Plant ID: NPO22441
Plant Latin Name: Senna Spectabilis
Taxonomy Genus: Senna
Taxonomy Family: Fabaceae
NCBI TaxonomyDB:
347003
Plant-of-the-World-Online:
n.a.
Brazil; China
Ingredient ID: NPC89749
Ingredient ID: NPC81010
Ingredient ID: NPC77572
Ingredient ID: NPC70744
Ingredient ID: NPC67978
Ingredient ID: NPC67917
Ingredient ID: NPC67377
Ingredient ID: NPC55983
Ingredient ID: NPC54379
Ingredient ID: NPC53069
Ingredient ID: NPC48053
Ingredient ID: NPC46744
Ingredient ID: NPC46451
Ingredient ID: NPC31311
Ingredient ID: NPC308267
Ingredient ID: NPC306973
Ingredient ID: NPC302642
Ingredient ID: NPC29883
Ingredient ID: NPC282420
Ingredient ID: NPC268470
Ingredient ID: NPC268334
Ingredient ID: NPC245561
Ingredient ID: NPC232071
Ingredient ID: NPC2314
Ingredient ID: NPC219913
Ingredient ID: NPC216459
Ingredient ID: NPC215019
Ingredient ID: NPC208657
Ingredient ID: NPC207757
Ingredient ID: NPC186255
Ingredient ID: NPC186128
Ingredient ID: NPC180832
Ingredient ID: NPC171409
Ingredient ID: NPC164014
Ingredient ID: NPC157220
Ingredient ID: NPC152331
Ingredient ID: NPC141704
Ingredient ID: NPC138487
Ingredient ID: NPC137100
Ingredient ID: NPC137001
Ingredient ID: NPC131204
Ingredient ID: NPC124569
Ingredient ID: NPC116895
Ingredient ID: NPC116027
Ingredient ID: NPC111888
Ingredient ID: NPC100079
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Cytochrome P450 | Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
Cytochrome P450 | Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
Therapeutic Target | Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Therapeutic Target | Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Therapeutic Target | Nuclear hormone receptor subfamily 1 | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
Therapeutic Target | Oxidoreductase | MAOA | Monoamine oxidase A | P21397 | CHEMBL1951 |
Therapeutic Target | Small molecule receptor (family A GPCR) | DRD5 | Dopamine D5 receptor | P21918 | CHEMBL1850 |
Therapeutic Target | Small molecule receptor (family A GPCR) | DRD2 | Dopamine D2 receptor | P14416 | CHEMBL217 |
Therapeutic Target | Small molecule receptor (family A GPCR) | DRD1 | Dopamine D1 receptor | P21728 | CHEMBL2056 |
Therapeutic Target | Small molecule receptor (family A GPCR) | DRD4 | Dopamine D4 receptor | P21917 | CHEMBL219 |
Therapeutic Target | Small molecule receptor (family A GPCR) | DRD3 | Dopamine D3 receptor | P35462 | CHEMBL234 |
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Therapeutic Target | Unclassified protein | SNCA | Alpha-synuclein | P37840 | CHEMBL6152 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 79 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01122771 | Phase III, Study of Three Short Course Combo (Ambisome®, Miltefosine, Paromomycin) Compared With AmBisome for the Treatment of VL in Bangladesh | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00145249 | Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT00451711 | Intermittent Liposomal Amphotericin B Primary Prophylaxis | acute myeloid leukemia | Amphotericin B (NPC67917) | NP level |
NCT00497601 | A Phase II Study To Assess Safety and Efficacy Of Short-Course Regimens Of Amphotericin B Emulsion In Kala-Azar | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00986713 | Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00047827 | Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00002742 | Antifungal Therapy for Fever and Neutropenia in Patients Receiving Treatment for Hematologic Cancer | chronic myeloproliferative disorder;leukemia;multiple myeloma;myelodysplastic syndrome;infection | Amphotericin B (NPC67917) | NP level |
NCT03333265 | Primary Chemoprevention of Familial Adenomatous Polyposis With Berberine Hydrochloride | colorectal adenoma | Berberine (NPC53069) | NP level |
NCT04799236 | Treatment of Mucosal Bolivian Leishmaniasis | mucocutaneous Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00263315 | Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00216346 | Safety and Efficacy Study of Paromomycin to Treat Visceral Leishmaniasis | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00370825 | Combination Chemotherapy for the Treatment of Indian Kala-Azar | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT04031833 | Encochleated Oral Amphotericin for Cryptococcal Meningitis Trial (EnACT) | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT01845727 | Topical 3% Amphotericin B Cream for the Treatment of Cutaneous Leishmaniasis in Colombia | cutaneous Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT02861261 | A Study on the Efficacy and Gut Microbiota of Berberine and Probiotics in Patients With Newly Diagnosed Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
