Plant ID: NPO13323
Plant Latin Name: Uncaria Quadrangularis
Taxonomy Genus: Uncaria
Taxonomy Family: Rubiaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Ingredient ID: NPC97593
Ingredient ID: NPC97105
Ingredient ID: NPC96441
Ingredient ID: NPC9008
Ingredient ID: NPC8411
Ingredient ID: NPC78825
Ingredient ID: NPC76640
Ingredient ID: NPC63561
Ingredient ID: NPC59948
Ingredient ID: NPC54016
Ingredient ID: NPC52924
Ingredient ID: NPC3258
Ingredient ID: NPC302854
Ingredient ID: NPC299426
Ingredient ID: NPC296282
Ingredient ID: NPC292423
Ingredient ID: NPC291064
Ingredient ID: NPC28936
Ingredient ID: NPC28840
Ingredient ID: NPC286641
Ingredient ID: NPC280312
Ingredient ID: NPC278758
Ingredient ID: NPC275992
Ingredient ID: NPC273796
Ingredient ID: NPC265594
Ingredient ID: NPC260857
Ingredient ID: NPC249597
Ingredient ID: NPC237348
Ingredient ID: NPC233300
Ingredient ID: NPC223621
Ingredient ID: NPC219996
Ingredient ID: NPC215394
Ingredient ID: NPC201238
Ingredient ID: NPC200605
Ingredient ID: NPC198182
Ingredient ID: NPC19763
Ingredient ID: NPC192068
Ingredient ID: NPC185630
Ingredient ID: NPC182915
Ingredient ID: NPC174316
Ingredient ID: NPC168687
Ingredient ID: NPC154476
Ingredient ID: NPC141272
Ingredient ID: NPC135920
Ingredient ID: NPC13580
Ingredient ID: NPC12798
Ingredient ID: NPC124247
Ingredient ID: NPC121474
Ingredient ID: NPC119914
Ingredient ID: NPC111679
Ingredient ID: NPC102686
Ingredient ID: NPC100002
Target Type | Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|---|
Therapeutic Target | Structural protein | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Clinical trials associated with plant from natural product (NP) & plant level:
Clinical trials type | Number of clinical trials | |
---|---|---|
NP level | 5 | |
NCT ID | Title | Condition | Form in clinical use | Associated by plant or compound |
---|---|---|---|---|
NCT01163487 | Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers | head and neck malignant neoplasia | Dichloroacetic Acid (NPC278758) | NP level |
NCT03356457 | Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes | Hyperglycemia | Dichloroacetic Acid (NPC278758) | NP level |
NCT01111097 | Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors | brain neoplasm;glioblastoma multiforme | Dichloroacetic Acid (NPC278758) | NP level |
NCT00068913 | Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome | MELAS | Dichloroacetic Acid (NPC278758) | NP level |
NCT00566410 | A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours | neoplasm | Dichloroacetic Acid (NPC278758) | NP level |
How do we define the Plant-Targeted Human Disease Association?
Associated human diseases of an individual plant are summurized based on FOUR types of association evidence, these include:
❶ Association by Therapeutic Target: Bioactive protein targets of the plant were defined in "Molecular Targets" section, target-disease associations collected from TTD database were subsequently used to build the associations between the plant and its targeted human diseases.
❷ Association by Disease Gene Reversion: Plant and a specific disease will be associated when >= 1 plant target gene overlaped with disease's DEGs.
❸ Association by Clinical Trials of Plant: Plant and a specific disease will be associated when >= 1 clinical trial (the plant is the intervetion) can be matched in ClinicalTrials.gov database.
❹ Association by Clinical Trials of Plant Ingredients: Plant and a specific disease will be associated when >= 1 clinical trial (the plant ingredient is the intervetion) can be matched in ClinicalTrials.gov database.
Associated Disease of the Plant |
Association Type & Detailed Evidence |
---|---|
MelasmaDisease Category: 14.Diseases of the skinDisease ICD-11 Code: ED60.1 |
NCT00068913
|
Glioblastoma, primary, NOSDisease Category: X.Extension CodesDisease ICD-11 Code: XH0MB1 |
NCT01111097
|
HyperkalaemiaDisease Category: 05.Endocrine, nutritional or metabolic diseasesDisease ICD-11 Code: 5C76 |
NCT03356457
|
Head and neck cancerDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2D42 |
NCT01163487
|
Primary neoplasms of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00 |
NCT01111097
|
NeoplasmsDisease Category: 02.NeoplasmsDisease ICD-11 Code: 02 |
NCT00566410
|
Malignant neoplasms of biliary tract, distal bile ductDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C15 |
LMNA
|
Diffuse large B-cell lymphomasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A81 |
LMNA
|
Adenocarcinoma of pancreasDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C10.0 |
LMNA
|
Mesothelioma of pleuraDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2C26.0 |
LMNA
|
Superficial ovarian endometriosisDisease Category: 16.Diseases of the genitourinary systemDisease ICD-11 Code: GA10.B4 |
LMNA
|
Chikungunya virus diseaseDisease Category: 01.Certain infectious or parasitic diseasesDisease ICD-11 Code: 1D40 |
LMNA
|
Glioblastoma of brainDisease Category: 02.NeoplasmsDisease ICD-11 Code: 2A00.00 |
LMNA
|