Natural Product: NPC67650

Natural Product ID:  NPC67650
Common Name:   Lasiodiplodin
IUPAC Name:   (9S)-15-hydroxy-13-methoxy-9-methyl-10-oxabicyclo[10.4.0]hexadeca-1(12),13,15-trien-11-one
Synonyms:   Lasiodiplodin
Molecular Formula:   C17H24O4
Standard InCHIKey:  OKWRDLQBKAOJNC-LBPRGKRZSA-N
Standard InCHI:  InChI=1S/C17H24O4/c1-12-8-6-4-3-5-7-9-13-10-14(18)11-15(20-2)16(13)17(19)21-12/h10-12,18H,3-9H2,1-2H3/t12-/m0/s1
Canonical SMILES:  COc1cc(O)cc2c1C(=O)O[C@@H](C)CCCCCCC2
First Find Year:  
Max Developmental Stage:  
Synthetic Gene Cluster:   BGC0001245 ;

  Species Source

Organism ID Organism Name Taxonomy Level Family SuperKingdom Isolation Part Collection Location Collection Time Reference
NPO6187 Sequoia sempervirens Species Cupressaceae Eukaryota UNPD*
NPO7534 Leptogorgia sarmentosa Species Gorgoniidae Eukaryota UNPD*
NPO8560 Aplidium tabascum Species Polyclinidae Eukaryota UNPD*
NPO1585 Onobrychis bobrovii Species Fabaceae Eukaryota UNPD*
NPO26058 Erycibe expansa Species Convolvulaceae Eukaryota Stems PMID[17158054]
NPO24931 Myelochroa aurulenta Species Parmeliaceae Eukaryota UNPD*
NPO25216 Senecio vellereus Species Asteraceae Eukaryota UNPD*
NPO5937 Garrya laurifolia Species Garryaceae Eukaryota UNPD*
NPO10221 Streptomyces alboniger Species Streptomycetaceae Bacteria UNPD*
NPO5536 Papaver persicum Species Papaveraceae Eukaryota UNPD*
NPO12600 Trametes cinnabarina Species Coriolaceae Eukaryota UNPD*
NPO2501 Trifolium strepens Species Fabaceae Eukaryota UNPD*
NPO7266 Goupia glabra Species Goupiaceae Eukaryota UNPD*
NPO495 Daemonorops draco Species Arecaceae Eukaryota UNPD*
NPO4858 Helipterum gnaphaloides Species Asteraceae Eukaryota UNPD*
NPO681 Mesua ferrea Species Calophyllaceae Eukaryota UNPD*
NPO1534 Jatropha gossypiifolia Species Euphorbiaceae Eukaryota TCMID*
NPO3707 Chromatium okenii Species Chromatiaceae Bacteria UNPD*
NPO9741 Actinopyga agassizi Species Holothuriidae Eukaryota UNPD*
NPO9717 Wibelia divaricata Species Davalliaceae Eukaryota UNPD*
NPO10376 Arcyria denudata Species Trichiidae Eukaryota UNPD*
NPO10849 Eucalyptus camaldulensis Species Myrtaceae Eukaryota UNPD*
NPO3302 Fusarium avenaceum Species Nectriaceae Eukaryota UNPD*
NPO4221 Fusarium sacchari Species Nectriaceae Eukaryota UNPD*
NPO5021 Podospora curvicolla Species Lasiosphaeriaceae Eukaryota UNPD*
NPO2703 Petteria ramentacea Species Fabaceae Eukaryota UNPD*
NPO7963 Excoecaria acerifolia Species Euphorbiaceae Eukaryota UNPD*
NPO6249 Garcinia mangostana Species Clusiaceae Eukaryota UNPD*
NPO8927 Poria selecta Species Coccinellidae Eukaryota UNPD*
NPO4064 Halimodendron halodendron Species Fabaceae Eukaryota UNPD*
NPO3449 Lonicera hypoleuca Species Caprifoliaceae Eukaryota UNPD*
NPO823 Senecio cathcartensis Species Asteraceae Eukaryota UNPD*
NPO11021 Moringa oleifera Species Moringaceae Eukaryota UNPD*
NPO8703 Monopteryx uaucu Species Fabaceae Eukaryota UNPD*
NPO10056 Nicotiana sylvestris Species Solanaceae Eukaryota UNPD*
NPO8339 Lithothamnion corallioides Species Hapalidiaceae Eukaryota UNPD*
NPO27924 Serpocaulon triseriale Species Polypodiaceae Eukaryota UNPD*
NPO4410 Laggera alata Species Asteraceae Eukaryota UNPD*
NPO7811 Scleronephthya pallida Species Nephtheidae Eukaryota UNPD*
NPO10391 Dolomiaea souliei Species Asteraceae Eukaryota UNPD*
NPO8354 Aster bellidiastrum Species Asteraceae Eukaryota UNPD*
NPO3905 Medinilla magnifica Species Melastomataceae Eukaryota UNPD*

