Plant ID: NPO19021
Plant Latin Name: Linaria Vulgaris
Taxonomy Genus: Linaria
Taxonomy Family: Plantaginaceae
NCBI TaxonomyDB:
43171
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC95392
Ingredient ID: NPC95292
Ingredient ID: NPC86354
Ingredient ID: NPC45638
Ingredient ID: NPC33929
Ingredient ID: NPC328683
Ingredient ID: NPC28913
Ingredient ID: NPC283130
Ingredient ID: NPC270043
Ingredient ID: NPC226662
Ingredient ID: NPC219323
Ingredient ID: NPC162313
Ingredient ID: NPC157663
Ingredient ID: NPC152384
Ingredient ID: NPC144566
Ingredient ID: NPC106937
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2B | Serotonin 2b (5-HT2b) receptor | P41595 | CHEMBL1833 |
Therapeutic Target | Small molecule receptor (family A GPCR) | HTR2C | Serotonin 2c (5-HT2c) receptor | P28335 | CHEMBL225 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 54 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT05452772 | 5-HT2A Agonist Psilocybin in the Treatment of Tobacco Use Disorder | nicotine dependence | Psilocybine (NPC106937) | NP level |
NCT05381974 | The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD | major depressive disorder | Psilocybine (NPC106937) | NP level |
NCT00957359 | Psilocybin Cancer Anxiety Study | cancer | Psilocybine (NPC106937) | NP level |
NCT02981173 | Psilocybin for the Treatment of Cluster Headache | pain | Psilocybine (NPC106937) | NP level |
NCT04218539 | Repeat Dosing of Psilocybin in Migraine Headache | migraine disorder | Psilocybine (NPC106937) | NP level |
NCT05416229 | Psilocybin-assisted Therapy for Treatment of Alcohol Use Disorder | alcohol dependence | Psilocybine (NPC106937) | NP level |
NCT04905121 | Phase 1b Study in Patients With Short-Lasting Unilateral Neuralgiform Headache Attacks (SUNHA) | Headache | Psilocybine (NPC106937) | NP level |
NCT02950467 | Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors | depressive disorder | Psilocybine (NPC106937) | NP level |
NCT03181529 | Effects of Psilocybin in Major Depressive Disorder | major depressive disorder | Psilocybine (NPC106937) | NP level |
NCT03341689 | Psilocybin for the Treatment of Migraine Headache | migraine disorder | Psilocybine (NPC106937) | NP level |
NCT03300947 | Psilocybin for Treatment of Obsessive Compulsive Disorder | obsessive-compulsive disorder | Psilocybine (NPC106937) | NP level |
NCT05068791 | Psilocybin-facilitated Treatment for Chronic Pain | fibromyalgia | Psilocybine (NPC106937) | NP level |
NCT05351541 | Psilocybin Therapy for Chronic Low Back Pain | Low back pain | Psilocybine (NPC106937) | NP level |
NCT01534494 | Effects and Therapeutic Potential of Psilocybin in Alcohol Dependence | alcohol dependence | Psilocybine (NPC106937) | NP level |
NCT05305105 | Effects of Psilocybin in Post-Treatment Lyme Disease | Lyme disease | Psilocybine (NPC106937) | NP level |
NCT04433845 | The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression. | treatment resistant depression | Psilocybine (NPC106937) | NP level |
NCT04280055 | Prophylactic Effects of Psilocybin on Chronic Cluster Headache | pain | Psilocybine (NPC106937) | NP level |
NCT03775200 | The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression | treatment resistant depression | Psilocybine (NPC106937) | NP level |
NCT02037126 | Psilocybin-facilitated Treatment for Cocaine Use | cocaine dependence | Psilocybine (NPC106937) | NP level |
NCT04670081 | Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression | depressive disorder | Psilocybine (NPC106937) | NP level |
NCT04842045 | Pilot RECAP Study in Healthy Volunteers | amnesia | Psilocybine (NPC106937) | NP level |
NCT03429075 | Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms | major depressive disorder | Psilocybine (NPC106937) | NP level |
NCT04433858 | An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD) | treatment resistant depression | Psilocybine (NPC106937) | NP level |
NCT04141501 | Clinical and Mechanistic Effects of Psilocybin in Alcohol Addicted Patients | alcohol dependence | Psilocybine (NPC106937) | NP level |
NCT04522804 | Study of Psilocybin Enhanced Group Psychotherapy in Patients With Cancer | cancer | Psilocybine (NPC106937) | NP level |
NCT05481736 | Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept Study | anorexia nervosa | Psilocybine (NPC106937) | NP level |
NCT00302744 | Effects of Psilocybin in Advanced-Stage Cancer Patients With Anxiety | anxiety | Psilocybine (NPC106937) | NP level |
NCT04739865 | The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression | treatment resistant depression | Psilocybine (NPC106937) | NP level |