NCT02082756 | Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment | prediabetes syndrome | Berberine (NPC53069) | NP level |
NCT01566552 | Single Dose Liposomal Amphotericin B for Visceral Leishmaniasis | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00425009 | Therapeutic Effects of Berberine in Patients With Type 2 Diabetes | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
NCT03636659 | Steady State Global Bioequivalence Study of Amphotericin B Liposome for Injection 50 mg/ Vial in Fed Condition | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT04267497 | Nebulised Liposomal Amphotericin for Invasive Pulmonary Aspergillosis (NAIFI01 Study) | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00163111 | A Clinical Study Intended To Compare Treatment With Voriconazole To Treatment With Amphotericin Followed By Fluconazole In Patients With Candidemia, A Serious Fungus Infection Of The Blood. | candidiasis | Amphotericin B (NPC67917) | NP level |
NCT00467883 | Pilot Study of High Dose Liposomal Amphotericin B Efficacy in Initial Zygomycosis Treatment | mucormycosis | Amphotericin B (NPC67917) | NP level |
NCT01310738 | Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Brazil | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00001017 | Comparison of Fluconazole and Amphotericin B in the Treatment of Brain Infections in Patients With AIDS | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT00003938 | Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients | cancer | Amphotericin B (NPC67917) | NP level |
NCT04018417 | Evaluation of Amphotericin B in Optisol-GS for Prevention of Post-Keratoplasty Fungal Infections. | Fuchs endothelial corneal dystrophy | Amphotericin B (NPC67917) | NP level |
NCT03486496 | Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR Mutation | lung adenocarcinoma | Berberine (NPC53069) | NP level |
NCT00832208 | Open-Label, Sequential Step, Safety and Efficacy Study to Determine the Optimal Single Dose of Ambisome for Patients With VL | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT02025491 | Liposomal Amphotericin in Disseminated Leishmaniasis | Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT02629419 | CAMB/MAT2203 in Patients With Mucocutaneous Candidiasis | Chronic mucocutaneous candidosis | Amphotericin B (NPC67917) | NP level |
NCT00001107 | Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants | candidiasis | Amphotericin B (NPC67917) | NP level |
NCT03281096 | A Research of Berberine Hydrochloride to Prevent Colorectal Adenomas in Patients With Previous Colorectal Cancer | colorectal adenoma | Berberine (NPC53069) | NP level |
NCT03945448 | Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT01067443 | Clinical Trial to Assess the Safety and Efficacy of Sodium Stibogluconate (SSG) and AmBisome® Combination, Miltefosine and AmBisome® and Miltefosine Alone for the Treatment Visceral Leishmaniasis in Eastern Africa | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT01058174 | Liver Transplant European Study Into the Prevention of Fungal Infection | fungal infectious disease | Amphotericin B (NPC67917) | NP level |
NCT00158730 | Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00012467 | Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT00003315 | Liposomal Amphotericin B With or Without Sargramostim in Treating Patients With Invasive Fungal Infection | infection | Amphotericin B (NPC67917) | NP level |
NCT05468372 | Amphotericin Versus Posaconazole for Pulmonary Mucormycosis | mucormycosis | Amphotericin B (NPC67917) | NP level |
NCT03327727 | VL-2397 Compared to Standard First-Line Treatment for Invasive Aspergillosis (IA) in Adults | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00000776 | Dexamethasone in Cryptococcal Meningitis | intracranial hypertension;cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT00177710 | Pharmacokinetic Profile of Inhaled Liposomal Amphotericin B in Lung Transplant Recipients - Ambisome Study | fungal infectious disease | Amphotericin B (NPC67917) | NP level |
NCT01293643 | A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077) | bacterial vaginosis;vulvovaginal candidiasis | Amphotericin B (NPC67917) | NP level |
NCT04502381 | Combined Inhalational With Intravenous Amphotericin B Versus Intravenous Amphotericin B Alone for Pulmonary Mucormycosis | mucormycosis | Amphotericin B (NPC67917) | NP level |
NCT00876824 | To Study the Effect Of Single Infusions Of Amphotericin B Lipid Preparations in Treatment of Patients Of Kala Azar | Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT03187691 | Safety and PK of Oral Encochleated Amphotericin B (CAMB/MAT2203) for Antifungal Prophylaxis in Patients Undergoing Induction Chemotherapy for Acute Myelogenous and Lymphoblastic Leukaemia | acute lymphoblastic leukemia;acute myeloid leukemia | Amphotericin B (NPC67917) | NP level |