  Biological Activity

Target ID Target Type Target Name Target Organism Activity Type Activity Relation Value Unit Reference
NPT637 Organism Fusarium oxysporum Fusarium oxysporum MIC = 100 ug/ml 16781152
NPT20 Organism Candida albicans Candida albicans MIC > 100 ug/ml 16781152
NPT3608 Organism Salmonella enteritidis Salmonella enterica subsp. enterica serovar Enteritidis MIC > 100 ug/ml 16781152
NPT19 Organism Escherichia coli Escherichia coli MIC > 100 ug/ml 16781152
NPT79 Organism Bacillus subtilis Bacillus subtilis MIC = 50 ug/ml 16781152
NPT16 Organism Staphylococcus aureus Staphylococcus aureus MIC = 25 ug/ml 16781152
NPT466 Cell Line U-937 Homo sapiens IC50 = 36000 nM 17158054
NPT466 Cell Line U-937 Homo sapiens IC50 = 28000 nM 17158054
NPT466 Cell Line U-937 Homo sapiens IC50 = 20000 nM 17158054
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 49.4 % 17432876
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 54.5 % 17432876
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 62.3 % 17432876
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 84.1 % 17432876
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 87.5 % 17432876
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 95.6 % 17432876
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 97.7 % 17432876
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 98.5 % 17432876
NPT3609 Protein Complex Chloroplast coupling factor 1 Spinacia oleracea Inhibition = 95 % 17432876
NPT2 Others Unspecified Inhibition = 27 % 17432876
NPT2 Others Unspecified Inhibition = 75 % 17432876
NPT2 Others Unspecified Inhibition = 87 % 17432876
NPT2 Others Unspecified Inhibition = 0 % 17432876
NPT2 Others Unspecified Inhibition = 40 % 17432876
NPT2 Others Unspecified Inhibition = 70 % 17432876
NPT2 Others Unspecified Inhibition = 80 % 17432876
NPT2 Others Unspecified Inhibition = 133 % 17432876
NPT2 Others Unspecified Inhibition = 200 % 17432876
NPT2 Others Unspecified Inhibition = 266 % 17432876
NPT597 Organism Spinacia oleracea Spinacia oleracea Inhibition = 100 % 17432876
NPT597 Organism Spinacia oleracea Spinacia oleracea IC50 = 35600 nM 17432876

  Similar Natural Products in NPASS

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules. Tc lies between [0, 1] where '1' indicates the highest similarity. What is Tanimoto coefficient

●  The left chart: Distribution of similarity level between NPC67650 and all remaining natural products in the NPASS database.
●  The right table: Most similar natural products (Tc>=0.56 or Top200).