NCT04982796 | Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder | methamphetamine dependence | Psilocybine (NPC106937) | NP level |
NCT04052568 | Effects of Psilocybin in Anorexia Nervosa | anorexia nervosa | Psilocybine (NPC106937) | NP level |
NCT04630964 | The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density | major depressive disorder | Psilocybine (NPC106937) | NP level |
NCT05312151 | The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder | post-traumatic stress disorder | Psilocybine (NPC106937) | NP level |
NCT05065294 | Psilocybin Therapy for Depression in Bipolar II Disorder | bipolar disorder | Psilocybine (NPC106937) | NP level |
NCT04718792 | Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility Study | alcohol dependence | Psilocybine (NPC106937) | NP level |
NCT04505189 | Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study | anorexia nervosa | Psilocybine (NPC106937) | NP level |
NCT05383313 | Psilocybin Versus Ketamine in Treatment-Resistant Depression | treatment resistant depression | Psilocybine (NPC106937) | NP level |
NCT04161066 | Adjunctive Effects of Psilocybin and a Formulation of Buprenorphine | opioid use disorder | Psilocybine (NPC106937) | NP level |
NCT05242029 | Psilocybin for Opioid Use Disorder in Patients on Methadone Maintenance With Ongoing Opioid Use | opioid use disorder | Psilocybine (NPC106937) | NP level |
NCT05370911 | Effects of Repeated Psilocybin Dosing in OCD | obsessive-compulsive disorder | Psilocybine (NPC106937) | NP level |
NCT03554174 | Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder | major depressive disorder | Psilocybine (NPC106937) | NP level |
NCT05322954 | Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder | methamphetamine dependence | Psilocybine (NPC106937) | NP level |
NCT02061293 | A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence | alcohol dependence | Psilocybine (NPC106937) | NP level |
NCT05029466 | Psilocybin for Treatment-Resistant Depression | treatment resistant depression | Psilocybine (NPC106937) | NP level |
NCT04661514 | Evaluation of Psilocybin in Anorexia Nervosa: Safety and Efficacy | anorexia nervosa | Psilocybine (NPC106937) | NP level |
NCT05227612 | Psilocybin-assisted CBT for Depression | major depressive disorder | Psilocybine (NPC106937) | NP level |
NCT05398484 | Psilocybin Therapy in Advanced Cancer | cancer | Psilocybine (NPC106937) | NP level |
NCT03356483 | Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. | obsessive-compulsive disorder | Psilocybine (NPC106937) | NP level |
NCT05421065 | Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder | alcohol dependence | Psilocybine (NPC106937) | NP level |
NCT04410913 | Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder | alcohol dependence | Psilocybine (NPC106937) | NP level |
NCT03866174 | A Study of Psilocybin for Major Depressive Disorder (MDD) | major depressive disorder | Psilocybine (NPC106937) | NP level |
NCT04754061 | Psilocybin for Psychological and Existential Distress in Palliative Care | depressive disorder | Psilocybine (NPC106937) | NP level |
NCT03380442 | Psilocybin and Depression | depressive disorder | Psilocybine (NPC106937) | NP level |
NCT04593563 | The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive Disorder | major depressive disorder | Psilocybine (NPC106937) | NP level |
NCT04950608 | Pilot Study of Psilocybin-Assisted Therapy for Demoralization in Patients Receiving Hospice Care | cancer | Psilocybine (NPC106937) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
DepressionDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70-6A7Z |
HTR2C,HTR2B
NCT04739865,NCT05029466,NCT04433845,NCT05383313,NCT03775200,NCT04433858 |
Single episode depressive disorder, severe, without psychotic symptomsDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A70.3 |
NCT03554174,NCT04593563,NCT04630964,NCT03429075,NCT05227612,NCT03866174,NCT05381974,NCT03181529
|
Alcohol dependenceDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40.2 |
NCT05416229,NCT01534494,NCT04141501,NCT05421065,NCT04410913,NCT02061293,NCT04718792
|
Depressive disorders, unspecifiedDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A7Z |
NCT04754061,NCT04670081,NCT03380442,NCT02950467
|
Anorexia nervosaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B80 |
NCT04052568,NCT04661514,NCT05481736,NCT04505189
|
Unspecified malignant neoplasms of unspecified sitesDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D4Z |
NCT04522804,NCT04950608,NCT00957359,NCT05398484
|
Pain, unspecifiedDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG3Z |
HTR2C
NCT02981173,NCT04280055 |
Obsessive-compulsive disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B20 |
NCT03300947,NCT03356483,NCT05370911
|
Attention deficit hyperactivity disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A05 |
HTR2B,HTR2C
|
Pituitary gland disorderDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A60-5A61 |
HTR2C,HTR2B
|
AnxietyDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB24.3 |
HTR2C
NCT00302744 |
Psychotic disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20-6A25 |
HTR2C,HTR2B
|
Stimulant dependence including amphetamines, methamphetamine or methcathinoneDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C46.2 |
NCT04982796,NCT05322954
|
Migraine disorder(TM1)Disease Category: 26.Supplementary Chapter Traditional Medicine Conditions - Module IDisease ICD-11 Code: SD10 |
NCT03341689,NCT04218539
|
Opioid use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C43 |
NCT04161066,NCT05242029
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
HTR2B,HTR2C
|
Psychoactive substances use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4G |
HTR2C
|
Pulmonary hypertensionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BB01 |
HTR2B
|
Chronic insomniaDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00 |
HTR2C
|
MigraineDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A80 |
HTR2C
|
ObesityDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5B80-5B81 |
HTR2C
|
Malignant haematopoietic neoplasmDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B33 |
HTR2C
|
Alzheimer diseaseDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A20 |
HTR2C
|
Sleep-wake disorderDisease Category: 07.Sleep-wake disordersDisease ICD-11 Code: 7A00-7B2Z |
HTR2C
|
SchizophreniaDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A20 |
HTR2C
|
Tonus and reflex abnormalityDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB47 |
HTR2C
|
Acute diabete complicationDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5A2Y |
HTR2C
|
ParkinsonismDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A00 |
HTR2C
|
Substance abuseDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C40 |
HTR2C
|
Tension-type headacheDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8A81 |
NCT04905121
|
Nicotine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C4A |
NCT05452772
|
AmnesiaDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MB21.1 |
NCT04842045
|
Bipolar disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6A60 |
NCT05065294
|
Lyme borreliosisDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1C1G |
NCT05305105
|
Chronic widespread painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: MG30.01 |
NCT05068791
|
Low back painDisease Category: 21.Symptoms, signs or clinical findings, not elsewhere classifiedDisease ICD-11 Code: ME84.2 |
NCT05351541
|
Post-traumatic stress disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6B40 |
NCT05312151
|
Cocaine use disorderDisease Category: 06.Mental, behavioural or neurodevelopmental disordersDisease ICD-11 Code: 6C45 |
NCT02037126
|
Carcinosarcoma of uterusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.43 |
HTR2C
|
Serous cystadenoma,borderline malignancy of ovaryDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C73.4 |
HTR2C
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
HTR2C
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
HTR2C
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
HTR2B
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
HTR2C
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
HTR2B
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
HTR2C
|
Melanoma of skinDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C30 |
HTR2C
|
Hepatocellular carcinoma of liverDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C12.02 |
HTR2C
|
Other specified malignant neoplasms of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.Y |
HTR2C
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
HTR2C
|
Malignant neoplasms of corpus uteri, unspecifiedDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C76.Z |
HTR2C
|
Malignant neoplasms of thymusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C27 |
HTR2C
|
Invasive carcinoma of breastDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C61 |
HTR2C
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
HTR2C
|
Carpal tunnel syndromeDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C10.0 |
HTR2B
|
Malignant neoplasms of adrenal glandDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D11 |
HTR2C
|