NCT02226185 | Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas Recurrence | colorectal adenoma | Berberine (NPC53069) | NP level |
NCT00008359 | Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment | cancer | Amphotericin B (NPC67917) | NP level |
NCT00371995 | Short Course of Miltefosine and Liposomal Amphotericin B for Kala-azar | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT02656797 | Topical Liposomal Amphotericin B Gel Treatment for Cutaneous Leishmaniasis | Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00003031 | Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT03196921 | Efficacy and Safety of Oral Encochleated Amphotericin B for the Treatment of Cryptococcal Infection | infection | Amphotericin B (NPC67917) | NP level |
NCT00628719 | Single Infusion of Liposomal Amphotericin B in Indian Visceral Leishmaniasis | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT02011958 | Efficacy Trial of Ambisome Given Alone and Ambisome Given in Combination With Miltefosine for the Treatment of VL HIV Positive Ethiopian Patients. | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT01857479 | A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis | allergic bronchopulmonary aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00235651 | Abelcet Radiotagging Protocol: Inhaled Lipid Complex Abelcet® in Lung Transplant Recipients | lung disease | Amphotericin B (NPC67917) | NP level |
NCT00002277 | A Comparison of Fluconazole and Amphotericin B in the Treatment of Fungal Infections | fungal infectious disease | Amphotericin B (NPC67917) | NP level |
NCT00002316 | The Safety and Effectiveness of RMP-7 Plus Amphotericin B in Patients With HIV and Cryptococcal Meningitis | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT02084004 | Effects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and Treatment | type 2 diabetes mellitus | Berberine (NPC53069) | NP level |
NCT00633282 | Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver Disease | non-alcoholic fatty liver disease | Berberine (NPC53069) | NP level |
NCT01945281 | Safety, Tolerability, and Efficacy of Caspofungin Versus Amphotericin B Deoxycholate in the Treatment of Invasive Candidiasis in Neonates and Infants (MK-0991-064) | Candidiasis, Invasive | Amphotericin B (NPC67917) | NP level |
NCT00419770 | The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) Study | mucormycosis | Amphotericin B (NPC67917) | NP level |
NCT00001646 | Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00106288 | Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia | candidiasis | Amphotericin B (NPC67917) | NP level |
NCT00847678 | Efficacy and Safety of Mycograb as Adjunctive Therapy for Cryptococcal Meningitis in Patients With AIDS | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT00177684 | Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) | fungal infectious disease | Amphotericin B (NPC67917) | NP level |
NCT02548832 | Bezafibrate Plus Berberine in Mixed Dyslipidemia | Combined hyperlipidemia | Berberine (NPC53069) | NP level |
NCT00815516 | Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis | candidiasis | Amphotericin B (NPC67917) | NP level |
NCT01032187 | Amphotericin B to Treat Visceral Leishmaniasis in Brazilian Children | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00334412 | COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT00936910 | Antifungal Locks to Treat Fungal-related Central Line Infections | fungal infectious disease | Amphotericin B (NPC67917) | NP level |
NCT00076869 | MK0991 in Combination With Standard Antifungal Agent(s) for the Treatment of Salvage Invasive Aspergillosis (0991-037) | aspergillosis | Amphotericin B (NPC67917) | NP level |
NCT02686853 | Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis | cryptococcal meningitis | Amphotericin B (NPC67917) | NP level |
NCT00624143 | Antifungal Prophylaxis in Pediatric Acute Leukemia | leukemia | Amphotericin B (NPC67917) | NP level |
NCT01437020 | SCH708980 With and Without AmBisome for Visceral Leishmaniasis | Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00418951 | Liposomal Amphotericin B (Ambisome) Versus Oral Voriconazole for the Prevention of Invasive Fungal Infections | acute myeloid leukemia;myelodysplastic syndrome | Amphotericin B (NPC67917) | NP level |
NCT00523965 | Combination Therapy in Indian Visceral Leishmaniasis | Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00696969 | Safety and Efficacy Study to Evaluate Different Combination Treatment Regimens for Visceral Leishmaniasis | visceral Leishmaniasis | Amphotericin B (NPC67917) | NP level |
