Natural Product: NPC129238

Natural Product IDNPC129238
Common Name
?
The InCHIKey will be temporarily assigned as the "Common Name" if no IUPAC name or alternative short name is available.
 BWRZDLYJNURUHS-CRWXNKLISA-N
IUPAC Name n.a.
Synonyms
Synthetic Gene Cluster n.a.
ChEMBL Identifier n.a.
PubChem CID n.a.
Chemical Classification
  • CHEMONTID:0000000 [Organic compounds]
    • [CHEMONTID:0000012] Lipids and lipid-like molecules
      • [CHEMONTID:0000259] Prenol lipids
        • [CHEMONTID:0001283] Terpene lactones
          • [CHEMONTID:0001543] Sesquiterpene lactones
            • [CHEMONTID:0001770] Guaianolides and derivatives

The Chemical Classification was calculated by Classyfire, a software for chemical taxonomy calculation. Reference: DOI:10.1186/s13321-016-0174-y.

  Chemical Representations

Standard InCHIKey BWRZDLYJNURUHS-CRWXNKLISA-N
Standard InCHI InChI=1S/C15H18O2/c1-8-4-7-12-10(3)15(16)17-14(12)13-9(2)5-6-11(8)13/h4,11-14H,2-3,5-7H2,1H3/t11-,12+,13-,14-/m0/s1
SMILES CC1=CC[C@@H]2C(=C)C(=O)O[C@@H]2[C@H]2C(=C)CC[C@@H]12

  Calculated Properties

Physi-Chem Properties

MedChem Properties

ADMET Properties (ADMETlab3.0)

ADMET: Absorption

ADMET: Distribution

ADMET: Metabolism

ADMET: Excretion

ADMET: Toxicity

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO26040 Dracocephalum komarovi Species Lamiaceae Eukaryota n.a. n.a. n.a. PMID[12542361]
NPO25979 Pseudopterogorgia australiensis Species Gorgoniidae Eukaryota n.a. n.a. n.a. PMID[15332869]
NPO25979 Pseudopterogorgia australiensis Species Gorgoniidae Eukaryota n.a. Indian Ocean n.a. PMID[15332869]
NPO25979 Pseudopterogorgia australiensis Species Gorgoniidae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO26419 Magnolia rostrata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO26596 Inula royleana Species Asteraceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO9560 Helenium vernale Species Asteraceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO11851 Excoecaria parvifolia Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO26040 Dracocephalum komarovi Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO7470 Choisya mollis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO18145 Annona papilionella Species Annonaceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO26615 Melampsora lini Species Melampsoraceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO26712 Cladrastis kentukea Species Fabaceae Eukaryota n.a. n.a. n.a. Database[COCONUT]
NPO26419 Magnolia rostrata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO26596 Inula royleana Species Asteraceae Eukaryota n.a. n.a. n.a. Database[HerDing]
NPO26419 Magnolia rostrata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26596 Inula royleana Species Asteraceae Eukaryota n.a. n.a. n.a. Database[TCMID]
NPO26419 Magnolia rostrata Species Magnoliaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26040 Dracocephalum komarovi Species Lamiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO18145 Annona papilionella Species Annonaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO11851 Excoecaria parvifolia Species Euphorbiaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO9560 Helenium vernale Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO25979 Pseudopterogorgia australiensis Species Gorgoniidae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26596 Inula royleana Species Asteraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26615 Melampsora lini Species Melampsoraceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO26712 Cladrastis kentukea Species Fabaceae Eukaryota n.a. n.a. n.a. Database[UNPD]
NPO7470 Choisya mollis Species Rutaceae Eukaryota n.a. n.a. n.a. Database[UNPD]

Note for Reference:
In addition to directly collecting NP source organism data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated them from below databases:
☉ UNPD: Universal Natural Products Database [PMID: 23638153].
☉ StreptomeDB: a database of streptomycetes natural products [PMID: 33051671].
☉ TM-MC: a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine [PMID: 26156871].
☉ TCM@Taiwan: a Traditional Chinese Medicine database [PMID: 21253603].
☉ TCMID: a Traditional Chinese Medicine database [PMID: 29106634].
☉ TCMSP: The traditional Chinese medicine systems pharmacology database and analysis platform [PMID: 24735618].
☉ HerDing: a herb recommendation system to treat diseases using genes and chemicals [PMID: 26980517].
☉ MetaboLights: a metabolomics database [PMID: 27010336].
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].