Similarity Score Similarity Level Natural Product ID
1.0 High Similarity NPC1704
0.9853 High Similarity NPC51106
0.9853 High Similarity NPC472006
0.9779 High Similarity NPC474385
0.9708 High Similarity NPC469542
0.9706 High Similarity NPC475730
0.9701 High Similarity NPC70380
0.9701 High Similarity NPC135837
0.964 High Similarity NPC107625
0.9638 High Similarity NPC277426
0.9638 High Similarity NPC280404
0.9638 High Similarity NPC86373
0.9638 High Similarity NPC210425
0.9635 High Similarity NPC469579
0.963 High Similarity NPC191835
0.963 High Similarity NPC212693
0.963 High Similarity NPC94248
0.9568 High Similarity NPC472034
0.9552 High Similarity NPC182496
0.9552 High Similarity NPC180905
0.95 High Similarity NPC472033
0.9493 High Similarity NPC250755
0.9485 High Similarity NPC478200
0.9485 High Similarity NPC33144
0.9485 High Similarity NPC472602
0.9433 High Similarity NPC210320
0.9433 High Similarity NPC472036
0.9429 High Similarity NPC134621
0.942 High Similarity NPC158634
0.942 High Similarity NPC313123
0.942 High Similarity NPC53649
0.942 High Similarity NPC90411
0.942 High Similarity NPC478217
0.9416 High Similarity NPC32360
0.9416 High Similarity NPC139634
0.9416 High Similarity NPC105456
0.9412 High Similarity NPC71256
0.9403 High Similarity NPC153783
0.9371 High Similarity NPC469670
0.9371 High Similarity NPC469619
0.9366 High Similarity NPC471641
0.9366 High Similarity NPC240253
0.9366 High Similarity NPC471642
0.9366 High Similarity NPC73411
0.9366 High Similarity NPC215711
0.9366 High Similarity NPC240622
0.9362 High Similarity NPC237208
0.9357 High Similarity NPC66404
0.9357 High Similarity NPC95123
0.9348 High Similarity NPC472601
0.9348 High Similarity NPC165172
0.9348 High Similarity NPC158472
0.9348 High Similarity NPC472600
0.9338 High Similarity NPC235115
0.9306 High Similarity NPC240768
0.9306 High Similarity NPC70016
0.9306 High Similarity NPC215921
0.9306 High Similarity NPC200773
0.9301 High Similarity NPC270160
0.9301 High Similarity NPC237440
0.9301 High Similarity NPC476684
0.9291 High Similarity NPC29577
0.9291 High Similarity NPC312789
0.9286 High Similarity NPC159721
0.9286 High Similarity NPC478202
0.9281 High Similarity NPC478201
0.9281 High Similarity NPC472605
0.9281 High Similarity NPC472603
0.9281 High Similarity NPC472604
0.9281 High Similarity NPC472035
0.9275 High Similarity NPC268052
0.927 High Similarity NPC178467
0.927 High Similarity NPC474849
0.927 High Similarity NPC194579
0.927 High Similarity NPC149372
0.927 High Similarity NPC65837
0.927 High Similarity NPC474771
0.9254 High Similarity NPC219892
0.9254 High Similarity NPC189823
0.9225 High Similarity NPC163846
0.9225 High Similarity NPC225173
0.922 High Similarity NPC151607
0.922 High Similarity NPC42540
0.9214 High Similarity NPC105648
0.9214 High Similarity NPC96692
0.9203 High Similarity NPC475974
0.9191 High Similarity NPC175943
0.9167 High Similarity NPC4423
0.9167 High Similarity NPC291049
0.9167 High Similarity NPC233267
0.9167 High Similarity NPC77325
0.9161 High Similarity NPC8817
0.9161 High Similarity NPC125801
0.9161 High Similarity NPC14098
0.9155 High Similarity NPC83272
0.9155 High Similarity NPC473692
0.9155 High Similarity NPC75694
0.9149 High Similarity NPC471643
0.9149 High Similarity NPC472610