NCT00002159 | A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis | blastomycosis;histoplasmosis | Amphotericin B (NPC67917) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Meningitis due to Cryptococcus neoformansDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D01.10 |
NCT02686853,NCT00847678,NCT00000776,NCT00145249,NCT03945448,NCT00001017,NCT00012467,NCT00002316,NCT04031833
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
ACHE,SNCA,CYP1B1,DRD2,CA2,DRD1,PPARG,LMNA
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
SNCA,MAOA,DRD4,ACHE,DRD3,DRD2,DRD1
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
DRD3,SNCA,PPARG,DRD4,MAOA,DRD2,ACHE
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
AKR1B1,DRD2,DRD1,DRD3,DRD4
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
CA2,DRD2,ACHE,PPARG,AKR1B1
|
Type 2 diabetes mellitusDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A11 |
PPARG,DRD2
NCT02084004,NCT00425009,NCT02861261 |
Skin fungal infection disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA60 |
NCT00177684,NCT00936910,NCT00177710,NCT01058174,NCT00002277
|
CandidosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F23 |
NCT00163111,NCT00001107,NCT01945281,NCT00815516,NCT00106288
|
PheochromocytomaDisease Category: X.Extension CodesDisease ICD-11 Code: XH3854 |
ACHE,SNCA,DRD2,CA2,DRD5
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
ACHE,CYP1B1,DRD2,DRD1,AKR1B1
|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
DRD3,DRD2,MAOA,DRD4
|
Allergic/hypersensitivity disorderDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A80-4A8Z |
DRD4,DRD5,DRD2,DRD1
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
DRD1,DRD2,DRD2,PPARG
|
Solid tumour/cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00-2F9Z |
CA2,PPARG,DRD3,DRD2
|
MucormycosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F2C |
NCT04502381,NCT00467883,NCT05468372,NCT00419770
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
ACHE,THPO,LMNA,AKR1B1
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
SNCA,DRD2,DRD1,LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
SNCA,CA2,LMNA,ACHE
|
Cytomegaloviral diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D82 |
CA2,DRD2,THPO,ACHE
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
ACHE,SNCA,DRD1,AKR1B1
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
DRD2,DRD3,DRD4
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
DRD2,ACHE,AKR1B1
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
DRD2,DRD4,DRD3
|
InsomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7A0Z |
DRD2,CYP2D6,CA2
|
Multiple myelomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A83 |
DRD3,DRD2
NCT00002742 |
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
DRD2,MAOA,ACHE
|
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
DRD2,DRD1,DRD4
|
Herpes simplex infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F00 |
NCT00002742,NCT03196921,NCT00003315
|
Acute myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60 |
NCT03187691,NCT00451711,NCT00418951
|
Colorectal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B91 |
NCT02226185,NCT03281096,NCT03333265
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
DRD5,CA2,AKR1B1
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
DRD2,CA2,DRD5
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
DRD4,LMNA,AKR1B1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
THPO,ACHE,CYP2D6
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
CYP1B1,CA2,LMNA
|
LeishmaniasisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F54 |
AKR1B1
NCT00216346,NCT01437020,NCT04799236,NCT00370825,NCT03636659,NCT01032187,NCT01566552,NCT00371995,NCT01845727,NCT00628719,NCT00696969,NCT00832208,NCT02025491,NCT00523965,NCT02656797,NCT01067443,NCT00876824,NCT00497601,NCT01122771,NCT02011958,NCT01310738 |
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
PPARG,AKR1B1
|
Rheumatoid arthritisDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA20 |
AKR1B1,CA2
|
General pain disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8E43 |
DRD2,MAOA
|
DementiaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D80-6D8Z |
ACHE,DRD1
|
Sexual dysfunctionDisease Category: 17.Conditions related to sexual healthDisease ICD-11 Code: HA00-HA01 |
DRD3,DRD2
|
Mature T-cell lymphomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A90 |
DRD3,DRD2
|
Endometrial cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76 |
DRD3,DRD2
|
Gastroduodenal motor/secretory disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA41 |
DRD3,DRD2
|
Essential hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00 |
DRD2,CA2
|
Brain cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
DRD2,DRD3
|
Heart failureDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD10-BD1Z |
