Ingredient ID: NPC89748
Ingredient ID: NPC89069
Ingredient ID: NPC77643
Ingredient ID: NPC75158
Ingredient ID: NPC71250
Ingredient ID: NPC66562
Ingredient ID: NPC50052
Ingredient ID: NPC47132
Ingredient ID: NPC35741
Ingredient ID: NPC325751
Ingredient ID: NPC321355
Ingredient ID: NPC318992
Ingredient ID: NPC31302
Ingredient ID: NPC310674
Ingredient ID: NPC283655
Ingredient ID: NPC281557
Ingredient ID: NPC277917
Ingredient ID: NPC277693
Ingredient ID: NPC273832
Ingredient ID: NPC273607
Ingredient ID: NPC272937
Ingredient ID: NPC263548
Ingredient ID: NPC231738
Ingredient ID: NPC214168
Ingredient ID: NPC204120
Ingredient ID: NPC203634
Ingredient ID: NPC199123
Ingredient ID: NPC171495
Ingredient ID: NPC167599
Ingredient ID: NPC121540
Ingredient ID: NPC113760
Ingredient ID: NPC112866
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Nuclear hormone receptor subfamily 1 | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 2 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01659580 | Phase III Trial of Dantonic® (T89) Capsule to Prevent and Treat Stable Angina | angina pectoris | Borneol (NPC283655) | NP level |
NCT02029118 | Acupoint Application in Patients With Stable Angina Pectoris (AASAP) | angina pectoris | Borneol (NPC283655) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Angina pectorisDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA40 |
NCT02029118,NCT01659580
|