0.9149 High Similarity NPC471731
0.9149 High Similarity NPC471639
0.9143 High Similarity NPC220106
0.9143 High Similarity NPC244923
0.9137 High Similarity NPC88269
0.9116 High Similarity NPC79998
0.9116 High Similarity NPC99381
0.9116 High Similarity NPC16082
0.9116 High Similarity NPC82592
0.911 High Similarity NPC273483
0.911 High Similarity NPC167903
0.9103 High Similarity NPC179178
0.9103 High Similarity NPC475460
0.9103 High Similarity NPC60413
0.9097 High Similarity NPC37139
0.9097 High Similarity NPC153417
0.9097 High Similarity NPC172329
0.9097 High Similarity NPC105415
0.9097 High Similarity NPC2569
0.9091 High Similarity NPC473023
0.9091 High Similarity NPC470357
0.9091 High Similarity NPC267509
0.9085 High Similarity NPC210966
0.9085 High Similarity NPC126882
0.9085 High Similarity NPC478203
0.9085 High Similarity NPC470932
0.9078 High Similarity NPC471640
0.9078 High Similarity NPC49108
0.9078 High Similarity NPC471733
0.9078 High Similarity NPC471644
0.9071 High Similarity NPC155205
0.9065 High Similarity NPC9121
0.9065 High Similarity NPC177307
0.9065 High Similarity NPC472403
0.9058 High Similarity NPC50455
0.9058 High Similarity NPC158481
0.9054 High Similarity NPC150227
0.9054 High Similarity NPC472050
0.9048 High Similarity NPC472799
0.9048 High Similarity NPC281477
0.9044 High Similarity NPC476389
0.9041 High Similarity NPC133856
0.9034 High Similarity NPC6923
0.903 High Similarity NPC293453
0.9028 High Similarity NPC137296
0.9028 High Similarity NPC12305
0.9021 High Similarity NPC257558
0.9021 High Similarity NPC32470
0.9014 High Similarity NPC310340
0.9007 High Similarity NPC16455
0.9007 High Similarity NPC37530
0.9007 High Similarity NPC307990
0.9 High Similarity NPC52358
0.9 High Similarity NPC275356
0.9 High Similarity NPC247409
0.9 High Similarity NPC474655
0.9 High Similarity NPC92655
0.8993 High Similarity NPC190020
0.8993 High Similarity NPC470398
0.8993 High Similarity NPC84935
0.8993 High Similarity NPC470397
0.8993 High Similarity NPC77679
0.8986 High Similarity NPC89625
0.8986 High Similarity NPC142027
0.8986 High Similarity NPC27407
0.8986 High Similarity NPC144027
0.8986 High Similarity NPC149618
0.8986 High Similarity NPC236974
0.8986 High Similarity NPC199926
0.8978 High Similarity NPC203817
0.8973 High Similarity NPC96501
0.8973 High Similarity NPC150928
0.8973 High Similarity NPC158866
0.8973 High Similarity NPC309979
0.8973 High Similarity NPC307780
0.8973 High Similarity NPC119929
0.8966 High Similarity NPC221352
0.8958 High Similarity NPC138978
0.8958 High Similarity NPC260946
0.8951 High Similarity NPC184702
0.8944 High Similarity NPC297985
0.8944 High Similarity NPC82913
0.8936 High Similarity NPC99441
0.8933 High Similarity NPC470339
0.8926 High Similarity NPC227062
0.8921 High Similarity NPC242712
0.8921 High Similarity NPC84699
0.8921 High Similarity NPC291454
0.8912 High Similarity NPC72958
0.8912 High Similarity NPC232645
0.8912 High Similarity NPC204350
0.8905 High Similarity NPC470160
0.8897 High Similarity NPC471734
0.8897 High Similarity NPC17840
0.8897 High Similarity NPC247477
0.8897 High Similarity NPC42292
0.8897 High Similarity NPC307732
0.8881 High Similarity NPC354984
0.8881 High Similarity NPC84266
0.8881 High Similarity NPC73028
0.8874 High Similarity NPC472055