DRD2,CA2
|
BCR-ABL1-negative chronic myeloid leukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A41 |
DRD2,DRD3
|
Stomach cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72 |
DRD3,DRD2
|
Non-alcoholic fatty liver diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB92 |
PPARG
NCT00633282 |
Acute upper respiratory infectionDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA07 |
DRD3,DRD2
|
NADisease Category: NADisease ICD-11 Code: NA |
DRD2
NCT00235651 |
Vaginal dischargeDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MF3A |
NCT01293643,NCT01293643
|
Myelodysplastic syndromeDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A37 |
NCT00002742,NCT00418951
|
LeukaemiaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A60-2B33 |
NCT00002742,NCT00624143
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT00003938,NCT00008359
|
Dengue fever, unspecifiedDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D2Z |
MAOA,DRD3
|
HepatoblastomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.01 |
DRD5,AKR1B1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
DRD4,DRD5
|
Other specified malignant neoplasms of kidney, except renal pelvisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C90.Y |
ACHE,DRD4
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
DRD4,DRD2
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
CA2,AKR1B1
|
Systemic lupus erythematosusDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A40.0 |
DRD2,ACHE
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
CYP2D6,CA2
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
PPARG,LMNA
|
Renal cell carcinoma, chromophobe typeDisease Category: X.Extension CodesDisease ICD-11 Code: XH6153 |
DRD2,CA2
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
CYP1B1,THPO
|
AspergillosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F20 |
NCT00986713,NCT00263315,NCT00158730,NCT00001646,NCT00047827,NCT00334412,NCT04267497,NCT00076869,NCT03327727,NCT00003031
|
Sjogren syndromeDisease Category: 04.Diseases of the immune systemDisease ICD-11 Code: 4A43 |
PPARG
|
GangreneDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MC85 |
DRD2
|
Acquired hypomelanotic disorderDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED63 |
MAOA
|
Myasthenia gravisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C6Y |
ACHE
|
GoutDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FA25 |
PPARG
|
MalariaDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F40-1F45 |
CYP2D6
|
ThyrotoxicosisDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A02 |
DRD2
|
Pancreatic cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10 |
DRD2
|
Duodenal ulcerDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DA63 |
CA2
|
Hyper-lipoproteinaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80 |
PPARG
|
AsthmaDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA23 |
DRD2
|
Low bone mass disorderDisease Category: 15.Diseases of the musculoskeletal system or connective tissueDisease ICD-11 Code: FB83 |
CA2
|
Tic disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A05 |
DRD1
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
THPO
|
Oesophageal/gastroduodenal disorderDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD90 |
ACHE
|
Inborn lipid metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C52 |
PPARG
|
Choreiform disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A01 |
DRD2
|
Intellectual development disorderDisease Category: 20.Developmental anomaliesDisease ICD-11 Code: LD90 |
DRD2
|
Mild neurocognitive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6D71 |
ACHE
|
Cerebral ischaemiaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B1Z |
DRD2
|
Faecal incontinenceDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME07 |
DRD2
|
Idiopathic interstitial pneumonitisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03 |
DRD2
|
HyperaemiaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A61-9B7Y |
DRD2
|
Nasopharyngeal cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B6B |
DRD3
|
Parasitic worm infestationDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F90 |
ACHE
|
Autonomic nervous system disorderDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D87 |
SNCA
|
Multiple sclerosisDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A40 |
PPARG
|
Breast cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C60-2C6Y |
CA2
|
Prostate cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82 |
MAOA
|
PediculosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1G00 |
ACHE
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
DRD1
|
Mood disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60-6E23 |
MAOA
|
