Drug Information

Drug ID:  NPD5277
Drug Name:  Salirasib
Molecular Formula:  C22H30O2S
Canonical SMILES:  C/C(=CCSc1ccccc1C(=O)O)/CC/C=C(/CCC=C(C)C)C
Standard InCHI:  InChI=1S/C22H30O2S/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-25-21-14-6-5-13-20(21)22(23)24/h5-6,9,11,13-15H,7-8,10,12,16H2,1-4H3,(H,23,24)/b18-11+,19-15+
Standard InCHIKey:  WUILNKCFCLNXOK-CFBAGHHKSA-N
Max Developmental Stage:  Phase 2
Max Developmental Stage Source:  ChEMBL

  Structural Similarity Between NPASS Natural Products and NPD5277

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient
Tanimoto coefficient is calculated based on PubChem 881-bit substructure fingerprints.


  Similar Natural Products

High Similarity Level: Tc>=0.85; Intermediate Similarity Level: 0.7 <= Tc < 0.85; Remote Similarity Level: 0.65 <= Tc < 0.7

Similarity Level Similarity Score Natural Product ID
Intermediate Similarity 0.8131 NPC253423
Intermediate Similarity 0.8077 NPC62765
Intermediate Similarity 0.8056 NPC229242
Intermediate Similarity 0.7982 NPC217621
Intermediate Similarity 0.787 NPC61944
Intermediate Similarity 0.7838 NPC304873
Intermediate Similarity 0.7838 NPC25458
Intermediate Similarity 0.7692 NPC318107
Intermediate Similarity 0.7679 NPC284477
Intermediate Similarity 0.7658 NPC228435
Intermediate Similarity 0.7658 NPC325497
Intermediate Similarity 0.7652 NPC249811
Intermediate Similarity 0.7632 NPC105899
Intermediate Similarity 0.7615 NPC130398
Intermediate Similarity 0.7611 NPC255676
Intermediate Similarity 0.7607 NPC476003
Intermediate Similarity 0.7589 NPC282895
Intermediate Similarity 0.7568 NPC78701
Intermediate Similarity 0.7568 NPC35448
Intermediate Similarity 0.7523 NPC261181
Intermediate Similarity 0.75 NPC146351
Intermediate Similarity 0.7477 NPC276775
Intermediate Similarity 0.7477 NPC92754
Intermediate Similarity 0.7477 NPC249912
Intermediate Similarity 0.7456 NPC474365
Intermediate Similarity 0.7456 NPC301943
Intermediate Similarity 0.7436 NPC85493
Intermediate Similarity 0.7417 NPC153053
Intermediate Similarity 0.7411 NPC225060
Intermediate Similarity 0.7395 NPC66208
Intermediate Similarity 0.7395 NPC321852
Intermediate Similarity 0.7345 NPC203925
Intermediate Similarity 0.7339 NPC110704
Intermediate Similarity 0.7311 NPC260818
Intermediate Similarity 0.7304 NPC291426
Intermediate Similarity 0.7288 NPC318327
Intermediate Similarity 0.7281 NPC70624
Intermediate Similarity 0.7241 NPC324786
Intermediate Similarity 0.7238 NPC285773
Intermediate Similarity 0.7217 NPC188895
Intermediate Similarity 0.7213 NPC186933
Intermediate Similarity 0.7193 NPC118343
Intermediate Similarity 0.7179 NPC269457
Intermediate Similarity 0.7179 NPC472919
Intermediate Similarity 0.7155 NPC329556
Intermediate Similarity 0.7143 NPC10251
Intermediate Similarity 0.7143 NPC469636
Intermediate Similarity 0.7143 NPC17417
Intermediate Similarity 0.7132 NPC475082
Intermediate Similarity 0.7131 NPC474363
Intermediate Similarity 0.7131 NPC211421
Intermediate Similarity 0.713 NPC42211
Intermediate Similarity 0.713 NPC322387
Intermediate Similarity 0.712 NPC474890
Intermediate Similarity 0.712 NPC161943
Intermediate Similarity 0.712 NPC273282
Intermediate Similarity 0.7119 NPC184658
Intermediate Similarity 0.7119 NPC187913
Intermediate Similarity 0.7107 NPC158282
Intermediate Similarity 0.7105 NPC160548
Intermediate Similarity 0.7105 NPC210529
Intermediate Similarity 0.7105 NPC175852
Intermediate Similarity 0.7097 NPC83718
Intermediate Similarity 0.7094 NPC249067
Intermediate Similarity 0.7094 NPC31786
Intermediate Similarity 0.7091 NPC70940
Intermediate Similarity 0.7091 NPC86670
Intermediate Similarity 0.7091 NPC274455
Intermediate Similarity 0.7083 NPC214067
Intermediate Similarity 0.7083 NPC95172
Intermediate Similarity 0.7083 NPC93084
Intermediate Similarity 0.7083 NPC196246
Intermediate Similarity 0.7083 NPC251854
Intermediate Similarity 0.7075 NPC44830
Intermediate Similarity 0.7073 NPC81808
Intermediate Similarity 0.7064 NPC329064
Intermediate Similarity 0.7059 NPC29883
Intermediate Similarity 0.7059 NPC56493
Intermediate Similarity 0.7059 NPC226699
Intermediate Similarity 0.7059 NPC34715
Intermediate Similarity 0.7049 NPC272524
Intermediate Similarity 0.704 NPC160199
Intermediate Similarity 0.7034 NPC209632
Intermediate Similarity 0.7025 NPC1082
Intermediate Similarity 0.7025 NPC474057
