Drug Information| Drug ID:   | NPD385 |
| Drug Name:   | Menthol; (-)-menthol |
| Molecular Formula:   | C10H20O |
| Canonical SMILES:   | C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C |
| Standard InCHI:   | "InChI=1S/C10H20O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-11H,4-6H2,1-3H3/t8-,9+,10-/m1/s1" |
| Standard InCHIKey:   | NOOLISFMXDJSKH-KXUCPTDWSA-N |
| Max Developmental Stage:   | Phase 3 |
| Max Developmental Stage Source:   | TTD; DrugBank; IUPHAR/BPS |
  Structural Similarity Between NPASS Natural Products and NPD385Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.
Tanimoto coefficient is calculated based on PubChem 881-bit substructure fingerprints.
  Similar Natural Products High Similarity: Tc>=0.85; Intermediate Similarity: 0.7 <= Tc < 0.85; Remote Similarity: 0.5 <= Tc < 0.7
| Similarity Level | Similarity Score | Natural Product ID |
|---|---|---|
| High Similarity | 1.0 | NPC287550 |
| High Similarity | 1.0 | NPC168552 |
| High Similarity | 1.0 | NPC223468 |
| High Similarity | 1.0 | NPC609546 |
| High Similarity | 1.0 | NPC147343 |
| High Similarity | 1.0 | NPC182727 |
| High Similarity | 1.0 | NPC84030 |
| High Similarity | 1.0 | NPC211444 |
| High Similarity | 1.0 | NPC326866 |
| High Similarity | 1.0 | NPC308453 |
| High Similarity | 1.0 | NPC307151 |
| High Similarity | 1.0 | NPC601778 |
| Remote Similarity | 0.5909 | NPC75293 |
| Remote Similarity | 0.5909 | NPC488287 |
| Remote Similarity | 0.5909 | NPC54145 |
| Remote Similarity | 0.5909 | NPC34429 |
| Remote Similarity | 0.5909 | NPC215242 |
| Remote Similarity | 0.5909 | NPC500151 |
| Remote Similarity | 0.5652 | NPC67508 |
| Remote Similarity | 0.5652 | NPC204242 |
| Remote Similarity | 0.5652 | NPC285267 |
| Remote Similarity | 0.5652 | NPC84824 |
| Remote Similarity | 0.5652 | NPC158956 |
| Remote Similarity | 0.5652 | NPC280821 |
| Remote Similarity | 0.5652 | NPC287446 |
| Remote Similarity | 0.5652 | NPC491219 |
| Remote Similarity | 0.5652 | NPC501577 |
| Remote Similarity | 0.5556 | NPC538340 |
| TTD   | DAP000876 |
| DrugBank   | DB00825 |
| ChEMBL   | CHEMBL470670 |
| IUPHAR/BPS   | 2430 |
| PharmaGKB   | PA164776605 |
| KEGG Drug   | D00064 |
| PubChem CID   | 16666 |
| ChEBI   | 15409 |
| CAS Number   | 2216-51-5 |
| Molecular Weight   | 156.15 |
| ALogP   | 0.6563 |
| MLogP   | 2.45 |
| XLogP   | 3.211 |
| HDA   | 1 |
| HBD   | 1 |
| Rotatable Bonds   | 5 |
| TPSA   | 20.23 |
| RO5 Violation   | 0 |