Unknown.
Brazil; Colombia; Peru; Guyana; Bolivia; Ecuador
Ingredient ID: NPC96806
Ingredient ID: NPC92474
Ingredient ID: NPC79788
Ingredient ID: NPC77296
Ingredient ID: NPC7642
Ingredient ID: NPC75028
Ingredient ID: NPC72022
Ingredient ID: NPC70204
Ingredient ID: NPC6828
Ingredient ID: NPC66995
Ingredient ID: NPC66667
Ingredient ID: NPC64242
Ingredient ID: NPC55920
Ingredient ID: NPC50713
Ingredient ID: NPC479190
Ingredient ID: NPC479189
Ingredient ID: NPC468984
Ingredient ID: NPC45428
Ingredient ID: NPC40187
Ingredient ID: NPC36565
Ingredient ID: NPC33867
Ingredient ID: NPC307063
Ingredient ID: NPC281471
Ingredient ID: NPC280582
Ingredient ID: NPC271585
Ingredient ID: NPC270249
Ingredient ID: NPC267753
Ingredient ID: NPC26741
Ingredient ID: NPC260833
Ingredient ID: NPC259162
Ingredient ID: NPC249288
Ingredient ID: NPC248889
Ingredient ID: NPC248500
Ingredient ID: NPC243728
Ingredient ID: NPC241720
Ingredient ID: NPC241199
Ingredient ID: NPC238532
Ingredient ID: NPC228892
Ingredient ID: NPC226723
Ingredient ID: NPC224999
Ingredient ID: NPC216358
Ingredient ID: NPC216257
Ingredient ID: NPC206264
Ingredient ID: NPC202229
Ingredient ID: NPC199837
Ingredient ID: NPC195232
Ingredient ID: NPC192074
Ingredient ID: NPC19101
Ingredient ID: NPC186806
Ingredient ID: NPC182466
Ingredient ID: NPC177818
Ingredient ID: NPC17743
Ingredient ID: NPC174668
Ingredient ID: NPC172282
Ingredient ID: NPC171615
Ingredient ID: NPC164957
Ingredient ID: NPC154738
Ingredient ID: NPC153870
Ingredient ID: NPC153588
Ingredient ID: NPC151968
Ingredient ID: NPC148965
Ingredient ID: NPC147335
Ingredient ID: NPC143227
Ingredient ID: NPC141136
Ingredient ID: NPC140777
Ingredient ID: NPC133948
Ingredient ID: NPC130382
Ingredient ID: NPC128986
Ingredient ID: NPC128225
Ingredient ID: NPC125892
Ingredient ID: NPC125072
Ingredient ID: NPC121797
Ingredient ID: NPC114928
Ingredient ID: NPC114687
Ingredient ID: NPC112274
Ingredient ID: NPC111607
Ingredient ID: NPC10366
Ingredient ID: NPC100684
Ingredient ID: NPC100048
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 11 | CYP11B1 | Cytochrome P450 11B1 | P15538 | CHEMBL1908 |
Cytochrome P450 | Cytochrome P450 family 17 | CYP17A1 | Cytochrome P450 17A1 | P05093 | CHEMBL3522 |
Cytochrome P450 | Cytochrome P450 family 24 | CYP24A1 | Cytochrome P450 24A1 | Q07973 | CHEMBL4521 |
Cytochrome P450 | Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Therapeutic Target | Oxidoreductase | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 12 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01994993 | Antibiotic Safety (SCAMP) | infection | Ampicillin (NPC468984) | NP level |
NCT02424734 | Safety, Tolerability and Efficacy of Ceftaroline in Paediatrics With Late-Onset Sepsis | Sepsis | Ampicillin (NPC468984) | NP level |
NCT00760006 | Preventing Complications in Cleft Palate Repair With Antibiotics | Cleft palate | Ampicillin (NPC468984) | NP level |
NCT01551394 | Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis | Sepsis | Ampicillin (NPC468984) | NP level |
NCT02099240 | Patients Response to Early Switch To Oral:Osteomyelitis Study | osteomyelitis | Ampicillin (NPC468984) | NP level |
NCT01138852 | Ampicillin/Sulbactam Versus Cefuroxime as Antimicrobial Prophylaxis for Cesarean Section | infection | Ampicillin (NPC468984) | NP level |
NCT00952796 | A Comparative Study of Ampicillin/Sulbactam Versus Moxifloxacin in the Treatment of Complicated Intra-abdominal Infections | infection | Ampicillin (NPC468984) | NP level |
NCT00879190 | Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis | chorioamnionitis | Ampicillin (NPC468984) | NP level |
NCT02007603 | Concentration of Ampicillin / Sulbactam and Amoxicillin / Clavulanic Acid in the Blood During Renal Replacement Therapy in Longterm Renal Replacement Therapy Patients | infection | Ampicillin (NPC468984) | NP level |
NCT01433757 | Ampicillin for DYT-1 Dystonia Motor Symptoms | dystonic disorder | Ampicillin (NPC468984) | NP level |
NCT04041791 | A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia | pneumonia | Ampicillin (NPC468984) | NP level |
NCT00630513 | T.E.A. Study Three Days Ertapenem Versus Three Days Ampicillin- Sulbactam | infection | Ampicillin (NPC468984) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT00952796,NCT01138852,NCT01994993,NCT02007603,NCT00630513
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
CYP27B1,CYP24A1,CYP17A1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
CYP4F2,CYP24A1,CYP27B1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
CYP17A1,CYP24A1,CYP27B1
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
CYP17A1,CYP27B1,CYP17A1
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CYP11B1,CYP17A1
|
SepsisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G40-1G41 |
NCT01551394,NCT02424734
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
CYP24A1,CYP27B1
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
CYP4F2,CYP24A1
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ALDH1A1,CYP24A1
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
CYP4F2,CYP24A1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
CYP24A1,CYP27B1
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
CYP24A1,CYP27B1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CYP3A4,CYP27B1
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CYP4F2,CYP27B1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
CYP24A1,CYP27B1
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
CYP4F2,CYP3A4
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
CYP24A1,CYP27B1
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
CYP3A4,CYP24A1
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
CYP17A1
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CYP3A4
|
Cushing syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A70 |
CYP11B1
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
CYP24A1
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
ALDH1A1
|
Atopic eczemaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA80 |
CYP3A4
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
CYP3A4
|
PneumoniaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA40 |
NCT04041791
|
Infection of amniotic sac or membranesDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA88.1 |
NCT00879190
|
Cleft palateDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LA42 |
NCT00760006
|
Dystonic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A02 |
NCT01433757
|
Osteomyelitis or osteitisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB84 |
NCT02099240
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
CYP27B1
|
Inflammatory bowel diseases, unspecifiedDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD7Z |
CYP24A1
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
CYP27B1
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
CYP27B1
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
CYP27B1
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
CYP24A1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
CYP27B1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
CYP27B1
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
ALDH1A1
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
CYP24A1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
CYP27B1
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CYP24A1
|
Malignant neoplasms of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
CYP17A1
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP27B1
|
Parkinson diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00.0 |
ALDH1A1
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
CYP27B1
|
Human immunodeficiency virus disease without mention of tuberculosis or malariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C62 |
CYP4F2
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
CYP3A4
|