  Similar Clinical/Approved Drugs

Similarity level is defined by Tanimoto coefficient (Tc) between two molecules.

●  The left chart: Distribution of similarity level between NPC67650 and all drugs/candidates.
●  The right table: Most similar clinical/approved drugs (Tc>=0.56 or Top200).

Similarity Score Similarity Level Drug ID Developmental Stage
0.9416 High Similarity NPD970 Clinical (unspecified phase)
0.9155 High Similarity NPD2533 Approved
0.9155 High Similarity NPD2534 Approved
0.9155 High Similarity NPD2532 Approved
0.8792 High Similarity NPD7819 Suspended
0.8531 High Similarity NPD1550 Clinical (unspecified phase)
0.8531 High Similarity NPD1552 Clinical (unspecified phase)
0.8521 High Similarity NPD1510 Phase 2
0.85 High Similarity NPD1240 Approved
0.8472 Intermediate Similarity NPD1549 Phase 2
0.8421 Intermediate Similarity NPD2393 Clinical (unspecified phase)
0.8397 Intermediate Similarity NPD6232 Discontinued
0.838 Intermediate Similarity NPD1607 Approved
0.8378 Intermediate Similarity NPD4378 Clinical (unspecified phase)
0.8377 Intermediate Similarity NPD7075 Discontinued
0.8356 Intermediate Similarity NPD3750 Approved
0.8355 Intermediate Similarity NPD1934 Approved
0.8333 Intermediate Similarity NPD2796 Approved
0.8333 Intermediate Similarity NPD2935 Discontinued
0.8333 Intermediate Similarity NPD6959 Discontinued
0.8311 Intermediate Similarity NPD6799 Approved
0.8301 Intermediate Similarity NPD7096 Clinical (unspecified phase)
0.8289 Intermediate Similarity NPD7411 Suspended
0.828 Intermediate Similarity NPD5710 Approved
0.828 Intermediate Similarity NPD5711 Approved
0.8247 Intermediate Similarity NPD8443 Clinical (unspecified phase)
0.8239 Intermediate Similarity NPD7473 Discontinued
0.8231 Intermediate Similarity NPD1878 Clinical (unspecified phase)
0.8227 Intermediate Similarity NPD6859 Clinical (unspecified phase)
0.8224 Intermediate Similarity NPD6599 Discontinued
0.8224 Intermediate Similarity NPD4380 Phase 2
0.8207 Intermediate Similarity NPD1551 Phase 2
0.8194 Intermediate Similarity NPD4868 Clinical (unspecified phase)
0.8194 Intermediate Similarity NPD7768 Phase 2
0.8182 Intermediate Similarity NPD230 Phase 1
0.8141 Intermediate Similarity NPD3749 Approved
0.8129 Intermediate Similarity NPD3817 Phase 2
0.8117 Intermediate Similarity NPD6801 Discontinued
0.8077 Intermediate Similarity NPD3882 Suspended
0.8067 Intermediate Similarity NPD1511 Approved
0.8065 Intermediate Similarity NPD2801 Approved
0.8063 Intermediate Similarity NPD7852 Clinical (unspecified phase)
0.8041 Intermediate Similarity NPD2800 Approved
0.8025 Intermediate Similarity NPD4381 Clinical (unspecified phase)
0.8025 Intermediate Similarity NPD5844 Phase 1
0.8014 Intermediate Similarity NPD3748 Approved
0.8013 Intermediate Similarity NPD7410 Clinical (unspecified phase)
0.8 Intermediate Similarity NPD6651 Approved
0.7987 Intermediate Similarity NPD4628 Phase 3
0.7987 Intermediate Similarity NPD6398 Clinical (unspecified phase)
0.7961 Intermediate Similarity NPD1512 Approved
0.795 Intermediate Similarity NPD6166 Phase 2
0.795 Intermediate Similarity NPD6167 Clinical (unspecified phase)
0.795 Intermediate Similarity NPD6168 Clinical (unspecified phase)
0.7941 Intermediate Similarity NPD9545 Approved
0.7919 Intermediate Similarity NPD1243 Approved
0.7919 Intermediate Similarity NPD7421 Clinical (unspecified phase)
0.7914 Intermediate Similarity NPD9717 Approved
0.7891 Intermediate Similarity NPD1509 Clinical (unspecified phase)
0.7866 Intermediate Similarity NPD7074 Phase 3
0.7853 Intermediate Similarity NPD3818 Discontinued
0.7838 Intermediate Similarity NPD6099 Approved
0.7838 Intermediate Similarity NPD6100 Approved
0.7834 Intermediate Similarity NPD1465 Phase 2
