CMAUP Plant Collective Molecular Activities

Plant Name: Dodonaea polyandra

Taxonomic Information:

Plant ID: NPO15884
Plant Latin Name: Dodonaea polyandra
Taxonomy Genus: Dodonaea
Taxonomy Family: Sapindaceae

Plant External Links:

NCBI TaxonomyDB: 569829
Plant-of-the-World-Online: 782948-1

Used in Medicines:

Country/Region:

Australia

Traditional Medicine System:

Geographical Distribution:

Australia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	NPSR1;
Hydrolase	ACHE;
Protein Kinase	MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R; AURKB;
Lyase	CA12; CA7; CA4;
Oxidoreductase	TYR;
Enzyme_unclassified	ALOX12; HSD17B2; HSD17B10; NOX4; ALOX15; POLB;
Transcription Factor	AHR;
Unclassified	LMNA; FABP3;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA4	Carbonic anhydrase IV	P22748	CHEMBL3729
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	3.251E-07	3.804E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.051E-07	4.230E-04	CYP1A1, CYP1A2, CYP1B1, NOX4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.227E-06	8.348E-04	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	2.026E-06	1.068E-03	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	2.059E-06	1.068E-03	ALOX12, AURKB, AXL, CDK1, FFAR4, IGF1R, KDR, LMNA, PIM1
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	2.026E-06	1.068E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0055114; oxidation-reduction process	3.026E-06	1.430E-03	ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, HSD17B10, HSD17B2, NOX4, TYR
MF	GO:0005488; binding	GO:0005506; iron ion binding	3.086E-06	1.430E-03	ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	3.278E-06	1.487E-03	ALOX15, AXL, CDK1, CYP1A1, CYP1A2, CYP1B1, KDR
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.565E-06	1.528E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	4.738E-06	1.842E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	4.738E-06	1.842E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	5.861E-06	2.123E-03	AXL, CYP1A1, CYP1A2, FABP3, FFAR1, FLT3, HSD17B2, TYR
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	6.074E-06	2.123E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	6.074E-06	2.123E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	6.441E-06	2.191E-03	AXL, FLT3, IGF1R, KDR, MET
CC	GO:0016020; membrane	GO:0016020; membrane	7.492E-06	2.435E-03	ACHE, ALOX12, ALOX15, AXL, CA12, CA4, CDK1, CYP1A1, CYP1A2, CYP1B1, FFAR1, FFAR4, FLT3, HSD17B10, HSD17B2, IGF1R, KDR, LMNA, MET, NOX4, NPSR1, PIM1, TYR
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	8.309E-06	2.622E-03	AURKB, FLT3, IGF1R, KDR, PIM1
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	8.712E-06	2.672E-03	AHR, ALOX12, CDK1, CYP1B1, FABP3, FLT3, IGF1R, KDR, LMNA, NOX4, PIM1
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.214E-05	3.477E-03	CYP1A1, CYP1A2
BP	GO:0032502; developmental process	GO:0007568; aging	1.839E-05	5.134E-03	AURKB, CDK1, CYP1A1, NOX4, POLB
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.886E-05	5.134E-03	CA12, CA4, CA7
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	2.021E-05	5.366E-03	ALOX12, ALOX15
MF	GO:0005488; binding	GO:0020037; heme binding	3.330E-05	8.147E-03	CYP1A1, CYP1A2, CYP1B1, NOX4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.472E-05	8.400E-03	CA12, CA4, CA7
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	3.584E-05	8.576E-03	ALOX15, AXL, CYP1A1, CYP1B1, FFAR4, FLT3, IGF1R, KDR, NOX4
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	4.187E-05	9.803E-03	ALOX12, CA12, CA7, FABP3, FFAR1, MET, NOX4, NPSR1
MF	GO:0060089; molecular transducer activity	GO:0005021; vascular endothelial growth factor-activated receptor activity	4.236E-05	9.813E-03	FLT3, KDR

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	6.769E-07	3.793E-05	HSD17B2, CYP1A1, CYP1B1, IGF1R
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.238E-06	3.793E-05	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.345E-05	4.045E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.649E-06	3.793E-05	CA12, CA4, CA7
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.431E-04	1.975E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.021E-04	2.324E-03	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	7.496E-04	7.389E-03	CYP1A2, ALOX15

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	GIST	NA	FLT3;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Glioma	C71	KDR;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	CLL	NA	FLT3;
NA: NA	HIV infections	NA	AHR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; FLT3; ACHE;
C00-D49: Neoplasms	Colon cancer	C50	FLT3;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA4; ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
C00-D49: Neoplasms	Melanoma	C43	KDR; TYR;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; AHR;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R; ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	CA4;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases