Plant ID: NPO16749
Plant Latin Name: Zostera Marina
Taxonomy Genus: Zostera
Taxonomy Family: Zosteraceae
NCBI TaxonomyDB:
29655
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC98307
Ingredient ID: NPC68271
Ingredient ID: NPC46801
Ingredient ID: NPC313179
Ingredient ID: NPC291886
Ingredient ID: NPC281457
Ingredient ID: NPC246026
Ingredient ID: NPC237869
Ingredient ID: NPC231324
Ingredient ID: NPC225423
Ingredient ID: NPC219919
Ingredient ID: NPC17810
Ingredient ID: NPC171148
Ingredient ID: NPC140619
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Drug Transporter | SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 11 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT00006202 | Lutein for Age-Related Macular Degeneration | macular degeneration | Lutein (NPC313179) | NP level |
NCT00275418 | Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease | Crohn's disease | Beta Carotene (NPC17810) | NP level |
NCT00029289 | Effects of Lutein in Retinitis Pigmentosa | retinitis pigmentosa | Lutein (NPC313179) | NP level |
NCT03750968 | Lutein & Zeaxanthin in Pregnancy - Carotenoid Supplementation During Pregnancy: Ocular and Systemic Effects | pregnancy | Lutein (NPC313179) | NP level |
NCT00000161 | Randomized Trials of Vitamin Supplements and Eye Disease | cataract;macular degeneration | Beta Carotene (NPC17810) | NP level |
NCT00000152 | Randomized Trial of Beta-Carotene and Macular Degeneration | macular degeneration | Beta Carotene (NPC17810) | NP level |
NCT00121589 | Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60 | macular degeneration | Lutein (NPC313179) | NP level |
NCT01048476 | Effects of Lutein and Zeaxanthin Supplementation on Age-related Macular Degeneration | age-related macular degeneration | Lutein (NPC313179) | NP level |
NCT00000541 | Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS) | myocardial infarction;Myocardial Ischemia | Beta Carotene (NPC17810) | NP level |
NCT03959592 | Macular Pigment and Visual Performance in Glaucoma Patients | glaucoma | Lutein (NPC313179) | NP level |
NCT00346333 | Clinical Trial of Lutein for Patients With Retinitis Pigmentosa Receiving Vitamin A | retinitis pigmentosa | Lutein (NPC313179) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
Macular degenerationDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B75 |
NCT00006202,NCT00000152,NCT00121589,NCT01048476,NCT00000161
|
Neuropathy, ataxia, and retinitis pigmentosaDisease Category: 08.Diseases of the nervous systemDisease ICD-11 Code: 8C73.1 |
NCT00029289,NCT00346333
|
CataractDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9B10 |
NCT00000161
|
Pregnancy/childbirth/puerperium maternal infectionDisease Category: 18.Pregnancy, childbirth or the puerperiumDisease ICD-11 Code: JB63 |
NCT03750968
|
Ischaemic heart diseases, unspecifiedDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA6Z |
NCT00000541
|
GlaucomaDisease Category: 09.Diseases of the visual systemDisease ICD-11 Code: 9C61 |
NCT03959592
|
Crohn diseaseDisease Category: 13.Diseases of the digestive systemDisease ICD-11 Code: DD70 |
NCT00275418
|
Myocardial infarctionDisease Category: 11.Diseases of the circulatory systemDisease ICD-11 Code: BA41-BA43 |
NCT00000541
|
Adenocarcinoma of stomachDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B72.0 |
SLCO1B1
|
Malignant neoplasm metastasis in lymph nodes of head, face or neckDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D60.0 |
SLCO1B1
|
Squamous cell carcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.2 |
SLCO1B1
|
Other specified malignant neoplasms ofcolonDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B90.Y |
SLCO1B1
|
Malignant neoplasms of oesophagusDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2B70 |
SLCO1B1
|
Urothelial carcinoma of bladderDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C94.2 |
SLCO1B1
|
Adenocarcinoma of prostateDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C82.0 |
SLCO1B1
|
Adenocarcinoma of bronchus or lungDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C25.0 |
SLCO1B1
|
Germ cell tumour of testisDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C80.2 |
SLCO1B1
|