Intermediate Similarity 0.7025 NPC305912
Intermediate Similarity 0.7018 NPC289201
Intermediate Similarity 0.7009 NPC160382
Intermediate Similarity 0.7 NPC474364
Intermediate Similarity 0.7 NPC224584
Intermediate Similarity 0.7 NPC100551
Remote Similarity 0.6983 NPC52472
Remote Similarity 0.6975 NPC6984
Remote Similarity 0.6975 NPC119271
Remote Similarity 0.6975 NPC30594
Remote Similarity 0.6975 NPC37622
Remote Similarity 0.6967 NPC82899
Remote Similarity 0.6967 NPC474314
Remote Similarity 0.6967 NPC270699
Remote Similarity 0.696 NPC131192
Remote Similarity 0.696 NPC128825
Remote Similarity 0.6952 NPC127343
Remote Similarity 0.6949 NPC114594
Remote Similarity 0.6949 NPC329282
Remote Similarity 0.6942 NPC216122
Remote Similarity 0.6942 NPC174099
Remote Similarity 0.6937 NPC185501
Remote Similarity 0.6935 NPC476357
Remote Similarity 0.6935 NPC306740
Remote Similarity 0.6929 NPC90522
Remote Similarity 0.6929 NPC472708
Remote Similarity 0.6929 NPC328459
Remote Similarity 0.6923 NPC45613
Remote Similarity 0.6917 NPC211439
Remote Similarity 0.6917 NPC141523
Remote Similarity 0.6916 NPC288903
Remote Similarity 0.6911 NPC128368
Remote Similarity 0.6905 NPC240664
Remote Similarity 0.6899 NPC269923
Remote Similarity 0.6899 NPC167323
Remote Similarity 0.6897 NPC245561
Remote Similarity 0.6885 NPC474157
Remote Similarity 0.6885 NPC116842
Remote Similarity 0.6875 NPC72977
Remote Similarity 0.6864 NPC60679
Remote Similarity 0.6864 NPC89886
Remote Similarity 0.6864 NPC13426
Remote Similarity 0.686 NPC31274
Remote Similarity 0.686 NPC265407
Remote Similarity 0.686 NPC99846
Remote Similarity 0.686 NPC269023
Remote Similarity 0.686 NPC83628
Remote Similarity 0.6855 NPC237366
Remote Similarity 0.6855 NPC307651
Remote Similarity 0.6855 NPC242136
Remote Similarity 0.6852 NPC44546
Remote Similarity 0.685 NPC94637
Remote Similarity 0.685 NPC27633
Remote Similarity 0.685 NPC94298
Remote Similarity 0.6847 NPC173443
Remote Similarity 0.6833 NPC95178
Remote Similarity 0.6833 NPC69332
Remote Similarity 0.6833 NPC29989
Remote Similarity 0.6829 NPC228609
Remote Similarity 0.6825 NPC158157
Remote Similarity 0.6822 NPC115188
Remote Similarity 0.6822 NPC179092
Remote Similarity 0.6822 NPC272454
Remote Similarity 0.6822 NPC244994
Remote Similarity 0.6822 NPC301987
Remote Similarity 0.6822 NPC26433
Remote Similarity 0.6822 NPC35856
Remote Similarity 0.6822 NPC292665
Remote Similarity 0.6822 NPC222876
Remote Similarity 0.6822 NPC159760
Remote Similarity 0.6822 NPC178395
Remote Similarity 0.6822 NPC165197
Remote Similarity 0.6818 NPC194326
Remote Similarity 0.6818 NPC179468
Remote Similarity 0.681 NPC179411
Remote Similarity 0.68 NPC210092
Remote Similarity 0.68 NPC474685
Remote Similarity 0.6797 NPC184579
Remote Similarity 0.6797 NPC233165
Remote Similarity 0.6797 NPC61779
Remote Similarity 0.6794 NPC85511
Remote Similarity 0.6794 NPC174991
Remote Similarity 0.6794 NPC477153
Remote Similarity 0.6789 NPC95965
Remote Similarity 0.6789 NPC294134
Remote Similarity 0.6783 NPC246679
Remote Similarity 0.6777 NPC156648
Remote Similarity 0.6774 NPC161611
Remote Similarity 0.6774 NPC17693
Remote Similarity 0.6772 NPC125252
Remote Similarity 0.6772 NPC269414
Remote Similarity 0.6769 NPC25168
Remote Similarity 0.6752 NPC280869
Remote Similarity 0.675 NPC243677
Remote Similarity 0.675 NPC13495
Remote Similarity 0.6748 NPC210089
Remote Similarity 0.6748 NPC475002
Remote Similarity 0.6748 NPC95126
Remote Similarity 0.6746 NPC322197
Remote Similarity 0.6742 NPC221798
Remote Similarity 0.6724 NPC270654
Remote Similarity 0.6721 NPC469511
Remote Similarity 0.6721 NPC17525
Remote Similarity 0.6721 NPC281604
Remote Similarity 0.672 NPC471721
Remote Similarity 0.672 NPC11824
Remote Similarity 0.6718 NPC297193
Remote Similarity 0.6718 NPC475192
Remote Similarity 0.6718 NPC472703
Remote Similarity 0.6718 NPC67300
Remote Similarity 0.6696 NPC81010
Remote Similarity 0.6696 NPC9822
Remote Similarity 0.6696 NPC220893
Remote Similarity 0.6696 NPC32977
Remote Similarity 0.6695 NPC469481

Drug Structure

External Identifiers

TTD   DNCL002573; DIB015318
DrugBank  
ChEMBL  
IUPHAR/BPS  
PharmaGKB  
KEGG Drug  
PubChem CID   5469318
ChEBI  
CAS Number  

Drug Properties

Molecular Weight  358.20
ALogP  4.383
MLogP  3.55
XLogP  7.191
HDA  2
HBD  1
Rotatable Bonds  15
TPSA  62.6
RO5 Violation  1