | schizophrenia | Galantamine (NPC78359) | NP level |
NCT00814658 | The Use of Galantamine (Reminyl ER) in Patients With MIXed Dementia: Effects on Cognition and Quality of Life | Dementia | Galantamine (NPC78359) | NP level |
NCT02872857 | Subarachnoid Hemorrhage Recovery And Galantamine | subarachnoid hemorrhage | Galantamine (NPC78359) | NP level |
NCT03124355 | Vagal Stimulation in POTS | orthostatic hypotension | Galantamine (NPC78359) | NP level |
NCT00509067 | Use of Galantamine and CDP-choline (Citicoline) to Treat Adults With Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT00463879 | Galantamine for Cognitive Deficits in Schizophrenia | schizophrenia | Galantamine (NPC78359) | NP level |
NCT00969696 | Galantamine Effects on Cognitive Function in Marijuana Users | memory impairment | Galantamine (NPC78359) | NP level |
NCT00000172 | Evaluation of Galantamine in the Treatment of Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
NCT00645190 | A Randomized, Double-blind, Flexible Dose, Multicenter Study to Evaluate the Effectiveness and Safety of Galantamine IR in Mild to Moderate Alzheimer's Disease | Alzheimer disease | Galantamine (NPC78359) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CA7,ACHE,CYP1B1,BCHE,CYP2C19,XDH,CBR1
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
NCT02234752,NCT00509067,NCT01012167,NCT02374567,NCT01100775,NCT00463879
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE
NCT02374567,NCT00230997,NCT02248636,NCT00814658 |
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
ACHE,CYP2D6,CA7,XDH,CBR1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CA4,CYP19A1,BCHE,CA7,CBR1
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
CA4,ACHE,BCHE,XDH
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ACHE,CYP19A1,BCHE,XDH
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
BCHE,CA7,XDH,CBR1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CA4,ACHE,BCHE,XDH
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
F3,CA4,XDH
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
NCT01417429,NCT01548638,NCT01669538
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CYP19A1,CA7,XDH
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
F3,ACHE,CBR1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CA7,XDH,CBR1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
CYP19A1,ACHE,CBR1
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CA4,CYP19A1,CYP19A1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP2C19,CYP1A1,ACHE
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
F3,ACHE,CYP1A1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CA7,CYP1B1,XDH
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP2D6,XDH,CYP1A1
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
CYP19A1,XDH,F3
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE,BCHE
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA4,CYP19A1
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
ACHE,CA4
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
ACHE,BCHE
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
CA4,CBR1
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CYP1A2,XDH
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CA4,F3
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
CA4,CYP19A1
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
CA4,F3
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
ACHE,CA4
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ACHE,CYP1B1
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP1B1,CYP19A1
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP1A2,CYP1A1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
ACHE,BCHE
NCT00304629,NCT00750529,NCT00309725,NCT00814801,NCT00000172,NCT00679627,NCT00301574,NCT00082602,NCT01677754,NCT01039194,NCT00645190 |
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
F3
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
CYP2D6
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
XDH
|
Bleeding disorderDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA20-GA21 |
F3
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
CYP19A1
|
Eexposure to noxious substances harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE61 |
BCHE
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
Inborn purine/pyrimidine/nucleotide metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C55 |
XDH
|
EncephalopathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E47 |
XDH
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
ACHE
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
XDH
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
XDH
|
EndometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10 |
CYP19A1
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ACHE
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Acute respiratory distress syndromeDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB00 |
F3
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
CYP2D6
|
Mineral deficiencyDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B5K |
XDH
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
OesophagitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA24 |
CYP19A1
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
XDH
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
BCHE
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
CYP19A1
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA4
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA4
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT02374567
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
NCT02234752
|
Human immunodeficiency virus disease without mention of associated disease or condition, clinical stage unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62.Z |
NCT03384784
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT00809835
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
NCT02374567
|
Autism spectrum disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A02 |
NCT00252603
|
HypoalphalipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C81.0 |
NCT01372306
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
NCT02365285
|
Orthostatic hypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA21 |
NCT03124355
|
Subarachnoid haemorrhageDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B01 |
NCT02872857
|
Dementia due to cerebrovascular diseaseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D81 |
NCT00035191
|
Age-associated cognitive declineDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.0 |
NCT00969696
|
Coeliac diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA95 |
CYP1A1
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CYP19A1
|
Atrial fibrillationDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BC81.3 |
CA7
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
BCHE
|
Myotonic dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C71.0 |
CYP1A1
|
KeratoconusDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A78.50 |
CA4
|
Pre-eclampsiaDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA24 |
CA4
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CYP1A1
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
XDH
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ACHE
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP1A2
|
Chronic rhinosinusitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA0A |
CYP1A1
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|