0.7806 Intermediate Similarity NPD3226 Approved
0.7805 Intermediate Similarity NPD7054 Approved
0.7794 Intermediate Similarity NPD9493 Approved
0.7792 Intermediate Similarity NPD920 Approved
0.7792 Intermediate Similarity NPD5403 Approved
0.7785 Intermediate Similarity NPD5402 Approved
0.777 Intermediate Similarity NPD2799 Discontinued
0.7763 Intermediate Similarity NPD643 Clinical (unspecified phase)
0.7758 Intermediate Similarity NPD7472 Approved
0.7746 Intermediate Similarity NPD1203 Approved
0.7725 Intermediate Similarity NPD4338 Clinical (unspecified phase)
0.7724 Intermediate Similarity NPD411 Approved
0.7714 Intermediate Similarity NPD422 Phase 1
0.7712 Intermediate Similarity NPD7390 Discontinued
0.7711 Intermediate Similarity NPD5953 Discontinued
0.7711 Intermediate Similarity NPD6797 Phase 2
0.7708 Intermediate Similarity NPD6832 Phase 2
0.7702 Intermediate Similarity NPD5494 Approved
0.7698 Intermediate Similarity NPD4626 Approved
0.7697 Intermediate Similarity NPD7804 Clinical (unspecified phase)
0.7687 Intermediate Similarity NPD447 Suspended
0.7682 Intermediate Similarity NPD2654 Approved
0.7667 Intermediate Similarity NPD2346 Discontinued
0.7665 Intermediate Similarity NPD6559 Discontinued
0.7665 Intermediate Similarity NPD7251 Discontinued
0.7662 Intermediate Similarity NPD5401 Approved
0.7662 Intermediate Similarity NPD7004 Clinical (unspecified phase)
0.7662 Intermediate Similarity NPD642 Clinical (unspecified phase)
0.766 Intermediate Similarity NPD1608 Approved
0.7658 Intermediate Similarity NPD37 Approved
0.7651 Intermediate Similarity NPD7033 Discontinued
0.7651 Intermediate Similarity NPD651 Clinical (unspecified phase)
0.764 Intermediate Similarity NPD6234 Discontinued
0.764 Intermediate Similarity NPD919 Approved
0.7626 Intermediate Similarity NPD5691 Approved
0.7625 Intermediate Similarity NPD4965 Approved
0.7625 Intermediate Similarity NPD4966 Approved
0.7625 Intermediate Similarity NPD4967 Phase 2
0.7619 Intermediate Similarity NPD7808 Phase 3
0.7619 Intermediate Similarity NPD943 Approved
0.7605 Intermediate Similarity NPD7993 Clinical (unspecified phase)
0.7603 Intermediate Similarity NPD1699 Clinical (unspecified phase)
0.7603 Intermediate Similarity NPD3764 Approved
0.76 Intermediate Similarity NPD5404 Approved
0.76 Intermediate Similarity NPD5408 Approved
0.76 Intermediate Similarity NPD5406 Approved
0.76 Intermediate Similarity NPD5405 Approved
0.759 Intermediate Similarity NPD7286 Phase 2
0.758 Intermediate Similarity NPD5808 Clinical (unspecified phase)
0.7572 Intermediate Similarity NPD7879 Clinical (unspecified phase)
0.7568 Intermediate Similarity NPD1899 Clinical (unspecified phase)
0.7564 Intermediate Similarity NPD6980 Clinical (unspecified phase)
0.755 Intermediate Similarity NPD2344 Approved
0.7546 Intermediate Similarity NPD7199 Phase 2
0.75 Intermediate Similarity NPD7229 Phase 3
0.75 Intermediate Similarity NPD2797 Approved
0.7484 Intermediate Similarity NPD6143 Clinical (unspecified phase)
0.7483 Intermediate Similarity NPD3268 Approved
0.7466 Intermediate Similarity NPD4908 Phase 1
0.7455 Intermediate Similarity NPD7184 Clinical (unspecified phase)
0.7453 Intermediate Similarity NPD4288 Approved
0.745 Intermediate Similarity NPD5124 Phase 1
0.745 Intermediate Similarity NPD5123 Clinical (unspecified phase)
0.7448 Intermediate Similarity NPD2798 Approved
0.7448 Intermediate Similarity NPD1019 Discontinued
0.7447 Intermediate Similarity NPD1778 Approved
0.7447 Intermediate Similarity NPD17 Approved
0.7431 Intermediate Similarity NPD1283 Approved
0.7413 Intermediate Similarity NPD9269 Phase 2
0.7412 Intermediate Similarity NPD4419 Clinical (unspecified phase)
0.7403 Intermediate Similarity NPD7003 Approved
