Plant ID: NPO27072
Plant Latin Name: Monochaetum Vulcanicum
Taxonomy Genus: Monochaetum
Taxonomy Family: Melastomataceae
NCBI TaxonomyDB:
1160581
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC71074
Ingredient ID: NPC52110
Ingredient ID: NPC51700
Ingredient ID: NPC39250
Ingredient ID: NPC308020
Ingredient ID: NPC300059
Ingredient ID: NPC281873
Ingredient ID: NPC278813
Ingredient ID: NPC274606
Ingredient ID: NPC257347
Ingredient ID: NPC243728
Ingredient ID: NPC230151
Ingredient ID: NPC208180
Ingredient ID: NPC208061
Ingredient ID: NPC206148
Ingredient ID: NPC201373
Ingredient ID: NPC173569
Ingredient ID: NPC150592
Ingredient ID: NPC142688
Ingredient ID: NPC133178
Ingredient ID: NPC127113
Ingredient ID: NPC119786
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Enzyme | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
Therapeutic Target | Enzyme | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Therapeutic Target | Enzyme | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | RORC | Nuclear receptor ROR-gamma | P51449 | CHEMBL1741186 |
Therapeutic Target | Oxidoreductase | HSD11B1 | 11-beta-hydroxysteroid dehydrogenase 1 | P28845 | CHEMBL4235 |
Therapeutic Target | Transcription factor | RELA | Nuclear factor NF-kappa-B p65 subunit | Q04206 | CHEMBL5533 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 11 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00420823 | A Study of Taurine in Patients With First-episode Psychosis Receiving Antipsychotic Treatment | mental or behavioural disorder | Taurine (NPC300059) | NP level |
NCT04874012 | Effect of Taurine on Glycemic, Lipid and Inflammatory Profile in Individuals With Type 2 Diabetes | type 2 diabetes mellitus | Taurine (NPC300059) | NP level |
NCT03216876 | A Study Of Ursolic Acid For Primary Sclerosing Cholangitis | sclerosing cholangitis | Ursolic Acid (NPC51700) | NP level |
NCT04403568 | Testing the Synergism of Phytonutrients, Curcumin and Ursolic Acid, to Target Molecular Pathways in the Prostate | prostate cancer | Ursolic Acid (NPC51700) | NP level |
NCT01192828 | Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine | homocystinuria | Taurine (NPC300059) | NP level |
NCT05342272 | Comparison of Gum® HydralTM Moisturizing Gel and Biotene® Oral Gel in Dry Mouth Sensation Reduction | xerostomia | Taurine (NPC300059) | NP level |
NCT00391001 | Taurine in Adolescents With Bipolar Disorder | bipolar disorder | Taurine (NPC300059) | NP level |
NCT00217165 | Taurine as an Anti-Manic Agent: A Double-Blind, Placebo-Controlled Study | bipolar disorder | Taurine (NPC300059) | NP level |
NCT02337933 | Effect of Ursolic Acid Administration on Insulin Sensitivity and Metabolic Syndrome | metabolic syndrome | Ursolic Acid (NPC51700) | NP level |
NCT01381354 | Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS) | multiple sclerosis | Taurine (NPC300059) | NP level |
NCT01816698 | Effects and Safety of Taurine Granule on Blood Pressure in Prehypertensive | hypertension | Taurine (NPC300059) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
BLM,HSD11B1,RECQL,CES1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
RELA,HSD11B1
NCT04874012 |
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
RORC,RELA
NCT01381354 |
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
BLM,HSD11B1,RECQL
|
Metabolic disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50-5D2Z |
HSD11B1
NCT02337933 |
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
RORC,RELA
|
Lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40 |
HSD11B1,RELA
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
RORC,RELA
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
RORC
HSD11B1 |
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
CES1,HSD11B1
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT00391001,NCT00217165
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
BLM,RORC
|
Chronic arterial occlusive diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD4Z |
CES1
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
RELA
|
Peroxisomal diseaseDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C57 |
CES1
|
Synthesis disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52-5C59 |
CES1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
RELA
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
HSD11B1
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
RELA
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
HSD11B1
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
RELA
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
RORC
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
HSD11B1
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
RELA
|
Irritable bowel syndromeDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD91 |
RELA
|
Muscular dystrophyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C70 |
RELA
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HSD11B1
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
HSD11B1
|
Fungal infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F29-1F2F |
RELA
|
Skin and skin-structure infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G0Z |
RELA
|
InfluenzaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1E30-1E32 |
HSD11B1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
RELA
|
Acute/subacute hepatic failureDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB91 |
RELA
|
Autoimmune diseaseDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40-4A45 |
RORC
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
HSD11B1
|
Disorders of methionine cycle or sulphur amino acid metabolismDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C50.B |
NCT01192828
|
Mental/behavioural/neurodevelopmental disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6E20-6E8Z |
NCT00420823
|
Primary sclerosing cholangitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB96.2 |
NCT03216876
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
NCT01816698
|
XerostomiaDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA02.1 |
NCT05342272
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
NCT04403568
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
RORC
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
RORC
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
HSD11B1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
BLM
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
BLM
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
BLM
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
BLM
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
BLM
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
RECQL
|
Tetralogy of FallotDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA88.2 |
RORC
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
BLM
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
BLM
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
BLM
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
BLM
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
BLM
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
BLM
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
BLM
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
BLM
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
HSD11B1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
BLM
|
Gliomas of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.0 |
BLM
|