  NP Quantity Composition/Concentration

Organism ID Organism Name Organism Material Preparation Organism Part NP Quantity (Standard) NP Quantity (Minimum) NP Quantity (Maximum) Quantity Unit Reference

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP quantitative records for specific NP domains (e.g., NPS from foods or herbs) from domain-specific databases. These databases include:
☉ DUKE: Dr. Duke's Phytochemical and Ethnobotanical Databases.
☉ PHENOL EXPLORER: is the first comprehensive database on polyphenol content in foods [PMID: 24103452], its homepage can be accessed at here.
☉ FooDB: a database of constituents, chemistry and biology of food species [www.foodb.ca].



 Biological Activity

Molecular-level activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference

In vitro activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference

In vivo activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference





 Experimental ADME

Experiment Model Experiment Tissue ADME Type ADME Relation ADME Value ADME Unit Reference





 Experimental Toxicity

Quantitative toxicity

Experiment Model Experiment Organism Toxicity Type Toxicity Relation Toxicity Value Toxicity Unit Reference

Common Abbreviations:
LC: Lethal Concentration; LD: Lethal Dose; LT:Lethal Time; NOAEL: No-observed-adverse-effect Level; BMDL: Benchmark Dose Lower Confidence Limit; BMD: Benchmark Dose; BMC:Benchmark Concentration; LOAEL: Lowest Observed Adverse Effect Level; RfD:Reference Dose; RfC:Reference Concentration; MRL: Minimal Risk Level; MEG: Maximum Exposure Guideline; PAC: Protective Action Criteria

Categorical toxicity labels

Hepatotoxicity Carcinogenicity Mutagenicity Cardiotoxicity Respiratory Toxicity Eye Irritation Endocrine Disruption
Hepatotoxicity Carcinogenicity Mutagenicity Cardiotoxicity Respiratory Toxicity Eye Irritation Endocrine Disruption

Note for Reference:
In addition to directly collecting NP quantitative data from primary literature (where reference will provided as NCBI PMID or DOI links), NPASS also integrated NP toxicity records from domain-specific databases. These databases include:
☉ ToxValDB: a curated database that compiles quantitative toxicity values for chemicals from diverse public sources to support toxicological research and risk assessment.
☉ TOXRIC: a comprehensive, free-to-access, online database providing toxicological/feature data. The toxicity labels are retrieved from this database. [PMID: 36400569]


  Chemically structural similarity

Similar Active Natural Products in NPASS

Top-200 similar NPs were calculated against the active-NP-set (includes approximately 50,000 NPs with experimentally-derived bioactivity available in NPASS)

Similarity is measured using the Tanimoto coefficient (Tc) , which compares the binary fingerprints of two molecules. Tc is calculated as the intersection divided by the union of '1' bits in the fingerprints, ranging from 0 to 1, with 1 indicating highest similarity.

●  The left chart: Distribution of similarity level between NPC129238 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.5 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC182550
0.7209 Intermediate Similarity NPC276356
0.7 Intermediate Similarity NPC143979
0.7 Intermediate Similarity NPC320537
0.551 Remote Similarity NPC246076
0.5417 Remote Similarity NPC208223
0.5283 Remote Similarity NPC64153
0.5283 Remote Similarity NPC608848
0.52 Remote Similarity NPC194859
0.52 Remote Similarity NPC224386

Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC129238 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.5 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
NPD

Bioactivity similarity

  Bioactivity similarity

Similar Natural Products in NPASS

Similarity level is defined by Bioactivity similarity was calculated based on bioactivity descriptors of compounds. The bioactivity descriptors were calculated by a recently developed AI algorithm Chemical Checker (CC) [Nature Biotechnology, 38:1087–1096, 2020; Nature Communications, 12:3932, 2021], which evaluated bioactivity similarities at five levels:
☉ A: chemistry similarity;
☉ B: biological targets similarity;
☉ C: networks similarity;
☉ D: cell-based bioactivity similarity;
☉ E: similarity based on clinical data.
Those 5 categories of CC bioactivity descriptors were calculated and then subjected to manifold projection using UMAP algorithm, to project all NPs on a 2-Dimensional space. The current NP was highlighted with a small circle in the 2-D map. Below figures: left-to-right, A-to-E.

A: chemistry similarity
B: biological targets similarity
C: networks similarity
D: cell-based bioactivity similarity
E: similarity based on clinical data