0.7389 Intermediate Similarity NPD6273 Approved
0.7383 Intermediate Similarity NPD4060 Phase 1
0.7376 Intermediate Similarity NPD9268 Approved
0.7365 Intermediate Similarity NPD2313 Discontinued
0.7365 Intermediate Similarity NPD1296 Phase 2
0.7365 Intermediate Similarity NPD4907 Clinical (unspecified phase)
0.7361 Intermediate Similarity NPD4749 Approved
0.7356 Intermediate Similarity NPD8397 Clinical (unspecified phase)
0.7355 Intermediate Similarity NPD2309 Approved
0.7349 Intermediate Similarity NPD3926 Phase 2
0.7346 Intermediate Similarity NPD5353 Approved
0.7343 Intermediate Similarity NPD1610 Phase 2
0.7343 Intermediate Similarity NPD1201 Approved
0.7333 Intermediate Similarity NPD6355 Discontinued
0.7329 Intermediate Similarity NPD6917 Clinical (unspecified phase)
0.7321 Intermediate Similarity NPD7228 Approved
0.732 Intermediate Similarity NPD6003 Clinical (unspecified phase)
0.732 Intermediate Similarity NPD6006 Clinical (unspecified phase)
0.732 Intermediate Similarity NPD6002 Phase 3
0.732 Intermediate Similarity NPD6005 Phase 3
0.732 Intermediate Similarity NPD6004 Phase 3
0.7303 Intermediate Similarity NPD4308 Phase 3
0.7297 Intermediate Similarity NPD3027 Phase 3
0.7297 Intermediate Similarity NPD4625 Phase 3
0.7279 Intermediate Similarity NPD9494 Approved
0.7273 Intermediate Similarity NPD3496 Discontinued
0.7267 Intermediate Similarity NPD7615 Clinical (unspecified phase)
0.7267 Intermediate Similarity NPD8312 Approved
0.7267 Intermediate Similarity NPD8313 Approved
0.7267 Intermediate Similarity NPD2979 Phase 3
0.726 Intermediate Similarity NPD1470 Approved
0.726 Intermediate Similarity NPD1164 Approved
0.7255 Intermediate Similarity NPD4476 Approved
0.7255 Intermediate Similarity NPD4477 Approved
0.7255 Intermediate Similarity NPD2438 Suspended
0.7251 Intermediate Similarity NPD3658 Clinical (unspecified phase)
0.725 Intermediate Similarity NPD7458 Discontinued
0.7248 Intermediate Similarity NPD6410 Clinical (unspecified phase)
0.7248 Intermediate Similarity NPD6798 Discontinued
0.7246 Intermediate Similarity NPD5242 Approved
0.7243 Intermediate Similarity NPD8151 Discontinued
0.7229 Intermediate Similarity NPD1247 Approved
0.7222 Intermediate Similarity NPD1281 Approved
0.7222 Intermediate Similarity NPD1547 Clinical (unspecified phase)
0.7219 Intermediate Similarity NPD3751 Discontinued
0.7219 Intermediate Similarity NPD7177 Discontinued
0.7206 Intermediate Similarity NPD74 Approved
0.7206 Intermediate Similarity NPD9266 Approved
0.7192 Intermediate Similarity NPD3225 Approved
0.7186 Intermediate Similarity NPD3787 Discontinued
0.7183 Intermediate Similarity NPD1548 Phase 1
0.7172 Intermediate Similarity NPD3972 Approved
0.7163 Intermediate Similarity NPD405 Clinical (unspecified phase)
0.7159 Intermediate Similarity NPD4287 Approved
0.7158 Intermediate Similarity NPD7435 Discontinued
0.7152 Intermediate Similarity NPD1612 Clinical (unspecified phase)
0.7152 Intermediate Similarity NPD1613 Approved
0.7143 Intermediate Similarity NPD3267 Approved
0.7143 Intermediate Similarity NPD3266 Approved
0.7143 Intermediate Similarity NPD8150 Discontinued
0.7134 Intermediate Similarity NPD6190 Approved
0.7132 Intermediate Similarity NPD9265 Clinical (unspecified phase)
0.7132 Intermediate Similarity NPD9264 Approved
0.7132 Intermediate Similarity NPD9267 Approved
0.7132 Intermediate Similarity NPD9263 Approved

Structure

External Identifiers

PubChem CID   14562696
ChEMBL   CHEMBL393258
ZINC  

Physicochemical Properties

Molecular Weight:  292.17
ALogP:  -2.2679
MLogP:  2.89
XLogP:  5.001
# Rotatable Bonds:  4
Polar Surface Area:  55.76
# H-Bond Aceptor:  2
# H-Bond Donor:  1
# Rings:  2
# Heavy Atoms:  21

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