Chronic kidney diseaseDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GB61 |
DRD2
|
Unspecific substance harmful effectDisease Category: 22.Injury, poisoning or certain other consequences of external causesDisease ICD-11 Code: NE6Z |
ACHE
|
Ischaemic/haemorrhagic strokeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8B20 |
THPO
|
Indeterminate colitisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD72 |
PPARG
|
PsoriasisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA90 |
DRD2
|
AbortionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA00 |
DRD1
|
Seborrhoeic dermatitisDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EA81 |
CA2
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
AKR1B1
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
PPARG
|
Skin tag/polypDisease Category: 14.Diseases of the skinDisease ICD-11 Code: EK71 |
MAOA
|
Diabetes mellitus, type unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A14 |
PPARG
|
Nausea/vomitingDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD90 |
DRD2
|
Restless legs syndromeDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A80 |
DRD2
|
HypotensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA20-BA21 |
DRD2
|
Psychoactive substances use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4G |
DRD3
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
PPARG
|
Digestive system diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DE2Z |
DRD2
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
DRD2
|
ItchingDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F28-1G07 |
DRD2
|
Cardiovascular diseaseDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA00-BE2Z |
DRD2
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
DRD2
|
Schizoaffective disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A21 |
DRD2
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
DRD2
|
Bacterial infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1A00-1C4Z |
CA2
|
ThrombosisDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DB61-GB90 |
AKR1B1
|
Carcinoid syndromeDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B10 |
DRD2
|
Lung cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25 |
DRD2
|
Breathing abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MD11 |
DRD2
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
PPARG
|
Endocrine gland neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2F37 |
DRD2
|
Postpartum haemorrhageDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JA43 |
DRD2
|
NeuropathyDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C0Z |
AKR1B1
|
Inborn porphyrin/heme metabolism errorDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C58 |
DRD2
|
HistoplasmosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F2A |
NCT00002159
|
Intermediate hyperglycaemia, unspecifiedDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A40.Z |
NCT02082756
|
Aspergillus-induced allergic or hypersensitivity conditionsDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CA82.4 |
NCT01857479
|
AdenocarcinomaDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D40 |
NCT03486496
|
Myeloproliferative neoplasm, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH5HH7 |
NCT00002742
|
Chronic mucocutaneous candidosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F23.14 |
NCT02629419
|
Endothelial corneal dystrophyDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9A70.0 |
NCT04018417
|
BlastomycosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1F22 |
NCT00002159
|
Other specified increased intracranial pressureDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8D60.Y |
NCT00000776
|
Precursor cell lymphoblastic leukaemia, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH5J37 |
NCT03187691
|
Mixed hyperlipidaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C80.2 |
NCT02548832
|
Zika virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D48 |
ACHE
|
Idiopathic pulmonary fibrosisDisease Category: 12.Diseases of the respiratory systemDisease ICD-11 Code: CB03.4 |
DRD5
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
DRD1
|
West Nile virus infectionDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D46 |
ACHE
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
DRD2
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
DRD4
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
ACHE
|
Malignant neoplasms of thyroid gland, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D10.Z |
CYP1B1
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
THPO
|
Heart failure, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BD1Z |
CYP1B1
|
Ebola virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D60.01 |
ACHE
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
SNCA
|